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Volumn 4, Issue 3, 2008, Pages 189-199

Curcumin conjugates and metallocomplexes as lead compounds for development of anticancer agents - A short review

Author keywords

Antiproliferative activity; Cancer; Curcumin; Curcumin conjugates and metallocomplexes

Indexed keywords

ANTINEOPLASTIC AGENT; CURCUMIN; CURCUMIN GOLD COMPLEX; CURCUMIN VANADYL COMPLEX; DIGLUTAMOYLCURCUMIN; DIGLYCINOYLCURCUMIN; DIVALINOYLCURCUMIN; IMATINIB; MACROGOL; NONSTEROID ANTIINFLAMMATORY AGENT; UNCLASSIFIED DRUG; VITAMIN;

EID: 65649109015     PISSN: 15734072     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340708786305934     Document Type: Review
Times cited : (4)

References (124)
  • 1
    • 23644455476 scopus 로고    scopus 로고
    • Drug therapy for acute myeloid leukemia
    • Tallman, M. S., Gilliland, D. G., Rowe, J. M. (2005) Drug therapy for acute myeloid leukemia. Blood, 106, 1154-1163.
    • (2005) Blood , vol.106 , pp. 1154-1163
    • Tallman, M.S.1    Gilliland, D.G.2    Rowe, J.M.3
  • 2
    • 33847234222 scopus 로고    scopus 로고
    • Treatment of relapsed or refractory acute promyelocytic leukemia
    • Tallman, M. S. (2007) Treatment of relapsed or refractory acute promyelocytic leukemia. Best Pract. Res. Clin. Haematol., 20, 57-65.
    • (2007) Best Pract. Res. Clin. Haematol , vol.20 , pp. 57-65
    • Tallman, M.S.1
  • 3
    • 0042844744 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the period 1981-2002
    • Newman, D. J., Cragg, G. M., Snader, K. M. (2003) Natural products as sources of new drugs over the period 1981-2002. J. Nat. Prod., 66, 1022-1037.
    • (2003) J. Nat. Prod , vol.66 , pp. 1022-1037
    • Newman, D.J.1    Cragg, G.M.2    Snader, K.M.3
  • 4
    • 11344292132 scopus 로고    scopus 로고
    • The role of natural product chemistry in drug discovery
    • Butler, M. S. (2004) The role of natural product chemistry in drug discovery. J. Nat. Prod., 67, 2141-2153.
    • (2004) J. Nat. Prod , vol.67 , pp. 2141-2153
    • Butler, M.S.1
  • 5
    • 17844399025 scopus 로고    scopus 로고
    • Natural products to drugs: Natural product derived compounds in clinical trials
    • Butler, M.S. (2005) Natural products to drugs: Natural product derived compounds in clinical trials. Nat. Prod. Rep., 22, 162-195.
    • (2005) Nat. Prod. Rep , vol.22 , pp. 162-195
    • Butler, M.S.1
  • 6
    • 1442310071 scopus 로고    scopus 로고
    • Current developments in the discovery and design of new drug candidates from plant natural product leads
    • Lee, K. H. (2004) Current developments in the discovery and design of new drug candidates from plant natural product leads. J. Nat. Prod., 67, 273-283.
    • (2004) J. Nat. Prod , vol.67 , pp. 273-283
    • Lee, K.H.1
  • 8
    • 50149096855 scopus 로고    scopus 로고
    • Wound healing agents: The role of natural and non-natural products in drug development
    • de Fátima, A., Modolo, L. V., Sanches, A. C. C., Porto, R. R. (2008) Wound healing agents: The role of natural and non-natural products in drug development. Mini-Rev. Med. Chem., 8, 879-888.
    • (2008) Mini-Rev. Med. Chem , vol.8 , pp. 879-888
    • de Fátima, A.1    Modolo, L.V.2    Sanches, A.C.C.3    Porto, R.R.4
  • 10
    • 6444221181 scopus 로고    scopus 로고
    • Turmeric and curcumin: Biological actions and medicinal applications
    • Chattopadhyay, I., Biswas, K., Bandyopadhyay, U., Banerjee, R. K. (2004) Turmeric and curcumin: Biological actions and medicinal applications. Curr. Sci., 87, 44-53.
    • (2004) Curr. Sci , vol.87 , pp. 44-53
    • Chattopadhyay, I.1    Biswas, K.2    Bandyopadhyay, U.3    Banerjee, R.K.4
  • 13
    • 33644780779 scopus 로고    scopus 로고
    • Antitumor agents 247. New 4-ethoxycarbonylethyl curcumin analogues as potential antiandrogenic agents
    • Lin, L., Shi, Q., Su, C. Y., Shih, C. C. Y., Lee, K. H. (2006) Antitumor agents 247. New 4-ethoxycarbonylethyl curcumin analogues as potential antiandrogenic agents. Bioorg. Med. Chem., 14, 2527-2534.
    • (2006) Bioorg. Med. Chem , vol.14 , pp. 2527-2534
    • Lin, L.1    Shi, Q.2    Su, C.Y.3    Shih, C.C.Y.4    Lee, K.H.5
  • 14
    • 33745642485 scopus 로고    scopus 로고
    • Antitumor agents. 250. Design and synthesis of new curcumin analogues as potential antiprostate cancer agents
    • Lin, L., Shi, Q., Nyarko, A. K., Bastow, K. F., Wu, C. -C., Su, C. -Y., Shih, C. C. -Y., Lee, K. -H. (2006) Antitumor agents. 250. Design and synthesis of new curcumin analogues as potential antiprostate cancer agents. J. Med. Chem., 49, 3963-3972.
    • (2006) J. Med. Chem , vol.49 , pp. 3963-3972
    • Lin, L.1    Shi, Q.2    Nyarko, A.K.3    Bastow, K.F.4    Wu, C.-C.5    Su, C.-Y.6    Shih, C.C.-Y.7    Lee, K.-H.8
  • 18
    • 0037420997 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of angiogenesis inhibitors: Aromatic enone and dienone analogues of curcumin
    • Robinson, T. P., Ehlers, T., Hubbard, R. B., Bai, X., Arbiser, J. L., Goldsmith, D. J., Bowen, J. P. (2003) Design, synthesis, and biological evaluation of angiogenesis inhibitors: Aromatic enone and dienone analogues of curcumin. Bioorg. Med. Chem., 13, 115-117.
    • (2003) Bioorg. Med. Chem , vol.13 , pp. 115-117
    • Robinson, T.P.1    Ehlers, T.2    Hubbard, R.B.3    Bai, X.4    Arbiser, J.L.5    Goldsmith, D.J.6    Bowen, J.P.7
  • 19
    • 0035404019 scopus 로고    scopus 로고
    • Biological acitivities of Curcuma longa L
    • Araújo, C. A. C., Leon, L. L. (2001) Biological acitivities of Curcuma longa L. Mem. Inst. Oswaldo Cruz, 96, 723-728.
    • (2001) Mem. Inst. Oswaldo Cruz , vol.96 , pp. 723-728
    • Araújo, C.A.C.1    Leon, L.L.2
  • 20
    • 0037236792 scopus 로고    scopus 로고
    • Anticancer potential of curcumin: Preclinical and clinical studies
    • Aggarwal, B. B., Kumar, A., Bharti, A. C. (2003) Anticancer potential of curcumin: Preclinical and clinical studies. Anticancer Res., 23, 363-398.
    • (2003) Anticancer Res , vol.23 , pp. 363-398
    • Aggarwal, B.B.1    Kumar, A.2    Bharti, A.C.3
  • 24
    • 84934442428 scopus 로고    scopus 로고
    • In The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease
    • Aggarwal, B. B, Surh, Y.-J, Shishodia, S, Eds, Chapter 5, p
    • Surh, Y. -J., Chun, K. -S. (2007) In The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease, Aggarwal, B. B.; Surh, Y.-J., Shishodia, S., Eds.; Springer US, Vol. 595, Chapter 5, p 149-172.
    • (2007) Springer US , vol.595 , pp. 149-172
    • Surh, Y.-J.1    Chun, K.-S.2
  • 28
    • 8544264618 scopus 로고    scopus 로고
    • Complementary inhibition of synoviocyte, smooth muscle cell or mouse lymphoma cell proliferation by a vanadyl curcumin complex compared to curcumin alone
    • Thompson, K. H., Bohmerle, K., Polishchuk, E., Martins, C., Toleikis, P., Tse, J., Yuen, V., McNeill, J. H., Orvig, C. (2004) Complementary inhibition of synoviocyte, smooth muscle cell or mouse lymphoma cell proliferation by a vanadyl curcumin complex compared to curcumin alone. J. Inorg. Biochem., 98, 2063-2070.
    • (2004) J. Inorg. Biochem , vol.98 , pp. 2063-2070
    • Thompson, K.H.1    Bohmerle, K.2    Polishchuk, E.3    Martins, C.4    Toleikis, P.5    Tse, J.6    Yuen, V.7    McNeill, J.H.8    Orvig, C.9
  • 32
    • 26044472889 scopus 로고    scopus 로고
    • Research of anti-proliferation of curcumin on A549 human lung cancer cells and its mechanism
    • Zhang, J., Qi, H., Wu, C. (2004) Research of anti-proliferation of curcumin on A549 human lung cancer cells and its mechanism. J. Chin. Med. Mat., 27, 923-927.
    • (2004) J. Chin. Med. Mat , vol.27 , pp. 923-927
    • Zhang, J.1    Qi, H.2    Wu, C.3
  • 33
  • 34
    • 0034836540 scopus 로고    scopus 로고
    • Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells
    • Pan, M. -H., Chang, W. -L., Lin-Shiau, S. -Y., Ho, C. -T., Lin, J. -K. (2001) Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells. J. Agric. Food Chem., 49, 1464-1474.
    • (2001) J. Agric. Food Chem , vol.49 , pp. 1464-1474
    • Pan, M.-H.1    Chang, W.-L.2    Lin-Shiau, S.-Y.3    Ho, C.-T.4    Lin, J.-K.5
  • 35
    • 33748528961 scopus 로고    scopus 로고
    • Induction of early apoptosis and ROS-generation activity in human gingival fibroblasts (HGF) and human submandibular gland carcinoma (HSG) cells treated with curcumin
    • Atsumi, T., Tonosaki, K., Fujisawa, S. (2006) Induction of early apoptosis and ROS-generation activity in human gingival fibroblasts (HGF) and human submandibular gland carcinoma (HSG) cells treated with curcumin. Arch. Oral Biol., 51, 913-921.
    • (2006) Arch. Oral Biol , vol.51 , pp. 913-921
    • Atsumi, T.1    Tonosaki, K.2    Fujisawa, S.3
  • 36
    • 33244476761 scopus 로고    scopus 로고
    • Antiproliferation and apoptosis induced by curcumin in human ovarian cancer cells
    • Shi, M., Cai, Q., Yao, L., Mao, Y., Ming, Y., Ouyang, G. (2006) Antiproliferation and apoptosis induced by curcumin in human ovarian cancer cells. Cell Biol. Inter., 30, 221-226.
    • (2006) Cell Biol. Inter , vol.30 , pp. 221-226
    • Shi, M.1    Cai, Q.2    Yao, L.3    Mao, Y.4    Ming, Y.5    Ouyang, G.6
  • 38
    • 0032466079 scopus 로고    scopus 로고
    • The inhibition of the estrogenic effects of pesticides and environmental chemicals by curcumin and isoflavonoids
    • Verma, S. P., Goldin, B. R., Lin, P. S. (1998) The inhibition of the estrogenic effects of pesticides and environmental chemicals by curcumin and isoflavonoids. Environ. Health Perspect., 106, 807-812.
    • (1998) Environ. Health Perspect , vol.106 , pp. 807-812
    • Verma, S.P.1    Goldin, B.R.2    Lin, P.S.3
  • 41
    • 29344455140 scopus 로고    scopus 로고
    • Synergistic inhibitory effects of curcumin and 5-fluorouracil on the growth of the human colon cancer cell line HT-29
    • Du, B., Jiang, L., Xia, Q., Zhong, L. (2006) Synergistic inhibitory effects of curcumin and 5-fluorouracil on the growth of the human colon cancer cell line HT-29. Chemotherapy, 52, 23-28.
    • (2006) Chemotherapy , vol.52 , pp. 23-28
    • Du, B.1    Jiang, L.2    Xia, Q.3    Zhong, L.4
  • 42
    • 38349130550 scopus 로고    scopus 로고
    • Synthesis of monofunctional curcumin derivatives, clicked curcumin dimer, and a PAMAN dendrimer curcumin conjugate for therapeutic applications
    • Shi, W., Dolai, S., Rizk, S., Hussai, A., Tariq, H., Averick, S., L'Amoreaux, W., El Idrissi, A., Banerjee, P., Raja, K. (2007) Synthesis of monofunctional curcumin derivatives, clicked curcumin dimer, and a PAMAN dendrimer curcumin conjugate for therapeutic applications. Org. Lett., 9, 5461-5464.
    • (2007) Org. Lett , vol.9 , pp. 5461-5464
    • Shi, W.1    Dolai, S.2    Rizk, S.3    Hussai, A.4    Tariq, H.5    Averick, S.6    L'Amoreaux, W.7    El Idrissi, A.8    Banerjee, P.9    Raja, K.10
  • 43
    • 50949093676 scopus 로고    scopus 로고
    • Design, synthesis and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine and demethylenated piperic acid and study of their antimicrobial and antiproliferative properties
    • In press
    • Dubey, S. K., Sharma, A. K., Narain, U., Misra, K., Pati, U. (2008) Design, synthesis and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine and demethylenated piperic acid and study of their antimicrobial and antiproliferative properties. Eur. J. Med. Chem. (In press).
    • (2008) Eur. J. Med. Chem
    • Dubey, S.K.1    Sharma, A.K.2    Narain, U.3    Misra, K.4    Pati, U.5
  • 44
    • 0345303681 scopus 로고    scopus 로고
    • Production of unnatural glucosides of curcumin with drastically enhanced water solubility by cell suspension cultures of Catharanthus roseus
    • Kaminaga, Y., Nagatsu, A., Akiyama, T., Sugimoto, N., Yamazaki, T., Maitani, T., Mizukami, H. (2003) Production of unnatural glucosides of curcumin with drastically enhanced water solubility by cell suspension cultures of Catharanthus roseus. FEBS Lett., 555, 311-316.
    • (2003) FEBS Lett , vol.555 , pp. 311-316
    • Kaminaga, Y.1    Nagatsu, A.2    Akiyama, T.3    Sugimoto, N.4    Yamazaki, T.5    Maitani, T.6    Mizukami, H.7
  • 46
    • 13444301277 scopus 로고    scopus 로고
    • Design, development and synthesis of mixed bioconjugates of piperic acidglycine, curcumin-glycine/alanine and curcumin-glycine-piperic acid and their antibacterial and antifungal properties
    • Mishra, S., Narain, U., Mishra, R., Misra, K. (2005) Design, development and synthesis of mixed bioconjugates of piperic acidglycine, curcumin-glycine/alanine and curcumin-glycine-piperic acid and their antibacterial and antifungal properties. Bioorg. Med. Chem., 13, 1477-1486.
    • (2005) Bioorg. Med. Chem , vol.13 , pp. 1477-1486
    • Mishra, S.1    Narain, U.2    Mishra, R.3    Misra, K.4
  • 47
    • 25644453377 scopus 로고    scopus 로고
    • Suzuki, M., Nakamura, T., Iyoki, S., Fujiwara, A., Watanabe, Y., Mohri, K., Isobe, K., Ono, K., Yano, S. (2005) Elucidation of anti 198 Current Bioactive Compounds 2008, 4, No. 3 de Fátima et al. allergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities. Biol. Pharm. Bull., 28, 438-1443.
    • Suzuki, M., Nakamura, T., Iyoki, S., Fujiwara, A., Watanabe, Y., Mohri, K., Isobe, K., Ono, K., Yano, S. (2005) Elucidation of anti 198 Current Bioactive Compounds 2008, Vol. 4, No. 3 de Fátima et al. allergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities. Biol. Pharm. Bull., 28, 438-1443.
  • 48
    • 34248157307 scopus 로고    scopus 로고
    • Synthesis of curcumin β-maltooligosaccharides through biocatalytic glycosylation with Strophanthus gratus cell culture and cyclodextrine glucanotransferase
    • Shimoda, K., Hara, T., Hamada, H., Hamada, H. (2007) Synthesis of curcumin β-maltooligosaccharides through biocatalytic glycosylation with Strophanthus gratus cell culture and cyclodextrine glucanotransferase. Tetrahedron Lett., 48, 4029-4032.
    • (2007) Tetrahedron Lett , vol.48 , pp. 4029-4032
    • Shimoda, K.1    Hara, T.2    Hamada, H.3    Hamada, H.4
  • 49
    • 17444422507 scopus 로고    scopus 로고
    • Synthesis, characterization and antitumour activities of some synthetic curcuminoid analogues and their copper complexes
    • John, V. D., Krishnankutty, K. (2005) Synthesis, characterization and antitumour activities of some synthetic curcuminoid analogues and their copper complexes. Trans. Metal Chem., 30, 229-233.
    • (2005) Trans. Metal Chem , vol.30 , pp. 229-233
    • John, V.D.1    Krishnankutty, K.2
  • 50
    • 33747460674 scopus 로고    scopus 로고
    • Antitumour activity of synthetic curcuminoid analogues (1,7-diaryl-1,6-heptadiene-3,5-diones) and their copper complexes
    • John, V. D., Krishnankutty, K. (2006) Antitumour activity of synthetic curcuminoid analogues (1,7-diaryl-1,6-heptadiene-3,5-diones) and their copper complexes. App. Organomet. Chem., 20, 477-482.
    • (2006) App. Organomet. Chem , vol.20 , pp. 477-482
    • John, V.D.1    Krishnankutty, K.2
  • 52
    • 0346508522 scopus 로고
    • Synthesis and antiarthritic study of a new orally active diferuloyl methane (curcumin) gold complex
    • Sharma, K. K., Chandra, S., Basu, D. K. (1987) Synthesis and antiarthritic study of a new orally active diferuloyl methane (curcumin) gold complex. Inorg. Chim. Acta, 135, 47-48.
    • (1987) Inorg. Chim. Acta , vol.135 , pp. 47-48
    • Sharma, K.K.1    Chandra, S.2    Basu, D.K.3
  • 53
    • 0347627467 scopus 로고    scopus 로고
    • Manganese complexes of curcumin and its derivatives: Evaluation for the radical scavenging ability and neuroprotective activity
    • Vajragupta, O., Boonchoong, P., Watanabe, H., Tohda, M., Kummasud, N., Sumanont, Y. (2003) Manganese complexes of curcumin and its derivatives: evaluation for the radical scavenging ability and neuroprotective activity. Free Rad. Biol. Med., 35, 1632-1644.
    • (2003) Free Rad. Biol. Med , vol.35 , pp. 1632-1644
    • Vajragupta, O.1    Boonchoong, P.2    Watanabe, H.3    Tohda, M.4    Kummasud, N.5    Sumanont, Y.6
  • 54
    • 33644528445 scopus 로고    scopus 로고
    • Prevention of kainic acidinduced changes in nitric oxide level and neuronal cell damage in the rat hippocampus by manganese complexes of curcumin and diacetylcurcumin
    • Sumanont, Y., Murakami, Y., Tohda, M., Vajragupta, O., Watanabe, H., Matsumoto, K. (2006) Prevention of kainic acidinduced changes in nitric oxide level and neuronal cell damage in the rat hippocampus by manganese complexes of curcumin and diacetylcurcumin. Life Sci., 78, 1884-1891.
    • (2006) Life Sci , vol.78 , pp. 1884-1891
    • Sumanont, Y.1    Murakami, Y.2    Tohda, M.3    Vajragupta, O.4    Watanabe, H.5    Matsumoto, K.6
  • 55
    • 34548653551 scopus 로고    scopus 로고
    • Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acidinduced neurotoxic responses in the rat hippocampus
    • Sumanont, Y., Murakami, Y., Tohda, M., Vajragupta, O., Watanabe, H., Matsumoto, K. (2007) Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acidinduced neurotoxic responses in the rat hippocampus. Biol. Pharm. Bull., 30, 1732-1739.
    • (2007) Biol. Pharm. Bull , vol.30 , pp. 1732-1739
    • Sumanont, Y.1    Murakami, Y.2    Tohda, M.3    Vajragupta, O.4    Watanabe, H.5    Matsumoto, K.6
  • 56
    • 0035716894 scopus 로고    scopus 로고
    • Enhanced antioxidant activities of metal conjugates of curcumin derivatives
    • Dutta, S., Murugkar, A., Gandhe, N., Padhye, S. (2001) Enhanced antioxidant activities of metal conjugates of curcumin derivatives. Metal Based Drugs, 8, 183-188.
    • (2001) Metal Based Drugs , vol.8 , pp. 183-188
    • Dutta, S.1    Murugkar, A.2    Gandhe, N.3    Padhye, S.4
  • 60
    • 29044433921 scopus 로고    scopus 로고
    • Inhibition of lipid peroxidation and protein oxidation in rat liver mitochondria by curcumin and its analogues
    • Wei, Q. Y., Chen, W. F., Zhou, B., Yang, L., Liu, Z. L. (2006) Inhibition of lipid peroxidation and protein oxidation in rat liver mitochondria by curcumin and its analogues. Biochim. Biophys. Acta, 1760, 70-77.
    • (2006) Biochim. Biophys. Acta , vol.1760 , pp. 70-77
    • Wei, Q.Y.1    Chen, W.F.2    Zhou, B.3    Yang, L.4    Liu, Z.L.5
  • 61
    • 4744375335 scopus 로고    scopus 로고
    • Prooxidant activity of curcumin: Copper-dependent formation of 8-hydroxy-2′-deoxyguanosine in DNA and induction of apoptotic cell death
    • Yoshino, M., Haneda, M., Naruse, M., Htay, H. H., Tsubouchi, R., Qiao, S. L., Li, W. H., Murakami, K., Yokochi, T. (2004) Prooxidant activity of curcumin: Copper-dependent formation of 8-hydroxy-2′-deoxyguanosine in DNA and induction of apoptotic cell death. Toxicol. Vitro, 18, 783-789.
    • (2004) Toxicol. Vitro , vol.18 , pp. 783-789
    • Yoshino, M.1    Haneda, M.2    Naruse, M.3    Htay, H.H.4    Tsubouchi, R.5    Qiao, S.L.6    Li, W.H.7    Murakami, K.8    Yokochi, T.9
  • 62
    • 33847711009 scopus 로고    scopus 로고
    • An emerging role for endothelial nitric oxide synthase in chronic inflammation and cancer
    • Ying, L., Hofseth, L.J. (2007) An emerging role for endothelial nitric oxide synthase in chronic inflammation and cancer. Cancer Res., 67, 1407-1410.
    • (2007) Cancer Res , vol.67 , pp. 1407-1410
    • Ying, L.1    Hofseth, L.J.2
  • 63
    • 0030865655 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor by nitric oxide in human glioblastoma and hepatocellular carcinoma cells
    • Chin, K., Kurashima, Y., Ogura, T., Tajiri, H., Yoshida, S., Esumi, H. (1997) Induction of vascular endothelial growth factor by nitric oxide in human glioblastoma and hepatocellular carcinoma cells. Oncogene, 15, 437-442.
    • (1997) Oncogene , vol.15 , pp. 437-442
    • Chin, K.1    Kurashima, Y.2    Ogura, T.3    Tajiri, H.4    Yoshida, S.5    Esumi, H.6
  • 64
    • 34547561688 scopus 로고    scopus 로고
    • Inducible nitric oxide synthasevascular endothelial growth factor axis: A potential target to inhibit tumor angiogenesis by dietary agents
    • Singh, R. P., Agarwal, R. (2007) Inducible nitric oxide synthasevascular endothelial growth factor axis: A potential target to inhibit tumor angiogenesis by dietary agents. Curr. Cancer Drug Targets, 7, 475-483.
    • (2007) Curr. Cancer Drug Targets , vol.7 , pp. 475-483
    • Singh, R.P.1    Agarwal, R.2
  • 65
    • 0030475604 scopus 로고    scopus 로고
    • Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis
    • Landino, L. M., Crews, B. C., Timmons, M. D., Morrow, J. D., Marnett, L. J. (1996) Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis. Proc. Natl. Acad. Sci. USA, 93, 15069-15074.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 15069-15074
    • Landino, L.M.1    Crews, B.C.2    Timmons, M.D.3    Morrow, J.D.4    Marnett, L.J.5
  • 66
    • 1542320024 scopus 로고    scopus 로고
    • Peroxynitrite irreversibly inactivates the human xenobioticmetabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) in human breast cancer cells: A cellular and mechanistic study
    • Dairou, J., Atmane, N., Rodrigues-Lima, F., Dupret, J. M. (2004) Peroxynitrite irreversibly inactivates the human xenobioticmetabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) in human breast cancer cells: A cellular and mechanistic study. J. Biol. Chem., 279, 7708-7714.
    • (2004) J. Biol. Chem , vol.279 , pp. 7708-7714
    • Dairou, J.1    Atmane, N.2    Rodrigues-Lima, F.3    Dupret, J.M.4
  • 67
    • 0026029402 scopus 로고
    • Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis
    • Huang, M. T., Lysz, T., Ferraro, T., Abidi, T. F., Laskin, J. D., Conney, A. H. (1991) Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res., 51, 813-819.
    • (1991) Cancer Res , vol.51 , pp. 813-819
    • Huang, M.T.1    Lysz, T.2    Ferraro, T.3    Abidi, T.F.4    Laskin, J.D.5    Conney, A.H.6
  • 68
    • 0029116349 scopus 로고
    • Selected eicosanoids increase the proliferation rate of human colon carcinoma cell lines and mouse colonocytes in vivo
    • Qiao, L., Kozoni, V., Tsioulias, G. J., Koutsos, M. I., Hanif, R., Shiff, S. J. (1995) Selected eicosanoids increase the proliferation rate of human colon carcinoma cell lines and mouse colonocytes in vivo. Biochim. Biophys. Acta, 1258, 215-223.
    • (1995) Biochim. Biophys. Acta , vol.1258 , pp. 215-223
    • Qiao, L.1    Kozoni, V.2    Tsioulias, G.J.3    Koutsos, M.I.4    Hanif, R.5    Shiff, S.J.6
  • 69
    • 0024869513 scopus 로고
    • AP1, a composite transcription factor implicated in abnormal growth control
    • Imler, J. L., Wasylyk, B. (1989) AP1, a composite transcription factor implicated in abnormal growth control. Prog. Growth Factor Res., 1, 69-77.
    • (1989) Prog. Growth Factor Res , vol.1 , pp. 69-77
    • Imler, J.L.1    Wasylyk, B.2
  • 70
    • 32144445578 scopus 로고    scopus 로고
    • Retinoids interfere with the AP1 signalling pathway in human breast cancer cells
    • Dedieu, S., Lefebvre, P. (2006) Retinoids interfere with the AP1 signalling pathway in human breast cancer cells. Cell Signal, 18, 889-898.
    • (2006) Cell Signal , vol.18 , pp. 889-898
    • Dedieu, S.1    Lefebvre, P.2
  • 71
  • 73
    • 33745342580 scopus 로고    scopus 로고
    • NFkappaB pathway: A good signaling paradigm and therapeutic target
    • Tergaonkar, V. (2006) NFkappaB pathway: A good signaling paradigm and therapeutic target. Int. J. Biochem. Cell Biol., 38, 1647-1653.
    • (2006) Int. J. Biochem. Cell Biol , vol.38 , pp. 1647-1653
    • Tergaonkar, V.1
  • 74
    • 34047235187 scopus 로고    scopus 로고
    • TNF/VEGF cross-talk in chronic inflammationrelated cancer initiation and progression: An early target in anticancer therapeutic strategy
    • Guadagni, F., Ferroni, P., Palmirotta, R., Portarena, I. Formica, V., Roselli, M. (2007) TNF/VEGF cross-talk in chronic inflammationrelated cancer initiation and progression: An early target in anticancer therapeutic strategy. In Vivo, 21, 147-161.
    • (2007) In Vivo , vol.21 , pp. 147-161
    • Guadagni, F.1    Ferroni, P.2    Palmirotta, R.3    Portarena, I.4    Formica, V.5    Roselli, M.6
  • 75
    • 38449100291 scopus 로고    scopus 로고
    • TNF and cancer: The two sides of the coin
    • Mocellin, S., Nitti, D. (2008) TNF and cancer: The two sides of the coin. Front. Biosci., 13, 2774-2783.
    • (2008) Front. Biosci , vol.13 , pp. 2774-2783
    • Mocellin, S.1    Nitti, D.2
  • 76
    • 5444237088 scopus 로고    scopus 로고
    • STAT proteins as novel targets for cancer drug discovery
    • Turkson, J. (2004) STAT proteins as novel targets for cancer drug discovery. Expert. Opin. Ther. Targets, 8, 409-422.
    • (2004) Expert. Opin. Ther. Targets , vol.8 , pp. 409-422
    • Turkson, J.1
  • 77
    • 33750520736 scopus 로고    scopus 로고
    • Curcumin regulates signal transducer and activator of transcription (STAT) expression in K562 cells
    • Blasius, R., Reuter, S., Henry, E., Dicato, M., Diederich, M. (2006) Curcumin regulates signal transducer and activator of transcription (STAT) expression in K562 cells. Biochem. Pharmacol., 72, 1547-1554.
    • (2006) Biochem. Pharmacol , vol.72 , pp. 1547-1554
    • Blasius, R.1    Reuter, S.2    Henry, E.3    Dicato, M.4    Diederich, M.5
  • 79
    • 18744378524 scopus 로고    scopus 로고
    • Effect of curcumin on STAT5 signaling molecule in K562 cells
    • Chen, W. H., Chen, Y., Gu, J. X., He, J. (2004) Effect of curcumin on STAT5 signaling molecule in K562 cells. Zhonghua Xue Ye Xue Za Zhi, 25, 151-153.
    • (2004) Zhonghua Xue Ye Xue Za Zhi , vol.25 , pp. 151-153
    • Chen, W.H.1    Chen, Y.2    Gu, J.X.3    He, J.4
  • 80
    • 0037097660 scopus 로고    scopus 로고
    • Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes
    • Natarajan, C., Bright, J. J. (2002) Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes. J. Immunol., 168, 6506-6513.
    • (2002) J. Immunol , vol.168 , pp. 6506-6513
    • Natarajan, C.1    Bright, J.J.2
  • 81
    • 29644438937 scopus 로고    scopus 로고
    • Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia
    • Rajasingh, J., Raikwar, H. P., Muthian, G., Johnson, C., Bright, J. J. (2006) Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia. Biochem. Biophys. Res. Commun., 340, 359-368.
    • (2006) Biochem. Biophys. Res. Commun , vol.340 , pp. 359-368
    • Rajasingh, J.1    Raikwar, H.P.2    Muthian, G.3    Johnson, C.4    Bright, J.J.5
  • 82
    • 38649124882 scopus 로고    scopus 로고
    • Mechanism of the anti-inflammatory effect of curcumin: PPAR-γ Activation
    • Jacob, A., Wu, R., Zhou, M., Wang, P. (2007) Mechanism of the anti-inflammatory effect of curcumin: PPAR-γ Activation. PPAR Res., 2007, 89369.
    • (2007) PPAR Res , vol.2007 , pp. 89369
    • Jacob, A.1    Wu, R.2    Zhou, M.3    Wang, P.4
  • 83
    • 13844306722 scopus 로고    scopus 로고
    • Activation of PPAR{gamma} by curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFR
    • Chen, A., Xu, J. (2005) Activation of PPAR{gamma} by curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFR. Am. J. Physiol. Gastrointest. Liver Physiol., 288, G447-G456.
    • (2005) Am. J. Physiol. Gastrointest. Liver Physiol , vol.288
    • Chen, A.1    Xu, J.2
  • 84
    • 30544455551 scopus 로고    scopus 로고
    • Curcumin induces human HT-29 colon adenocarcinoma cell apoptosis by activating p53 and regulating apoptosisrelated protein expression
    • Song, G., Mao, Y. B., Cai, Q. F., Yao, L. M., Ouyang, G. L., Bao, S. D. (2005) Curcumin induces human HT-29 colon adenocarcinoma cell apoptosis by activating p53 and regulating apoptosisrelated protein expression. Braz. J. Med. Biol. Res., 38, 1791-1798.
    • (2005) Braz. J. Med. Biol. Res , vol.38 , pp. 1791-1798
    • Song, G.1    Mao, Y.B.2    Cai, Q.F.3    Yao, L.M.4    Ouyang, G.L.5    Bao, S.D.6
  • 85
    • 36348937833 scopus 로고    scopus 로고
    • Curcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human glioma
    • Liu, E., Wu, J., Cao, W., Zhang, J., Liu, W., Jiang, X., Zhang, X. (2007) Curcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human glioma. J. Neurooncol., 85, 263-270.
    • (2007) J. Neurooncol , vol.85 , pp. 263-270
    • Liu, E.1    Wu, J.2    Cao, W.3    Zhang, J.4    Liu, W.5    Jiang, X.6    Zhang, X.7
  • 86
    • 35648949978 scopus 로고    scopus 로고
    • Beta-catenin signaling in biological control and cancer
    • Gavert, N., Ben-Ze'ev, A. (2007) Beta-catenin signaling in biological control and cancer. J. Cell Biochem., 102, 820-828.
    • (2007) J. Cell Biochem , vol.102 , pp. 820-828
    • Gavert, N.1    Ben-Ze'ev, A.2
  • 87
    • 34548513061 scopus 로고    scopus 로고
    • The Wnt/β-catenin signaling pathway as a target in drug discovery
    • Takahashi-Yanaga, F., Sasaguri, T. (2007) The Wnt/β-catenin signaling pathway as a target in drug discovery. J. Pharmacol. Sci., 104, 293-302.
    • (2007) J. Pharmacol. Sci , vol.104 , pp. 293-302
    • Takahashi-Yanaga, F.1    Sasaguri, T.2
  • 88
    • 34547843479 scopus 로고    scopus 로고
    • The Wnt/beta-catenin pathway in Wilms tumors and prostate cancers
    • Tycko, B., Li, C. M., Buttyan, R. (2007) The Wnt/beta-catenin pathway in Wilms tumors and prostate cancers. Curr. Mol. Med., 7, 479-489.
    • (2007) Curr. Mol. Med , vol.7 , pp. 479-489
    • Tycko, B.1    Li, C.M.2    Buttyan, R.3
  • 89
    • 19444362674 scopus 로고    scopus 로고
    • The inhibitory mechanism of curcumin and its derivative against beta-catenin/ Tcf signaling
    • Park, C. H., Hahm, E. R., Park, S., Kim, H. K., Yang, C. H. (2005) The inhibitory mechanism of curcumin and its derivative against beta-catenin/ Tcf signaling. FEBS Lett., 579, 2965-2971.
    • (2005) FEBS Lett , vol.579 , pp. 2965-2971
    • Park, C.H.1    Hahm, E.R.2    Park, S.3    Kim, H.K.4    Yang, C.H.5
  • 90
    • 0037028207 scopus 로고    scopus 로고
    • Betacatenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells
    • Jaiswal, A. S., Marlow, B. P., Gupta, N., Narayan, S. (2002) Betacatenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. Oncogene, 21, 8414-8127.
    • (2002) Oncogene , vol.21 , pp. 8414-8127
    • Jaiswal, A.S.1    Marlow, B.P.2    Gupta, N.3    Narayan, S.4
  • 91
    • 13844293171 scopus 로고    scopus 로고
    • Curcumin, a multi-functional chemopreventive agent, blocks growth of colon cancer cells by targeting betacatenin-mediated transactivation and cell-cell adhesion pathways
    • Narayan, S. (2004) Curcumin, a multi-functional chemopreventive agent, blocks growth of colon cancer cells by targeting betacatenin-mediated transactivation and cell-cell adhesion pathways. J. Mol. Histol., 35, 301-307.
    • (2004) J. Mol. Histol , vol.35 , pp. 301-307
    • Narayan, S.1
  • 92
    • 0031725843 scopus 로고    scopus 로고
    • Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells
    • Ciolino, H. P., Daschner, P. J., Wang, T. T., Yeh, G. C. (1998) Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells. Biochem. Pharmacol., 56, 197-206.
    • (1998) Biochem. Pharmacol , vol.56 , pp. 197-206
    • Ciolino, H.P.1    Daschner, P.J.2    Wang, T.T.3    Yeh, G.C.4
  • 93
    • 0035140448 scopus 로고    scopus 로고
    • Effects of turmeric on the activities of benzo(a)pyrene-induced cytochrome P-450 isozymes
    • Thapliyal, R., Deshpande, S. S., Maru, G. B. (2001) Effects of turmeric on the activities of benzo(a)pyrene-induced cytochrome P-450 isozymes. J. Environ. Pathol. Toxicol. Oncol., 20, 59-63.
    • (2001) J. Environ. Pathol. Toxicol. Oncol , vol.20 , pp. 59-63
    • Thapliyal, R.1    Deshpande, S.S.2    Maru, G.B.3
  • 94
    • 0035018226 scopus 로고    scopus 로고
    • Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo
    • Thapliyal, R., Maru, G. B. (2001) Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo. Food Chem. Toxicol., 39, 541-547.
    • (2001) Food Chem. Toxicol , vol.39 , pp. 541-547
    • Thapliyal, R.1    Maru, G.B.2
  • 95
    • 84934438047 scopus 로고    scopus 로고
    • Curcumin as an inhibitor of angiogenesis
    • Bhandarkar, S. S., Arbiser, J. L. (2007) Curcumin as an inhibitor of angiogenesis. Adv. Exp. Med. Biol., 595, 185-195.
    • (2007) Adv. Exp. Med. Biol , vol.595 , pp. 185-195
    • Bhandarkar, S.S.1    Arbiser, J.L.2
  • 96
    • 33644863311 scopus 로고    scopus 로고
    • Effects of TNF-alpha and curcumin on the expression of VEGF in Raji and U937 cells and on angiogenesis in ECV304 cells
    • Chen, W. H., Chen, Y., Cui, G. H. (2005) Effects of TNF-alpha and curcumin on the expression of VEGF in Raji and U937 cells and on angiogenesis in ECV304 cells. Chin. Med. J. (Engl), 118, 2052-2057.
    • (2005) Chin. Med. J. (Engl) , vol.118 , pp. 2052-2057
    • Chen, W.H.1    Chen, Y.2    Cui, G.H.3
  • 97
    • 3042748129 scopus 로고    scopus 로고
    • Multiple roles of COX-2 in tumor angiogenesis: A target for antiangiogenic therapy
    • Gately, S., Li, W. W. (2004) Multiple roles of COX-2 in tumor angiogenesis: A target for antiangiogenic therapy. Semin. Oncol., 31, 2-11.
    • (2004) Semin. Oncol , vol.31 , pp. 2-11
    • Gately, S.1    Li, W.W.2
  • 99
    • 24044459285 scopus 로고    scopus 로고
    • Matrix metalloproteinases and angiogenesis
    • Rundhaug, J. E. (2005) Matrix metalloproteinases and angiogenesis. J. Cell. Mol. Med., 9, 267-285.
    • (2005) J. Cell. Mol. Med , vol.9 , pp. 267-285
    • Rundhaug, J.E.1
  • 100
    • 8744252318 scopus 로고    scopus 로고
    • Epidermal growth factor stimulates urokinase-type plasminogen activator expression in human gingival fibroblasts. Possible modulation by genistein and curcumin
    • Smith, P. C., Santibañez, J. F., Morales, J. P., Martinez, J. (2004) Epidermal growth factor stimulates urokinase-type plasminogen activator expression in human gingival fibroblasts. Possible modulation by genistein and curcumin. J. Periodontal. Res., 39, 380-387.
    • (2004) J. Periodontal. Res , vol.39 , pp. 380-387
    • Smith, P.C.1    Santibañez, J.F.2    Morales, J.P.3    Martinez, J.4
  • 102
    • 35748958414 scopus 로고    scopus 로고
    • Anti-inflammatory effect of curcumin involves downregulation of MMP-9 in blood mononuclear cells
    • Saja, K., Babu, M. S., Karunagaran, D., Sudhakaran, P. R. (2007) Anti-inflammatory effect of curcumin involves downregulation of MMP-9 in blood mononuclear cells. Int. Immunopharmacol., 7, 1659-1667.
    • (2007) Int. Immunopharmacol , vol.7 , pp. 1659-1667
    • Saja, K.1    Babu, M.S.2    Karunagaran, D.3    Sudhakaran, P.R.4
  • 103
    • 39749093675 scopus 로고    scopus 로고
    • Curcumin sensitizes TRAIL-resistant xenografts: Molecular mechanisms of apoptosis, metastasis and angiogenesis
    • Shankar, S., Ganapathy, S., Chen, Q., Srivastava, R. K. (2008) Curcumin sensitizes TRAIL-resistant xenografts: Molecular mechanisms of apoptosis, metastasis and angiogenesis. Mol. Cancer, 7, 16.
    • (2008) Mol. Cancer , vol.7 , pp. 16
    • Shankar, S.1    Ganapathy, S.2    Chen, Q.3    Srivastava, R.K.4
  • 104
    • 0037245268 scopus 로고    scopus 로고
    • Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and E-cadherin
    • Ray, S., Chattopadhyay, N., Mitra, A., Siddiqi, M., Chatterjee, A. (2003) Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and E-cadherin. J. Environ. Pathol. Toxicol. Oncol., 22, 49-58.
    • (2003) J. Environ. Pathol. Toxicol. Oncol , vol.22 , pp. 49-58
    • Ray, S.1    Chattopadhyay, N.2    Mitra, A.3    Siddiqi, M.4    Chatterjee, A.5
  • 105
    • 3042558087 scopus 로고    scopus 로고
    • Effect of curcumin on gelatinase A (MMP-2) activity in B16F10 melanoma cells
    • Banerji, A., Chakrabarti, J., Mitra, A., Chatterjee, A. (2004) Effect of curcumin on gelatinase A (MMP-2) activity in B16F10 melanoma cells. Cancer Lett., 211, 235-242.
    • (2004) Cancer Lett , vol.211 , pp. 235-242
    • Banerji, A.1    Chakrabarti, J.2    Mitra, A.3    Chatterjee, A.4
  • 106
    • 0032520716 scopus 로고    scopus 로고
    • Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kB activation
    • Kumar, A., Dhawan, S., Hardegen, N. J., Aggarwal, B. B. (1998) Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kB activation. Biochem. Pharmacol., 55, 775-783.
    • (1998) Biochem. Pharmacol , vol.55 , pp. 775-783
    • Kumar, A.1    Dhawan, S.2    Hardegen, N.J.3    Aggarwal, B.B.4
  • 107
    • 0038348303 scopus 로고    scopus 로고
    • Proinflammatory agents accumulate during donor liver cold preservation: A study on increased adhesion molecule expression and abrogation by curcumin in cultured endothelial cells
    • Fuller, B., Dijk, S., Butler, P., Hoang, V., Davidson, B. (2003) Proinflammatory agents accumulate during donor liver cold preservation: a study on increased adhesion molecule expression and abrogation by curcumin in cultured endothelial cells. Cryobiology, 46, 284-288.
    • (2003) Cryobiology , vol.46 , pp. 284-288
    • Fuller, B.1    Dijk, S.2    Butler, P.3    Hoang, V.4    Davidson, B.5
  • 108
    • 16844371915 scopus 로고    scopus 로고
    • Induction of apoptosis by curcumin and its implications for cancer therapy
    • Karunagaran, D., Rashmi, R., Kumar, T. R. (2005) Induction of apoptosis by curcumin and its implications for cancer therapy. Curr. Cancer Drug. Targets, 5, 117-129.
    • (2005) Curr. Cancer Drug. Targets , vol.5 , pp. 117-129
    • Karunagaran, D.1    Rashmi, R.2    Kumar, T.R.3
  • 109
    • 43949131788 scopus 로고    scopus 로고
    • Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells
    • Mackenzie, G. G., Queisser, N., Wolfson, M. L., Fraga, C. G. Adamo, A. M. Oteiza, P. I. (2008) Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells. Int. J. Cancer, 123, 56-65.
    • (2008) Int. J. Cancer , vol.123 , pp. 56-65
    • Mackenzie, G.G.1    Queisser, N.2    Wolfson, M.L.3    Fraga, C.G.4    Adamo, A.M.5    Oteiza, P.I.6
  • 110
    • 0035203946 scopus 로고    scopus 로고
    • Induction of stress response renders human tumor cell lines resistant to curcumin-mediated apoptosis: Role of reactive oxygen intermediates
    • Khar, A., Ali, A. M., Pardhasaradhi, B. V., Varalakshmi, C., Anjum, R., Kumari, A. L. (2001) Induction of stress response renders human tumor cell lines resistant to curcumin-mediated apoptosis: Role of reactive oxygen intermediates. Cell Stress Chaperones, 6, 368-376.
    • (2001) Cell Stress Chaperones , vol.6 , pp. 368-376
    • Khar, A.1    Ali, A.M.2    Pardhasaradhi, B.V.3    Varalakshmi, C.4    Anjum, R.5    Kumari, A.L.6
  • 111
    • 0042169007 scopus 로고    scopus 로고
    • Molecular mechanisms of curcumin-induced cytotoxicity: Induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt
    • Woo, J. H., Kim, Y. H., Choi, Y. J., Kim, D. G., Lee, K. S., Bae, J. H., Min, D. S., Chang, J. S., Jeong, Y. J. Lee, Y. H., Park, J. W., Kwon, T. K. (2003) Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis, 24, 1199-1208.
    • (2003) Carcinogenesis , vol.24 , pp. 1199-1208
    • Woo, J.H.1    Kim, Y.H.2    Choi, Y.J.3    Kim, D.G.4    Lee, K.S.5    Bae, J.H.6    Min, D.S.7    Chang, J.S.8    Jeong, Y.J.9    Lee, Y.H.10    Park, J.W.11    Kwon, T.K.12
  • 112
    • 45349087492 scopus 로고    scopus 로고
    • Effect of curcumin on expression of survivin, Bcl-2 and Bax in human multiple myeloma cell line
    • Liu, B., Bai, Q. X., Chen, X. Q., Gao, G. X., Gu, H. T. (2007) Effect of curcumin on expression of survivin, Bcl-2 and Bax in human multiple myeloma cell line. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 15, 762-766.
    • (2007) Zhongguo Shi Yan Xue Ye Xue Za Zhi , vol.15 , pp. 762-766
    • Liu, B.1    Bai, Q.X.2    Chen, X.Q.3    Gao, G.X.4    Gu, H.T.5
  • 114
    • 33847133360 scopus 로고    scopus 로고
    • Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines
    • Aggarwal, B. B., Banerjee, S., Bharadwaj, U., Sung, B., Shishodia, S., Sethi, G. (2007) Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines. Biochem. Pharmacol., 73, 1024-1032.
    • (2007) Biochem. Pharmacol , vol.73 , pp. 1024-1032
    • Aggarwal, B.B.1    Banerjee, S.2    Bharadwaj, U.3    Sung, B.4    Shishodia, S.5    Sethi, G.6
  • 115
    • 84934440253 scopus 로고    scopus 로고
    • Antitumor, anti-invasion, and antimetastatic effects of curcumin
    • Kuttan, G., Kumar, K. B., Guruvayoorappan, C., Kuttan, R. (2007) Antitumor, anti-invasion, and antimetastatic effects of curcumin. Adv. Exp. Med. Biol., 595, 173-184.
    • (2007) Adv. Exp. Med. Biol , vol.595 , pp. 173-184
    • Kuttan, G.1    Kumar, K.B.2    Guruvayoorappan, C.3    Kuttan, R.4
  • 116
    • 34247895505 scopus 로고    scopus 로고
    • Curcumin-induced GADD153 upregulation: Modulation by glutathione
    • Scott, D. W., Loo, G. (2007) Curcumin-induced GADD153 upregulation: modulation by glutathione. J. Cell Biochem., 101, 307-320.
    • (2007) J. Cell Biochem , vol.101 , pp. 307-320
    • Scott, D.W.1    Loo, G.2
  • 117
    • 27144468987 scopus 로고    scopus 로고
    • Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice
    • Aggarwal, B. B., Shishodia, S., Takada, Y., Banerjee, S., Newman, R. A., Bueso-Ramos, C. E., Price, J. E. (2005) Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin. Cancer Res., 11, 7490-7498.
    • (2005) Clin. Cancer Res , vol.11 , pp. 7490-7498
    • Aggarwal, B.B.1    Shishodia, S.2    Takada, Y.3    Banerjee, S.4    Newman, R.A.5    Bueso-Ramos, C.E.6    Price, J.E.7
  • 118
    • 14844303304 scopus 로고    scopus 로고
    • Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factorkappaB and the serine/ threonine kinase Akt and is independent of tubulin polymerization
    • Bava, S. V., Puliappadamba, V. T., Deepti, A., Nair, A., Karunagaran, D., Anto, R. J. (2005) Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factorkappaB and the serine/ threonine kinase Akt and is independent of tubulin polymerization. J. Biol. Chem., 280, 6301-6308.
    • (2005) J. Biol. Chem , vol.280 , pp. 6301-6308
    • Bava, S.V.1    Puliappadamba, V.T.2    Deepti, A.3    Nair, A.4    Karunagaran, D.5    Anto, R.J.6
  • 119
    • 1542426626 scopus 로고    scopus 로고
    • Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3
    • Chendil, D., Ranga, R. S., Meigooni, D., Sathishkumar, S., Ahmed, M. M. (2004) Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3. Oncogene, 23, 1599-1607.
    • (2004) Oncogene , vol.23 , pp. 1599-1607
    • Chendil, D.1    Ranga, R.S.2    Meigooni, D.3    Sathishkumar, S.4    Ahmed, M.M.5
  • 120
    • 36849021582 scopus 로고    scopus 로고
    • Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway
    • Choi, B. H., Kim, C. G., Lim, Y., Shin, S. Y., Lee, Y. H. (2008) Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway. Cancer Lett., 259, 111-118.
    • (2008) Cancer Lett , vol.259 , pp. 111-118
    • Choi, B.H.1    Kim, C.G.2    Lim, Y.3    Shin, S.Y.4    Lee, Y.H.5
  • 121
    • 23844455227 scopus 로고    scopus 로고
    • Effect of curcumin on multidrug resistance in resistant human gastric carcinoma cell line SGC7901/VCR
    • Tang, X. Q., Bi, H., Feng, J. Q., Cao, J. G. (2005) Effect of curcumin on multidrug resistance in resistant human gastric carcinoma cell line SGC7901/VCR. Acta Pharmacol. Sin., 26, 1009-1016.
    • (2005) Acta Pharmacol. Sin , vol.26 , pp. 1009-1016
    • Tang, X.Q.1    Bi, H.2    Feng, J.Q.3    Cao, J.G.4
  • 122
    • 33748356494 scopus 로고    scopus 로고
    • Modulation of the function of the multidrug resistance-linked ATPbinding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin
    • Chearwae, W., Shukla, S., Limtrakul, P., Ambudkar, S. V. (2006) Modulation of the function of the multidrug resistance-linked ATPbinding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin. Mol. Cancer Ther., 5, 1995-2006.
    • (2006) Mol. Cancer Ther , vol.5 , pp. 1995-2006
    • Chearwae, W.1    Shukla, S.2    Limtrakul, P.3    Ambudkar, S.V.4
  • 123
    • 34447506459 scopus 로고    scopus 로고
    • Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin
    • Limtrakul, P., Chearwae, W., Shukla, S., Phisalphong, C., Ambudkar, S. V. (2007) Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin. Mol. Cell Biochem., 296, 85-95.
    • (2007) Mol. Cell Biochem , vol.296 , pp. 85-95
    • Limtrakul, P.1    Chearwae, W.2    Shukla, S.3    Phisalphong, C.4    Ambudkar, S.V.5
  • 124
    • 34447548595 scopus 로고    scopus 로고
    • New cyclodextrin bioconjugates for active tumour targeting
    • Salmaso, S., Bersani, S., Semenzato, A., Caliceti, P. (2007) New cyclodextrin bioconjugates for active tumour targeting. J. Drug Target, 15, 379-390.
    • (2007) J. Drug Target , vol.15 , pp. 379-390
    • Salmaso, S.1    Bersani, S.2    Semenzato, A.3    Caliceti, P.4


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