Curcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human glioma

Journal of Neuro-Oncology

Volumn 85, Issue 3, 2007, Pages 263-270

  Liu, Enyu ^a   Wu, Jing ^b   Cao, Weidong ^a   Zhang, Jianning ^a   Liu, Weiping ^a   Jiang, Xiaofan ^a   Zhang, Xiang ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b NEMOURS ALFRED I DUPONT HOSPITAL FOR CHILDREN   (United States)

Author keywords

Apoptosis; Cell cycle arrest; Curcumin; Glioma; ING (inhibitor of growth) family

Indexed keywords

CURCUMIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; GENOMIC DNA; GROWTH INHIBITOR; PROTEIN P53;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTROPHORESIS; GLIOMA; GLIOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE, TUMOR; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; G2 PHASE; GLIOMA; GROWTH INHIBITORS; HOMEODOMAIN PROTEINS; HUMANS; STATISTICS, NONPARAMETRIC; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 36348937833     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-007-9421-4     Document Type: Article

References (46)

1. Maher EA, Furnari FB, Bachoo RM,Rowitch DH,Louis DN, Cavenee WK, DePinho RA (2001) Malignant glioma: Genetics and biology of a gravematter. Genes Dev 15:1311-1333
2. Norden AD, Wen PY (2006) Glioma therapy in adults. Neurologist 12(6):279-292
3. Ahsan H, Parveen N, Khan NU, Hadi SM (1999) Pro-oxidant, antioxidant and cleavage activities on DNA of curcumin and derivatives demethoxycurcumin and isdeme- thoxycurcumin. Chem-Biol Inter 121:161-175
4. Aggarwal BB, Kumar A, Bharti AC (2003) Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 23:363-398
5. Han SS, Keum YS, Seo HJ, Surh YJ (2002) Curcumin suppresses activation of NF-kappaB and AP-1 induced by phorbol ester in cultured human promyelocytic leukemia cells. J Biochem Mol Biol 31:337-342
6. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS, Brenner DA, Sartor RB (1999) Curcumin blocks cytokine-mediated NF-B activation and proinflammatory gene expression by inhibiting inhibitory factor I-B kinase activity. J Immunol 163:3474-3483
7. Ambegaokar SS, Wu L, Alamshahi K, Lau J, Jazayeri L, Chan S, Khanna P, Hsieh E, Timiras PS (2003) Curcumin inhibits dose-dependently and time-dependently neuroglial cell proliferation and growth. Neuro Endocrinol Lett. 24(6):469-473
8. Woo MS, Jung SH, Kim SY, Hyun JW, Ko KH, Kim WK, Kim HS (2005) Curcumin suppresses phorbol ester-induced matrix metalloproteinase-9 expression by inhibiting the PKC to MAPK signaling pathways in human astroglioma cells. Biochem Biophys Res Commun 335(4):1017-1025
9. Jiang H, Deng CS, Zhang M, Xia J (2006) Curcumin-attenuated trinitrobenzene sulphonic acid induces chronic colitis by inhibiting expression of cyclooxygenase-2. World J Gastroenterol 12(24):3848-3853
10. Kim SY, Jung SH, Kim HS (2005) Curcumin is a potent broad spectrum inhibitor of matrix metalloproteinase gene expression in human astroglioma cells. Biochem Biophys Res Commun 337(2):510-516
11. Su CC, Chen GW, Lin JG, Wu LT, Chung JG (2006) Curcumin inhibits cell migration of human colon cancer colo 205 cells through the inhibition of nuclear factor kappa B/p65 and down-regulates cyclooxygenase-2 and matrix metalloproteinase-2 expressions. Anticancer Res 26(2A):1281-1288
12. Lee KW, Kim JH, Lee HJ, Surh YJ (2005) Curcumin inhibits phorbol ester-induced up-regulation of cyclooxygenase-2 and matrix metalloproteinase-9 by blocking ERK1/2 phosphorylation and NF-kappaB transcriptional activity in MCF10A human breast epithelial cells. Antioxid Redox Signal. 7(11-12):1612-1620
13. Shi X, Gozani O (2005) The fellowships of the INGs. J Cell Biochem 96:1127-1136
14. Gong W, Suzuki K, Russell M, Riabowol K (2005) Function of the ING family of PHD proteins in cancer. Int J Biochem Cell Biol 37(5):1054-1065
15. Campos EI, Chin MY, Kuo WH, Li G (2004). Biological functions of the ING family tumor suppressors. Cell Mol Life Sci 61(19-20):2597-2613
16. Nagashima M, Shiseki M, Miura K, Hagiwara K, Linke SP, Pedeux R, Wang XW, Yokota J, Riabowol K, Harris CC (2001) DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. Proc Natl Acad Sci USA 98(17):9671-9676
17. Feng X, Hara Y, Riabowol K (2002) Different HATS of the ING1 gene family. Trends Cell Biol 12(11):532-538
18. Zhu Z, Lin J, Qu JH, Feitelson MA, Ni CR, Li FM, Zhu MH (2005) Inhibitory effect of tumor suppressor p33(ING1b) and its synergy with p53 gene in hepatocellular carcinoma. World J Gastroenterol 11(13):1903-1909
19. Goeman F, Thormeyer D, Abad M, Serrano M, Schmidt O, Palmero I, Baniahmad A (2005) Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: Involvement of two silencing domains and effect of Ras. Mol Cell Biol 25(1):422-431
20. Nouman GS, Anderson JJ, Lunec J, Angus B (2003) The role of the tumour suppressor p33 ING1b in human neoplasia. J Clin Pathol 56(7):491-496
21. Wang Y, Wang J, Li G (2006) Leucine zipper like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis. FEBS Lett 580(16):3787-3793
22. Nagashima M, Shiseki M, Pedeux RM, Okamura S, Kitahama Shiseki M, Miura K, Yokota J, Harris CC (2003) A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis. Oncogene 22(3):343-350
23. Kim S, Chin K, Gray JW, Bishop JM (2004) A screen for genes that suppress loss of contact inhibition: Identification of ING4 as a candidate tumor suppressor gene in human cancer. Proc Natl Acad Sci USA 101(46):16251-16256
24. Gunduz M, Nagatsuka H, Demircan K, Gunduz E, Cengiz B, Ouchida M, Tsujigiwa H, Yamachika E, Fukushima K, Beder L, Hirohata S, Ninomiya Y, Nishizaki K, Shimizu K, Nagai N (2005) Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas. Gene 356:109-117
25. Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E, Barnett GH, Jain RK (2004) The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. Nature 428(6980):328-332
26. Zhang X, Xu LS, Wang ZQ, Wang KS, Li N, Cheng ZH, Huang SZ, Wei DZ, Han ZG (2004) ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells. FEBS Lett 570(1-3):7-12
27. Duvoix A, Blasius R, Delhalle S, Schnekenburger M, Morceau F, Henry E, Dicato M, Diederich M (2005) Chemopreventive and therapeutic effects of curcumin. Cancer Lett 223(2):181-190
28. Moragoda L, Jaszewski R, Majumdar AP (2001) Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells. Anticancer Res 21(2A):873-878
29. Somasundaram S, Edmund NA, Moore DT, Small GW, Shi YY, Orlowski RZ. (2002) Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Res 62(13):3868-3875
30. Manson MM, Farmer PB, Gescher A, Steward WP (2005) Innovative agents in cancer prevention. Recent-Results-Cancer-Res 166:257-275
31. Karunagaran D, Rashmi R, Kumar TR (2005) Induction of apoptosis by curcumin and its implications for cancer therapy. Curr Cancer Drug Targets 5(2):117-129
32. Hong JH, Ahn KS, Bae E, Jeon SS, Choi HY (2006) The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo. Prostate Cancer Prostatic Dis 9(2):147-152
33. Aggarwal BB, Kumar A, Bharti AC (2003) Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 23(1A):363-398
34. Ambegaokar SS, Wu L, Alamshahi K, Lau J, Jazayeri L, Chan S, Khanna P, Hsieh E, Timiras PS (2003) Curcumin inhibits dose-dependently and time-dependently neuroglial cell proliferation and growth. Neuro Endocrinol Lett 24(6):469-473
35. Kim SY, Jung SH, Kim HS (2005) Curcumin is a potent broad spectrum inhibitor of matrix metalloproteinase gene expression in human astroglioma cells. Biochem Biophys Res Commun 337(2):510-516
36. Kim GY, Kim KH, Lee SH, Yoon MS, Lee HJ, Moon DO, Lee CM, Ahn SC, Park YC, Park YM (2005) Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets. J Immunol 174(12):8116-8124
37. Bharti AC, Takada Y, Aggarwal BB (2004) Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis. J Immunol 172(10):5940-5947
38. Nagai S, Kurimoto M, Washiyama K, Hirashima Y, Kumanishi T, Endo S (2005) Inhibition of cellular proliferation and induction of apoptosis by curcumin in human malignant astrocytoma cell lines. J Neurooncol 74(2):105-111
39. Kang SK, Cha SH, Jeon HG (2006) Curcumin induced histone hypoacetylation enhances caspase-3 dependent glioma cell death and neurogenesis of neural progenitor cells. Stem Cells Dev 15(2):165-174
40. Nourani A, Howe L, Pray Grant MG, Workman JL, Grant PA, Cote J (2003) Opposite role of yeast ING family members in p53 dependent transcriptional activation. J Biol Chem 278(21):19171-19175
41. Garkavtsev I, Boucher Y (2005) An intact ING1-P53 pathway can potentiate the cytotoxic effects of taxol. Cancer Biol Ther 4(1):48-49
42. Tachibana M, Kawamata H, Fujimori T, Omotehara F, Horiuchi H, Ohkura Y, Igarashi S, Kotake K, Kubota K (2004) Dysfunction of p53 pathway in human colorectal cancer: Analysis of p53 gene mutation and the expression of the p53-associated factors p14ARF, p33ING1, p21WAF1 and MDM2. Int J Oncol 25(4):913-920
43. Shiseki M, Nagashima M, Pedeux RM, Kitahama Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC (2003) p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. Cancer Res 63(10):2373-2378
44. Kim S (2005) HuntING4 new tumor suppressors. Cell Cycle 4(4):516-517
45. Zhang X, Wang KS, Wang ZQ, Xu LS, Wang QW, Chen F, Wei DZ, Han ZG (2005) Nuclear localization signal of ING4 plays a key role in its binding to p53. Biochem-Biophys Res Commun 331(4):1032-1038
46. Motoko U, Jiang CS, Zhi-Ming Z, Curtis CH (2006) Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility. J Biol Chem 281(45):34677-34686