Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines

Biochemical Pharmacology

Volumn 73, Issue 7, 2007, Pages 1024-1032

  Aggarwal, Bharat B ^a   Banerjee, Sanjeev ^a   Bharadwaj, Uddalak ^a   Sung, Bokyung ^a   Shishodia, Shishir ^a   Sethi, Gautam ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Curcumin; Cyclin E; p21; p27; p53; Proteasome

Indexed keywords

ANDROGEN; CURCUMIN; CYCLIN E; ESTROGEN; LACTACYSTIN; N ACETYLLEUCYLLEUCYLNORLEUCINAL; PROTEASOME INHIBITOR; PROTEIN P21; PROTEIN P27; PROTEIN P53; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN;

ARTICLE; BREAST CANCER; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DOWN REGULATION; DRUG PROTEIN BINDING; DRUG TARGETING; FLOW CYTOMETRY; GENE OVEREXPRESSION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; LEUKEMIA CELL; LUNG CANCER; LYMPHOMA CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTO ONCOGENE; TUMOR CELL LINE; UPREGULATION; WESTERN BLOTTING;

CELL LINE, TUMOR; CURCUMIN; CYCLIN E; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; HUMANS; MALE; NEOPLASMS; ONCOGENE PROTEINS; UBIQUITIN; UP-REGULATION;

EID: 33847133360     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.12.010     Document Type: Article

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