Prooxidant activity of curcumin: Copper-dependent formation of 8-hydroxy-2′-deoxyguanosine in DNA and induction of apoptotic cell death

Toxicology in Vitro

Volumn 18, Issue 6, 2004, Pages 783-789

  Yoshino, Masataka ^a   Haneda, Miyako ^a   Naruse, Makoto ^b   Htay, Hla Hla ^a   Tsubouchi, Ryoko ^a   Qiao, Shan Lou ^a   Li, Wei Hua ^a   Murakami, Keiko ^a   Yokochi, Takashi ^b  

^a AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b AICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

8 Hydroxy 2 deoxyguanosine; Apoptosis; Curcumin; DNA damage; Hydroxyl radical

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CAPSAICIN; CAPSAICIN DERIVATIVE; CAPSAICINOID DERIVATIVE; CATALASE; COPPER ION; CURCUMIN; DIKETONE; HYDROXYL RADICAL; PHENOL; PLASMID DNA; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; DNA STRAND BREAKAGE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; OXIDATIVE STRESS; TIME;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; CATTLE; COPPER; CURCUMIN; DEOXYGUANOSINE; DNA DAMAGE; FLOW CYTOMETRY; HL-60 CELLS; HUMANS; HYDROXYL RADICAL; OXIDANTS; PLASMIDS; REACTIVE OXYGEN SPECIES; THYMUS GLAND;

CURCUMA LONGA;

EID: 4744375335     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2004.03.009     Document Type: Article

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