Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury

Stroke

Volumn 40, Issue 5, 2009, Pages 1877-1885

  Wang, Xin ^a   Figueroa, Bryan E ^a   Stavrovskaya, Irina G ^a   Zhang, Yi ^a   Sirianni, Ana C ^a   Zhu, Shan ^a   Day, Arthur L ^a   Kristal, Bruce S ^a   Friedlander, Robert M ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CYTOCHROME C; GLUCOSE; INTERLEUKIN 1BETA CONVERTING ENZYME; MELATONIN; METHAZOLAMIDE; OXYGEN; ANTIOXIDANT; CARBONATE DEHYDRATASE INHIBITOR; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN NERVE CELL; CELL DEATH; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME RELEASE; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOCHONDRION; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; CELL MEMBRANE POTENTIAL; DEGENERATIVE DISEASE; ENZYMOLOGY; METABOLISM; MITOCHONDRIAL MEMBRANE; NERVE CELL; NICK END LABELING; PATHOLOGY; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; BLOTTING, WESTERN; BRAIN ISCHEMIA; CARBONIC ANHYDRASE INHIBITORS; CASPASE 1; CASPASE 3; CELL DEATH; CYTOCHROMES C; ENZYME ACTIVATION; IN SITU NICK-END LABELING; INTERLEUKIN-1BETA; L-LACTATE DEHYDROGENASE; MELATONIN; MEMBRANE POTENTIALS; METHAZOLAMIDE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; NEURODEGENERATIVE DISEASES; NEURONS; NEUROPROTECTIVE AGENTS;

EID: 65549160834     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.108.540765     Document Type: Article

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