Chronic and acute melatonin effects in gerbil global forebrain ischemia: Long-term neural and behavioral outcome

Journal of Pineal Research

Volumn 44, Issue 2, 2008, Pages 149-156

  Rennie, Kerry ^a   De Butte, Maxine ^b   Fréchette, Mylène ^a   Pappas, Bruce A ^a  

^a CARLETON UNIVERSITY   (Canada)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Activity; Carotid occlusion; Hippocampus; Neurogenesis; Stereology

Indexed keywords

MELATONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; BRAIN SURGERY; CAROTID ARTERY OBSTRUCTION; CELL LOSS; CONTROLLED STUDY; DENTATE GYRUS; DRUG MECHANISM; DRUG TISSUE LEVEL; FOREBRAIN; GLIA CELL; HISTOLOGY; IMMUNOREACTIVITY; MALE; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NONHUMAN; PERIOPERATIVE PERIOD;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN ISCHEMIA; CELL COUNT; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; GERBILLINAE; MALE; MELATONIN; NEURONS; PROSENCEPHALON; RANDOM ALLOCATION; STROKE; TIME FACTORS; TREATMENT OUTCOME;

EID: 39149124788     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2007.00502.x     Document Type: Article

References (41)

1. Macleod MR, O'collins T, Horky LL et al. Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke. J Pineal Res 2005 38 : 35 41.
2. Borlongan CV, Yamamoto M, Takei N et al. Glial cell survival is enhanced during melatonin-induced neuroprotection against cerebral ischemia. FASEB J 2000 14 : 1307 1317.
3. Kilic Ü, Kilic E, Reiter RJ et al. Signal transduction pathways involved in melatonin-induced neuroprotection after focal cerebral ischemia in mice. J Pineal Res 2005 38 : 67 71.
4. Kilic E, Kilic Ü, Reiter RJ et al. Tissue-plasminogen activator-induced ischemic brain injury is reversed by melatonin: role of iNOS and Akt. J Pineal Res 2005 39 : 151 155.
5. Lee E-J, Wu T-S, Lee M-Y et al. Delayed treatment with melatonin enhances electrophysiological recovery following transient focal cerebral ischemia in rats. J Pineal Res 2004 36 : 33 42.
6. Chen T-Y, Lee M-Y, Chen H-Y et al. Melatonin attenuates the postischemic increase in blood-brain barrier permeability and decreases hemorrhagic transformation of tissue-plasminogen activator therapy following ischemic stroke in mice. J Pineal Res 2006 40 : 242 250.
7. Lee E-J, Lee M-Y, Chen H-Y et al. Melatonin attenuates gray and white matter damage in a mouse model of transient focal cerebral ischemia. J Pineal Res 2005 38 : 42 52.
8. Letechipia-Vallejo G, López-Loeza E, Espinosa-González V et al. Long-term morphological and functional evaluation of the neuroprotective effects of post-ischemic treatment with melatonin in rats. J Pineal Res 2007 42 : 139 146.
9. Levine S, Sohn D. Cerebral ischemia in infant and adult gerbils. Relation to incomplete circle of Willis. Arch Pathol 1969 87 : 315 317.
10. Kahn K. The natural course of cerebral infarction in the gerbil. Neurology 1972 22 : 510 515.
11. Cuzzocrea S, Constantino G, Gitto E et al. Protective effects of melatonin in ischemic brain injury. J Pineal Res 2000 29 : 217 227.
12. Wang D, Corbett D. Cerebral ischemia, locomotor activity and spatial mapping. Brain Res 1990 533 : 78 82.
13. Colbourne F, Corbett D. Delayed postischemic hypothermia: a six month survival study using behavioral and histological assessments of neuroprotection. J Neurosci 1995 15 : 7250 7260.
14. West MJ, Slomianka L, Gundersen HJ. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 1991 231 : 482 497.
15. O'callaghan JP, Sriram K. Glial fibrillary acidic protein and related glial proteins as biomarkers of neurotoxicity. Expert Opin Drug Saf 2005 4 : 433 442.
16. Rao MS, Shetty AK. Efficacy of doublecortin as a marker to analyse the absolute number and dendritic growth of newly generated neurons in the adult dentate gyrus. Eur J Neurosci 2004 19 : 234 246.
17. Couillard-Despres S, Winner B, Schaubeck S et al. Doublecortin expression levels in adult brain reflect neurogenesis. Eur J Neurosci 2005 21 : 1 14.
18. Guerrero JM, Reiter RJ, Ortiz GG. Melatonin prevents increases in neural nitric oxide and cyclic GMP production after transient brain ischemia and reperfusion in the Mongolian gerbil (Meriones Unguiculatus). J Pineal Res 1997 23 : 24 31.
19. Cho S, Joh TH, Baik HH. Melatonin administration protects CA1 hippocampal neurons after transient forebrain ischemia in rats. Brain Res 1997 755 : 335 338.
20. Joo J-Y, Uz T, Manev H. Opposite effects of pinealectomy and melatonin administration on brain damage following cerebral focal ischemia in rat. Restor Neurol Neurosci 1998 13 : 185 191.
21. Pei Z, Pang SF, Cheung RTF. Pretreatment with melatonin reduces volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. J Pineal Res 2002 32 : 168 172.
22. Rasmussen DD, Boldt BM, Wilkinson CW et al. Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin and plasma insulin to youthful levels. Endocrinology 1999 140 : 1009 1012.
23. De butte M, Pappas BA. Pinealectomy causes hippocampal CA1 and CA3 cell loss: reversal by melatonin supplementation. Neurobiol Aging 2007 8 : 6 13.
24. Laidley DT, Colbourne F, Corbett D. Increased behavioral and histological variability arising from changes in cerebrovascular anatomy of the Mongolian gerbil. Curr Neurovasc Res 2005 2 : 401 407.
25. Seal JB, Buchh BN, Marks JD. New variability in cerebrovascular anatomy determines severity of hippocampal injury following forebrain ischemia in the Mongolian gerbil. Brain Res 2006 1074 : 451 459.
26. Ming GL, Song H. Adult neurogenesis in the mammalian central nervous system. Annu Rev Neurosci 2005 28 : 223 250.
27. Bendel O, Bueters T, Von euler M et al. Reappearance of hippocampal CA1 neurons after ischemia is associated with recovery of learning and memory. J Cereb Blood Flow Metab 2005 25 : 1586 1595.
28. Schmidt W, Revmann KG. Proliferating cells differentiate into neurons in the hippocampal CA1 region of gerbils after global cerebral ischemia. Neurosci Lett 2002 334 : 153 156.
29. Csernansky JG, Martin MV, Czeisler B et al. Neuroprotective effects of olanzapine in a rat model of neurodevelopmental injury. Pharmacol Biochem Behav 2006 83 : 208 213.
30. Kim M-J, Kim HK, Kim B-S et al. Melatonin increases cell proliferation in the dentate gyrus of maternally separated rats. J Pineal Res 2004 37 : 193 197.
31. Banasr M, Soumier A, Hery M et al. Agomelatine, a new antidepressant, induces regional changes in hippocampal neurogenesis. Biol Psychiatry 2006 59 : 1087 1096.
32. Yeleswaram K, Mclaughlin LG, Knipe JO et al. Pharmacokinetics and oral bioavailability of exogenous melatonin in preclinical animal models and clinical implications. J Pineal Res 1997 22 : 45 51.
33. Kilic E, Özdemir YG, Bolay H et al. Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia. J Cereb Blood Flow Metab 1999 19 : 511 516.
34. Sinha K, Degaonkar MN, Jagannathan NR et al. Effect of melatonin on ischemia reperfusion injury induced by middle cerebral artery occlusion in rats. Eur J Pharmacol 2001 428 : 185 192.
35. Pei Z, Fung PCW, Cheung RTF. Melatonin reduces nitric oxide level during ischemia but not blood-brain barrier breakdown during reperfusion in a rat middle cerebral artery occlusion stroke model. J Pineal Res 2003 34 : 110 118.
36. Pei Z, Pang SF, Cheung RTF. Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. Stroke 2003 34 : 770 775.
37. Gupta YK, Chaudhary G, Sinha K. Enhanced protection by melatonin and meloxicam combination in a middle cerebral artery occlusion model of acute ischemic stroke in rat. Can J Physiol Pharmacol 2002 80 : 210 217.
38. Torii K, Uneyama H, Nishino H et al. Melatonin suppresses cerebral edema caused by middle cerebral artery occlusion/reperfusion in rats assessed by magnetic resonance imaging. J Pineal Res 2004 36 : 18 24.
39. Kilic E, Kilic Ü, Yulug B et al. Melatonin reduces disseminate neuronal death after mild focal ischemia in mice via inhibition of caspase-3 and is suitable as an add-on treatment to tissue-plasminogen activator. J Pineal Res 2004 36 : 171 176.
40. Kilic E, Kilic Ü, Reiter RJ et al. AL Prophylactic use of melatonin protects against cerebral ischemia in mice: role of endothelin converting enzyme-1. J Pineal Res 2004 37 : 247 251.
41. Letechipia-Vallejo G, Gonzàlez-Burgos I, Cervantes M. Neuroprotective effect of melatonin on brain damage induced by acute global cerebral ischemia in cats. Arch Med Res 2001 32 : 186 192.