Nortriptyline protects mitochondria and reduces cerebral ischemia/hypoxia injury

Stroke

Volumn 39, Issue 2, 2008, Pages 455-462

  Zhang, Wen Hua ^a,b   Wang, Hongyan ^a   Wang, Xin ^a   Narayanan, Malini V ^a   Stavrovskaya, Irina G ^c   Kristal, Bruce S ^c,d   Friedlander, Robert M ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b SHANDONG UNIVERSITY   (China)

^c BURKE MEDICAL RESEARCH INSTITUTE   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Cell death; Cerebral ischemia; Mitochondrial permeability transition; Neuroprotection; Nortriptyline

Indexed keywords

CASPASE 3; GLUCOSE; NORTRIPTYLINE; OXYGEN; ADRENERGIC RECEPTOR AFFECTING AGENT; APOPTOSIS INDUCING FACTOR; CALCIUM; CARRIER PROTEIN; CYTOCHROME C; DIABLO PROTEIN, MOUSE; MITOCHONDRIAL PROTEIN; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BRAIN CELL; BRAIN FUNCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL DEATH; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVATION; HYPOXIA; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MOLECULAR MODEL; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BRAIN CORTEX; C57BL MOUSE; CEREBRAL ARTERY DISEASE; CONVALESCENCE; DRUG EFFECT; METABOLISM; MITOCHONDRION; NERVE CELL; PATHOLOGY; REPERFUSION INJURY;

ADRENERGIC UPTAKE INHIBITORS; ANIMALS; APOPTOSIS INDUCING FACTOR; CALCIUM; CARRIER PROTEINS; CELL DEATH; CEREBRAL CORTEX; CYTOCHROMES C; GLUCOSE; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; NORTRIPTYLINE; OXYGEN; RECOVERY OF FUNCTION; REPERFUSION INJURY;

EID: 39349115731     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.107.496810     Document Type: Article

References (31)