Combined TLR2 and TLR4 ligation in the context of bacterial or helminth extracts in human monocyte derived dendritic cells: Molecular correlates for Th1/Th2 polarization

BMC Immunology

Volumn 10, Issue , 2009, Pages

  van Riet, Elly ^a,e   Everts, Bart ^a   Retra, Kim ^a,b   Phylipsen, Marion ^a   van Hellemond, Jaap J ^b,c   Tielens, Aloysius G M ^b,c   van der Kleij, Desiree ^a,d   Hartgers, Franca C ^a   Yazdanbakhsh, Maria ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d TNO   (Netherlands)

^e LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; NOTCH4 RECEPTOR; PHOSPHOLIPID; PROTEIN C FOS; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; BACTERIAL ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PARASITE ANTIGEN; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

ARTICLE; ASCARIS LUMBRICOIDES; CONTROLLED STUDY; DENDRITIC CELL; ENZYME ACTIVATION; ESCHERICHIA COLI; GENE ACTIVITY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LISTERIA MONOCYTOGENES; LYMPHOCYTE FUNCTION; NONHUMAN; POLARIZATION; SCHISTOSOMA MANSONI; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; ANIMAL; CYTOLOGY; GENE EXPRESSION; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MONOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTIGENS, BACTERIAL; ANTIGENS, HELMINTH; ASCARIS LUMBRICOIDES; DENDRITIC CELLS; ENZYME ACTIVATION; ESCHERICHIA COLI; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; LISTERIA MONOCYTOGENES; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SCHISTOSOMA MANSONI; SIGNAL TRANSDUCTION; TH1 CELLS; TH2 CELLS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 65449152209     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/1471-2172-10-9     Document Type: Article

References (65)

1. Kapsenberg ML Dendritic-cell control of pathogen-driven T-cell polarization Nat Rev Immunol 2003, 3:984-993 10.1038/nri1246 14647480
2. Colonna M Pulendran B Iwasaki A Dendritic cells at the host-pathogen interface Nat Immunol 2006, 7:117-120 10.1038/ni0206-117 16424884
3. Granucci F Zanoni I Ricciardi-Castagnoli P Central role of dendritic cells in the regulation and deregulation of immune responses Cell Mol Life Sci 2008, 18327662
4. de Jong EC Vieira PL Kalinski P Schuitemaker JH Tanaka Y Wierenga EA et al Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse th cell-polarizing signals J Immunol 2002, 168:1704-1709 11823500
5. Yazdanbakhsh M van den BA Maizels RM Th2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease Trends Immunol 2001, 22:372-377 10.1016/S1471-4906(01)01958-5 11429321
6. Kleij van der D Latz E Brouwers JF Kruize YC Schmitz M Kurt-Jones EA et al A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine acivates Toll-like receptor 2 and affects immune polarization J Biol Chem 2002, 277:48122-48129 10.1074/jbc.M206941200 12359728
7. Iwasaki A Medzhitov R Toll-like receptor control of the adaptive immune responses Nat Immunol 2004, 5:987-995 10.1038/ni1112 15454922
8. Reis e Sousa Toll-like receptors and dendritic cells: For whom the bug tolls Semin Immunol 2004, 16:27-34 10.1016/j.smim.2003.10.004 14751761
9. Akira S Uematsu S Takeuchi O Pathogen Recognition and Innate Immunity Cell 2006, 124:783-801 10.1016/j.cell.2006.02.015 16497588
10. MacDonald AS Maizels RM Alarming dendritic cells for Th2 induction J Exp Med 2008, 205:13-17 2234366 18195077 10.1084/jem.20072665
11. Underhill DM Collaboration between the innate immune receptors dectin-1, TLRs, and Nods Immunol Rev 2007, 219:75-87 10.1111/ j.1600-065X.2007.00548.x 17850483
12. Khayrullina T Yen JH Jing H Ganea D In vitro differentiation of dendritic cells in the presence of prostaglandin E2 alters the IL-12/ IL-23 balance and promotes differentiation of Th17 cells J Immunol 2008, 181:721-735 18566439
13. Acosta-Rodriguez EV Napolitani G Lanzavecchia A Sallusto F Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells Nat Immunol 2007, 8:942-949 10.1038/ni1496 17676045
14. Banerjee A Gerondakis S Coordinating TLR-activated signaling pathways in cells of the immune system Immunol Cell Biol 2007, 85:420-424 10.1038/ sj.icb.7100098 17637696
15. Dillon S Agrawal A Van Dyke T Landreth G McCauley L Koh A et al expDC-RNAA Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells J Immunol 2004, 172:4733-4743 15067049
16. Han J Lee JD Bibbs L Ulevitch RJ A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells Science 1994, 265:808-811 10.1126/ science.7914033 7914033
17. Aggarwal BB Signalling pathways of the TNF superfamily: A double-edged sword Nat Rev Immunol 2003, 3:745-756 10.1038/nri1184 12949498
18. Agrawal S Agrawal A Doughty B Gerwitz A Blenis J Van Dyke T et al Cutting edge: Different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos J Immunol 2003, 171:4984-4989 14607893
19. Akira S Takeda K Kaisho T Toll-like receptors: Critical proteins linking innate and acquired immunity Nat Immunol 2001, 2:675-680 10.1038/90609 11477402
20. Alexander WS Starr R Metcalf D Nicholson SE Farley A Elefanty AG et al Suppressors of cytokine signaling (SOCS): Negative regulators of signal transduction J Leukoc Biol 1999, 66:588-592 10534114
21. Amsen D Blander JM Lee GR Tanigaki K Honjo T Flavell RA Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells Cell 2004, 117:515-526 10.1016/ S0092-8674(04)00451-9 15137944
22. Balkhy HH Heinzel FP Endotoxin fails to induce IFN-gamma in endotoxin-tolerant mice: Deficiencies in both IL-12 heterodimer production and IL-12 responsiveness J Immunol 1999, 162:3633-3638 10092824
23. Bleharski JR Li H Meinken C Graeber TG Ochoa MT Yamamura M et al Use of genetic profiling in leprosy to discriminate clinical forms of the disease Science 2003, 301:1527-1530 10.1126/science.1087785 12970564
24. Burns K Martinon F Esslinger C Pahl H Schneider P Bodmer JL et al MyD88, an adapter protein involved in interleukin-1 signaling J Biol Chem 1998, 273:12203-12209 10.1074/jbc.273.20.12203 9575168
25. Butte MJ Keir ME Phamduy TB Sharpe AH Freeman GJ Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses Immunity 2007, 27:111-122 10.1016/ j.immuni.2007.05.016 17629517
26. Chen Z Laurence A O'Shea JJ Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation Semin Immunol 2007, 2323678 18166487
27. Delgado M Gonzalez-Rey E Ganea D VIP/PACAP preferentially attract Th2 effectors through differential regulation of chemokine production by dendritic cells FASEB J 2004, 18:1453-1455 15231725
28. Grohmann U Fallarino F Puccetti P Tolerance, DCs and tryptophan: Much ado about IDO Trends Immunol 2003, 24:242-248 10.1016/ S1471-4906(03)00072-3 12738417
29. Habicht A Kewalaramani R Vu MD Demirci G Blazar BR Sayegh MH et al Striking dichotomy of PD-L1 and PD-L2 pathways in regulating alloreactive CD4(+) and CD8(+) T cells in vivo Am J Transplant 2007, 7:2683-2692 10.1111/j.1600-6143.2007.01999.x 17924994
30. Hardy MP McGGettrick AF O'Neill LA Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene Biochem J 2004, 380:83-93 1224148 14960149 10.1042/BJ20040030
31. Inohara N Nunez G NODs: Intracellular proteins involved in inflammation and apoptosis Nat Rev Immunol 2003, 3:371-382 10.1038/nri1086 12766759
32. Ivanov II Zhou L Littman DR Transcriptional regulation of Th17 cell differentiation Semin Immunol 2007, 18053739
33. Jeffrey KL Brummer T Rolph MS Liu SM Callejas NA Grumont RJ et al Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1 Nat Immunol 2006, 7:274-283 10.1038/ni1310 16474395
34. Kabelitz D Wesch D Oberg HH Regulation of regulatory T cells: Role of dendritic cells and toll-like receptors Crit Rev Immunol 2006, 26:291-306 17073555
35. Kawai T Takeuchi O Fujita T Inoue J Muhlradt PF Sato S et al Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes J Immunol 2001, 167:5887-5894 11698465
36. Langrish CL McKenzie BS Wilson NJ de Waal MR Kastelein RA Cua DJ IL-12 and IL-23: Master regulators of innate and adaptive immunity Immunol Rev 2004, 202:96-105 10.1111/j.0105-2896.2004.00214.x 15546388
37. Mahnke K Johnson TS Ring S Enk AH Tolerogenic dendritic cells and regulatory T cells: A two-way relationship J Dermatol Sci 2007, 46:159-167 10.1016/j.jdermsci.2007.03.002 17428639
38. Pauleau AL Murray PJ Role of nod2 in the response of macrophages to toll-like receptor agonists Mol Cell Biol 2003, 23:7531-7539 207570 14560001 10.1128/MCB.23.21.7531-7539.2003
39. Schaller MA Neupane R Rudd BD Kunkel SL Kallal LE Lincoln P et al Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines J Exp Med 2007, 204:2925-2934 2118527 17998388 10.1084/jem.20070661
40. Sharpe AH Wherry EJ Ahmed R Freeman GJ The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection Nat Immunol 2007, 8:239-245 10.1038/ni1443 17304234
41. Sloane DE Tedla N Awoniyi M Macglashan DW Jr Borges L Austen KF et al Leukocyte immunoglobulin-like receptors: Novel innate receptors for human basophil activation and inhibition Blood 2004, 104:2832-2839 10.1182/blood-2004-01-0268 15242876
42. Strobl H Knapp W TGF-beta1 regulation of dendritic cells Microbes Infect 1999, 1:1283-1290 10.1016/S1286-4579(99)00256-7 10611756
43. Takeda K Akira S TLR signaling pathways Semin Immunol 2004, 16:3-9 10.1016/j.smim.2003.10.003 14751757
44. Watanabe T Kitani A Murray PJ Strober W NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses Nat Immunol 2004, 5:800-808 10.1038/ni1092 15220916
45. Weighardt H Jusek G Mages J Lang R Hoebe K Beutler B et al Identification of a TLR4- and TRIF-dependent activation program of dendritic cells Eur J Immunol 2004, 34:558-564 10.1002/eji.200324714 14768061
46. Yamamoto M Sato S Hemmi H Hoshino K Kaisho T Sanjo H et al Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway Science 2003, 301:640-643 10.1126/science.1087262 12855817
47. Yoshimura A Naka T Kubo M SOCS proteins, cytokine signalling and immune regulation Nat Rev Immunol 2007, 7:454-465 10.1038/nri2093 17525754
48. Zhang G Ghosh S Negative regulation of toll-like receptor-mediated signaling by Tollip J Biol Chem 2002, 277:7059-7065 10.1074/ jbc.M109537200 11751856
49. Nakahara T Moroi Y Uchi H Furue M Differential role of MAPK signaling in human dendritic cell maturation and Th1/Th2 engagement J Dermatol Sci 2006, 42:1-11 10.1016/j.jdermsci.2005.11.004 16352421
50. Thomas PG Carter MR Atochina O Da'Dara AA Piskorska D McGuire E et al Maturation of dendritic cell 2 phenotype by a helminth glycan uses a Toll-like receptor 4-dependent mechanism J Immunol 2003, 171:5837-5841 14634093
51. Goodridge HS Harnett W Liew FY Harnett MM Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses Immunology 2003, 109:415-425 1782981 12807488 10.1046/j.1365-2567.2003.01689.x
52. Worsley AG Leibundgut-Landmann S Slack E Phng LK Gerhardt H Sousa CR at al Dendritic cell expression of the Notch ligand jagged2 is not essential for Th2 response induction in vivo Eur J Immunol 2008, 38:1043-1049 10.1002/eji.200737335 18350543
53. Sun J Krawczyk CJ Pearce EJ Suppression of th2 cell development by notch ligands delta1 and delta4 J Immunol 2008, 180:1655-1661 18209061
54. Yang D Chen Q Su SB Zhang P Kurosaka K Caspi RR et al Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses J Exp Med 2008, 205:79-90 2234357 18195069 10.1084/jem.20062027
55. Netea MG Sutmuller R Hermann C Graaf Van der CA Meer Van der JW van Krieken JH et al Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells J Immunol 2004, 172:3712-3718 15004175
56. Sieling PA Chung W Duong BT Godowski PJ Modlin RL Toll-Like Receptor 2 Ligands as Adjuvants for Human Th1 Responses J Immunol 2003, 170:194-200 12496400
57. Takeuchi O Kawai T Muhlradt PF Morr M Radolf JD Zychlinsky A et al Discrimination of bacterial lipoproteins by Toll-like receptor 6 Int Immunol 2001, 13:933-940 10.1093/intimm/13.7.933 11431423
58. Takeuchi O Sato S Horiuchi T Hoshino K Takeda K Dong Z et al Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins J Immunol 2002, 169:10-14 12077222
59. Gringhuis SI den Dunnen J Litjens M van het Hof B van Kooyk Y Geijtenbeek TBH C-Type Lectin DC-SIGN Modulates Toll-like Receptor Signaling via Raf-1 Kinase-Dependent Acetylation of Transcription Factor NF-[kappa]B Immunity 2007, 26:605-616 10.1016/j.immuni.2007.03.012 17462920
60. Takeuchi O Hoshino K Kawai T Sanjo H Takada H Ogawa T et al Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components Immunity 1999, 11:443-451 10.1016/ S1074-7613(00)80119-3 10549626
61. Kim JG Lee SJ Kagnoff MF Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors Infect Immun 2004, 72:1487-1495 356064 14977954 10.1128/IAI.72.3.1487-1495.2004
62. Kobayashi KS Chamaillard M Ogura Y Henegariu O Inohara N Nunez G et al Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract Science 2005, 307:731-734 10.1126/science.1104911 15692051
63. Lee MS Kim YJ Signaling pathways downstream of pattern-recognition receptors and their cross talk Annu Rev Biochem 2007, 76:447-480 10.1146/ annurev.biochem.76.060605.122847 17328678
64. Retra K van Riet E Adegnika AA Everts B van Geest S Kremsner PG et al Immunologic activity of schistosomal and bacterial TLR2 ligands in Gabonese children Parasite Immunol 2008, 30:39-46 18086015
65. The Perkin-Elmer Corporation User bulletin #2. ABI Prism 7700 Sequence Detection system. P/N 4303859 Rev.A, Stock No 777802-001 2005