Striking dichotomy of PD-L1 and PD-L2 pathways in regulating alloreactive CD4+ and CD8+ T cells in vivo

American Journal of Transplantation

Volumn 7, Issue 12, 2007, Pages 2683-2692

  Habicht, A ^a   Kewalaramani, R ^a   Vu, M D ^b   Demirci, G ^b   Blazar, B R ^c   Sayegh, M H ^a   Li, X C ^b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Apoptosis; Costimulation; PD 1; Regulation; T cell activation

Indexed keywords

ALLOANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; LIGAND; PROGRAMMED DEATH LIGAND 1; PROGRAMMED DEATH LIGAND 2; UNCLASSIFIED DRUG;

ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; GRAFT VERSUS HOST REACTION; IMMUNE RESPONSE; IMMUNOREGULATION; IMMUNOSTIMULATION; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD28; ANTIGENS, CD80; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; GRAFT VS HOST DISEASE; ISOANTIGENS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, KNOCKOUT; PEPTIDES; SIGNAL TRANSDUCTION;

EID: 35748957454     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2007.01999.x     Document Type: Article

References (30)

1. Rothstein DM, Sayegh MH. T-cell costimulatory pathways in allograft rejection and tolerance. Immunol Rev 2003 196 : 85 108.
2. Greenwald RJ, Freeman GJ, Sharpe AH. The B7 family revisited. Annu Rev Immunol 2005 23 : 515 548.
3. Salomon B, Bluestone JA. Complexities CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu Rev Immunol 2001 19 : 225 252.
4. Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol 2007 8 : 239 245.
5. Okazaki T, Iwai Y, Honjo T. New regulatory co-receptors: Inducible co-stimulator and PD-1. Curr Opin Immunol 2002 14 : 779 782.
6. Nishimura H, Nose M, Hiai H, Minato N, Honjo T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999 11 : 141 151.
7. Nishimura H, Okazaki T, Tanaka Y et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 2001 291 : 319 322.
8. Ansari MJI, Salama AD, Chitnis T et al. The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice. J Exp Med 2003 198 : 63 69.
9. Salama AD, Chitnis T, Imitola J et al. Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis. J Exp Med 2003 198 : 71 78.
10. Fife BT, Guleria I, Gubbels Bupp M et al. Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway. J Exp Med 2006 203 : 2737 2747.
11. Blazar BR, Carreno BM, Panoskaltsis-Mortari A et al. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-{gamma}-dependent mechanism. J Immunol 2003 171 : 1272 1277.
12. Latchman YE, Liang SC, Wu Y et al. PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc Natl Acad Sci U S A 2004 101 : 10691 10696.
13. Khoury SJ, Sayegh MH. The roles of the new negative T cell costimulatory pathways in regulating autoimmunity. Immunity 2004 20 : 529 538.
14. Keir ME, Liang SC, Guleria I et al. Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med 2006 203 : 883 895.
15. Matsumoto K, Inoue H, Nakano T et al. B7-DC regulates asthmatic response by an IFN-{gamma}-dependent mechanism. J Immunol 2004 172 : 2530 2541.
16. Zhu B, Guleria I, Khosroshahi A et al. Differential role of programmed death-ligand 1 and programmed death-ligand 2 in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitis. J Immunol 2006 176 : 3480 3489.
17. Subudhi SK, Zhou P, Yerian LM et al. Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection. J Clin Invest 2004 113 : 694 700.
18. Kanai T, Totsuka T, Uraushihara K et al. Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. J Immunol 2003 171 : 4156 4163.
19. Ozkaynak E, Wang L, Goodearl A et al. Programmed death-1 targeting can promote allograft survival. J Immunol 2002 169 : 6546 6553.
20. Gao W, Demirci G, Strom TB, Li XC. Stimulating PD-1 negative signals concurrent with blocking CD154 costimulation induces long-term islet allograft survival. Transplantation 2003 76 : 994 999.
21. Ito T, Ueno T, Clarkson MR et al. Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo. J Immunol 2005 174 : 6648 6656.
22. Sandner SE, Clarkson MR, Salama AD et al. Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo. J Immunol 2005 174 : 3408 3415.
23. Wells AD, Gudmundsdottir H, Turka LA. Following the fate of individual T cells throughout activation and clonal expansion. J Clin Invest 1997 100 : 3173 3183.
24. + T cell mediated rejection. J Immunol 2004 173 : 214 221.
25. Vu MD, Li XC. Study of T cell costimulatory blockade in vivo at a single cell level. In : Ludewig B, Hoffmann MW, eds. Adoptive immunotherapy. Totowa : Humana, 2004 : 409 420.
26. Li Y, Li XC, Zheng XX, Wells AD, Turka LA, Strom TB. Blocking both signal 1 and signal 2 of T cell activation prevents of apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat Med 1999 5 : 1298 1302.
27. Demirci G, Gao W, Zheng XX, Malek TR, Strom TB, Li XC. On CD28/CD40 ligand costimulation, common {gamma}-chain signals, and the alloimmune response. J Immunol 2002 168 : 4382 4390.
28. Yao S, Chen L. Reviving exhausted T lymphocytes during chronic virus infection by B7-H1 blockade. Trends Mol Med 2006 12 : 244 246.
29. Carter LL, Fouser LA, Jussif JM et al. PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2. Eur J Immunol 2002 32 : 634 643.
30. Brown JA, Dorfman DM, Ma F-R et al. Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J Immunol 2003 170 : 1257 1266.