메뉴 건너뛰기




Volumn 113, Issue 15, 2009, Pages 3475-3484

CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; B7 ANTIGEN; CD28 ANTIGEN; CD40 LIGAND MONOCLONAL ANTIBODY; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

EID: 65349134818     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-01-133736     Document Type: Article
Times cited : (33)

References (75)
  • 1
    • 0028860210 scopus 로고
    • Mixed allo-geneic chimerism and renal allograft tolerance in cynomolgus monkeys
    • Kawai T, Cosimi AB, Colvin RB, et al. Mixed allo-geneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation. 1995;59: 256-262.
    • (1995) Transplantation , vol.59 , pp. 256-262
    • Kawai, T.1    Cosimi, A.B.2    Colvin, R.B.3
  • 3
    • 33746931587 scopus 로고    scopus 로고
    • Myeloma responses and tolerance following combined kidney and nonmyeloablative marrow transplanta-tion: In vivo and in vitro analyses
    • FudabaY, SpitzerTR, Shaffer J, et al. Myeloma responses and tolerance following combined kidney and nonmyeloablative marrow transplanta-tion: in vivo and in vitro analyses. Am J Trans-plant. 2006;6:2121-2133.
    • (2006) Am J Trans-plant , vol.6 , pp. 2121-2133
    • Fudaba, Y.1    Spitzer, T.R.2    Shaffer, J.3
  • 4
    • 0035025762 scopus 로고    scopus 로고
    • Mixed chimerism and transplant tolerance
    • Sykes M. Mixed chimerism and transplant tolerance. Immunity. 2001;14:417-424.
    • (2001) Immunity , vol.14 , pp. 417-424
    • Sykes, M.1
  • 5
    • 0032526283 scopus 로고    scopus 로고
    • Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central Tcell tolerance
    • Wekerle T, Sayegh MH, Hill J, et al. Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central Tcell tolerance. J Exp Med. 1998;187:2037-2044.
    • (1998) J Exp Med , vol.187 , pp. 2037-2044
    • Wekerle, T.1    Sayegh, M.H.2    Hill, J.3
  • 6
    • 0034071426 scopus 로고    scopus 로고
    • Allogeneic bone marrow transplantation with co-stimulatory block-ade induces macrochimerism and tolerance with out cytoreductive host treatment
    • Wekerle T, Kurtz J, Ito H, et al. Allogeneic bone marrow transplantation with co-stimulatory block-ade induces macrochimerism and tolerance with out cytoreductive host treatment. Nat Med. 2000; 6:464-469.
    • (2000) Nat Med , vol.6 , pp. 464-469
    • Wekerle, T.1    Kurtz, J.2    Ito, H.3
  • 7
    • 0034654374 scopus 로고    scopus 로고
    • Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 anti-body: Absence of graft-versus-host disease, in-duction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice
    • Seung E, Iwakoshi N, Woda BA, et al. Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 anti-body: absence of graft-versus-host disease, in-duction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice. Blood. 2000;95:2175-2182.
    • (2000) Blood , vol.95 , pp. 2175-2182
    • Seung, E.1    Iwakoshi, N.2    Woda, B.A.3
  • 8
    • 85047692674 scopus 로고    scopus 로고
    • Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning
    • Seung E, Mordes JP, Rossini AA, Greiner DL. Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning. J Clin Invest. 2003; 112:795-808.
    • (2003) J Clin Invest , vol.112 , pp. 795-808
    • Seung, E.1    Mordes, J.P.2    Rossini, A.A.3    Greiner, D.L.4
  • 9
    • 0034235458 scopus 로고    scopus 로고
    • Cutting edge: Administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chi- merism and donor-specific tolerance without cy- toreductive conditioning
    • Durham MM, Bingaman AW, Adams AB, et al. Cutting edge: administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chi- merism and donor-specific tolerance without cy- toreductive conditioning. J Immunol. 2000;165:1-4.
    • (2000) J Immunol , vol.165 , pp. 1-4
    • Durham, M.M.1    Bingaman, A.W.2    Adams, A.B.3
  • 10
  • 11
    • 0035284740 scopus 로고    scopus 로고
    • CD4T cell- mediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is depen-ent on CD40-CD40 ligand interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this path-way
    • Ito H, Kurtz J, Shaffer J, Sykes M. CD4T cell- mediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is depen-ent on CD40-CD40 ligand interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this path-way. J Immunol. 2001;166:2970-2981.
    • (2001) J Immunol , vol.166 , pp. 2970-2981
    • Ito, H.1    Kurtz, J.2    Shaffer, J.3    Sykes, M.4
  • 12
    • 2542450949 scopus 로고    scopus 로고
    • Mechanisms of early peripheral CD4 T cell tolerance induction by anti-CD154 monoclo-nal antibody and allogeneic bone marrow trans-plantation: Evidence for anergy and deletion, but not regulatory cells
    • Kurtz J, Shaffer J, Lie A, Anosova N, Benichou G, Sykes M. Mechanisms of early peripheral CD4 T cell tolerance induction by anti-CD154 monoclo-nal antibody and allogeneic bone marrow trans-plantation: evidence for anergy and deletion, but not regulatory cells. Blood. 2004;103:4336-4343.
    • (2004) Blood , vol.103 , pp. 4336-4343
    • Kurtz, J.1    Shaffer, J.2    Lie, A.3    Anosova, N.4    Benichou, G.5    Sykes, M.6
  • 13
    • 0035879193 scopus 로고    scopus 로고
    • Costimu- lation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce trans-plantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppres- sion
    • Adams AB, Durham MM, Kean L, et al. Costimu- lation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce trans-plantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppres- sion. J Immunol. 2001;167:1103-1111.
    • (2001) J Immunol , vol.167 , pp. 1103-1111
    • Adams, A.B.1    Durham, M.M.2    Kean, L.3
  • 15
    • 21244483043 scopus 로고    scopus 로고
    • Roles of deletion and regulation in creating mixed chimerism and allograft tolerance using a non- lymphoablative irradiation-free protocol
    • Domenig C, Sanchez-Fueyo A, Kurtz J, et al. Roles of deletion and regulation in creating mixed chimerism and allograft tolerance using a non- lymphoablative irradiation-free protocol. J Immu-nol. 2005;175:51-60.
    • (2005) J Immu-nol , vol.175 , pp. 51-60
    • Domenig, C.1    Sanchez-Fueyo, A.2    Kurtz, J.3
  • 16
    • 20544457031 scopus 로고    scopus 로고
    • The role of non-deletional tolerance mechanisms in a murine model of mixed chimerism with costimulation blockade
    • Bigenzahn S, Blaha P, Koporc Z, et al. The role of non-deletional tolerance mechanisms in a murine model of mixed chimerism with costimulation blockade. Am J Transplant. 2005;5:1237-1247.
    • (2005) Am J Transplant , vol.5 , pp. 1237-1247
    • Bigenzahn, S.1    Blaha, P.2    Koporc, Z.3
  • 17
    • 0035502524 scopus 로고    scopus 로고
    • Mechanisms involved in the establishment of tol-erance through costimulatory blockade and BMT: Lack of requirement for CD40L-mediated signal--ing for tolerance or deletion of donor-reactive CD4+ cells
    • Kurtz J, Ito H, WekerleT, Shaffer J, Sykes M. Mechanisms involved in the establishment of tol-erance through costimulatory blockade and BMT: lack of requirement for CD40L-mediated signal--ing for tolerance or deletion of donor-reactive CD4+ cells. Am J Transplant. 2001;1:339-349.
    • (2001) Am J Transplant , vol.1 , pp. 339-349
    • Kurtz, J.1    Ito, H.2    Wekerle, T.3    Shaffer, J.4    Sykes, M.5
  • 18
    • 26044443747 scopus 로고    scopus 로고
    • Early regulation of CD8 Tcell alloreactivity by CD4 + CD25- T cells in recipients of anti-CD154 antibody and allogeneic BMT is followed by rapid peripheral deletion of donor-reactive CD8+ T cells, precluding a role for sustained regulation
    • Fehr T, Takeuchi Y, Kurtz J, Wekerle T, Sykes M. Early regulation of CD8 Tcell alloreactivity by CD4 + CD25- T cells in recipients of anti-CD154 antibody and allogeneic BMT is followed by rapid peripheral deletion of donor-reactive CD8+ T cells, precluding a role for sustained regulation. Eur J Immunol. 2005;35:2679-2690.
    • (2005) Eur J Immunol , vol.35 , pp. 2679-2690
    • Fehr, T.1    Takeuchi, Y.2    Kurtz, J.3    Wekerle, T.4    Sykes, M.5
  • 19
    • 0742318926 scopus 로고    scopus 로고
    • Earlier low-dose TBI or DST overcomes CD8+ T-cell-mediated alloresistance to alloge-neic marrow in recipients of anti-CD40L
    • 19
    • 19.Takeuchi Y, Ito H, Kurtz J, Wekerle T, Ho L, Sykes M. Earlier low-dose TBI or DST overcomes CD8+ T-cell-mediated alloresistance to alloge-neic marrow in recipients of anti-CD40L. Am J Transplant. 2004;4:31-40.
    • (2004) Am J Transplant , vol.4 , pp. 31-40
    • Takeuchi, Y.1    Ito, H.2    Kurtz, J.3    Wekerle, T.4    Ho, L.5    Sykes, M.6
  • 21
    • 85047693292 scopus 로고    scopus 로고
    • CD28 ligation induces transplantation tolerance byIFN- gamma-dependent depletion of T cells that recog-nize alloantigens
    • Yu XZ, Albert MH, Martin PJ, Anasetti C. CD28 ligation induces transplantation tolerance byIFN- gamma-dependent depletion of T cells that recog-nize alloantigens. J Clin Invest. 2004;113:1624-1630.
    • (2004) J Clin Invest , vol.113 , pp. 1624-1630
    • Yu, X.Z.1    Albert, M.H.2    Martin, P.J.3    Anasetti, C.4
  • 22
    • 0037310650 scopus 로고    scopus 로고
    • CD28/B7 regu-lation of anti-CD3-mediated immunosuppression invivo
    • Tang Q, Smith JA, Szot GL, et al. CD28/B7 regu-lation of anti-CD3-mediated immunosuppression invivo. J Immunol. 2003;170:1510-1516.
    • (2003) J Immunol , vol.170 , pp. 1510-1516
    • Tang, Q.1    Smith, J.A.2    Szot, G.L.3
  • 23
    • 0035059417 scopus 로고    scopus 로고
    • Complexities of CD28/ B7: CTLA-4 costimulatory pathways in autoimmu- nity and transplantation
    • Salomon B, Bluestone JA. Complexities of CD28/ B7: CTLA-4 costimulatory pathways in autoimmu- nity and transplantation. Annu Rev Immunol.2001;19:225- 252.
    • (2001) Annu Rev Immunol , vol.19 , pp. 225-252
    • Salomon, B.1    Bluestone, J.A.2
  • 24
    • 0025268937 scopus 로고
    • In vivo administration of interleukin 2 plus T cell-depleted syngeneic marrow prevents graft-versus- host disease mortality and permits alloengraft- ment
    • Sykes M, Romick ML, Hoyles KA, Sachs DH. In vivo administration of interleukin 2 plus T cell-depleted syngeneic marrow prevents graft-versus- host disease mortality and permits alloengraft- ment. J Exp Med. 1990;171:645-658.
    • (1990) J Exp Med , vol.171 , pp. 645-658
    • Sykes, M.1    Romick, M.L.2    Hoyles, K.A.3    Sachs, D.H.4
  • 25
    • 0030024697 scopus 로고    scopus 로고
    • Additional monoclonal antibody (mAB) injections can re-place thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irra-diation
    • Tomita Y, Sachs DH, Khan A, Sykes M. Additional monoclonal antibody (mAB) injections can re-place thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irra-diation. Transplantation. 1996;61:469-477.
    • (1996) Transplantation , vol.61 , pp. 469-477
    • Tomita, Y.1    Sachs, D.H.2    Khan, A.3    Sykes, M.4
  • 26
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multior- gan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multior- gan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity. 1995;3:541-547.
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 27
    • 0033579816 scopus 로고    scopus 로고
    • B7-1 or 27-2 is required to produce the lymphoprolifera- tive phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
    • Mandelbrot DA, McAdam AJ, Sharpe AH. B7-1 or 27-2 is required to produce the lymphoprolifera- tive phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). J Exp Med. 1999;189:435-440.
    • (1999) J Exp Med , vol.189 , pp. 435-440
    • Mandelbrot, D.A.1    McAdam, A.J.2    Sharpe, A.H.3
  • 28
    • 0035069856 scopus 로고    scopus 로고
    • Induction of toler-ance by mixed chimerism with nonmyeloblative host conditioning: The importance of overcoming intrathymic alloresistance
    • Nikolic B, Khan A, Sykes M. Induction of toler-ance by mixed chimerism with nonmyeloblative host conditioning: the importance of overcoming intrathymic alloresistance. Biol Blood Marrow Transplant. 2001;7:144-153.
    • (2001) Biol Blood Marrow Transplant , vol.7 , pp. 144-153
    • Nikolic, B.1    Khan, A.2    Sykes, M.3
  • 29
    • 0029960141 scopus 로고    scopus 로고
    • Superanti- gen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expan-sion in vitro and in vivo
    • Krummel MF, Sullivan TJ, Allison JP. Superanti- gen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expan-sion in vitro and in vivo. Int Immunol. 1996;8:519-523.
    • (1996) Int Immunol , vol.8 , pp. 519-523
    • Krummel, M.F.1    Sullivan, T.J.2    Allison, J.P.3
  • 30
    • 0033682056 scopus 로고    scopus 로고
    • B7/ CD28 costimulation is essential for the homeosta- sis of the CD4+CD25+ immunoregulatoryT cells that control autoimmune diabetes
    • Salomon B, Lenschow DJ, Rhee L, et al. B7/ CD28 costimulation is essential for the homeosta- sis of the CD4+CD25+ immunoregulatoryT cells that control autoimmune diabetes. Immunity.2000;12:431-440.
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1    Lenschow, D.J.2    Rhee, L.3
  • 31
    • 0141920662 scopus 로고    scopus 로고
    • Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory Tcells
    • Tang Q, Henriksen KJ, Boden EK, et al. Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory Tcells. J Immunol.2003;171:3348- 3352.
    • (2003) J Immunol , vol.171 , pp. 3348-3352
    • Tang, Q.1    Henriksen, K.J.2    Boden, E.K.3
  • 32
    • 33746336533 scopus 로고    scopus 로고
    • The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatoryT-cell biology
    • Sansom DM, Walker LS. The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatoryT-cell biology. Immunol Rev. 2006;212:131-148.
    • (2006) Immunol Rev , vol.212 , pp. 131-148
    • Sansom, D.M.1    Walker, L.S.2
  • 33
    • 0037810672 scopus 로고    scopus 로고
    • The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens
    • Lohr J, Knoechel B, Jiang S, Sharpe AH, Abbas AK. The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens. Nat Immunol. 2003;4:664-669.
    • (2003) Nat Immunol , vol.4 , pp. 664-669
    • Lohr, J.1    Knoechel, B.2    Jiang, S.3    Sharpe, A.H.4    Abbas, A.K.5
  • 34
    • 4043147851 scopus 로고    scopus 로고
    • B7-CD28 inter-action promotes proliferation and survival but suppresses differentiation of CD4-CD8- Tcells in the thymus
    • Zheng X, Gao JX, Chang X, et al. B7-CD28 inter-action promotes proliferation and survival but suppresses differentiation of CD4-CD8- Tcells in the thymus. J Immunol. 2004;173:2253-2261.
    • (2004) J Immunol , vol.173 , pp. 2253-2261
    • Zheng, X.1    Gao, J.X.2    Chang, X.3
  • 35
    • 25444442035 scopus 로고    scopus 로고
    • Regu-lated costimulation in the thymus is critical for T cell development: Dysregulated CD28 costimula- tion can bypass the pre-TCR checkpoint
    • Williams JA, Hathcock KS, Klug D, et al. Regu-lated costimulation in the thymus is critical for T cell development: dysregulated CD28 costimula- tion can bypass the pre-TCR checkpoint. J Immu-nol. 2005;175:4199-4207.
    • (2005) J Immu-nol , vol.175 , pp. 4199-4207
    • Williams, J.A.1    Hathcock, K.S.2    Klug, D.3
  • 36
    • 0034663892 scopus 로고    scopus 로고
    • Opening a windowon thy- mic positive selection: Developmental changes in the influence of cosignaling by integrins and CD28 on selection events induced byTCR en-gagement
    • Lucas B, Germain RN. Opening a windowon thy- mic positive selection: developmental changes in the influence of cosignaling by integrins and CD28 on selection events induced byTCR en-gagement. J Immunol. 2000;165:1889-1895.
    • (2000) J Immunol , vol.165 , pp. 1889-1895
    • Lucas, B.1    Germain, R.N.2
  • 38
    • 28244436724 scopus 로고    scopus 로고
    • Cooperation between 4-1BB and ICOS in the immune response to influenza virus revealed by studies of CD28/ICOS-deficient mice
    • Vidric M, Suh WK, Dianzani U, MakTW, Watts TH. Cooperation between 4-1BB and ICOS in the immune response to influenza virus revealed by studies of CD28/ICOS-deficient mice. J Immunol.2005;175:7288-7296.
    • (2005) J Immunol , vol.175 , pp. 7288-7296
    • Vidric, M.1    Suh, W.K.2    Dianzani, U.3    Mak, T.W.4    Watts, T.H.5
  • 39
    • 33644881883 scopus 로고    scopus 로고
    • Role of natural killer cell subsets in cardiac allograft rejection
    • McNerney ME, Lee KM, Zhou P, et al. Role of natural killer cell subsets in cardiac allograft rejection. Am J Transplant. 2006;6:505-513.
    • (2006) Am J Transplant , vol.6 , pp. 505-513
    • McNerney, M.E.1    Lee, K.M.2    Zhou, P.3
  • 40
    • 0012465040 scopus 로고    scopus 로고
    • Different mechanisms of cardiac allograft rejection in wild- type and CD28-deficient mice
    • Szot GL, Zhou P, Rulifson I, et al. Different mechanisms of cardiac allograft rejection in wild- type and CD28-deficient mice. Am J Transplant.2001;1:38-46.
    • (2001) Am J Transplant , vol.1 , pp. 38-46
    • Szot, G.L.1    Zhou, P.2    Rulifson, I.3
  • 41
    • 15844380367 scopus 로고    scopus 로고
    • Regulation of CTLA-4 expression during T cell activation
    • Perkins D, Wang Z, Donovan C, et al. Regulation of CTLA-4 expression during T cell activation.J Immunol. 1996;156:4154-4159.
    • (1996) J Immunol , vol.156 , pp. 4154-4159
    • Perkins, D.1    Wang, Z.2    Donovan, C.3
  • 43
    • 0344299189 scopus 로고    scopus 로고
    • Cutting edge: Lymphoproliferative dis-ease in the absence of CTLA-4 is not Tcell au-tonomous
    • Bachmann MF, Kohler G, Ecabert B, MakTW, Kopf M. Cutting edge: lymphoproliferative dis-ease in the absence of CTLA-4 is not Tcell au-tonomous. J Immunol. 1999;163:1128-1131.
    • (1999) J Immunol , vol.163 , pp. 1128-1131
    • Bachmann, M.F.1    Kohler, G.2    Ecabert, B.3    Mak, T.W.4    Kopf, M.5
  • 44
    • 0035107510 scopus 로고    scopus 로고
    • Normal pathogen-spe-cific immune responses mounted by CTLA-4-defi- cient T cells: A paradigm reconsidered
    • Bachmann MF, Gallimore A, Jones E, Ecabert B, Acha-Orbea H, Kopf M. Normal pathogen-spe-cific immune responses mounted by CTLA-4-defi- cient T cells: a paradigm reconsidered. Eur J Im-munol. 2001;31:450-458.
    • (2001) Eur J Im-munol , vol.31 , pp. 450-458
    • Bachmann, M.F.1    Gallimore, A.2    Jones, E.3    Ecabert, B.4    Acha-Orbea, H.5    Kopf, M.6
  • 45
    • 33749132564 scopus 로고    scopus 로고
    • Blockade of CTLA-4 on CD4+CD25+ regulatoryT cells abrogates their function in vivo
    • Read S, Greenwald R, Izcue A, et al. Blockade of CTLA-4 on CD4+CD25+ regulatoryT cells abrogates their function in vivo. J Immunol. 2006;177:4376-4383.
    • (2006) J Immunol , vol.177 , pp. 4376-4383
    • Read, S.1    Greenwald, R.2    Izcue, A.3
  • 46
    • 33746748176 scopus 로고    scopus 로고
    • Inhibition of T cell activation and autoimmune diabetes using a B cell surface- linked CTLA-4 agonist
    • Fife BT, Griffin MD, Abbas AK, Locksley RM, Bluestone JA. Inhibition of T cell activation and autoimmune diabetes using a B cell surface- linked CTLA-4 agonist. J Clin Invest. 2006;116:2252-2261.
    • (2006) J Clin Invest , vol.116 , pp. 2252-2261
    • Fife, B.T.1    Griffin, M.D.2    Abbas, A.K.3    Locksley, R.M.4    Bluestone, J.A.5
  • 47
    • 0036180686 scopus 로고    scopus 로고
    • CTLA-4 regulates cell cycle progression during a primary immune response
    • Greenwald RJ, Oosterwegel MA, van der Woude D, et al. CTLA-4 regulates cell cycle progression during a primary immune response. Eur J Immu-nol. 2002;32:366-373.
    • (2002) Eur J Immu-nol , vol.32 , pp. 366-373
    • Greenwald, R.J.1    Oosterwegel, M.A.2    van der Woude, D.3
  • 48
    • 0029120245 scopus 로고
    • CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
    • Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med. 1995;182:459-465.
    • (1995) J Exp Med , vol.182 , pp. 459-465
    • Krummel, M.F.1    Allison, J.P.2
  • 49
    • 0036301503 scopus 로고    scopus 로고
    • CTLA-4: New insights into its biological function and use in tu-mor immunotherapy
    • Egen JG, Kuhns MS, Allison JP. CTLA-4: new insights into its biological function and use in tu-mor immunotherapy. Nat Immunol. 2002;3:611-618.
    • (2002) Nat Immunol , vol.3 , pp. 611-618
    • Egen, J.G.1    Kuhns, M.S.2    Allison, J.P.3
  • 50
    • 0035803552 scopus 로고    scopus 로고
    • Cyto-toxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function
    • Martin M, Schneider H, AzouzA, Rudd CE. Cyto-toxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function. J Exp Med. 2001;194:1675-1681.
    • (2001) J Exp Med , vol.194 , pp. 1675-1681
    • Martin, M.1    Schneider, H.2    Azouz, A.3    Rudd, C.E.4
  • 51
    • 0037141091 scopus 로고    scopus 로고
    • Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immu- nological synapse under conditions of inhibition of Tcell activation
    • Darlington PJ, Baroja ML, Chau TA, et al. Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immu- nological synapse under conditions of inhibition of Tcell activation. J Exp Med. 2002;195:1337-1347.
    • (2002) J Exp Med , vol.195 , pp. 1337-1347
    • Darlington, P.J.1    Baroja, M.L.2    Chau, T.A.3
  • 52
    • 0037244012 scopus 로고    scopus 로고
    • Negative regulation of T cell receptor-lipid raft interaction by cytotoxic Tlymphocyte-associated antigen 4
    • Chikuma S, Imboden JB, Bluestone JA. Negative regulation of T cell receptor-lipid raft interaction by cytotoxic Tlymphocyte-associated antigen 4. J Exp Med. 2003;197:129-135.
    • (2003) J Exp Med , vol.197 , pp. 129-135
    • Chikuma, S.1    Imboden, J.B.2    Bluestone, J.A.3
  • 53
    • 0034823168 scopus 로고    scopus 로고
    • Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy
    • Wells AD, Walsh MC, Bluestone JA, Turka LA. Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy. J Clin Invest. 2001;108:895-903.
    • (2001) J Clin Invest , vol.108 , pp. 895-903
    • Wells, A.D.1    Walsh, M.C.2    Bluestone, J.A.3    Turka, L.A.4
  • 55
    • 0035903329 scopus 로고    scopus 로고
    • An- ergy in peripheral memory CD4(+) T cells in-duced by low avidity engagement of T cell receptor
    • Mirshahidi S, Huang CT, Sadegh-Nasseri S. An- ergy in peripheral memory CD4(+) T cells in-duced by low avidity engagement of T cell receptor. J Exp Med. 2001;194:719-731.
    • (2001) J Exp Med , vol.194 , pp. 719-731
    • Mirshahidi, S.1    Huang, C.T.2    Sadegh-Nasseri, S.3
  • 57
    • 0035889885 scopus 로고    scopus 로고
    • An-tagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal an- ergy: Enhanced cell cycle progression promotes recall antigen responsiveness
    • Vanasek TL, Khoruts A, Zell T, Mueller DL. An-tagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal an- ergy: enhanced cell cycle progression promotes recall antigen responsiveness. J Immunol. 2001;167:5636-5644.
    • (2001) J Immunol , vol.167 , pp. 5636-5644
    • Vanasek, T.L.1    Khoruts, A.2    Zell, T.3    Mueller, D.L.4
  • 58
    • 0032538819 scopus 로고    scopus 로고
    • Engagement of cyto-toxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells
    • Chen W, Jin W, Wahl SM. Engagement of cyto-toxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells. J Exp Med. 1998;188:1849-1857.
    • (1998) J Exp Med , vol.188 , pp. 1849-1857
    • Chen, W.1    Jin, W.2    Wahl, S.M.3
  • 59
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact- dependent immunosuppression by CD4(+)CD25(+) regulatory Tcells is mediated by cell surface-bound transforming growth factor beta
    • Nakamura K, Kitani A, Strober W. Cell contact- dependent immunosuppression by CD4(+)CD25(+) regulatory Tcells is mediated by cell surface-bound transforming growth factor beta. J Exp Med. 2001;194:629-644.
    • (2001) J Exp Med , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 60
    • 0036784567 scopus 로고    scopus 로고
    • Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (ex-tracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ ligand-deficient mice
    • Schneider H, Mandelbrot DA, Greenwald RJ, et al. Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (ex-tracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ ligand-deficient mice. J Immunol. 2002;169:3475-3479.
    • (2002) J Immunol , vol.169 , pp. 3475-3479
    • Schneider, H.1    Mandelbrot, D.A.2    Greenwald, R.J.3
  • 62
    • 0032543987 scopus 로고    scopus 로고
    • Fas-independent death of activated CD4(+) T lymphocytes induced by CTLA-4 crosslinking
    • Scheipers P, Reiser H. Fas-independent death of activated CD4(+) T lymphocytes induced by CTLA-4 crosslinking. Proc Natl Acad Sci U S A. 1998;95:10083-10088.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 10083-10088
    • Scheipers, P.1    Reiser, H.2
  • 63
    • 33749038866 scopus 로고    scopus 로고
    • Reversal of the TCR stop signal by CTLA-4
    • Schneider H, Downey J, Smith A, et al. Reversal of the TCR stop signal by CTLA-4. Science.2006;313:1972-1975.
    • (2006) Science , vol.313 , pp. 1972-1975
    • Schneider, H.1    Downey, J.2    Smith, A.3
  • 64
    • 0038351921 scopus 로고    scopus 로고
    • Lack of role for CsA-sensitive or Fas pathways in the tolerization of CD4 T cells via BMT and anti-CD40L
    • Kurtz J, Lie A, Griffith M, et al. Lack of role for CsA-sensitive or Fas pathways in the tolerization of CD4 T cells via BMT and anti-CD40L. Am J Transplant. 2003;3:804-816.
    • (2003) Am J Transplant , vol.3 , pp. 804-816
    • Kurtz, J.1    Lie, A.2    Griffith, M.3
  • 65
    • 0033980596 scopus 로고    scopus 로고
    • Treatment of allo- graft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of allo- reactive CD8+ T cells and prolonged graft sur-vival in a CTLA4-dependent manner
    • Iwakoshi NN, Mordes JP, Markees TG, Phillips NE, Rossini AA, Greiner DL. Treatment of allo- graft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of allo- reactive CD8+ T cells and prolonged graft sur-vival in a CTLA4-dependent manner. J Immunol.2000;164:512- 521.
    • (2000) J Immunol , vol.164 , pp. 512-521
    • Iwakoshi, N.N.1    Mordes, J.P.2    Markees, T.G.3    Phillips, N.E.4    Rossini, A.A.5    Greiner, D.L.6
  • 66
    • 33645964628 scopus 로고    scopus 로고
    • CTLA-4 engagement and regulatory CD4+CD25+ T cells indepen-dently control CD8+-mediated responses under costimulation blockade
    • Coenen JJ, Koenen HJ, van Rijssen E, Boon L, Joosten I, Hilbrands LB. CTLA-4 engagement and regulatory CD4+CD25+ T cells indepen-dently control CD8+-mediated responses under costimulation blockade. J Immunol. 2006;176:5240-5246.
    • (2006) J Immunol , vol.176 , pp. 5240-5246
    • Coenen, J.J.1    Koenen, H.J.2    van Rijssen, E.3    Boon, L.4    Joosten, I.5    Hilbrands, L.B.6
  • 67
    • 0347994958 scopus 로고    scopus 로고
    • B7 expression on T cells down-regulates immune responses through CTLA-4 ligation viaT-T interactions [corrections]
    • Taylor PA, Lees CJ, Fournier S, Allison JP, Sharpe AH, Blazar BR. B7 expression on T cells down-regulates immune responses through CTLA-4 ligation viaT-T interactions [corrections]. J Immunol. 2004;172:34-39.
    • (2004) J Immunol , vol.172 , pp. 34-39
    • Taylor, P.A.1    Lees, C.J.2    Fournier, S.3    Allison, J.P.4    Sharpe, A.H.5    Blazar, B.R.6
  • 68
    • 3142708571 scopus 로고    scopus 로고
    • Engagement of B7 on effector T cells by regulatory T cells pre-vents autoimmune disease
    • Paust S, Lu L, McCarty N, Cantor H. Engagement of B7 on effector T cells by regulatory T cells pre-vents autoimmune disease. Proc Natl Acad Sci U S A. 2004;101:10398-10403.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 10398-10403
    • Paust, S.1    Lu, L.2    McCarty, N.3    Cantor, H.4
  • 69
    • 34447646310 scopus 로고    scopus 로고
    • Programmed death-1 ligand 1 inter-acts specifically with the B7-1 costimulatory mole-cule to inhibit T cell responses
    • Butte MJ, Keir ME, PhamduyTB, Sharpe AH, Freeman GJ. Programmed death-1 ligand 1 inter-acts specifically with the B7-1 costimulatory mole-cule to inhibit T cell responses. Immunity. 2007; 27:111-122.
    • (2007) Immunity , vol.27 , pp. 111-122
    • Butte, M.J.1    Keir, M.E.2    Phamduy, T.B.3    Sharpe, A.H.4    Freeman, G.J.5
  • 70
  • 71
    • 0042441104 scopus 로고    scopus 로고
    • Mecha-nisms of donor-specific transfusion tolerance: Preemptive induction of clonal T-cell exhaustion via indirect presentation
    • Quezada SA, Fuller B, Jarvinen LZ, et al. Mecha-nisms of donor-specific transfusion tolerance: preemptive induction of clonal T-cell exhaustion via indirect presentation. Blood. 2003;102:1920-1926.
    • (2003) Blood , vol.102 , pp. 1920-1926
    • Quezada, S.A.1    Fuller, B.2    Jarvinen, L.Z.3
  • 72
    • 4344617233 scopus 로고    scopus 로고
    • Mechanism of action of donor-specific transfusion in inducing tolerance: Role of donor MHC molecules, donor co-stimulatory molecules, and indirect antigen presentation
    • Kishimoto K, Yuan X, Auchincloss H Jr, Sharpe AH, Mandelbrot DA, Sayegh MH. Mechanism of action of donor-specific transfusion in inducing tolerance: role of donor MHC molecules, donor co-stimulatory molecules, and indirect antigen presentation. J Am Soc Nephrol. 2004;15:2423- 2428.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 2423-2428
    • Kishimoto, K.1    Yuan, X.2    Auchincloss Jr, H.3    Sharpe, A.H.4    Mandelbrot, D.A.5    Sayegh, M.H.6
  • 73
    • 47949126592 scopus 로고    scopus 로고
    • Alloreactive CD8T cell tolerance requires recipient B cells, dendritic cells, and MHC class II
    • FehrT, Haspot F, Mollov J, Chittenden M, Hogan T, Sykes M. Alloreactive CD8T cell tolerance requires recipient B cells, dendritic cells, and MHC class II. J Immunol. 2008;181:165-173.
    • (2008) J Immunol , vol.181 , pp. 165-173
    • Fehr, T.1    Haspot, F.2    Mollov, J.3    Chittenden, M.4    Hogan, T.5    Sykes, M.6
  • 74
    • 0023143676 scopus 로고
    • Antigen presentation by chemically modified splenocytes induces anti-gen-specific T cell unresponsiveness in vitro and in vivo
    • Jenkins MK, Schwartz RH. Antigen presentation by chemically modified splenocytes induces anti-gen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med. 1987;165:302-319.
    • (1987) J Exp Med , vol.165 , pp. 302-319
    • Jenkins, M.K.1    Schwartz, R.H.2
  • 75
    • 33745811329 scopus 로고    scopus 로고
    • A novel pathway of antigen presen-tation by dendritic and endothelial cells: Implica-tions for allorecognition and infectious diseases
    • Smyth LA, Herrera OB, Golshayan D, Lombardi G, Lechler RI. A novel pathway of antigen presen-tation by dendritic and endothelial cells: implica-tions for allorecognition and infectious diseases. Transplantation. 2006;82:S15-S18.
    • (2006) Transplantation , vol.82
    • Smyth, L.A.1    Herrera, O.B.2    Golshayan, D.3    Lombardi, G.4    Lechler, R.I.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.