B7-CD28 interaction promotes proliferation and survival but suppresses differentiation of CD4-CD8- T cells in the thymus

Journal of Immunology

Volumn 173, Issue 4, 2004, Pages 2253-2261

  Zheng, Xincheng ^a   Gao, Jian Xin ^a   Chang, Xing ^a   Wang, Yin ^a   Liu, Yan ^a   Wen, Jing ^a   Zhang, Huiming ^a   Zhang, Jian ^b   Liu, Yang ^a   Zheng, Pan ^a  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HERMES ANTIGEN; INTERLEUKIN 2 RECEPTOR; RAG2 PROTEIN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; HOMEOSTASIS; IMMUNOCOMPETENCE; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; THYMOCYTE; WESTERN BLOTTING;

EID: 4043147851     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.4.2253     Document Type: Article

References (52)

1. Norton, S. D., L. Zuckerman, K. B. Urdahl, R. Shefner, J. Miller, and M. K. Jenkins. 1992. The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cells. J. Immunol. 149:1556.
2. + cytotoxic T lymphocytes in the absence of exogenous help. J. Exp. Med. 177:1791.
3. Harding, F. A., J. G. McArthur, J. A. Gross, D. H. Raulet, and J. P. Allison. 1992. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356:607.
4. Ramarathinam, L., M. Castle, Y. Wu, and Y. Liu. 1994. T cell costimulation by B7/BB1 induces CD8 T cell-dependent tumor rejection: an important role of BT/BB1 in the induction, recruitment, and effector function of antitumor T cells. J. Exp. Med. 179:1205.
5. Zheng, P., S. Sarma, Y. Guo, and Y. Liu. 1999. Two mechanisms for tumor evasion of preexisting cytotoxic T-cell responses: lessons from recurrent tumors. Cancer Res. 59:3461.
6. Sarma, S., Y. Guo, Y. Guilloux, C. Lee, X. F. Bai, and Y. Liu. 1999. Cytotoxic T lymphocytes to an unmutated tumor rejection antigen P1A: normal development but restrained effector function in vivo. J. Exp. Med. 189:811.
7. Bai, X. F., J. Bender, J. Liu, H. Zhang, Y. Wang, O. Li, P. Du, P. Zheng, and Y. Liu. 2001. Local costimulation reinvigorates tumor-specific cytolytic T lymphocytes for experimental therapy in mice with large tumor burdens. J. Immunol. 167:3936.
8. Allison, J., L. A. Stephens, T. W. Kay, C. Kurts, W. R. Heath, J. F. Miller, and M. F. Krummel. 1998. The threshold for autoimmune T cell killing is influenced by B7-1. Eur. J. Immunol. 28:949.
9. Chang, T. T., C. Jabs, R. A. Sobel, V. K. Kuchroo, and A. H. Sharpe. 1999. Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis. J. Exp. Med. 190:733.
10. Gao, J.-X., H. Zhang, X. F. Bai, J. Wen, X. Zheng, J. Liu, P. Zheng, and Y. Liu. 2002. Peripheral blockade of B7-1 and B7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells. J. Exp. Med. 195:959.
11. Noel, P. J., M. L. Alegre, S. L. Reiner, and C. B. Thompson. 1998. Impaired negative selection in CD28-deficient mice. Cell Immunol. 187:131.
12. Kishimoto, H., and J. Sprent. 1999. Several different cell surface molecules control negative selection of medullary thymocytes. J. Exp. Med. 190:65.
13. Li, R., and D. M. Page. 2001. Requirement for a complex array of costimulators in the negative selection of autoreactive thymocytes in vivo. J. Immunol. 166:6050.
14. Buhlmann, J. E., S. K. Elkin, and A. H. Sharpe. 2003. A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection. J. Immunol. 170:5421.
15. Cibotti, R., J. A. Punt, K. S. Dash, S. O. Sharrow, and A. Singer. 1997. Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals. Immunity 6:245.
16. + thymocytes in vitro induces early aspects of positive selection, but not apoptosis. J. Immunol. 158:65.
17. + immunoregulatory T cells that control autoimmune diabetes. Immunity 12:431.
18. Salomon, B., and J. A. Bluestone. 2001. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu. Rev. Immunol. 19:225.
19. Bour-Jordan, H., and J. A. Blueston. 2002. CD28 function: a balance of costimulatory and regulatory signals. J. Clin. Immunol. 22:1.
20. high regulatory cells in human peripheral blood. J. Immunol. 167:1245.
21. Michie, A. M., J. R. Carlyle, T. M. Schmitt, B. Ljutic, S. K. Cho, Q. Fong, and J. C. Zuniga-Pflucker. 2000. Clonal characterization of a bipotent T cell and NK cell progenitor in the mouse fetal thymus. J. Immunol. 164:1730.
22. Baird, A. M., R. M. Gerstein, and L. J. Berg. 1999. The role of cytokine receptor signaling in lymphocyte development. Curr. Opin. Immunol. 11:157.
23. -/- mice. J. Immunol. 157:2366.
24. Waskow, C., and H. R. Rodewald. 2002. Lymphocyte development in neonatal and adult c-Kit-deficient (c-KitW/W) mice. Adv. Exp. Med. Biol. 512:1.
25. Rodewald, H. R., M. Ogawa, C. Haller, C. Waskow, and J. P. DiSanto. 1997. Pro-thymocyte expansion by c-kit and the common cytokine receptor γ chain is essential for repertoire formation. Immunity 6:265.
26. Rodewald, H. R., K. Kretzschmar, W. Swat, and S. Takeda. 1995. Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo. Immunity 3:313.
27. Mombaerts, P., J. Iacomini, R. S. Johnson, K. Herrup, S. Tonegawa, and V. E. Papaioannou. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68:869.
28. Shinkai, Y., G. Rathbun, K. P. Lam, E. M. Oltz, V. Stewart, M. Mendelsohn, J. Charron, M. Datta, F. Young, A. M. Stall, et al. 1992. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68:855.
29. - thymocyte differentiation. J. Immunol. 152:4783.
30. Mombaerts, P., A. R. Clarke, M. A. Rudnicki, J. Iacomini, S. Itohara, J. J. Lafaille, L. Wang, Y. Ichikawa, R. Jaenisch, M. L. Hooper, et al. 1992. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature 360:225.
31. Fehling, H. J., A. Krotkova, C. Saint-Ruf, and H. von Boehmer. 1995. Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells. Nature 375:795.
32. Borriello, F., M. P. Sethna, S. D. Boyd, A. N. Schweitzer, E. A. Tivol, D. Jacoby, T. B. Strom, E. M. Simpson, G. J. Freeman, and A. H. Sharpe. 1997. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity 6:303.
33. Shahinian, A., K. Pfeffer, K. P. Lee, T. M. Kundig, K. Kishihara, A. Wakeham, K. Kawai, P. S. Ohashi, C. B. Thompson, and T. W. Mak. 1993. Differential T cell costimulatory requirements in CD28-deficient mice. Science 261:609.
34. Bachmann, M. F., A. Gallimore, E. Jones, B. Ecabert, H. Acha-Orbea, and M. Kopf. 2001. Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsidered. Eur. J. Immunol. 31:450.
35. + double-positive thymocytes in mice with compromised CD3 complex signaling. J. Immunol. 162:2741.
36. Zheng, X., J. X. Gao, H. Zhang, T. L. Geiger, Y. Liu, and P. Zheng. 2002. Clonal deletion of simian virus 40 large T antigen-specific T cells in the transgenic adenocarcinoma of mouse prostate mice: an important role for clonal deletion in shaping the repertoire of T cells specific for antigens overexpressed in solid tumors. J. Immunol. 169:4761.
37. Wu, Y., Y. Guo, and Y. Liu. 1993. A major costimulatory molecule on antigen-presenting cells, CTLA4 ligand A, is distinct from B7. J. Exp. Med. 178:1789.
38. Hathcock, K. S., G. Laszlo, H. B. Dickler, J. Bradshaw, P. Linsley, and R. J. Hodes. 1993. Identification of an alternative CTLA-4 ligand costimulatory for T cell activation. Science 262:905.
39. Yamada, A., K. Kishimoto, V. M. Dong, M. Sho, A. D. Salama, N. G. Anosova, G. Benichou, D. A. Mandelbrot, A. H. Sharpe, L. A. Turka, et al., 2001. CD28-independent costimulation of T cells in alloimmune responses. J. Immunol. 167:140.
40. Mandelbrot, D. A., M. A. Oosterwegel, K. Shimizu, A. Yamada, G. J. Freeman, R. N. Mitchell, M. H. Sayegh, and A. H. Sharpe. 2001. B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4. J. Clin. Invest. 107:881.
41. Chambers, C. A., D. Cado, T. Truong, and J. P. Allison. 1997. Thymocyte development is normal in CTLA-4-deficient mice. Proc. Natl. Acad. Sci. USA 94:9296.
42. Levelt, C. N., and K. Eichmann. 1995. Receptors and signals in early thymic selection. Immunity 3:667.
43. Fehling, H. J., and H. von Boehmer. 1997. Early αβ T cell development in the thymus of normal and genetically altered mice. Curr. Opin. Immunol. 9:263.
44. +) thymocytes in normal and genetically modified mice. J. Immunol. 154:5103.
45. Vasseur, F., A. Le Campion, and C. Penit. 2001. Scheduled kinetics of cell proliferation and phenotypic changes during immature thymocyte generation. Eur. J. Immunol. 31:3038.
46. MacDonald, H. R. 2002. Development and selection of NKT cells. Curr. Opin. Immunol. 14:250.
47. L. Immunity 3:87.
48. + thymocytes. J. Immunol. 152:3254.
49. Huesmann, M., B. Scott, P. Kisielow, and H. von Boehmer. 1991. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice. Cell 66:533.
50. Desiderio, S., W. C. Lin, and Z. Li. 1996. The cell cycle and V(D)J recombination. Curr. Top. Microbiol. Immunol. 217:45.
51. Lee, J., and S. Desiderio. 1999. Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair. Immunity 11:771.
52. Mizuta, R., M. Mizuta, S. Araki, and D. Kitamura. 2002. RAG2 is down-regulated by cytoplasmic sequestration and ubiquitin-dependent degradation. J. Biol. Chem. 277:41423.