CD4 T cell-mediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is dependent on CD40-CD40 ligand interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this pathway

Journal of Immunology

Volumn 166, Issue 5, 2001, Pages 2970-2981

  Ito, H ^a   Kurtz, J ^a   Shaffer, J ^a   Sykes, M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD40 ANTIGEN; MONOCLONAL ANTIBODY;

ALLOGENIC BONE MARROW TRANSPLANTATION; ALLOIMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; CHIMERA; CONTROLLED STUDY; FEMALE; IMMUNOLOGICAL TOLERANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RELIABILITY; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

EID: 0035284740     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.5.2970     Document Type: Article

References (75)

1. Immunogenetic consequences of vascular anastomoses between bovine twins
2. The use of skin grafting to distinguish between monozygotic and dizygotic twins in cattle
3. Tolerance to homografts, twin diagnosis, and the freemartin condition in cattle
4. "Actively acquired tolerance" of foreign cells
5. Mixed chimerism and permanent specific transplantation tolerance induced by a non-lethal preparative regimen
6. Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a non-myeloablative regimen
7. Thymic dependence of loss of tolerance in mixed allogeneic bone marrow chimeras after depletion of donor antigen
8. Intrathymic deletion of alloreactive T cells in mixed bone marrow chimeras prepared with a non-myeloablative conditioning regimen
9. Additional mAb injections can replace thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mAbs and 3 Gy whole body irradiation
10. Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance
11. Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance
12. T cell subsets resisting induction of mixed chimerism across various histocompatibility barriers
13. In vivo administration of interleukin 2 plus T cell-depleted syngeneic marrow prevents graft-versus-host disease mortality and permits alloengraftment
14. Ex vivo coating of islet cell allografts with murine CTLA4/Fc promotes graft tolerance
15. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors
16. + activated T lymphocytes produce an in vitro skin graft-versus-host reaction in an organotypic skin culture model
17. Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment
18. MIs: A retrovirus exploits the immune system
19. + T cells
20. Genes encoding ligands for deletion of Vβ11 T cells cosegregate with mammary tumour virus genomes
21. The MHC molecule I-E is necessary but not sufficient for the clonal deletion of VB11 bearing T cells
22. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
23. Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand
24. CTLA4-lg and anti-CD40 ligand prevent renal allograft rejection in primates
25. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
26. Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154
27. + T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand (CD40L:CD154) antibody lose their graft-versus-host disease lethality capacity but retain nominal antigen responses
28. CD40 and CD154 in cell-mediated immunity
29. Immunological ignorance of silent antigens as an explanation of tumor evasion
30. + cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection
31. + T-helper and T-killer cell
32. Help for cytotoxic-T-cell responses is mediated by CD40 signalling
33. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
34. CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection
35. + cytotoxic T lymphocytes
36. + T cell tolerance to peripherally expressed antigens
37. Major histocompatibility complex class 1-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction
38. Inhibition of in vitro immunoglobulin production by IL-12 in murine chronic graft-vs.-host disease: Synergism with IL-18
39. TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation
40. CD4 T cells and their role in antitumor immune responses
41. Licence to kill
42. Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells
43. Toll, a new piece in the puzzle of innate immunity
44. T cell stimulation in vivo by lipopolysaccharide (LPS)
45. Coordinated events during bacteria-induced DC maturation
46. Fcγ receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class 1-restricted antigen presentation after immune complex internalization
47. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge
48. Type I interferon-mediated stimulation of T cells by CpG DNA
49. CpG oligonucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis
50. Studies on the expression of spontaneous and induced interferons in mouse peritoneal macrophages by means of monoclonal antibodies to mouse interferons
51. Cachectin/tumor necrosis factor exerts endocrine, paracrine and autocrine control of inflammatory responses
52. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells
53. Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
54. + T lymphocytes
55. Synergistic effects of IL-7 and IL-12 on human T cell activation
56. + T cells of Tc1 and Tc2 phenotype
57. Cellular and molecular mechanisms of the IL-12-induced increase in allospecific murine cytolytic T cell activity: Implications for the age-related decline in CTL
58. Type 1 IFN modulates innate and specific antiviral immunity
59. Differential T cell costimulatory requirements in CD28-deficient mice
60. Skin allograft rejection in CD28-deficient mice
61. T cell co-stimulatory molecules other than CD28
62. + T cells do not require costimulation for proliferation and differentiation into cytotoxic effector cells
63. + T cells play a critical role in costimulation blockade-resistant allograft rejection
64. + T cells
65. + T cells and prolonged graft survival in a CTLA4-dependent manner
66. + T cells can trigger allograft rejection
67. + T cell tolerance and linked suppression
68. + T cell mediate CD40-independent maturation of dendritic cells in vivo
69. + T cells
70. Tissue-specific expression of messenger RNAs encoding endogenous viral superantigen
71. Paracrine transfer of mouse mammary tumor virus superantigen
72. Mouse intestinal epithelial cells express the self superantigen MLs1
73. Transplantation tolerance is unrelated to superantigen-dependent deletion and anergy
74. Thymic aging and T cell regeneration
75. + T-cell regenerative pathway result in prolonged T-cell subset imbalance after intensive chemotherapy