-
1
-
-
27644477433
-
Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice
-
Anderson C., Crimmins S., Wilson J.A., Korbel G.A., Ploegh H.L., and Wilson S.M. Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice. J. Neurochem. 95 (2005) 724-731
-
(2005)
J. Neurochem.
, vol.95
, pp. 724-731
-
-
Anderson, C.1
Crimmins, S.2
Wilson, J.A.3
Korbel, G.A.4
Ploegh, H.L.5
Wilson, S.M.6
-
2
-
-
0031036896
-
Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease
-
Anglade P., Vyas S., Javoy-Agid F., Herrero M.T., Michel P.P., Marquez J., Mouatt-Prigent A., Ruberg M., Hirsch E.C., and Agid Y. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol. Histopathol. 12 (1997) 25-31
-
(1997)
Histol. Histopathol.
, vol.12
, pp. 25-31
-
-
Anglade, P.1
Vyas, S.2
Javoy-Agid, F.3
Herrero, M.T.4
Michel, P.P.5
Marquez, J.6
Mouatt-Prigent, A.7
Ruberg, M.8
Hirsch, E.C.9
Agid, Y.10
-
3
-
-
34248530304
-
Chaperone-mediated autophagy in aging and neurodegeneration: lessons from alpha-synuclein
-
Bandhyopadhyay U., and Cuervo A.M. Chaperone-mediated autophagy in aging and neurodegeneration: lessons from alpha-synuclein. Exp. Gerontol. (2006)
-
(2006)
Exp. Gerontol.
-
-
Bandhyopadhyay, U.1
Cuervo, A.M.2
-
4
-
-
33646482114
-
Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies
-
Barrachina M., Castano E., Dalfo E., Maes T., Buesa C., and Ferrer I. Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies. Neurobiol. Dis. 22 (2006) 265-273
-
(2006)
Neurobiol. Dis.
, vol.22
, pp. 265-273
-
-
Barrachina, M.1
Castano, E.2
Dalfo, E.3
Maes, T.4
Buesa, C.5
Ferrer, I.6
-
5
-
-
0033607801
-
Degradation of alpha-synuclein by proteasome
-
Bennett M.C., Bishop J.F., Leng Y., Chock P.B., Chase T.N., and Mouradian M.M. Degradation of alpha-synuclein by proteasome. J. Biol. Chem. 274 (1999) 33855-33858
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 33855-33858
-
-
Bennett, M.C.1
Bishop, J.F.2
Leng, Y.3
Chock, P.B.4
Chase, T.N.5
Mouradian, M.M.6
-
6
-
-
31544454404
-
Rapamycin alleviates toxicity of different aggregate-prone proteins
-
Berger Z., Ravikumar B., Menzies F.M., Oroz L.G., Underwood B.R., Pangalos M.N., Schmitt I., Wullner U., Evert B.O., O'Kane C.J., and Rubinsztein D.C. Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum. Mol. Genet. 15 (2006) 433-442
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 433-442
-
-
Berger, Z.1
Ravikumar, B.2
Menzies, F.M.3
Oroz, L.G.4
Underwood, B.R.5
Pangalos, M.N.6
Schmitt, I.7
Wullner, U.8
Evert, B.O.9
O'Kane, C.J.10
Rubinsztein, D.C.11
-
7
-
-
33644797646
-
Alpha-synuclein and chaperones in dementia with Lewy bodies
-
Cantuti-Castelvetri I., Klucken J., Ingelsson M., Ramasamy K., McLean P.J., Frosch M.P., Hyman B.T., and Standaert D.G. Alpha-synuclein and chaperones in dementia with Lewy bodies. J. Neuropathol. Exp. Neurol. 64 (2005) 1058-1066
-
(2005)
J. Neuropathol. Exp. Neurol.
, vol.64
, pp. 1058-1066
-
-
Cantuti-Castelvetri, I.1
Klucken, J.2
Ingelsson, M.3
Ramasamy, K.4
McLean, P.J.5
Frosch, M.P.6
Hyman, B.T.7
Standaert, D.G.8
-
8
-
-
17644392138
-
Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans
-
Cao S., Gelwix C.C., Caldwell K.A., and Caldwell G.A. Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans. J. Neurosci. 25 (2005) 3801-3812
-
(2005)
J. Neurosci.
, vol.25
, pp. 3801-3812
-
-
Cao, S.1
Gelwix, C.C.2
Caldwell, K.A.3
Caldwell, G.A.4
-
9
-
-
0028220243
-
Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease
-
Cataldo A.M., Hamilton D.J., and Nixon R.A. Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease. Brain Res. 640 (1994) 68-80
-
(1994)
Brain Res.
, vol.640
, pp. 68-80
-
-
Cataldo, A.M.1
Hamilton, D.J.2
Nixon, R.A.3
-
10
-
-
33746533924
-
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
-
Cooper A.A., Gitler A.D., Cashikar A., Haynes C.M., Hill K.J., Bhullar B., Liu K., Xu K., Strathearn K.E., Liu F., Cao S., Caldwell K.A., Caldwell G.A., Marsischky G., Kolodner R.D., Labaer J., Rochet J.C., Bonini N.M., and Lindquist S. Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 313 (2006) 324-328
-
(2006)
Science
, vol.313
, pp. 324-328
-
-
Cooper, A.A.1
Gitler, A.D.2
Cashikar, A.3
Haynes, C.M.4
Hill, K.J.5
Bhullar, B.6
Liu, K.7
Xu, K.8
Strathearn, K.E.9
Liu, F.10
Cao, S.11
Caldwell, K.A.12
Caldwell, G.A.13
Marsischky, G.14
Kolodner, R.D.15
Labaer, J.16
Rochet, J.C.17
Bonini, N.M.18
Lindquist, S.19
-
11
-
-
0034510572
-
Unique properties of lamp2a compared to other lamp2 isoforms
-
Cuervo A.M., and Dice J.F. Unique properties of lamp2a compared to other lamp2 isoforms. J. Cell Sci. 113 Pt 24 (2000) 4441-4450
-
(2000)
J. Cell Sci. 113 Pt
, vol.24
, pp. 4441-4450
-
-
Cuervo, A.M.1
Dice, J.F.2
-
12
-
-
4344659685
-
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
-
Cuervo A.M., Stefanis L., Fredenburg R., Lansbury P.T., and Sulzer D. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305 (2004) 1292-1295
-
(2004)
Science
, vol.305
, pp. 1292-1295
-
-
Cuervo, A.M.1
Stefanis, L.2
Fredenburg, R.3
Lansbury, P.T.4
Sulzer, D.5
-
13
-
-
0037195109
-
Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP
-
Dauer W., Kholodilov N., Vila M., Trillat A.C., Goodchild R., Larsen K.E., Staal R., Tieu K., Schmitz Y., Yuan C.A., Rocha M., Jackson-Lewis V., Hersch S., Sulzer D., Przedborski S., Burke R., and Hen R. Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 14524-14529
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 14524-14529
-
-
Dauer, W.1
Kholodilov, N.2
Vila, M.3
Trillat, A.C.4
Goodchild, R.5
Larsen, K.E.6
Staal, R.7
Tieu, K.8
Schmitz, Y.9
Yuan, C.A.10
Rocha, M.11
Jackson-Lewis, V.12
Hersch, S.13
Sulzer, D.14
Przedborski, S.15
Burke, R.16
Hen, R.17
-
14
-
-
0018713875
-
Lysosomes and protein degradation
-
Dean R.T. Lysosomes and protein degradation. Ciba Found. Symp. (1979) 139-149
-
(1979)
Ciba Found. Symp.
, pp. 139-149
-
-
Dean, R.T.1
-
15
-
-
34548299555
-
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability
-
Ding W.X., Ni H.M., Gao W., Yoshimori T., Stolz D.B., Ron D., and Yin X.M. Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am. J. Pathol. 171 (2007) 513-524
-
(2007)
Am. J. Pathol.
, vol.171
, pp. 513-524
-
-
Ding, W.X.1
Ni, H.M.2
Gao, W.3
Yoshimori, T.4
Stolz, D.B.5
Ron, D.6
Yin, X.M.7
-
16
-
-
38949096081
-
Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome
-
Ding W.X., and Yin X.M. Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome. Autophagy 4 (2008) 141-150
-
(2008)
Autophagy
, vol.4
, pp. 141-150
-
-
Ding, W.X.1
Yin, X.M.2
-
17
-
-
3542993306
-
Mice lacking alpha-synuclein have an attenuated loss of striatal dopamine following prolonged chronic MPTP administration
-
Drolet R.E., Behrouz B., Lookingland K.J., and Goudreau J.L. Mice lacking alpha-synuclein have an attenuated loss of striatal dopamine following prolonged chronic MPTP administration. Neurotoxicology 25 (2004) 761-769
-
(2004)
Neurotoxicology
, vol.25
, pp. 761-769
-
-
Drolet, R.E.1
Behrouz, B.2
Lookingland, K.J.3
Goudreau, J.L.4
-
18
-
-
34247113888
-
Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II)
-
Fujita E., Kouroku Y., Isoai A., Kumagai H., Misutani A., Matsuda C., Hayashi Y.K., and Momoi T. Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II). Hum. Mol. Genet. 16 (2007) 618-629
-
(2007)
Hum. Mol. Genet.
, vol.16
, pp. 618-629
-
-
Fujita, E.1
Kouroku, Y.2
Isoai, A.3
Kumagai, H.4
Misutani, A.5
Matsuda, C.6
Hayashi, Y.K.7
Momoi, T.8
-
19
-
-
50549085408
-
Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration
-
Gao H.M., Kotzbauer P.T., Uryu K., Leight S., Trojanowski J.Q., and Lee V.M. Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration. J. Neurosci. 28 (2008) 7687-7698
-
(2008)
J. Neurosci.
, vol.28
, pp. 7687-7698
-
-
Gao, H.M.1
Kotzbauer, P.T.2
Uryu, K.3
Leight, S.4
Trojanowski, J.Q.5
Lee, V.M.6
-
20
-
-
0037118259
-
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein
-
Giasson B.I., Duda J.E., Quinn S.M., Zhang B., Trojanowski J.Q., and Lee V.M. Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron 34 (2002) 521-533
-
(2002)
Neuron
, vol.34
, pp. 521-533
-
-
Giasson, B.I.1
Duda, J.E.2
Quinn, S.M.3
Zhang, B.4
Trojanowski, J.Q.5
Lee, V.M.6
-
21
-
-
33745192802
-
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
-
Hara T., Nakamura K., Matsui M., Yamamoto A., Nakahara Y., Suzuki-Migishima R., Yokoyama M., Mishima K., Saito I., Okano H., and Mizushima N. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441 (2006) 885-889
-
(2006)
Nature
, vol.441
, pp. 885-889
-
-
Hara, T.1
Nakamura, K.2
Matsui, M.3
Yamamoto, A.4
Nakahara, Y.5
Suzuki-Migishima, R.6
Yokoyama, M.7
Mishima, K.8
Saito, I.9
Okano, H.10
Mizushima, N.11
-
22
-
-
32344444326
-
Down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat model
-
Hayashita-Kinoh H., Yamada M., Yokota T., Mizuno Y., and Mochizuki H. Down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat model. Biochem. Biophys. Res. Commun. 341 (2006) 1088-1095
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.341
, pp. 1088-1095
-
-
Hayashita-Kinoh, H.1
Yamada, M.2
Yokota, T.3
Mizuno, Y.4
Mochizuki, H.5
-
23
-
-
34249802905
-
Ubiquitin-proteasome system alterations in a striatal cell model of Huntington's disease
-
Hunter J.M., Lesort M., and Johnson G.V. Ubiquitin-proteasome system alterations in a striatal cell model of Huntington's disease. J. Neurosci. Res. 85 (2007) 1774-1788
-
(2007)
J. Neurosci. Res.
, vol.85
, pp. 1774-1788
-
-
Hunter, J.M.1
Lesort, M.2
Johnson, G.V.3
-
24
-
-
0030830270
-
Immunocytochemical co-localization of the proteasome in ubiquitinated structures in neurodegenerative diseases and the elderly
-
Ii K., Ito H., Tanaka K., and Hirano A. Immunocytochemical co-localization of the proteasome in ubiquitinated structures in neurodegenerative diseases and the elderly. J. Neuropathol. Exp. Neurol. 56 (1997) 125-131
-
(1997)
J. Neuropathol. Exp. Neurol.
, vol.56
, pp. 125-131
-
-
Ii, K.1
Ito, H.2
Tanaka, K.3
Hirano, A.4
-
25
-
-
36949031267
-
Alpha-synucleinopathy models and human neuropathology: similarities and differences
-
Kahle P.J. Alpha-synucleinopathy models and human neuropathology: similarities and differences. Acta Neuropathol. 115 (2008) 87-95
-
(2008)
Acta Neuropathol.
, vol.115
, pp. 87-95
-
-
Kahle, P.J.1
-
27
-
-
33847690636
-
Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age
-
Kiffin R., Kaushik S., Zeng M., Bandyopadhyay U., Zhang C., Massey A.C., Martinez-Vicente M., and Cuervo A.M. Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age. J. Cell Sci. 120 (2007) 782-791
-
(2007)
J. Cell Sci.
, vol.120
, pp. 782-791
-
-
Kiffin, R.1
Kaushik, S.2
Zeng, M.3
Bandyopadhyay, U.4
Zhang, C.5
Massey, A.C.6
Martinez-Vicente, M.7
Cuervo, A.M.8
-
28
-
-
33244460534
-
Mice lacking alpha-synuclein are resistant to mitochondrial toxins
-
Klivenyi P., Siwek D., Gardian G., Yang L., Starkov A., Cleren C., Ferrante R.J., Kowall N.W., Abeliovich A., and Beal M.F. Mice lacking alpha-synuclein are resistant to mitochondrial toxins. Neurobiol. Dis. 21 (2006) 541-548
-
(2006)
Neurobiol. Dis.
, vol.21
, pp. 541-548
-
-
Klivenyi, P.1
Siwek, D.2
Gardian, G.3
Yang, L.4
Starkov, A.5
Cleren, C.6
Ferrante, R.J.7
Kowall, N.W.8
Abeliovich, A.9
Beal, M.F.10
-
29
-
-
33646800306
-
Loss of autophagy in the central nervous system causes neurodegeneration in mice
-
Komatsu M., Waguri S., Chiba T., Murata S., Iwata J.I., Tanida I., Ueno T., Koike M., Uchiyama Y., Kominami E., and Tanaka K. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441 (2006) 880-884
-
(2006)
Nature
, vol.441
, pp. 880-884
-
-
Komatsu, M.1
Waguri, S.2
Chiba, T.3
Murata, S.4
Iwata, J.I.5
Tanida, I.6
Ueno, T.7
Koike, M.8
Uchiyama, Y.9
Kominami, E.10
Tanaka, K.11
-
30
-
-
36849089101
-
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
-
Komatsu M., Waguri S., Koike M., Sou Y.S., Ueno T., Hara T., Mizushima N., Iwata J.I., Ezaki J., Murata S., Hamazaki J., Nishito Y., Iemura S.I., Natsume T., Yanagawa T., Uwayama J., Warabi E., Yoshida H., Ishii T., Kobayashi A., Yamamoto M., Yue Z., Uchiyama Y., Kominami E., and Tanaka K. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131 (2007) 1149-1163
-
(2007)
Cell
, vol.131
, pp. 1149-1163
-
-
Komatsu, M.1
Waguri, S.2
Koike, M.3
Sou, Y.S.4
Ueno, T.5
Hara, T.6
Mizushima, N.7
Iwata, J.I.8
Ezaki, J.9
Murata, S.10
Hamazaki, J.11
Nishito, Y.12
Iemura, S.I.13
Natsume, T.14
Yanagawa, T.15
Uwayama, J.16
Warabi, E.17
Yoshida, H.18
Ishii, T.19
Kobayashi, A.20
Yamamoto, M.21
Yue, Z.22
Uchiyama, Y.23
Kominami, E.24
Tanaka, K.25
more..
-
31
-
-
1442275729
-
Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway
-
Lee H.J., Khoshaghideh F., Patel S., and Lee S.J. Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway. J. Neurosci. 24 (2004) 1888-1896
-
(2004)
J. Neurosci.
, vol.24
, pp. 1888-1896
-
-
Lee, H.J.1
Khoshaghideh, F.2
Patel, S.3
Lee, S.J.4
-
32
-
-
33749240943
-
Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery
-
Lee V.M., and Trojanowski J.Q. Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery. Neuron 52 (2006) 33-38
-
(2006)
Neuron
, vol.52
, pp. 33-38
-
-
Lee, V.M.1
Trojanowski, J.Q.2
-
33
-
-
33947537591
-
Proteomic identification of novel proteins in cortical lewy bodies
-
Leverenz J.B., Umar I., Wang Q., Montine T.J., McMillan P.J., Tsuang D.W., Jin J., Pan C., Shin J., Zhu D., and Zhang J. Proteomic identification of novel proteins in cortical lewy bodies. Brain Pathol. 17 (2007) 139-145
-
(2007)
Brain Pathol.
, vol.17
, pp. 139-145
-
-
Leverenz, J.B.1
Umar, I.2
Wang, Q.3
Montine, T.J.4
McMillan, P.J.5
Tsuang, D.W.6
Jin, J.7
Pan, C.8
Shin, J.9
Zhu, D.10
Zhang, J.11
-
34
-
-
7244243876
-
Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation
-
Li W., Lesuisse C., Xu Y., Troncoso J.C., Price D.L., and Lee M.K. Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation. J. Neurosci. 24 (2004) 7400-7409
-
(2004)
J. Neurosci.
, vol.24
, pp. 7400-7409
-
-
Li, W.1
Lesuisse, C.2
Xu, Y.3
Troncoso, J.C.4
Price, D.L.5
Lee, M.K.6
-
35
-
-
30644471051
-
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death
-
Martin L.J., Pan Y., Price A.C., Sterling W., Copeland N.G., Jenkins N.A., Price D.L., and Lee M.K. Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J. Neurosci. 26 (2006) 41-50
-
(2006)
J. Neurosci.
, vol.26
, pp. 41-50
-
-
Martin, L.J.1
Pan, Y.2
Price, A.C.3
Sterling, W.4
Copeland, N.G.5
Jenkins, N.A.6
Price, D.L.7
Lee, M.K.8
-
36
-
-
38849174979
-
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy
-
Martinez-Vicente M., Talloczy Z., Kaushik S., Massey A.C., Mazzulli J., Mosharov E.V., Hodara R., Fredenburg R., Wu D.C., Follenzi A., Dauer W., Przedborski S., Ischiropoulos H., Lansbury P.T., Sulzer D., and Cuervo A.M. Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J. Clin. Invest. (2008)
-
(2008)
J. Clin. Invest.
-
-
Martinez-Vicente, M.1
Talloczy, Z.2
Kaushik, S.3
Massey, A.C.4
Mazzulli, J.5
Mosharov, E.V.6
Hodara, R.7
Fredenburg, R.8
Wu, D.C.9
Follenzi, A.10
Dauer, W.11
Przedborski, S.12
Ischiropoulos, H.13
Lansbury, P.T.14
Sulzer, D.15
Cuervo, A.M.16
-
37
-
-
0034681471
-
Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders
-
Masliah E., Rockenstein E., Veinbergs I., Mallory M., Hashimoto M., Takeda A., Sagara Y., Sisk A., and Mucke L. Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science 287 (2000) 1265-1269
-
(2000)
Science
, vol.287
, pp. 1265-1269
-
-
Masliah, E.1
Rockenstein, E.2
Veinbergs, I.3
Mallory, M.4
Hashimoto, M.5
Takeda, A.6
Sagara, Y.7
Sisk, A.8
Mucke, L.9
-
38
-
-
33645829816
-
Consequences of the selective blockage of chaperone-mediated autophagy
-
Massey A.C., Kaushik S., Sovak G., Kiffin R., and Cuervo A.M. Consequences of the selective blockage of chaperone-mediated autophagy. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 5805-5810
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 5805-5810
-
-
Massey, A.C.1
Kaushik, S.2
Sovak, G.3
Kiffin, R.4
Cuervo, A.M.5
-
40
-
-
0035859226
-
Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons
-
McLean P.J., Kawamata H., and Hyman B.T. Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons. Neuroscience 104 (2001) 901-912
-
(2001)
Neuroscience
, vol.104
, pp. 901-912
-
-
McLean, P.J.1
Kawamata, H.2
Hyman, B.T.3
-
41
-
-
0037227397
-
Altered proteasomal function in sporadic Parkinson's disease
-
McNaught K.S., Belizaire R., Isacson O., Jenner P., and Olanow C.W. Altered proteasomal function in sporadic Parkinson's disease. Exp. Neurol. 179 (2003) 38-46
-
(2003)
Exp. Neurol.
, vol.179
, pp. 38-46
-
-
McNaught, K.S.1
Belizaire, R.2
Isacson, O.3
Jenner, P.4
Olanow, C.W.5
-
42
-
-
0037036904
-
Proteasome inhibition causes nigral degeneration with inclusion bodies in rats
-
McNaught K.S., Bjorklund L.M., Belizaire R., Isacson O., Jenner P., and Olanow C.W. Proteasome inhibition causes nigral degeneration with inclusion bodies in rats. Neuroreport 13 (2002) 1437-1441
-
(2002)
Neuroreport
, vol.13
, pp. 1437-1441
-
-
McNaught, K.S.1
Bjorklund, L.M.2
Belizaire, R.3
Isacson, O.4
Jenner, P.5
Olanow, C.W.6
-
43
-
-
0035910634
-
Proteasomal function is impaired in substantia nigra in Parkinson's disease
-
McNaught K.S., and Jenner P. Proteasomal function is impaired in substantia nigra in Parkinson's disease. Neurosci. Lett. 297 (2001) 191-194
-
(2001)
Neurosci. Lett.
, vol.297
, pp. 191-194
-
-
McNaught, K.S.1
Jenner, P.2
-
44
-
-
0036456584
-
Aggresome-related biogenesis of Lewy bodies
-
McNaught K.S., Shashidharan P., Perl D.P., Jenner P., and Olanow C.W. Aggresome-related biogenesis of Lewy bodies. Eur. J. Neurosci. 16 (2002) 2136-2148
-
(2002)
Eur. J. Neurosci.
, vol.16
, pp. 2136-2148
-
-
McNaught, K.S.1
Shashidharan, P.2
Perl, D.P.3
Jenner, P.4
Olanow, C.W.5
-
45
-
-
0037159608
-
Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease
-
Meredith G.E., Totterdell S., Petroske E., Santa C.K., Callison Jr. R.C., and Lau Y.S. Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease. Brain Res. 956 (2002) 156-165
-
(2002)
Brain Res.
, vol.956
, pp. 156-165
-
-
Meredith, G.E.1
Totterdell, S.2
Petroske, E.3
Santa, C.K.4
Callison Jr., R.C.5
Lau, Y.S.6
-
46
-
-
0024576287
-
Lysosome instability in aged rat brain
-
Nakamura Y., Takeda M., Suzuki H., Morita H., Tada K., Hariguchi S., and Nishimura T. Lysosome instability in aged rat brain. Neurosci. Lett. 97 (1989) 215-220
-
(1989)
Neurosci. Lett.
, vol.97
, pp. 215-220
-
-
Nakamura, Y.1
Takeda, M.2
Suzuki, H.3
Morita, H.4
Tada, K.5
Hariguchi, S.6
Nishimura, T.7
-
47
-
-
14844303381
-
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study
-
Nixon R.A., Wegiel J., Kumar A., Yu W.H., Peterhoff C., Cataldo A., and Cuervo A.M. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J. Neuropathol. Exp. Neurol. 64 (2005) 113-122
-
(2005)
J. Neuropathol. Exp. Neurol.
, vol.64
, pp. 113-122
-
-
Nixon, R.A.1
Wegiel, J.2
Kumar, A.3
Yu, W.H.4
Peterhoff, C.5
Cataldo, A.6
Cuervo, A.M.7
-
48
-
-
40449139321
-
Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease
-
Nuber S., Petrasch-Parwez E., Winner B., Winkler J., von H.S., Schmidt T., Boy J., Kuhn M., Nguyen H.P., Teismann P., Schulz J.B., Neumann M., Pichler B.J., Reischl G., Holzmann C., Schmitt I., Bornemann A., Kuhn W., Zimmermann F., Servadio A., and Riess O. Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease. J. Neurosci. 28 (2008) 2471-2484
-
(2008)
J. Neurosci.
, vol.28
, pp. 2471-2484
-
-
Nuber, S.1
Petrasch-Parwez, E.2
Winner, B.3
Winkler, J.4
von, H.S.5
Schmidt, T.6
Boy, J.7
Kuhn, M.8
Nguyen, H.P.9
Teismann, P.10
Schulz, J.B.11
Neumann, M.12
Pichler, B.J.13
Reischl, G.14
Holzmann, C.15
Schmitt, I.16
Bornemann, A.17
Kuhn, W.18
Zimmermann, F.19
Servadio, A.20
Riess, O.21
more..
-
49
-
-
34250183177
-
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
-
Pandey U.B., Nie Z., Batlevi Y., McCray B.A., Ritson G.P., Nedelsky N.B., Schwartz S.L., DiProspero N.A., Knight M.A., Schuldiner O., Padmanabhan R., Hild M., Berry D.L., Garza D., Hubbert C.C., Yao T.P., Baehrecke E.H., and Taylor J.P. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447 (2007) 859-863
-
(2007)
Nature
, vol.447
, pp. 859-863
-
-
Pandey, U.B.1
Nie, Z.2
Batlevi, Y.3
McCray, B.A.4
Ritson, G.P.5
Nedelsky, N.B.6
Schwartz, S.L.7
DiProspero, N.A.8
Knight, M.A.9
Schuldiner, O.10
Padmanabhan, R.11
Hild, M.12
Berry, D.L.13
Garza, D.14
Hubbert, C.C.15
Yao, T.P.16
Baehrecke, E.H.17
Taylor, J.P.18
-
50
-
-
79955694568
-
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
-
Qiao L., Hamamichi S., Caldwell K.A., Caldwell G.A., Yacoubian T.A., Wilson S., Xie Z.L., Speake L.D., Parks R., Crabtree D., Liang Q., Crimmins S., Schneider L., Uchiyama Y., Iwatsubo T., Zhou Y., Peng L., Lu Y., Standaert D.G., Walls K.C., Shacka J.J., Roth K.A., and Zhang J. Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity. Mol. Brain 1 (2008) 17
-
(2008)
Mol. Brain
, vol.1
, pp. 17
-
-
Qiao, L.1
Hamamichi, S.2
Caldwell, K.A.3
Caldwell, G.A.4
Yacoubian, T.A.5
Wilson, S.6
Xie, Z.L.7
Speake, L.D.8
Parks, R.9
Crabtree, D.10
Liang, Q.11
Crimmins, S.12
Schneider, L.13
Uchiyama, Y.14
Iwatsubo, T.15
Zhou, Y.16
Peng, L.17
Lu, Y.18
Standaert, D.G.19
Walls, K.C.20
Shacka, J.J.21
Roth, K.A.22
Zhang, J.23
more..
-
51
-
-
4344583898
-
Involvement of macroautophagy in the dissolution of neuronal inclusions
-
Rideout H.J., Lang-Rollin I., and Stefanis L. Involvement of macroautophagy in the dissolution of neuronal inclusions. Int. J. Biochem. Cell Biol. 36 (2004) 2551-2562
-
(2004)
Int. J. Biochem. Cell Biol.
, vol.36
, pp. 2551-2562
-
-
Rideout, H.J.1
Lang-Rollin, I.2
Stefanis, L.3
-
52
-
-
0036432029
-
Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitination
-
Rideout H.J., and Stefanis L. Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitination. Mol. Cell. Neurosci. 21 (2002) 223-238
-
(2002)
Mol. Cell. Neurosci.
, vol.21
, pp. 223-238
-
-
Rideout, H.J.1
Stefanis, L.2
-
53
-
-
2642553802
-
Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice
-
Robertson D.C., Schmidt O., Ninkina N., Jones P.A., Sharkey J., and Buchman V.L. Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice. J. Neurochem. 89 (2004) 1126-1136
-
(2004)
J. Neurochem.
, vol.89
, pp. 1126-1136
-
-
Robertson, D.C.1
Schmidt, O.2
Ninkina, N.3
Jones, P.A.4
Sharkey, J.5
Buchman, V.L.6
-
54
-
-
0038307156
-
Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies
-
Sampathu D.M., Giasson B.I., Pawlyk A.C., Trojanowski J.Q., and Lee V.M. Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies. Am. J. Pathol. 163 (2003) 91-100
-
(2003)
Am. J. Pathol.
, vol.163
, pp. 91-100
-
-
Sampathu, D.M.1
Giasson, B.I.2
Pawlyk, A.C.3
Trojanowski, J.Q.4
Lee, V.M.5
-
55
-
-
34247161367
-
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein
-
Sarkar S., Davies J.E., Huang Z., Tunnacliffe A., and Rubinsztein D.C. Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J. Biol. Chem. 282 (2007) 5641-5652
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 5641-5652
-
-
Sarkar, S.1
Davies, J.E.2
Huang, Z.3
Tunnacliffe, A.4
Rubinsztein, D.C.5
-
56
-
-
37849042536
-
A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin
-
Sarkar S., Krishna G., Imarisio S., Saiki S., O'Kane C.J., and Rubinsztein D.C. A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. Hum. Mol. Genet. 17 (2008) 170-178
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 170-178
-
-
Sarkar, S.1
Krishna, G.2
Imarisio, S.3
Saiki, S.4
O'Kane, C.J.5
Rubinsztein, D.C.6
-
57
-
-
33645916698
-
Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations
-
Sarkar S., and Rubinsztein D.C. Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations. Autophagy 2 (2006) 132-134
-
(2006)
Autophagy
, vol.2
, pp. 132-134
-
-
Sarkar, S.1
Rubinsztein, D.C.2
-
58
-
-
51549106105
-
Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species
-
Sevlever D., Jiang P., and Yen S.H. Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species. Biochemistry (2008)
-
(2008)
Biochemistry
-
-
Sevlever, D.1
Jiang, P.2
Yen, S.H.3
-
59
-
-
21244499845
-
The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways
-
Shin Y., Klucken J., Patterson C., Hyman B.T., and McLean P.J. The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways. J. Biol. Chem. 280 (2005) 23727-23734
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 23727-23734
-
-
Shin, Y.1
Klucken, J.2
Patterson, C.3
Hyman, B.T.4
McLean, P.J.5
-
60
-
-
0242300619
-
Alpha-synuclein locus triplication causes Parkinson's disease
-
Singleton A.B., Farrer M., Johnson J., Singleton A., Hague S., Kachergus J., Hulihan M., Peuralinna T., Dutra A., Nussbaum R., Lincoln S., Crawley A., Hanson M., Maraganore D., Adler C., Cookson M.R., Muenter M., Baptista M., Miller D., Blancato J., Hardy J., and Gwinn-Hardy K. Alpha-synuclein locus triplication causes Parkinson's disease. Science 302 (2003) 841
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
Lincoln, S.11
Crawley, A.12
Hanson, M.13
Maraganore, D.14
Adler, C.15
Cookson, M.R.16
Muenter, M.17
Baptista, M.18
Miller, D.19
Blancato, J.20
Hardy, J.21
Gwinn-Hardy, K.22
more..
-
61
-
-
0035976835
-
Alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome
-
Tofaris G.K., Layfield R., and Spillantini M.G. Alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome. FEBS Lett. 509 (2001) 22-26
-
(2001)
FEBS Lett.
, vol.509
, pp. 22-26
-
-
Tofaris, G.K.1
Layfield, R.2
Spillantini, M.G.3
-
63
-
-
0041589248
-
Alpha-synuclein is degraded by both autophagy and the proteasome
-
Webb J.L., Ravikumar B., Atkins J., Skepper J.N., and Rubinsztein D.C. Alpha-synuclein is degraded by both autophagy and the proteasome. J. Biol. Chem. 278 (2003) 25009-25013
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 25009-25013
-
-
Webb, J.L.1
Ravikumar, B.2
Atkins, J.3
Skepper, J.N.4
Rubinsztein, D.C.5
-
64
-
-
42249106042
-
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
-
Williams A., Sarkar S., Cuddon P., Ttofi E.K., Saiki S., Siddiqi F.H., Jahreiss L., Fleming A., Pask D., Goldsmith P., O'Kane C.J., Floto R.A., and Rubinsztein D.C. Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat. Chem. Biol. 4 (2008) 295-305
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 295-305
-
-
Williams, A.1
Sarkar, S.2
Cuddon, P.3
Ttofi, E.K.4
Saiki, S.5
Siddiqi, F.H.6
Jahreiss, L.7
Fleming, A.8
Pask, D.9
Goldsmith, P.10
O'Kane, C.J.11
Floto, R.A.12
Rubinsztein, D.C.13
-
65
-
-
0345189365
-
Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein
-
Willingham S., Outeiro T.F., DeVit M.J., Lindquist S.L., and Muchowski P.J. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Science 302 (2003) 1769-1772
-
(2003)
Science
, vol.302
, pp. 1769-1772
-
-
Willingham, S.1
Outeiro, T.F.2
DeVit, M.J.3
Lindquist, S.L.4
Muchowski, P.J.5
-
66
-
-
26444587508
-
Macroautophagy-a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease
-
Yu W.H., Cuervo A.M., Kumar A., Peterhoff C.M., Schmidt S.D., Lee J.H., Mohan P.S., Mercken M., Farmery M.R., Tjernberg L.O., Jiang Y., Duff K., Uchiyama Y., Naslund J., Mathews P.M., Cataldo A.M., and Nixon R.A. Macroautophagy-a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J. Cell Biol. 171 (2005) 87-98
-
(2005)
J. Cell Biol.
, vol.171
, pp. 87-98
-
-
Yu, W.H.1
Cuervo, A.M.2
Kumar, A.3
Peterhoff, C.M.4
Schmidt, S.D.5
Lee, J.H.6
Mohan, P.S.7
Mercken, M.8
Farmery, M.R.9
Tjernberg, L.O.10
Jiang, Y.11
Duff, K.12
Uchiyama, Y.13
Naslund, J.14
Mathews, P.M.15
Cataldo, A.M.16
Nixon, R.A.17
|