Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake

Diabetologia

Volumn 52, Issue 5, 2009, Pages 912-920

  Gao, X F ^a   Chen, W ^a   Kong, X P ^b   Xu, A M ^a,c   Wang, Z G ^d   Sweeney, G ^e   Wu, D ^a  

^a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^b 458th Hospital of PLA   (China)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d Shanghai Nan Fang Model Organism Research Center   (China)

^e YORK UNIVERSITY   (Canada)

Author keywords

CPT1 activity; Cpt1 expression; Cpt1c knockout; Fatty acid oxidation; Gluconeogenesis; Glucose intolerance; Glucose uptake; Hypothalamus; Non esterified fatty acid; Oxidative genes expression

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE I; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; EMBRYO; ENZYME ACTIVITY; FATTY ACID OXIDATION; FEMALE; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; LIPID DIET; LIVER; MALE; MOUSE; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE; TRIACYLGLYCEROL BLOOD LEVEL; WILD TYPE;

ANIMALS; BASE SEQUENCE; BODY WEIGHT; CARNITINE O-PALMITOYLTRANSFERASE; CHOLESTEROL; DIETARY FATS; GLUCONEOGENESIS; GLUCOSE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HETEROZYGOTE; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUSCLE, SKELETAL; OBESITY; RNA INTERFERENCE; RNA, MESSENGER; TRIGLYCERIDES;

EID: 64149110214     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1284-0     Document Type: Article

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