Homozygous carnitine palmitoyltransferase 1a (liver isoform) deficiency is lethal in the mouse

Molecular Genetics and Metabolism

Volumn 86, Issue 1-2, 2005, Pages 179-187

  Nyman, Lara R ^a   Cox, Keith B ^a   Hoppel, Charles L ^b,c   Kerner, Janos ^b   Barnoski, Barry L ^d   Hamm, Doug A ^a   Tian, Liqun ^a   Schoeb, Trenton R ^a   Wood, Philip A ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Carnitine palmitoyltransferase 1; Gene targeting; Inborn error of metabolism; Lethal trait; Mouse model

Indexed keywords

ACYLTRANSFERASE; CARNITINE PALMITOYLTRANSFERASE 1A; FATTY ACID; GLUCOSE; MESSENGER RNA; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CARNITINE PALMITOYLTRANSFERASE 1A DEFICIENCY; CHROMOSOME 19; COLD TOLERANCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET RESTRICTION; DISEASE MODEL; EMBRYO; ENZYME ACTIVITY; ENZYME DEFICIENCY; EXON; FATTY LIVER; FEMALE; FETUS; FLUORESCENCE IN SITU HYBRIDIZATION; GENE; GENE DELETION; GENE EXPRESSION; GENE LOCUS; GENE TARGETING; GENE VECTOR; GENETIC RECOMBINATION; GERM LINE; GESTATION PERIOD; GLUCOSE BLOOD LEVEL; HEART; HETEROZYGOSITY; HOMOZYGOSITY; HOMOZYGOTE; INHERITANCE; KIDNEY; KNOCKOUT GENE; KNOCKOUT MOUSE; LETHALITY; LIVER; MALE; MOUSE; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; SEX DIFFERENCE; STEM CELL; TESTIS; WHITE ADIPOSE TISSUE;

ANIMALS; BASE SEQUENCE; CARNITINE O-PALMITOYLTRANSFERASE; CHROMOSOME MAPPING; DNA PRIMERS; FEMALE; GENES, LETHAL; HOMOZYGOTE; IN SITU HYBRIDIZATION, FLUORESCENCE; LIVER; MALE; MICE; RNA, MESSENGER;

EID: 26244431937     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2005.07.021     Document Type: Article

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