메뉴 건너뛰기




Volumn 14, Issue 11, 2009, Pages 4173-4188

CD137, implications in immunity and potential for therapy

Author keywords

4 1BB; Antibody; Autoimmune disease; Cancer; CD137; Immunotherapy; OX40; Review; Tumor

Indexed keywords

MURINAE;

EID: 63849254074     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3521     Document Type: Article
Times cited : (43)

References (107)
  • 1
    • 33644823867 scopus 로고    scopus 로고
    • Immunotherapy with agonistic anti-CD137: Two sides of a coin
    • Sun Y, J H Chen, Y Fu, Immunotherapy with agonistic anti-CD137: two sides of a coin. Cell Mol. Immunol 1, 31-36(2004)
    • (2004) Cell Mol. Immunol. , vol.1 , pp. 31-36
    • Sun, Y.1    Chen, J.H.2    Fu, Y.3
  • 3
    • 14244269194 scopus 로고    scopus 로고
    • Biological activities of reverse signal transduction through CD137 ligand
    • DOI 10.1189/jlb.0904558
    • Schwarz H, Biological activities of reverse signal transduction through CD137 ligand. J. Leukoc. Biol 77, 281-286(2005) (Pubitemid 40289556)
    • (2005) Journal of Leukocyte Biology , vol.77 , Issue.3 , pp. 281-286
    • Schwarz, H.1
  • 4
    • 0029916309 scopus 로고    scopus 로고
    • ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival
    • Schwarz H, F J Blanco, K J von, J Valbracht, M Lotz, ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival. Blood 87, 2839-2845(1996) (Pubitemid 26102233)
    • (1996) Blood , vol.87 , Issue.7 , pp. 2839-2845
    • Schwarz, H.1    Blanco, F.J.2    Von Kempis, J.3    Valbracht, J.4    Lotz, M.5
  • 5
    • 34548507983 scopus 로고    scopus 로고
    • + T cells
    • DOI 10.1111/j.1365-2222.2007.02785.x
    • Polte T, A Jagemann, J Foell, R S Mittler, G Hansen, CD137 ligand prevents the development of T-helper type 2 cell-mediated allergic asthma by interferongamma-producing CD8+ T cells. Clin. Exp. Allergy 37, 1374-1385(2007) (Pubitemid 47372292)
    • (2007) Clinical and Experimental Allergy , vol.37 , Issue.9 , pp. 1374-1385
    • Polte, T.1    Jagemann, A.2    Foell, J.3    Mittler, R.S.4    Hansen, G.5
  • 7
    • 0027133102 scopus 로고
    • A receptor induced by lymphocyte activation (ILA): A new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family
    • Schwarz H, J Tuckwell, M Lotz, A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis- factor receptor family. Gene 134, 295-298(1993)
    • (1993) Gene , vol.134 , pp. 295-298
    • Schwarz, H.1    Tuckwell, J.2    Lotz, M.3
  • 11
    • 0028899550 scopus 로고
    • ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages
    • Schwarz H, J Valbracht, J Tuckwell, K J von, M Lotz, ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages. Blood 85, 1043-1052(1995)
    • (1995) Blood , vol.85 , pp. 1043-1052
    • Schwarz, H.1    Valbracht, J.2    Tuckwell, J.3    Von, K.J.4    Lotz, M.5
  • 12
    • 0032535119 scopus 로고    scopus 로고
    • NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies
    • DOI 10.1006/cimm.1998.1396
    • Melero I, J V Johnston, W W Shufford, R S Mittler, L Chen, NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell. Immunol 190, 167-172(1998) (Pubitemid 29011104)
    • (1998) Cellular Immunology , vol.190 , Issue.2 , pp. 167-172
    • Melero, I.1    Johnston, J.V.2    Shufford, W.W.3    Mittler, R.S.4    Chen, L.5
  • 16
    • 0036658720 scopus 로고    scopus 로고
    • CD137 is expressed by follicular dendritic cells and costimulates B lymphocyte activation in germinal centers
    • Pauly S, K Broll, M Wittmann, G Giegerich, H Schwarz, CD137 is expressed by follicular dendritic cells and costimulates B lymphocyte activation in germinal centers. J. Leukoc. Biol 72, 35-42(2002)
    • (2002) J. Leukoc. Biol. , vol.72 , pp. 35-42
    • Pauly, S.1    Broll, K.2    Wittmann, M.3    Giegerich, G.4    Schwarz, H.5
  • 17
    • 0030732028 scopus 로고    scopus 로고
    • Differentiation-dependent and stimulus-specific expression of ILA, the human 4-1BB-homologue, in cells of mesenchymal origin
    • von K J, H Schwarz, M Lotz, Differentiationdependent and stimulus-specific expression of ILA, the human 4-1BB-homologue, in cells of mesenchymal origin. Osteoarthritis. Cartilage 5, 394-406(1997) (Pubitemid 27522759)
    • (1997) Osteoarthritis and Cartilage , vol.5 , Issue.6 , pp. 394-406
    • Von Kempis, J.1    Schwarz, H.2    Lotz, M.3
  • 18
    • 0141869781 scopus 로고    scopus 로고
    • Expression of CD137 and its ligand in human neurons, astrocytes, and microglia: Modulation by FGF-2
    • DOI 10.1002/jnr.10727
    • Reali C, M Curto, V Sogos, F Scintu, S Pauly, H Schwarz, F Gremo, Expression of CD137 and its ligand in human neurons, astrocytes, and microglia: modulation by FGF-2. J. Neurosci. Res 74, 67-73(2003) (Pubitemid 37176668)
    • (2003) Journal of Neuroscience Research , vol.74 , Issue.1 , pp. 67-73
    • Reali, C.1    Curto, M.2    Sogos, V.3    Scintu, F.4    Pauly, S.5    Schwarz, H.6    Gremo, F.7
  • 20
    • 33846784977 scopus 로고    scopus 로고
    • CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity
    • DOI 10.1096/fj.05-4739com
    • Drenkard D, F M Becke, J Langstein, T Spruss, L A Kunz-Schughart, T E Tan, Y C Lim, H Schwarz, CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity. FASEB J 21, 456-463(2007) (Pubitemid 46213493)
    • (2007) FASEB Journal , vol.21 , Issue.2 , pp. 456-463
    • Drenkard, D.1    Becke, F.M.2    Langstein, J.3    Spruss, T.4    Kunz-Schughart, L.A.5    Teng, E.T.6    Yaw, C.L.7    Schwarz, H.8
  • 23
    • 63349088189 scopus 로고    scopus 로고
    • Genes, transcripts and proteins of CD137 receptor and ligand
    • Eds: Chen L P, Springer, NY
    • Vinay D S, B S Kwon, Genes, transcripts and proteins of CD137 receptor and ligand. In: CD137 Pathway: Immunology and Diseases. Eds: Chen L P, Springer, NY (2006)
    • (2006) CD137 Pathway: Immunology and Diseases
    • Vinay, D.S.1    Kwon, B.S.2
  • 24
    • 0031587969 scopus 로고    scopus 로고
    • CD137, a member of the tumor necrosis factor receptor family, is located on chromosome 1p36, in a cluster of related genes, and colocalizes with several malignancies
    • DOI 10.1006/bbrc.1997.6870
    • Schwarz H, K Arden, M Lotz, CD137, a member of the tumor necrosis factor receptor family, is located on chromosome 1p36, in a cluster of related genes, and colocalizes with several malignancies. Biochem. Biophys. Res. Commun 235, 699-703(1997) (Pubitemid 27326546)
    • (1997) Biochemical and Biophysical Research Communications , vol.235 , Issue.3 , pp. 699-703
    • Schwarz, H.1    Arden, K.2    Lotz, M.3
  • 28
    • 0346365360 scopus 로고    scopus 로고
    • CD137 and CD137 ligand constitutively coexpressed on human T and B leukemia cells signal proliferation and survival
    • DOI 10.1002/ijc.11574
    • Palma C, M Binaschi, M Bigioni M, C A Maggi, C Goso, CD137 and CD137 ligand constitutively coexpressed on human T and B leukemia cells signal proliferation and survival. Int. J. Cancer 108, 390-398(2004) (Pubitemid 37549604)
    • (2004) International Journal of Cancer , vol.108 , Issue.3 , pp. 390-398
    • Palma, C.1    Binaschi, M.2    Bigioni, M.3    Maggi, C.A.4    Goso, C.5
  • 30
    • 0028009709 scopus 로고
    • 4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-μ-primed splenic B cells
    • Pollok K E, Y J Kim, J Hurtado, Z Zhou, K K Kim, B S Kwon, 4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-mu-primed splenic B cells. Eur. J. Immunol 24, 367-374(1994) (Pubitemid 24041126)
    • (1994) European Journal of Immunology , vol.24 , Issue.2 , pp. 367-374
    • Pollok, K.E.1    Kim, Y.-J.2    Hurtado, J.3    Zhou, Z.4    Kim, K.K.5    Kwon, B.S.6
  • 31
    • 0345257063 scopus 로고    scopus 로고
    • A functional anti-human 4-1BB ligand monoclonal antibody that enhances proliferation of monocytes by reverse signaling of 4-1BBL
    • Ju S W, S G Ju, F M Wang, Z J Gu, Y H Qiu, G H Yu, H B Ma, X G Zhang, A functional anti-human 4-1BB ligand monoclonal antibody that enhances proliferation of monocytes by reverse signaling of 4-1BBL. Hybrid. Hybridomics 22, 333-338(2003)
    • (2003) Hybrid. Hybridomics , vol.22 , pp. 333-338
    • Ju, S.W.1    Ju, S.G.2    Wang, F.M.3    Gu, Z.J.4    Qiu, Y.H.5    Yu, G.H.6    Ma, H.B.7    Zhang, X.G.8
  • 32
    • 1642432076 scopus 로고    scopus 로고
    • 4-1BB-ligand is regulated on human dendritic cells and induces the production of IL-12
    • DOI 10.1016/j.cellimm.2003.11.003
    • Laderach D, A Wesa, A Galy, 4-1BB-ligand is regulated on human dendritic cells and induces the production of IL-12. Cell Immunol 226, 37-44(2003) (Pubitemid 38121296)
    • (2003) Cellular Immunology , vol.226 , Issue.1 , pp. 37-44
    • Laderach, D.1    Wesa, A.2    Galy, A.3
  • 33
    • 0036968709 scopus 로고    scopus 로고
    • + progenitor cells
    • DOI 10.1089/152581602321080556
    • Kim Y J, G Li, H E Broxmeyer, 4-1BB ligand stimulation enhances myeloid dendritic cell maturation from human umbilical cord blood CD34+ progenitor cells. J. Hematother. Stem Cell Res 11, 895-903(2002) (Pubitemid 36139770)
    • (2002) Journal of Hematotherapy and Stem Cell Research , vol.11 , Issue.6 , pp. 895-903
    • Kim, Y.-J.1    Li, G.2    Broxmeyer, H.E.3
  • 34
    • 0346995358 scopus 로고    scopus 로고
    • Lipopolysaccharide preferentially induces 4-1BB ligand expression on human monocyte-derived dendritic cells
    • Lee, P K, C J Chang, C M Lin, Lipopolysaccharide preferentially induces 4-1BB ligand expression on human monocyte-derived dendritic cells. Immunol. Lett 90, 215-221(2003)
    • (2003) Immunol. Lett , vol.90 , pp. 215-221
    • Lee, P.K.1    Chang, C.J.2    Lin, C.M.3
  • 36
    • 0028955074 scopus 로고
    • Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP
    • De Benedette M A, N R Chu, K E Pollok, J Hurtado, W F Wade, B S Kwon, T H Watts, Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP. J. Exp. Med 181, 985-992(1995)
    • (1995) J. Exp. Med , vol.181 , pp. 985-992
    • De Benedette, M.A.1    Chu, N.R.2    Pollok, K.E.3    Hurtado, J.4    Wade, W.F.5    Kwon, B.S.6    Watts, T.H.7
  • 37
    • 17444421193 scopus 로고    scopus 로고
    • short via phosphatidylinositol 3-kinase and AKT/protein kinase B
    • DOI 10.1002/eji.200425686
    • Starck L, C Scholz, B Dorken, P T Daniel, Costimulation by CD137/4-1BB inhibits T cell apoptosis and induces Bcl-xL and c-FLIP (short) via phosphatidylinositol 3-kinase and AKT/protein kinase B. Eur. J. Immunol 35, 1257-1266(2005) (Pubitemid 40542233)
    • (2005) European Journal of Immunology , vol.35 , Issue.4 , pp. 1257-1266
    • Starck, L.1    Scholz, C.2    Dorken, B.3    Daniel, P.T.4
  • 40
    • 0037094139 scopus 로고    scopus 로고
    • 4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function
    • Wen T, J Bukczynski, T H Watts, 4-1BB ligandmediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function. J. Immunol 168, 4897-4906(2002) (Pubitemid 34495951)
    • (2002) Journal of Immunology , vol.168 , Issue.10 , pp. 4897-4906
    • Wen, T.1    Bukczynski, J.2    Watts, T.H.3
  • 41
    • 0036171757 scopus 로고    scopus 로고
    • Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB
    • DOI 10.1038/nbt0202-143
    • Maus M V, A K Thomas, D G Leonard, D Allman, K Addya, K Schlienger, J L Riley, C H June, Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB. Nat. Biotechnol 20, 143-148(2002) (Pubitemid 34158029)
    • (2002) Nature Biotechnology , vol.20 , Issue.2 , pp. 143-148
    • Maus, M.V.1    Thomas, A.K.2    Leonard, D.G.B.3    Allman, D.4    Addya, K.5    Schlienger, K.6    Riley, J.L.7    June, C.H.8
  • 42
    • 0036175995 scopus 로고    scopus 로고
    • 4-1BB (CD137) controls the clonal expansion and survival of CD8 T cells in vivo but does not contribute to the development of cytotoxicity
    • DOI 10.1002/1521-4141(200202)32:2<521::AID-IMMU521>3.0.CO;2-X
    • Cooper D, P Bansal-Pakala, M Croft, 4-1BB (CD137) controls the clonal expansion and survival of CD8 T cells in vivo but does not contribute to the development of cytotoxicity. Eur. J. Immunol 32, 521-529(2002) (Pubitemid 34173343)
    • (2002) European Journal of Immunology , vol.32 , Issue.2 , pp. 521-529
    • Cooper, D.1    Bansal-Pakala, P.2    Croft, M.3
  • 45
    • 0033571176 scopus 로고    scopus 로고
    • Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy
    • Mittler R S, T S Bailey, K Klussman, M D Trailsmith, M K Hoffmann, Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy. J. Exp. Med 190, 1535-1540(1999)
    • (1999) J. Exp. Med , vol.190 , pp. 1535-1540
    • Mittler, R.S.1    Bailey, T.S.2    Klussman, K.3    Trailsmith, M.D.4    Hoffmann, M.K.5
  • 47
    • 4444340010 scopus 로고    scopus 로고
    • Engagement of the CD137 (4-1BB) costimulatory molecule inhibits and reverses the autoimmune process in collagen-induced arthritis and establishes lasting disease resistance
    • DOI 10.1111/j.1365-2567.2004.01952.x
    • Foell J L, B I ez-Mendiondo, O H Diez, U Holzer, P Ruck, A S Bapat, M K Hoffmann, R S Mittler, G E Dannecker, Engagement of the CD137 (4-1BB) costimulatory molecule inhibits and reverses the autoimmune process in collagen-induced arthritis and establishes lasting disease resistance. Immunology 113, 89-98(2004) (Pubitemid 39178847)
    • (2004) Immunology , vol.113 , Issue.1 , pp. 89-98
    • Foell, J.L.1    Diez-Mendiondo, B.I.2    Diez, O.H.3    Holzer, U.4    Ruck, P.5    Bapat, A.S.6    Hoffmann, M.K.7    Mittler, R.S.8    Dannecker, G.E.9
  • 49
    • 33747119866 scopus 로고    scopus 로고
    • 4-1BB-mediated amelioration of experimental autoimmune uveoretinitis is caused by indoleamine 2,3-dioxygenase-dependent mechanisms
    • DOI 10.1016/j.cyto.2006.04.008, PII S1043466606001384
    • Choi B K, T Asai, D S Vinay, Y H Kim, B S Kwon, 4-1BB-mediated amelioration of experimental autoimmune uveoretinitis is caused by indoleamine 2, 3-dioxygenase-dependent mechanisms. Cytokine 34, 233-242(2006) (Pubitemid 44224104)
    • (2006) Cytokine , vol.34 , Issue.5-6 , pp. 233-242
    • Choi, B.K.1    Asai, T.2    Vinay, D.S.3    Kim, Y.H.4    Kwon, B.S.5
  • 50
    • 1642432078 scopus 로고    scopus 로고
    • + regulatory T cells in induced tolerance to experimental autoimmune thyroiditis
    • DOI 10.1016/j.cellimm.2003.11.002
    • Morris G P, L Chen, Y C Kong, CD137 signaling interferes with activation and function of CD4+CD25+ regulatory T cells in induced tolerance to experimental autoimmune thyroiditis. Cell Immunol 226, 20-29(2003) (Pubitemid 38121294)
    • (2003) Cellular Immunology , vol.226 , Issue.1 , pp. 20-29
    • Morris, G.P.1    Chen, L.2    Kong, Y.-C.M.3
  • 51
    • 4043089873 scopus 로고    scopus 로고
    • + regulatory T cells
    • Zheng G, B Wang, A Chen, The 4-1BB costimulation augments the proliferation of CD4+CD25+ regulatory T cells. J. Immunol 173, 2428-2434(2004) (Pubitemid 39063099)
    • (2004) Journal of Immunology , vol.173 , Issue.4 , pp. 2428-2434
    • Zheng, G.1    Wang, B.2    Chen, A.3
  • 52
    • 0037090337 scopus 로고    scopus 로고
    • Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection
    • Bertram E M, P Lau, T H Watts, Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection. J. Immunol 168, 3777-3785(2002) (Pubitemid 34298377)
    • (2002) Journal of Immunology , vol.168 , Issue.8 , pp. 3777-3785
    • Bertram, E.M.1    Lau, P.2    Watts, T.H.3
  • 53
    • 0032711836 scopus 로고    scopus 로고
    • 4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses
    • Tan J T, J K Whitmire, R Ahmed, T C Pearson, C P Larsen, 4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses. J. Immunol 163, 4859-4868(1999) (Pubitemid 29501250)
    • (1999) Journal of Immunology , vol.163 , Issue.9 , pp. 4859-4868
    • Tan, J.T.1    Whitmire, J.K.2    Ahmed, R.3    Pearson, T.C.4    Larsen, C.P.5
  • 54
    • 0036467421 scopus 로고    scopus 로고
    • Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis
    • Sun Y, X Lin, H M Chen, Q Wu, S K Subudhi, L Chen, Y X Fu, Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis. J. Immunol 168, 1457-1465(2002) (Pubitemid 34094519)
    • (2002) Journal of Immunology , vol.168 , Issue.3 , pp. 1457-1465
    • Sun, Y.1    Lin, X.2    Chen, H.M.3    Wu, Q.4    Subudhi, S.K.5    Chen, L.6    Fu, Y.-X.7
  • 57
    • 4344694114 scopus 로고    scopus 로고
    • Ligands working as receptors: Reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system
    • DOI 10.1016/j.cytogfr.2004.03.011, PII S135961010400022X
    • Eissner G, W Kolch, P Scheurich, Ligands working as receptors: reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system. Cytokine Growth Factor Rev 15, 353-366(2004) (Pubitemid 39140699)
    • (2004) Cytokine and Growth Factor Reviews , vol.15 , Issue.5 , pp. 353-366
    • Eissner, G.1    Kolch, W.2    Scheurich, P.3
  • 58
    • 0034054851 scopus 로고    scopus 로고
    • Eph receptors and ephrins: Regulators of guidance and assembly
    • Wilkinson D G Eph receptors and ephrins: regulators of guidance and assembly. Int. Rev. Cytol 196, 177-244(2000) (Pubitemid 30130841)
    • (2000) International Review of Cytology , vol.196 , pp. 177-244
    • Wilkinson, D.G.1
  • 61
    • 0032032236 scopus 로고    scopus 로고
    • CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling
    • Langstein J, J Michel, J Fritsche, M Kreutz, R Andreesen, H Schwarz, CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling. J. Immunol 160, 2488-2494(1998) (Pubitemid 28119935)
    • (1998) Journal of Immunology , vol.160 , Issue.5 , pp. 2488-2494
    • Langstein, J.1    Michel, J.2    Fritsche, J.3    Kreutz, M.4    Andreesen, R.5    Schwarz, H.6
  • 62
    • 0033229705 scopus 로고    scopus 로고
    • CD137 induces proliferation and endomitosis in monocytes
    • Langstein J, J Michel, H Schwarz, CD137 induces proliferation and endomitosis in monocytes. Blood 94, 3161-3168(1999) (Pubitemid 29512724)
    • (1999) Blood , vol.94 , Issue.9 , pp. 3161-3168
    • Langstein, J.1    Michel, J.2    Schwarz, H.3
  • 63
    • 0033063934 scopus 로고    scopus 로고
    • Identification of CD137 as a potent monocyte survival factor
    • Langstein J, H Schwarz, Identification of CD137 as a potent monocyte survival factor. J. Leukoc. Biol 65, 829-833(1999) (Pubitemid 29279533)
    • (1999) Journal of Leukocyte Biology , vol.65 , Issue.6 , pp. 829-833
    • Langstein, J.1    Schwarz, H.2
  • 64
    • 34249077931 scopus 로고    scopus 로고
    • Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages
    • DOI 10.1038/ni1471, PII NI1471
    • Kang Y J, S O Kim, S Shimada, M Otsuka, A Seit-Nebi, B S Kwon, T H Watts, J Han, Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages. Nat. Immunol 8, 601-609(2007) (Pubitemid 46785124)
    • (2007) Nature Immunology , vol.8 , Issue.6 , pp. 601-609
    • Kang, Y.J.1    Kim, S.O.2    Shimada, S.3    Otsuka, M.4    Seit-Nebi, A.5    Kwon, B.S.6    Watts, T.H.7    Han, J.8
  • 66
    • 0032882013 scopus 로고    scopus 로고
    • CD137-induced apoptosis is independent of CD95
    • DOI 10.1046/j.1365-2567.1999.00851.x
    • Michel J, S Pauly, J Langstein, P H Krammer, H Schwarz, CD137-induced apoptosis is independent of CD95. Immunology 98, 42-46(1999) (Pubitemid 29425907)
    • (1999) Immunology , vol.98 , Issue.1 , pp. 42-46
    • Michel, J.1    Pauly, S.2    Langstein, J.3    Krammer, P.H.4    Schwarz, H.5
  • 67
    • 34447539929 scopus 로고    scopus 로고
    • Signal transduction mechanisms of CD137 ligand in human monocytes
    • DOI 10.1016/j.cellsig.2007.04.014, PII S0898656807001271
    • Sollner L, D O K Shaqireen, J T Wu, H Schwarz, Signal transduction mechanisms of CD137 ligand in human monocytes. Cell Signal 19, 1899-1908(2007) (Pubitemid 47082541)
    • (2007) Cellular Signalling , vol.19 , Issue.9 , pp. 1899-1908
    • Sollner, L.1    Shaqireen Kwajah, M.M.2    Wu, J.T.3    Schwarz, H.4
  • 68
    • 0028864038 scopus 로고
    • A mRNA variant encoding a soluble form of 4-1BB, a member of the murine NGF/TNF receptor family
    • Setareh M, H Schwarz, M Lotz, A mRNA variant encoding a soluble form of 4-1BB, a member of the murine NGF/TNF receptor family. Gene 164, 311-315(1995)
    • (1995) Gene , vol.164 , pp. 311-315
    • Setareh, M.1    Schwarz, H.2    Lotz, M.3
  • 69
    • 0031974419 scopus 로고    scopus 로고
    • A soluble form of CD137 (ILA/4-1BB), a member of the TNF receptor family, is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis
    • DOI 10.1002/(SICI)1521-4141(199801)28:01<290::AID-IMMU290>3.0.CO;2- S
    • Michel J, J Langstein, F Hofstadter, H Schwarz, A soluble form of CD137 (ILA/4-1BB), a member of the TNF receptor family, is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis. Eur. J. Immunol 28, 290-295(1998) (Pubitemid 28048299)
    • (1998) European Journal of Immunology , vol.28 , Issue.1 , pp. 290-295
    • Michel, J.1    Langstein, J.2    Hofstadter, F.3    Schwarz, H.4
  • 70
    • 0033937367 scopus 로고    scopus 로고
    • Expression of soluble CD137 correlates with activation-induced cell death of lymphocytes
    • DOI 10.1006/cyto.1999.0623
    • Michel J, H Schwarz, Expression of soluble CD137 correlates with activation-induced cell death of lymphocytes. Cytokine 12, 742-746(2000) (Pubitemid 30453509)
    • (2000) Cytokine , vol.12 , Issue.6 , pp. 742-746
    • Michel, J.1    Schwarz, H.2
  • 71
    • 0029117913 scopus 로고
    • Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28
    • Hurtado J C, S H Kim, K E Pollok, Z H Lee, B S Kwon, (1995) Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28. J. Immunol 155, 3360-3367
    • (1995) J. Immunol. , vol.155 , pp. 3360-3367
    • Hurtado, J.C.1    Kim, S.H.2    Pollok, K.E.3    Lee, Z.H.4    Kwon, B.S.5
  • 72
    • 18644383814 scopus 로고    scopus 로고
    • Levels of soluble CD137 are enhanced in sera of leukemia and lymphoma patients and are strongly associated with chronic lymphocytic leukemia [7]
    • DOI 10.1038/sj.leu.2403675
    • Furtner M, R H Straub, S Kruger, H Schwarz, Levels of soluble CD137 are enhanced in sera of leukemia and lymphoma patients and are strongly associated with chronic lymphocytic leukemia. Leukemia 19, 883-885(2005) (Pubitemid 40663117)
    • (2005) Leukemia , vol.19 , Issue.5 , pp. 883-885
    • Furtner, M.1    Straub, R.H.2    Kruger, S.3    Schwarz, H.4
  • 73
    • 0036388529 scopus 로고    scopus 로고
    • Heightened intrathecal release of soluble CD137 in patients with multiple sclerosis
    • Sharief M K Heightened intrathecal release of soluble CD137 in patients with multiple sclerosis. Eur. J. Neurol 9, 49-54(2002)
    • (2002) Eur. J. Neurol , vol.9 , pp. 49-54
    • Sharief, M.K.1
  • 74
    • 1642291001 scopus 로고    scopus 로고
    • Serum concentrations of soluble 4-1BB, and 4-1BB ligand correlated with the disease severity in rheumatoid arthritis
    • Jung H W, S W Choi, J I Choi, B S Kwon, Serum concentrations of soluble 4-1BB and 4-1BB ligand correlated with the disease severity in rheumatoid arthritis. Exp. Mol. Med 36, 13-22(2004) (Pubitemid 38379632)
    • (2004) Experimental and Molecular Medicine , vol.36 , Issue.1 , pp. 13-22
    • Jung, H.W.1    Choi, S.W.2    Choi, J.I.L.3    Kwon, B.S.4
  • 76
    • 35949002157 scopus 로고    scopus 로고
    • Characterization and application of three novel monoclonal antibodies against human 4-1BB: Distinct epitopes of human 4-1BB on lung tumor cells and immune cells
    • DOI 10.1111/j.1399-0039.2007.00943.x
    • Zhang G B, Q M Dong, J Q Hou, Y Ge, S G Ju, B F Lu, X G Zhang, Characterization and application of three novel monoclonal antibodies against human 4-1BB: distinct epitopes of human 4-1BB on lung tumor cells and immune cells. Tissue Antigens 70, 470-479(2007) (Pubitemid 350075794)
    • (2007) Tissue Antigens , vol.70 , Issue.6 , pp. 470-479
    • Zhang, G.-B.1    Dong, Q.-M.2    Hou, J.-Q.3    Ge, Y.4    Ju, S.-G.5    Lu, B.-F.6    Zhang, X.-G.7
  • 78
    • 3142644996 scopus 로고    scopus 로고
    • Tumour-associated macrophages as a prototypic type II polarised phagocyte population: Role in tumour progression
    • DOI 10.1016/j.ejca.2004.03.016, PII S0959804904002850
    • Mantovani A, P Allavena, A Sica, Tumourassociated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression. Eur. J. Cancer 40, 1660-1667(2004) (Pubitemid 38902900)
    • (2004) European Journal of Cancer , vol.40 , Issue.11 , pp. 1660-1667
    • Mantovani, A.1    Allavena, P.2    Sica, A.3
  • 79
    • 0035478649 scopus 로고    scopus 로고
    • Soluble CD137 (4-1BB) ligand is released following leukocyte activation and is found in sera of patients with hematological malignancies
    • Salih H R, H M Schmetzer, C Burke, G C Starling, R Dunn, R Pelka-Fleischer, V Nuessler, P A Kiener, Soluble CD137 (4-1BB) ligand is released following leukocyte activation and is found in sera of patients with hematological malignancies. J. Immunol 167, 4059-4066(2001) (Pubitemid 32910853)
    • (2001) Journal of Immunology , vol.167 , Issue.7 , pp. 4059-4066
    • Salih, H.R.1    Schmetzer, H.M.2    Burke, C.3    Starling, G.C.4    Dunn, R.5    Pelka-Fleischer, R.6    Nuessler, V.7    Kiener, P.A.8
  • 80
    • 33745727598 scopus 로고    scopus 로고
    • Serum levels of sCD137 (4-1BB) ligand are prognostic factors for progression in acute myeloid leukemia but not in non-Hodgkin's lymphoma
    • Hentschel N, M Krusch, P A Kiener, H J Kolb, H R Salih, H M Schmetzer, Serum levels of sCD137 (4-1BB) ligand are prognostic factors for progression in acute myeloid leukemia but not in non-Hodgkin's lymphoma. Eur. J. Haematol 77, 91-101(2006)
    • (2006) Eur. J. Haematol , vol.77 , pp. 91-101
    • Hentschel, N.1    Krusch, M.2    Kiener, P.A.3    Kolb, H.J.4    Salih, H.R.5    Schmetzer, H.M.6
  • 83
    • 18944375012 scopus 로고    scopus 로고
    • Enhanced CD4 T cell responsiveness in the absence of 4-1BB
    • Lee S W, A T Vella, B S Kwon, M Croft, Enhanced CD4 T cell responsiveness in the absence of 4-1BB. J. Immunol 174, 6803-6808(2005) (Pubitemid 40705643)
    • (2005) Journal of Immunology , vol.174 , Issue.11 , pp. 6803-6808
    • Lee, S.-W.1    Vella, A.T.2    Kwon, B.S.3    Croft, M.4
  • 84
    • 35048866361 scopus 로고    scopus 로고
    • Role of endogenous 4-1BB in the development of systemic lupus erythematosus
    • DOI 10.1111/j.1365-2567.2007.02653.x
    • Vinay D S, J H Choi, J D Kim, B K Choi, B S Kwon, Role of endogenous 4-1BB in the development of systemic lupus erythematosus. Immunology 122, 394-400(2007) (Pubitemid 47556476)
    • (2007) Immunology , vol.122 , Issue.3 , pp. 394-400
    • Vinay, D.S.1    Choi, J.H.2    Kim, J.D.3    Choi, B.K.4    Kwon, B.S.5
  • 85
    • 22444434764 scopus 로고    scopus 로고
    • Genetic and functional association of the immune signaling molecule 4-1BB (CD137/TNFRSF9) with type 1 diabetes
    • DOI 10.1016/j.jaut.2005.04.007, PII S0896841105000764
    • Cannons J L, G Chamberlain, J Howson, L J Smink, J A Todd, L B Peterson, L S Wicker, T H Watts, Genetic and functional association of the immune signaling molecule 4-1BB (CD137/TNFRSF9) with type 1 diabetes. J. Autoimmun 25, 13-20(2005) (Pubitemid 41008662)
    • (2005) Journal of Autoimmunity , vol.25 , Issue.1 , pp. 13-20
    • Cannons, J.L.1    Chamberlain, G.2    Howson, J.3    Smink, L.J.4    Todd, J.A.5    Peterson, L.B.6    Wicker, L.S.7    Watts, T.H.8
  • 86
    • 0034916937 scopus 로고    scopus 로고
    • Functional CD137 receptors are expressed by eosinophils from patients with IgE-mediated allergic responses but not by eosinophils from patients with non-IgE-mediated eosinophilic disorders
    • DOI 10.1067/mai.2001.116864
    • Heinisch I V, C Bizer, W Volgger, H U Simon, Functional CD137 receptors are expressed by eosinophils from patients with IgE-mediated allergic responses but not by eosinophils from patients with non-IgE-mediated eosinophilic disorders. J. Allergy Clin. Immunol 108, 21-28(2001) (Pubitemid 32662228)
    • (2001) Journal of Allergy and Clinical Immunology , vol.108 , Issue.1 , pp. 21-28
    • Heinisch, I.V.W.M.1    Bizer, C.2    Volgger, W.3    Simon, H.-U.4
  • 87
    • 42149174964 scopus 로고    scopus 로고
    • 4-1BB engagement costimulates NKT cell activation and exacerbates NKT cell ligandinduced airway hyperresponsiveness and inflammation
    • Kim D H, W S Chang, Y S Lee, K A Lee, Y K Kim, B S Kwon, C Y Kang, 4-1BB engagement costimulates NKT cell activation and exacerbates NKT cell ligandinduced airway hyperresponsiveness and inflammation. J. Immunol 180, 2062-2068(2008)
    • (2008) J. Immunol. , vol.180 , pp. 2062-2068
    • Kim, D.H.1    Chang, W.S.2    Lee, Y.S.3    Lee, K.A.4    Kim, Y.K.5    Kwon, B.S.6    Kang, C.Y.7
  • 88
    • 41149173311 scopus 로고    scopus 로고
    • The promise of 4-1BB (CD137)-mediated immunomodulation and the immunotherapy of cancer
    • DOI 10.1111/j.1600-065X.2008.00621.x
    • Lynch D H, The promise of 4-1BB (CD137) - mediated immunomodulation and the immunotherapy of cancer. Immunol. Rev 222, 277-286(2008) (Pubitemid 351430383)
    • (2008) Immunological Reviews , vol.222 , Issue.1 , pp. 277-286
    • Lynch, D.H.1
  • 89
    • 1842861793 scopus 로고    scopus 로고
    • Humanization of agonistic anti-human 4-1BB monoclonal antibody using a phage-displayed combinatorial library
    • DOI 10.1016/j.jim.2004.01.006, PII S0022175904000365
    • Son J H, U H Lee, J J Lee, B Kwon, B S Kwon, J W Park, Humanization of agonistic anti-human 4-1BB monoclonal antibody using a phage-displayed combinatorial library. J. ImmunolMethods 286, 187-201(2004) (Pubitemid 38490407)
    • (2004) Journal of Immunological Methods , vol.286 , Issue.1-2 , pp. 187-201
    • Son, J.H.1    Lee, U.H.2    Lee, J.J.3    Kwon, B.4    Kwon, B.S.5    Park, J.W.6
  • 92
    • 4344718859 scopus 로고    scopus 로고
    • 4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function
    • Lee S J, L Myers, G Muralimohan, J Dai, Y Qiao, Z Li, R S Mittler, A T Vella, 4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function. J. Immunol 173, 3002-3012(2004) (Pubitemid 39142005)
    • (2004) Journal of Immunology , vol.173 , Issue.5 , pp. 3002-3012
    • Lee, S.-J.1    Myers, L.2    Muralimohan, G.3    Dai, J.4    Qiao, Y.5    Li, Z.6    Mittler, R.S.7    Vella, A.T.8
  • 93
    • 23944461007 scopus 로고    scopus 로고
    • Vaccination with dendritic cells pulsed with apoptotic tumors in combination with Anti-OX40 and Anti-4-1BB monoclonal antibodies induces T cell-mediated protective immunity in Her-2/neu transgenic mice
    • DOI 10.1002/ijc.21098
    • Cuadros C, A L Dominguez, P L Lollini, M Croft, R S Mittler, P Borgstrom, J Lustgarten, Vaccination with dendritic cells pulsed with apoptotic tumors in combination with anti-OX40 and anti-4-1BB monoclonal antibodies induces T cell-mediated protective immunity in Her-2/neu transgenic mice. Int. J. Cancer 116, 934-943(2005) (Pubitemid 41209201)
    • (2005) International Journal of Cancer , vol.116 , Issue.6 , pp. 934-943
    • Cuadros, C.1    Dominguez, A.L.2    Lollini, P.-L.3    Croft, M.4    Mittler, R.S.5    Borgstrom, P.6    Lustgarten, J.7
  • 94
    • 34848866873 scopus 로고    scopus 로고
    • CD134 costimulation couples the CD137 pathway to induce production of supereffector CD8 T cells that become IL-7 dependent
    • Lee S J, R J Rossi, S K Lee, M Croft, B S Kwon, R S Mittler, A T Vella, CD134 Costimulation Couples the CD137 Pathway to Induce Production of Supereffector CD8 T Cells That Become IL-7 Dependent. J. Immunol 179, 2203-2214(2007)
    • (2007) J. Immunol. , vol.179 , pp. 2203-2214
    • Lee, S.J.1    Rossi, R.J.2    Lee, S.K.3    Croft, M.4    Kwon, B.S.5    Mittler, R.S.6    Vella, A.T.7
  • 97
    • 4043169040 scopus 로고    scopus 로고
    • 4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine
    • DOI 10.1111/j.1365-2567.2004.01917.x
    • Munks M W, D V Mourich, R S Mittler, A D Weinberg, A B Hill, 4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine. Immunology 112, 559-566(2004) (Pubitemid 39061480)
    • (2004) Immunology , vol.112 , Issue.4 , pp. 559-566
    • Munks, M.W.1    Mourich, D.V.2    Mittler, R.S.3    Weinberg, A.D.4    Hill, A.B.5
  • 98
    • 33846070524 scopus 로고    scopus 로고
    • 4-1BBL coexpression enhances HIV-specific CD8 T cell memory in a poxvirus prime-boost vaccine
    • DOI 10.1016/j.vaccine.2006.06.007, PII S0264410X06007134
    • Harrison J M, E M Bertram, D B Boyle, B E Coupar, C Ranasinghe, I A Ramshaw, 4-1BBL coexpression enhances HIV-specific CD8 T cell memory in a poxvirus prime-boost vaccine. Vaccine 24, 6867-6874(2006) (Pubitemid 46107184)
    • (2006) Vaccine , vol.24 , Issue.47-48 , pp. 6867-6874
    • Harrison, J.M.1    Bertram, E.M.2    Boyle, D.B.3    Coupar, B.E.H.4    Ranasinghe, C.5    Ramshaw, I.A.6
  • 99
    • 40049091217 scopus 로고    scopus 로고
    • 4-1BBL induces TNF receptorassociated factor 1-dependent Bim modulation in human T cells and is a critical component in the costimulationdependent rescue of functionally impaired HIV-specific CD8 T cells
    • Wang C, T Wen, J P Routy, N F Bernard, R P Sekaly, T H Watts, 4-1BBL induces TNF receptorassociated factor 1-dependent Bim modulation in human T cells and is a critical component in the costimulationdependent rescue of functionally impaired HIV-specific CD8 T cells. J. Immunol 179, 8252-8263(2007)
    • (2007) J. Immunol. , vol.179 , pp. 8252-8263
    • Wang, C.1    Wen, T.2    Routy, J.P.3    Bernard, N.F.4    Sekaly, R.P.5    Watts, T.H.6
  • 100
    • 4444345650 scopus 로고    scopus 로고
    • CD137: Costimulator turns suppressor?
    • DOI 10.1111/j.1365-2567.2004.01963.x
    • Al-Shamkhani A, CD137: costimulator turns suppressor? Immunology 113, 23-25(2004) (Pubitemid 39178840)
    • (2004) Immunology , vol.113 , Issue.1 , pp. 23-25
    • Al-Shamkhani, A.1
  • 101
    • 22444432047 scopus 로고    scopus 로고
    • Interfacing T-cell effector and regulatory function through CD137 (4-1BB) co-stimulation
    • DOI 10.1016/j.it.2005.06.003, PII S1471490605001547
    • Myers L M, A T Vella, Interfacing T-cell effector and regulatory function through CD137 (4-1BB) costimulation. Trends Immunol 26, 440-446(2005) (Pubitemid 41008081)
    • (2005) Trends in Immunology , vol.26 , Issue.8 , pp. 440-446
    • Myers, L.M.1    Vella, A.T.2
  • 102
    • 0035284861 scopus 로고    scopus 로고
    • Ligation of 4-1BB (CDw137) regulates graft-versus-host disease, graft-versus-leukemia, and graft rejection in allogeneic bone marrow transplant recipients
    • Blazar B R, B S Kwon, A Panoskaltsis-Mortari, K B Kwak, J J Peschon, P A Taylor, Ligation of 4-1BB (CDw137) regulates graft-versus-host disease, graftversus-leukemia, and graft rejection in allogeneic bone marrow transplant recipients. J. Immunol 166, 3174-3183(2001) (Pubitemid 33117315)
    • (2001) Journal of Immunology , vol.166 , Issue.5 , pp. 3174-3183
    • Blazar, B.R.1    Kwon, B.S.2    Panoskaltsis-Mortari, A.3    Kwak, K.B.4    Peschon, J.J.5    Taylor, P.A.6
  • 103
    • 14944342177 scopus 로고    scopus 로고
    • + T cells
    • DOI 10.1182/blood-2004-06-2080
    • Kim J, W S Choi, S La, J H Suh, B S Kim, H R Cho, B S Kwon, B Kwon, Stimulation with 4-1BB (CD137) inhibits chronic graft-versus-host disease by inducing activation-induced cell death of donor CD4+ T cells. Blood 105, 2206-2213(2005) (Pubitemid 40731814)
    • (2005) Blood , vol.105 , Issue.5 , pp. 2206-2213
    • Kim, J.1    Choi, W.S.2    La, S.3    Suh, J.-H.4    Kim, B.-S.5    Cho, H.R.6    Kwon, B.S.7    Kwon, B.8
  • 105
    • 0034733682 scopus 로고    scopus 로고
    • A domain in TNF receptors that mediates ligand-independent receptor assembty and signaling
    • DOI 10.1126/science.288.5475.2351
    • Chan F K, H J Chun, L Zheng, R M Siegel, K L Bui, M J Lenardo, A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science 288, 2351-2354(2000) (Pubitemid 30448156)
    • (2000) Science , vol.288 , Issue.5475 , pp. 2351-2354
    • Chan, F.K.-M.1    Chun, H.J.2    Zheng, L.3    Siegel, R.M.4    Bui, K.L.5    Lenardo, M.J.6
  • 106
    • 23944468041 scopus 로고    scopus 로고
    • Haploinsufficiency, rather than the effect of an excessive production of soluble CD95 (CD95ΔTM), is the basis for ALPS Ia in a family with duplicated 3′ splice site AG in CD95 intron 5 on one allele
    • DOI 10.1182/blood-2004-08-3104
    • Roesler J, J M Izquierdo, M Ryser, A Rosen-Wolff, M Gahr, J Valcarcel, M J Lenardo, L Zheng, Haploinsufficiency, rather than the effect of an excessive production of soluble CD95 (CD95{Delta}TM), is the basis for ALPS Ia in a family with duplicated 3' splice site AG in CD95 intron 5 on one allele. Blood 106, 1652-1659(2005) (Pubitemid 41208578)
    • (2005) Blood , vol.106 , Issue.5 , pp. 1652-1659
    • Roesler, J.1    Izquierdo, J.-M.2    Ryser, M.3    Rosen-Wolff, A.4    Gahr, M.5    Valcarcel, J.6    Lenardo, M.J.7    Zheng, L.8
  • 107
    • 38849164304 scopus 로고    scopus 로고
    • Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist
    • Redmond W L, M J Gough, B Charbonneau, T L Ratliff, A D Weinberg, Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist. J. Immunol 179, 7244-7253(2007)
    • (2007) J. Immunol. , vol.179 , pp. 7244-7253
    • Redmond, W.L.1    Gough, M.J.2    Charbonneau, B.3    Ratliff, T.L.4    Weinberg, A.D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.