CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB × NZW F1 mice

Journal of Clinical Investigation

Volumn 111, Issue 10, 2003, Pages 1505-1518

  Foell, Juergen ^a,f   Strahotin, Simona ^a   O'Neil, Shawn P ^a,e   McCausland, Megan M ^a   Suwyn, Carolyn ^a   Haber, Michael ^b   Chander, Praveen N ^c   Bapat, Abhijit S ^c   Yan, Xiao Jie ^d   Chiorazzi, Nicholas ^d   Hoffmann, Michael K ^c   Mittler, Robert S ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

^c NEW YORK MEDICAL COLLEGE   (United States)

^d Institute for Medical Research   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f MARTIN LUTHER UNIVERSITÄT HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD137 ANTIGEN; CD4 ANTIGEN; CD40 LIGAND MONOCLONAL ANTIBODY; CELL NUCLEUS ANTIGEN; CTLA4 IMMUNOGLOBULIN MONOCLONAL ANTIBODY; DOUBLE STRANDED DNA; GLUCOCORTICOID; IMMUNOGLOBULIN G ANTIBODY; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD137; OKT 4; STEROID; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; ANTINUCLEAR ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 2; INTERLEUKIN 4; LEUKOCYTE ANTIGEN; NERVE GROWTH FACTOR RECEPTOR; TNFRSF9 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR RECEPTOR;

ACUTE DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; AUTOIMMUNE DISEASE; CHRONIC DISEASE; CLONAL ANERGY; CONTROLLED STUDY; DENDRITIC CELL; DISEASE COURSE; FEMALE; IMMUNE COMPLEX DISEASE; IMMUNOSUPPRESSIVE TREATMENT; LIFESPAN; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STEROID THERAPY; SYSTEMIC LUPUS ERYTHEMATOSUS; ADOPTIVE TRANSFER; ANIMAL; ANTIBODY PRODUCTION; B LYMPHOCYTE; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; CD4+ T LYMPHOCYTE; CROSS BREEDING; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; IMMUNOLOGY; METABOLISM; NEW ZEALAND BLACK MOUSE; PROTEINURIA; TRANSPLANTATION; TREATMENT OUTCOME;

ACUTE DISEASE; ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIBODIES, MONOCLONAL; ANTIBODY FORMATION; ANTIGENS, CD; ANTIGENS, CD137; AUTOANTIBODIES; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; CROSSES, GENETIC; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN-2; INTERLEUKIN-4; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED BALB C; MICE, INBRED NZB; MICE, INBRED STRAINS; PROTEINURIA; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; TREATMENT OUTCOME;

EID: 0038312910     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200317662     Document Type: Article

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