Costimulation by CD137/4-1BB inhibits T cell apoptosis and induces Bcl-xL and c-FLIPshort via phosphatidylinositol 3-kinase and AKT/protein kinase B

European Journal of Immunology

Volumn 35, Issue 4, 2005, Pages 1257-1266

  Stärck, Lilian ^a   Scholz, Christian ^a   Dörken, Bernd ^a   Daniel, Peter T ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

4 1BB; c FLIPshort; PI3 kinase; T cell

Indexed keywords

CD137 ANTIGEN; CD28 ANTIGEN; FLICE INHIBITORY PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL XL; PROTEIN KINASE B; TUMOR NECROSIS FACTOR RECEPTOR;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWNSTREAM PROCESSING; ENZYME INHIBITION; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MOLECULAR BIOLOGY; PRIORITY JOURNAL; PROTEIN FAMILY; SIGNAL TRANSDUCTION; T LYMPHOCYTE; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIGENS, CD; ANTIGENS, CD137; APOPTOSIS; BCL-X PROTEIN; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CELL DIVISION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; T-LYMPHOCYTES;

EID: 17444421193     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200425686     Document Type: Article

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