Humanization of agonistic anti-human 4-1BB monoclonal antibody using a phage-displayed combinatorial library

Journal of Immunological Methods

Volumn 286, Issue 1-2, 2004, Pages 187-201

  Son, Ji Hee ^a   Lee, Unn Hwa ^a   Lee, Jeong Jin ^b   Kwon, Byungsuk ^a   Kwon, Byoung Se ^a   Park, Jeong Woo ^a  

^a University of Ulsan   (South Korea)

^b LG Chemical Ltd   (South Korea)

Author keywords

Anti human 4 1BB monoclonal antibody; CDR; Combinatorial library; Complementarity determining region; FR; Framework region; Humanization; J; Joining region; mAb; Monoclonal antibody; scFv; Single chain variable fragment; V

Indexed keywords

EPITOPE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 4 1BB; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY COMBINING SITE; ARTICLE; BINDING AFFINITY; COMBINATORIAL LIBRARY; CONTROLLED STUDY; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHAGE DISPLAY; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD137; BASE SEQUENCE; DNA; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FLOW CYTOMETRY; GENE LIBRARY; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; INTERFERON TYPE II; INTERLEUKIN-4; KINETICS; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; POLYMERASE CHAIN REACTION; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SURFACE PLASMON RESONANCE;

MURINAE;

EID: 1842861793     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jim.2004.01.006     Document Type: Article

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