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Volumn 222, Issue 1, 2008, Pages 277-286

The promise of 4-1BB (CD137)-mediated immunomodulation and the immunotherapy of cancer

Author keywords

4 1BB; Cancer; CD137; Immunotherapy; Monoclonal antibody; TNFR SF

Indexed keywords

ALEMTUZUMAB; CD137 ANTIGEN; CD137 LIGAND; CETUXIMAB; IBRITUMOMAB TIUXETAN; PANITUMUMAB; RITUXIMAB; TOSITUMOMAB I 131; TRASTUZUMAB; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR;

EID: 41149173311     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.2008.00621.x     Document Type: Review
Times cited : (101)

References (112)
  • 1
    • 0000937789 scopus 로고
    • Contribution to the Knowledge of Sarcoma
    • Coley WB. Contribution to the Knowledge of Sarcoma. Ann Surg 1891 14 : 199 220.
    • (1891) Ann Surg , vol.14 , pp. 199-220
    • Coley, W.B.1
  • 2
    • 41149158767 scopus 로고
    • End results in Hodgkin's disease and lymphosarcoma treated by the mixed toxins of Erysipelas and Bacillus prodigiosus, alone or compined with radiation
    • Coley WB. End results in Hodgkin's disease and lymphosarcoma treated by the mixed toxins of Erysipelas and Bacillus prodigiosus, alone or compined with radiation. Ann Surg 1928 88 : 641 667.
    • (1928) Ann Surg , vol.88 , pp. 641-667
    • Coley, W.B.1
  • 3
    • 40449127743 scopus 로고
    • Action of bacterial polysaccharide on tumors. III. Repeated response of Sarcoma 37, in tolerant mice, to Serratia Marcenscens endotoxin
    • O'Malley WE, Achinstein B, Shear MJ. Action of bacterial polysaccharide on tumors. III. Repeated response of Sarcoma 37, in tolerant mice, to Serratia Marcenscens endotoxin. Cancer Res 1963 23 : 890 895.
    • (1963) Cancer Res , vol.23 , pp. 890-895
    • O'Malley, W.E.1    Achinstein, B.2    Shear, M.J.3
  • 4
    • 0023658648 scopus 로고
    • Another chapter in the long history of endotoxin
    • Old LJ. Another chapter in the long history of endotoxin. Nature 1987 330 : 602.
    • (1987) Nature , vol.330 , pp. 602
    • Old, L.J.1
  • 5
    • 0024009890 scopus 로고
    • Tumor necrosis factor
    • Old LJ. Tumor necrosis factor. Sci Am 1988 258 : 59.
    • (1988) Sci Am , vol.258 , pp. 59
    • Old, L.J.1
  • 6
    • 0024405827 scopus 로고
    • The biology of cachectin/TNF - A primary mediator of the host response
    • Beutler B, Cerami A. The biology of cachectin/TNF - a primary mediator of the host response. Ann Rev Immunol 1989 7 : 625 655.
    • (1989) Ann Rev Immunol , vol.7 , pp. 625-655
    • Beutler, B.1    Cerami, A.2
  • 7
    • 0027365746 scopus 로고
    • Molecular cloning of a ligand for the inducible T cell gene 4-1BB: A member of an emerging family of cytokines with homology to tumor necrosis factor
    • Goodwin RG, et al. Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur J Immunol 1993 23 : 2631 2641.
    • (1993) Eur J Immunol , vol.23 , pp. 2631-2641
    • Goodwin, R.G.1
  • 8
    • 0028306175 scopus 로고
    • Tumor necrosis factor receptor superfamily members and their ligands
    • Armitage RJ. Tumor necrosis factor receptor superfamily members and their ligands. Curr Opin Immunol 1994 6 : 407 413.
    • (1994) Curr Opin Immunol , vol.6 , pp. 407-413
    • Armitage, R.J.1
  • 9
    • 0027982497 scopus 로고
    • A family of ligands for the TNF receptor superfamily
    • Cosman D. A family of ligands for the TNF receptor superfamily. Stem Cells 1994 12 : 440 455.
    • (1994) Stem Cells , vol.12 , pp. 440-455
    • Cosman, D.1
  • 10
    • 0029075329 scopus 로고
    • Tumor necrosis factor ligand superfamily: Involvement in the pathology of malignant lymphomas
    • Gruss HJ, Dower SK. Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas. Blood 1995 85 : 3378 3404.
    • (1995) Blood , vol.85 , pp. 3378-3404
    • Gruss, H.J.1    Dower, S.K.2
  • 11
    • 0030033193 scopus 로고    scopus 로고
    • Transducers of life and death: TNF receptor superfamily and associated proteins
    • Baker SJ, Reddy EP. Transducers of life and death: TNF receptor superfamily and associated proteins. Oncogene 1996 12 : 1 9.
    • (1996) Oncogene , vol.12 , pp. 1-9
    • Baker, S.J.1    Reddy, E.P.2
  • 12
    • 0029951011 scopus 로고    scopus 로고
    • The nerve growth factor/tumor necrosis factor receptor family
    • Lotz M, Setareh M, von Kempis J, Schwarz H. The nerve growth factor/tumor necrosis factor receptor family. J Leukoc Biol 1996 60 : 1 7.
    • (1996) J Leukoc Biol , vol.60 , pp. 1-7
    • Lotz, M.1    Setareh, M.2    Von Kempis, J.3    Schwarz, H.4
  • 13
    • 0030048494 scopus 로고    scopus 로고
    • Apoptosis mediated by the TNF-related cytokine and receptor families
    • Ware CF, VanArsdale S, VanArsdale TL. Apoptosis mediated by the TNF-related cytokine and receptor families. J Cell Biochem 1996 60 : 47 55.
    • (1996) J Cell Biochem , vol.60 , pp. 47-55
    • Ware, C.F.1    Vanarsdale, S.2    Vanarsdale, T.L.3
  • 14
    • 0344247505 scopus 로고
    • CDNA sequences of two inducible T-cell genes
    • Kwon BS, Weissman SM. cDNA sequences of two inducible T-cell genes. Proc Natl Acad Sci USA 1989 86 : 1963 1967.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 1963-1967
    • Kwon, B.S.1    Weissman, S.M.2
  • 15
    • 0028899550 scopus 로고
    • ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages
    • Schwarz H, Valbracht J, Tuckwell J, von Kempis J, Lotz M. ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages. Blood 1995 85 : 1043 1052.
    • (1995) Blood , vol.85 , pp. 1043-1052
    • Schwarz, H.1    Valbracht, J.2    Tuckwell, J.3    Von Kempis, J.4    Lotz, M.5
  • 16
    • 20244386539 scopus 로고
    • Molecular and biological characterization of human 4-1BB and its ligand
    • Alderson MR, et al. Molecular and biological characterization of human 4-1BB and its ligand. Eur J Immunol 1994 24 : 2219 2227.
    • (1994) Eur J Immunol , vol.24 , pp. 2219-2227
    • Alderson, M.R.1
  • 17
    • 0022432237 scopus 로고
    • Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression
    • Fransen L, et al. Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression. Nucleic Acids Res 1985 13 : 4417 4429.
    • (1985) Nucleic Acids Res , vol.13 , pp. 4417-4429
    • Fransen, L.1
  • 19
    • 0025756330 scopus 로고
    • Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific
    • Lewis M, et al. Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. Proc Natl Acad Sci USA 1991 88 : 2830 2834.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 2830-2834
    • Lewis, M.1
  • 20
    • 0023257834 scopus 로고
    • Mouse lymphotoxin and tumor necrosis factor: Structural analysis of the cloned genes, physical linkage, and chromosomal position
    • Gardner SM, Mock BA, Hilgers J, Huppi KE, Roeder WD. Mouse lymphotoxin and tumor necrosis factor: structural analysis of the cloned genes, physical linkage, and chromosomal position. J Immunol 1987 139 : 476 483.
    • (1987) J Immunol , vol.139 , pp. 476-483
    • Gardner, S.M.1    Mock, B.A.2    Hilgers, J.3    Huppi, K.E.4    Roeder, W.D.5
  • 21
    • 0028053599 scopus 로고
    • Human Fas ligand: Gene structure, chromosomal location and species specificity
    • Takahashi T, Tanaka M, Inazawa J, Abe T, Suda T, Nagata S. Human Fas ligand: gene structure, chromosomal location and species specificity. Int Immunol 1994 6 : 1567 1574.
    • (1994) Int Immunol , vol.6 , pp. 1567-1574
    • Takahashi, T.1    Tanaka, M.2    Inazawa, J.3    Abe, T.4    Suda, T.5    Nagata, S.6
  • 22
    • 0028429962 scopus 로고
    • The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster
    • Lynch DH, et al. The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster. Immunity 1994 1 : 131 136.
    • (1994) Immunity , vol.1 , pp. 131-136
    • Lynch, D.H.1
  • 23
    • 0028223847 scopus 로고
    • Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
    • Takahashi T, et al. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 1994 76 : 969 976.
    • (1994) Cell , vol.76 , pp. 969-976
    • Takahashi, T.1
  • 24
    • 0026530828 scopus 로고
    • The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen
    • Watanabe-Fukunaga R, et al. The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J Immunol 1992 148 : 1274 1279.
    • (1992) J Immunol , vol.148 , pp. 1274-1279
    • Watanabe-Fukunaga, R.1
  • 25
    • 13344285339 scopus 로고
    • Identification and characterization of a new member of the TNF family that induces apoptosis
    • Wiley SR, et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 1995 3 : 673 682.
    • (1995) Immunity , vol.3 , pp. 673-682
    • Wiley, S.R.1
  • 26
    • 0027162651 scopus 로고
    • CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF
    • Smith CA, et al. CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Cell 1993 73 : 1349 1360.
    • (1993) Cell , vol.73 , pp. 1349-1360
    • Smith, C.A.1
  • 27
    • 0030061149 scopus 로고    scopus 로고
    • Structure and expression of murine CD30 and its role in cytokine production
    • Bowen MA, Lee RK, Miragliotta G, Nam SY, Podack ER. Structure and expression of murine CD30 and its role in cytokine production. J Immunol 1996 156 : 442 449.
    • (1996) J Immunol , vol.156 , pp. 442-449
    • Bowen, M.A.1    Lee, R.K.2    Miragliotta, G.3    Nam, S.Y.4    Podack, E.R.5
  • 28
    • 0026497687 scopus 로고
    • Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin e secretion
    • Spriggs MK, et al. Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion. J Exp Med 1992 176 : 1543 1550.
    • (1992) J Exp Med , vol.176 , pp. 1543-1550
    • Spriggs, M.K.1
  • 29
    • 0026527783 scopus 로고
    • Differential increase of an alternatively polyadenylated mRNA species of murine CD40 upon B lymphocyte activation
    • Torres RM, Clark EA. Differential increase of an alternatively polyadenylated mRNA species of murine CD40 upon B lymphocyte activation. J Immunol 1992 148 : 620 626.
    • (1992) J Immunol , vol.148 , pp. 620-626
    • Torres, R.M.1    Clark, E.A.2
  • 30
    • 0028023305 scopus 로고
    • Molecular characterization of murine and human OX40/OX40 ligand systems: Identification of a human OX40 ligand as the HTLV-1-regulated protein gp34
    • Baum PR, et al. Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. EMBO J 1994 13 : 3992 4001.
    • (1994) EMBO J , vol.13 , pp. 3992-4001
    • Baum, P.R.1
  • 31
    • 0028297408 scopus 로고
    • The human OX40 homolog: CDNA structure, expression and chromosomal assignment of the ACT35 antigen
    • Latza U, et al. The human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigen. Eur J Immunol 1994 24 : 677 683.
    • (1994) Eur J Immunol , vol.24 , pp. 677-683
    • Latza, U.1
  • 32
    • 29244444176 scopus 로고    scopus 로고
    • Production of recombinant human trimeric CD137L (4-1BBL). Cross-linking is essential to its T cell co-stimulation activity
    • Rabu C, Quemener A, Jacques Y, Echasserieau K, Vusio P, Lang F. Production of recombinant human trimeric CD137L (4-1BBL). Cross-linking is essential to its T cell co-stimulation activity. J Biol Chem 2005 280 : 41472 41481.
    • (2005) J Biol Chem , vol.280 , pp. 41472-41481
    • Rabu, C.1    Quemener, A.2    Jacques, Y.3    Echasserieau, K.4    Vusio, P.5    Lang, F.6
  • 33
    • 0032374052 scopus 로고    scopus 로고
    • Role of 4-1BB in immune responses
    • Vinay DS, Kwon BS. Role of 4-1BB in immune responses. Semin Immunol 1998 10 : 481 489.
    • (1998) Semin Immunol , vol.10 , pp. 481-489
    • Vinay, D.S.1    Kwon, B.S.2
  • 34
    • 0027285735 scopus 로고
    • Inducible T cell antigen 4-1BB. Analysis of expression and function
    • Pollok KE, et al. Inducible T cell antigen 4-1BB. Analysis of expression and function. J Immunol 1993 150 : 771 781.
    • (1993) J Immunol , vol.150 , pp. 771-781
    • Pollok, K.E.1
  • 35
    • 0029117913 scopus 로고
    • Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28
    • Hurtado JC, Kim SH, Pollok KE, Lee ZH, Kwon BS. Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28. J Immunol 1995 155 : 3360 3367.
    • (1995) J Immunol , vol.155 , pp. 3360-3367
    • Hurtado, J.C.1    Kim, S.H.2    Pollok, K.E.3    Lee, Z.H.4    Kwon, B.S.5
  • 36
    • 0032535119 scopus 로고    scopus 로고
    • NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies
    • Melero I, Johnston JV, Shufford WW, Mittler RS, Chen L. NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell Immunol 1998 190 : 167 172.
    • (1998) Cell Immunol , vol.190 , pp. 167-172
    • Melero, I.1    Johnston, J.V.2    Shufford, W.W.3    Mittler, R.S.4    Chen, L.5
  • 37
    • 0037464491 scopus 로고    scopus 로고
    • NF-kappaB and AP-1 regulate activation-dependent CD137 (4-1BB) expression in T cells
    • Kim JO, Kim HW, Baek KM, Kang CY. NF-kappaB and AP-1 regulate activation-dependent CD137 (4-1BB) expression in T cells. FEBS Lett 2003 541 : 163 170.
    • (2003) FEBS Lett , vol.541 , pp. 163-170
    • Kim, J.O.1    Kim, H.W.2    Baek, K.M.3    Kang, C.Y.4
  • 38
    • 0027227899 scopus 로고
    • Novel T cell antigen 4-1BB associates with the protein tyrosine kinase p56lck1
    • Kim YJ, et al. Novel T cell antigen 4-1BB associates with the protein tyrosine kinase p56lck1. J Immunol 1993 151 : 1255 1262.
    • (1993) J Immunol , vol.151 , pp. 1255-1262
    • Kim, Y.J.1
  • 39
    • 0031962348 scopus 로고    scopus 로고
    • 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB
    • Arch RH, Thompson CB. 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. Mol Cell Biol 1998 18 : 558 565.
    • (1998) Mol Cell Biol , vol.18 , pp. 558-565
    • Arch, R.H.1    Thompson, C.B.2
  • 40
    • 0034541168 scopus 로고    scopus 로고
    • Role of TNF receptor-associated factor 2 and p38 mitogen-activated protein kinase activation during 4-1BB-dependent immune response
    • Cannons JL, Choi Y, Watts TH. Role of TNF receptor-associated factor 2 and p38 mitogen-activated protein kinase activation during 4-1BB-dependent immune response. J Immunol 2000 165 : 6193 6204.
    • (2000) J Immunol , vol.165 , pp. 6193-6204
    • Cannons, J.L.1    Choi, Y.2    Watts, T.H.3
  • 42
    • 0030845586 scopus 로고    scopus 로고
    • 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses
    • Shuford WW, et al. 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med 1997 186 : 47 55.
    • (1997) J Exp Med , vol.186 , pp. 47-55
    • Shuford, W.W.1
  • 43
    • 0029916309 scopus 로고    scopus 로고
    • ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival
    • Schwarz H, Blanco FJ, von Kempis J, Valbracht J, Lotz M. ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival. Blood 1996 87 : 2839 2845.
    • (1996) Blood , vol.87 , pp. 2839-2845
    • Schwarz, H.1    Blanco, F.J.2    Von Kempis, J.3    Valbracht, J.4    Lotz, M.5
  • 44
    • 0031569279 scopus 로고    scopus 로고
    • Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death
    • Hurtado JC, Kim YJ, Kwon BS. Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death. J Immunol 1997 158 : 2600 2609.
    • (1997) J Immunol , vol.158 , pp. 2600-2609
    • Hurtado, J.C.1    Kim, Y.J.2    Kwon, B.S.3
  • 45
    • 0033137063 scopus 로고    scopus 로고
    • Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal
    • Takahashi C, Mittler RS, Vella AT. Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal. J Immunol 1999 162 : 5037 5040.
    • (1999) J Immunol , vol.162 , pp. 5037-5040
    • Takahashi, C.1    Mittler, R.S.2    Vella, A.T.3
  • 46
    • 0036800027 scopus 로고    scopus 로고
    • 4-1BB co-stimulation enhances human CD8(+) T cell priming by augmenting the proliferation and survival of effector CD8(+) T cells
    • Laderach D, Movassagh M, Johnson A, Mittler RS, Galy A. 4-1BB co-stimulation enhances human CD8(+) T cell priming by augmenting the proliferation and survival of effector CD8(+) T cells. Int Immunol 2002 14 : 1155 1167.
    • (2002) Int Immunol , vol.14 , pp. 1155-1167
    • Laderach, D.1    Movassagh, M.2    Johnson, A.3    Mittler, R.S.4    Galy, A.5
  • 48
    • 0033063934 scopus 로고    scopus 로고
    • Identification of CD137 as a potent monocyte survival factor
    • Langstein J, Schwarz H. Identification of CD137 as a potent monocyte survival factor. J Leukoc Biol 1999 65 : 829 833.
    • (1999) J Leukoc Biol , vol.65 , pp. 829-833
    • Langstein, J.1    Schwarz, H.2
  • 49
    • 0032754036 scopus 로고    scopus 로고
    • Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus
    • DeBenedette MA, et al. Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus. J Immunol 1999 163 : 4833 4841.
    • (1999) J Immunol , vol.163 , pp. 4833-4841
    • Debenedette, M.A.1
  • 51
    • 0036075444 scopus 로고    scopus 로고
    • In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses
    • Halstead ES, Mueller YM, Altman JD, Katsikis PD. In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses. Nat Immunol 2002 3 : 536 541.
    • (2002) Nat Immunol , vol.3 , pp. 536-541
    • Halstead, E.S.1    Mueller, Y.M.2    Altman, J.D.3    Katsikis, P.D.4
  • 53
    • 0027982995 scopus 로고
    • Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity
    • Chen L, et al. Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity. J Exp Med 1994 179 : 523 532.
    • (1994) J Exp Med , vol.179 , pp. 523-532
    • Chen, L.1
  • 54
    • 0033938756 scopus 로고    scopus 로고
    • Enhanced therapeutic potential of adoptive immunotherapy by in vitro CD28/4-1BB costimulation of tumor-reactive T cells against a poorly immunogenic, major histocompatibility complex class I-negative A9P melanoma
    • Strome SE, et al. Enhanced therapeutic potential of adoptive immunotherapy by in vitro CD28/4-1BB costimulation of tumor-reactive T cells against a poorly immunogenic, major histocompatibility complex class I-negative A9P melanoma. J Immunother 2000 23 : 430 437.
    • (2000) J Immunother , vol.23 , pp. 430-437
    • Strome, S.E.1
  • 55
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998 392 : 245 252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 56
    • 0035137306 scopus 로고    scopus 로고
    • Dendritic cells (I): Biological functions
    • Satthaporn S, Eremin O. Dendritic cells (I): biological functions. J R Coll Surg Edinb 2001 46 : 9 19.
    • (2001) J R Coll Surg Edinb , vol.46 , pp. 9-19
    • Satthaporn, S.1    Eremin, O.2
  • 57
    • 0030840111 scopus 로고    scopus 로고
    • Dendritic cells as adjuvants for immune-mediated resistance to tumors
    • Schuler G, Steinman RM. Dendritic cells as adjuvants for immune-mediated resistance to tumors. J Exp Med 1997 186 : 1183 1187.
    • (1997) J Exp Med , vol.186 , pp. 1183-1187
    • Schuler, G.1    Steinman, R.M.2
  • 58
    • 0026537347 scopus 로고
    • CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
    • Harding FA, McArthur JG, Gross JA, Raulet DH, Allison JP. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 1992 356 : 607 609.
    • (1992) Nature , vol.356 , pp. 607-609
    • Harding, F.A.1    McArthur, J.G.2    Gross, J.A.3    Raulet, D.H.4    Allison, J.P.5
  • 59
    • 0035500781 scopus 로고    scopus 로고
    • CTLA-4 is not required for induction of CD8(+) T cell anergy in vivo
    • Frauwirth KA, Alegre ML, Thompson CB. CTLA-4 is not required for induction of CD8(+) T cell anergy in vivo. J Immunol 2001 167 : 4936 4941.
    • (2001) J Immunol , vol.167 , pp. 4936-4941
    • Frauwirth, K.A.1    Alegre, M.L.2    Thompson, C.B.3
  • 60
    • 0033168651 scopus 로고    scopus 로고
    • CD8+ T cells become nonresponsive (anergic) following activation in the presence of costimulation
    • Deeths MJ, Kedl RM, Mescher MF. CD8+ T cells become nonresponsive (anergic) following activation in the presence of costimulation. J Immunol 1999 163 : 102 110.
    • (1999) J Immunol , vol.163 , pp. 102-110
    • Deeths, M.J.1    Kedl, R.M.2    Mescher, M.F.3
  • 61
    • 0033179147 scopus 로고    scopus 로고
    • Critical role of costimulation in the activation of naive antigen-specific TCR transgenic CD8+ T cells in vitro
    • Chai JG, et al. Critical role of costimulation in the activation of naive antigen-specific TCR transgenic CD8+ T cells in vitro. J Immunol 1999 163 : 1298 1305.
    • (1999) J Immunol , vol.163 , pp. 1298-1305
    • Chai, J.G.1
  • 62
    • 0034323850 scopus 로고    scopus 로고
    • Review article: Molecular signals and genetic reprogramming in peripheral T-cell differentiation
    • Noble A. Review article: molecular signals and genetic reprogramming in peripheral T-cell differentiation. Immunology 2000 101 : 289 299.
    • (2000) Immunology , vol.101 , pp. 289-299
    • Noble, A.1
  • 63
    • 0032544067 scopus 로고    scopus 로고
    • CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma
    • Hurwitz AA, Yu TF, Leach DR, Allison JP. CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma. Proc Natl Acad Sci USA 1998 95 : 10067 10071.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 10067-10071
    • Hurwitz, A.A.1    Yu, T.F.2    Leach, D.R.3    Allison, J.P.4
  • 64
    • 0033517152 scopus 로고    scopus 로고
    • Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
    • van Elsas A, Hurwitz AA, Allison JP. Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J Exp Med 1999 190 : 355 366.
    • (1999) J Exp Med , vol.190 , pp. 355-366
    • Van Elsas, A.1    Hurwitz, A.A.2    Allison, J.P.3
  • 65
    • 0035056017 scopus 로고    scopus 로고
    • CTLA-4-mediated inhibition in regulation of T cell responses: Mechanisms and manipulation in tumor immunotherapy
    • Chambers CA, Kuhns MS, Egen JG, Allison JP. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu Rev Immunol 2001 19 : 565 594.
    • (2001) Annu Rev Immunol , vol.19 , pp. 565-594
    • Chambers, C.A.1    Kuhns, M.S.2    Egen, J.G.3    Allison, J.P.4
  • 67
    • 0034292414 scopus 로고    scopus 로고
    • CD4 help-independent induction of cytotoxic CD8 cells to allogeneic P815 tumor cells is absolutely dependent on costimulation
    • Zhan Y, Corbett AJ, Brady JL, Sutherland RM, Lew AM. CD4 help-independent induction of cytotoxic CD8 cells to allogeneic P815 tumor cells is absolutely dependent on costimulation. J Immunol 2000 165 : 3612 3619.
    • (2000) J Immunol , vol.165 , pp. 3612-3619
    • Zhan, Y.1    Corbett, A.J.2    Brady, J.L.3    Sutherland, R.M.4    Lew, A.M.5
  • 68
    • 0027392843 scopus 로고
    • Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells
    • Townsend SE, Allison JP. Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells. Science 1993 259 : 368 370.
    • (1993) Science , vol.259 , pp. 368-370
    • Townsend, S.E.1    Allison, J.P.2
  • 69
    • 0031839501 scopus 로고    scopus 로고
    • The role of B7-CD28 co-stimulation in tumor rejection
    • Yu X, Abe R, Hodes RJ. The role of B7-CD28 co-stimulation in tumor rejection. Int Immunol 1998 10 : 791 797.
    • (1998) Int Immunol , vol.10 , pp. 791-797
    • Yu, X.1    Abe, R.2    Hodes, R.J.3
  • 71
    • 0033179610 scopus 로고    scopus 로고
    • Synergistic action of fms-like tyrosine kinase 3 ligand and CD40 ligand in the induction of dendritic cells and generation of antitumor immunity in vivo
    • Borges L, et al. Synergistic action of fms-like tyrosine kinase 3 ligand and CD40 ligand in the induction of dendritic cells and generation of antitumor immunity in vivo. J Immunol 1999 163 : 1289 1297.
    • (1999) J Immunol , vol.163 , pp. 1289-1297
    • Borges, L.1
  • 72
    • 0035020885 scopus 로고    scopus 로고
    • Antitumor effect on murine renal cell carcinoma by autologous tumor vaccines genetically modified with granulocyte-macrophage colony-stimulating factor and interleukin-6 cells
    • Kinoshita Y, et al. Antitumor effect on murine renal cell carcinoma by autologous tumor vaccines genetically modified with granulocyte-macrophage colony-stimulating factor and interleukin-6 cells. J Immunother 2001 24 : 205 211.
    • (2001) J Immunother , vol.24 , pp. 205-211
    • Kinoshita, Y.1
  • 73
    • 0032848439 scopus 로고    scopus 로고
    • Generation of protective immunity against an immunogenic carcinoma requires CD40/CD40L and B7/CD28 interactions but not CD4(+) T cells
    • Eck SC, Turka LA. Generation of protective immunity against an immunogenic carcinoma requires CD40/CD40L and B7/CD28 interactions but not CD4(+) T cells. Cancer Immunol Immunother 1999 48 : 336 341.
    • (1999) Cancer Immunol Immunother , vol.48 , pp. 336-341
    • Eck, S.C.1    Turka, L.A.2
  • 74
    • 0035047535 scopus 로고    scopus 로고
    • Role of hematopoietic growth factors/flt3 ligand in expansion and regulation of dendritic cells
    • McKenna HJ. Role of hematopoietic growth factors/flt3 ligand in expansion and regulation of dendritic cells. Curr Opin Hematol 2001 8 : 149 154.
    • (2001) Curr Opin Hematol , vol.8 , pp. 149-154
    • McKenna, H.J.1
  • 75
    • 0025166798 scopus 로고
    • Antitumor effects of alpha-interferon and gamma-interferon on a murine renal cancer (Renca) in vitro and in vivo
    • Sayers TJ, Wiltrout TA, McCormick K, Husted C, Wiltrout RH. Antitumor effects of alpha-interferon and gamma-interferon on a murine renal cancer (Renca) in vitro and in vivo. Cancer Res 1990 50 : 5414 5420.
    • (1990) Cancer Res , vol.50 , pp. 5414-5420
    • Sayers, T.J.1    Wiltrout, T.A.2    McCormick, K.3    Husted, C.4    Wiltrout, R.H.5
  • 76
    • 0030067276 scopus 로고    scopus 로고
    • Administration of interleukin 12 with pulse interleukin 2 and the rapid and complete eradication of murine renal carcinoma
    • Wigginton JM, Komschlies KL, Back TC, Franco JL, Brunda MJ, Wiltrout RH. Administration of interleukin 12 with pulse interleukin 2 and the rapid and complete eradication of murine renal carcinoma. J Natl Cancer Inst 1996 88 : 38 43.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 38-43
    • Wigginton, J.M.1    Komschlies, K.L.2    Back, T.C.3    Franco, J.L.4    Brunda, M.J.5    Wiltrout, R.H.6
  • 77
    • 0031007143 scopus 로고    scopus 로고
    • Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
    • Melero I, et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med 1997 3 : 682 685.
    • (1997) Nat Med , vol.3 , pp. 682-685
    • Melero, I.1
  • 78
    • 0037103147 scopus 로고    scopus 로고
    • 4-1BB-specific monoclonal antibody promotes the generation of tumor-specific immune responses by direct activation of CD8 T cells in a CD40-dependent manner
    • Miller RE, et al. 4-1BB-specific monoclonal antibody promotes the generation of tumor-specific immune responses by direct activation of CD8 T cells in a CD40-dependent manner. J Immunol 2002 169 : 1792 1800.
    • (2002) J Immunol , vol.169 , pp. 1792-1800
    • Miller, R.E.1
  • 79
    • 0001585396 scopus 로고    scopus 로고
    • Control of homeostasis of CD8+ memory T cells by opposing cytokines
    • Ku CC, Murakami M, Sakamoto A, Kappler J, Marrack P. Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science 2000 288 : 675 678.
    • (2000) Science , vol.288 , pp. 675-678
    • Ku, C.C.1    Murakami, M.2    Sakamoto, A.3    Kappler, J.4    Marrack, P.5
  • 80
    • 34548512807 scopus 로고    scopus 로고
    • Established B16 tumors are rejected following treatment with GM-CSF-secreting tumor cell immunotherapy in combination with anti-4-1BB mAb
    • Li B, Lin J, Vanroey M, Jure-Kunkel M, Jooss K. Established B16 tumors are rejected following treatment with GM-CSF-secreting tumor cell immunotherapy in combination with anti-4-1BB mAb. Clin Immunol 2007 125 : 76 87.
    • (2007) Clin Immunol , vol.125 , pp. 76-87
    • Li, B.1    Lin, J.2    Vanroey, M.3    Jure-Kunkel, M.4    Jooss, K.5
  • 81
    • 8544249166 scopus 로고    scopus 로고
    • Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines
    • Ito F, et al. Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines. Cancer Res 2004 64 : 8411 8419.
    • (2004) Cancer Res , vol.64 , pp. 8411-8419
    • Ito, F.1
  • 82
    • 27144497304 scopus 로고    scopus 로고
    • The systemic administration of Ig-4-1BB ligand in combination with IL-12 gene transfer eradicates hepatic colon carcinoma
    • Xu DP, Sauter BV, Huang TG, Meseck M, Woo SL, Chen SH. The systemic administration of Ig-4-1BB ligand in combination with IL-12 gene transfer eradicates hepatic colon carcinoma. Gene Ther 2005 12 : 1526 1533.
    • (2005) Gene Ther , vol.12 , pp. 1526-1533
    • Xu, D.P.1    Sauter, B.V.2    Huang, T.G.3    Meseck, M.4    Woo, S.L.5    Chen, S.H.6
  • 83
    • 3042658705 scopus 로고    scopus 로고
    • Anti-CD137 antibodies in the treatment of autoimmune disease and cancer
    • Mittler RS, et al. Anti-CD137 antibodies in the treatment of autoimmune disease and cancer. Immunol Res 2004 29 : 197 208.
    • (2004) Immunol Res , vol.29 , pp. 197-208
    • Mittler, R.S.1
  • 84
    • 41149084671 scopus 로고    scopus 로고
    • Functional characterization of fully human anti-CD137 antibodies
    • Jure-Kunkel MN, et al. Functional characterization of fully human anti-CD137 antibodies. P Am Assoc Canc Res 2006 1117.
    • (2006) P Am Assoc Canc Res , pp. 1117
    • Jure-Kunkel, M.N.1
  • 85
    • 0031906785 scopus 로고    scopus 로고
    • Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: Synergy with the CD28 co-stimulatory pathway
    • Melero I, Bach N, Hellstrom KE, Aruffo A, Mittler RS, Chen L. Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway. Eur J Immunol 1998 28 : 1116 1121.
    • (1998) Eur J Immunol , vol.28 , pp. 1116-1121
    • Melero, I.1    Bach, N.2    Hellstrom, K.E.3    Aruffo, A.4    Mittler, R.S.5    Chen, L.6
  • 86
    • 0033560179 scopus 로고    scopus 로고
    • 4-1BBL cooperates with B7-1 and B7-2 in converting a B cell lymphoma cell line into a long-lasting antitumor vaccine
    • Guinn BA, DeBenedette MA, Watts TH, Berinstein NL. 4-1BBL cooperates with B7-1 and B7-2 in converting a B cell lymphoma cell line into a long-lasting antitumor vaccine. J Immunol 1999 162 : 5003 5010.
    • (1999) J Immunol , vol.162 , pp. 5003-5010
    • Guinn, B.A.1    Debenedette, M.A.2    Watts, T.H.3    Berinstein, N.L.4
  • 87
    • 0034536944 scopus 로고    scopus 로고
    • Tumour rejection by gene transfer of 4-1BB ligand into a CD80(+) murine squamous cell carcinoma and the requirements of co-stimulatory molecules on tumour and host cells
    • Mogi S, et al. Tumour rejection by gene transfer of 4-1BB ligand into a CD80(+) murine squamous cell carcinoma and the requirements of co-stimulatory molecules on tumour and host cells. Immunology 2000 101 : 541 547.
    • (2000) Immunology , vol.101 , pp. 541-547
    • Mogi, S.1
  • 88
    • 0029859405 scopus 로고    scopus 로고
    • Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma
    • Caruso M, et al. Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma. Proc Natl Acad Sci USA 1996 93 : 11302 11306.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 11302-11306
    • Caruso, M.1
  • 89
    • 0033286867 scopus 로고    scopus 로고
    • Characterization of a novel immunocytolytic factor secreted by pancreatic adenocarcinoma
    • Divino CM, Chen SH, Yang W, Thung S, Brower ST, Woo SL. Characterization of a novel immunocytolytic factor secreted by pancreatic adenocarcinoma. Oncol Res 1999 11 : 489 495.
    • (1999) Oncol Res , vol.11 , pp. 489-495
    • Divino, C.M.1    Chen, S.H.2    Yang, W.3    Thung, S.4    Brower, S.T.5    Woo, S.L.6
  • 90
    • 0028484545 scopus 로고
    • CTLA-4 can function as a negative regulator of T cell activation
    • Walunas TL, et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1994 1 : 405 413.
    • (1994) Immunity , vol.1 , pp. 405-413
    • Walunas, T.L.1
  • 91
    • 0029120245 scopus 로고
    • CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
    • Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med 1995 182 : 459 465.
    • (1995) J Exp Med , vol.182 , pp. 459-465
    • Krummel, M.F.1    Allison, J.P.2
  • 92
    • 0030694234 scopus 로고    scopus 로고
    • The emerging role of CTLA-4 as an immune attenuator
    • Thompson CB, Allison JP. The emerging role of CTLA-4 as an immune attenuator. Immunity 1997 7 : 445 450.
    • (1997) Immunity , vol.7 , pp. 445-450
    • Thompson, C.B.1    Allison, J.P.2
  • 93
    • 0036301503 scopus 로고    scopus 로고
    • CTLA-4: New insights into its biological function and use in tumor immunotherapy
    • Egen JG, Kuhns MS, Allison JP. CTLA-4: new insights into its biological function and use in tumor immunotherapy. Nat Immunol 2002 3 : 611 618.
    • (2002) Nat Immunol , vol.3 , pp. 611-618
    • Egen, J.G.1    Kuhns, M.S.2    Allison, J.P.3
  • 94
    • 33646794392 scopus 로고    scopus 로고
    • Checkpoint blockade in cancer immunotherapy
    • Korman AJ, Peggs KS, Allison JP. Checkpoint blockade in cancer immunotherapy. Adv Immunol 2006 90 : 297 339.
    • (2006) Adv Immunol , vol.90 , pp. 297-339
    • Korman, A.J.1    Peggs, K.S.2    Allison, J.P.3
  • 96
    • 22944436502 scopus 로고    scopus 로고
    • A critical role for the programmed death ligand 1 in fetomaternal tolerance
    • Guleria I, et al. A critical role for the programmed death ligand 1 in fetomaternal tolerance. J Exp Med 2005 202 : 231 237.
    • (2005) J Exp Med , vol.202 , pp. 231-237
    • Guleria, I.1
  • 97
    • 38449105902 scopus 로고    scopus 로고
    • A link between PDL1 and T regulatory cells in fetomaternal tolerance
    • Habicht A, et al. A link between PDL1 and T regulatory cells in fetomaternal tolerance. J Immunol 2007 179 : 5211 5219.
    • (2007) J Immunol , vol.179 , pp. 5211-5219
    • Habicht, A.1
  • 98
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion [Erratum in: Nat Med 2002;8:1039]
    • Dong H, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion [Erratum in: Nat Med 2002;8:1039]. Nat Med 2002 8 : 793 800.
    • (2002) Nat Med , vol.8 , pp. 793-800
    • Dong, H.1
  • 99
    • 13444270323 scopus 로고    scopus 로고
    • Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity
    • Hirano F, et al. Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res 2005 65 : 1089 1096.
    • (2005) Cancer Res , vol.65 , pp. 1089-1096
    • Hirano, F.1
  • 100
    • 34250156711 scopus 로고    scopus 로고
    • Soluble PD-1 facilitates 4-1BBL-triggered antitumor immunity against murine H22 hepatocarcinoma in vivo
    • Xiao H, et al. Soluble PD-1 facilitates 4-1BBL-triggered antitumor immunity against murine H22 hepatocarcinoma in vivo. Clin Cancer Res 2007 13 : 1823 1830.
    • (2007) Clin Cancer Res , vol.13 , pp. 1823-1830
    • Xiao, H.1
  • 101
    • 0035284861 scopus 로고    scopus 로고
    • Ligation of 4-1BB (CDw137) regulates graft-versus-host disease, graft-versus-leukemia, and graft rejection in allogeneic bone marrow transplant recipients
    • Blazar BR, Kwon BS, Panoskaltsis-Mortari A, Kwak KB, Peschon JJ, Taylor PA. Ligation of 4-1BB (CDw137) regulates graft-versus-host disease, graft-versus-leukemia, and graft rejection in allogeneic bone marrow transplant recipients. J Immunol 2001 166 : 3174 3183.
    • (2001) J Immunol , vol.166 , pp. 3174-3183
    • Blazar, B.R.1    Kwon, B.S.2    Panoskaltsis-Mortari, A.3    Kwak, K.B.4    Peschon, J.J.5    Taylor, P.A.6
  • 102
    • 0038312910 scopus 로고    scopus 로고
    • CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB × NZW F1 mice
    • Foell J, et al. CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB × NZW F1 mice. J Clin Invest 2003 111 : 1505 1518.
    • (2003) J Clin Invest , vol.111 , pp. 1505-1518
    • Foell, J.1
  • 103
    • 25444495636 scopus 로고    scopus 로고
    • Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of inflammatory bowel disease
    • Lee J, et al. Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of inflammatory bowel disease. Immunol Lett 2005 101 : 210 216.
    • (2005) Immunol Lett , vol.101 , pp. 210-216
    • Lee, J.1
  • 104
    • 4444340010 scopus 로고    scopus 로고
    • Engagement of the CD137 (4-1BB) costimulatory molecule inhibits and reverses the autoimmune process in collagen-induced arthritis and establishes lasting disease resistance
    • Foell JL, et al. Engagement of the CD137 (4-1BB) costimulatory molecule inhibits and reverses the autoimmune process in collagen-induced arthritis and establishes lasting disease resistance. Immunology 2004 113 : 89 98.
    • (2004) Immunology , vol.113 , pp. 89-98
    • Foell, J.L.1
  • 105
    • 7044261952 scopus 로고    scopus 로고
    • 4-1BB-mediated immunotherapy of rheumatoid arthritis [Erratum in: Nat Med 2004;10:1261]
    • Seo SK, et al. 4-1BB-mediated immunotherapy of rheumatoid arthritis [Erratum in: Nat Med 2004;10:1261]. Nat Med 2004 10 : 1088 1094.
    • (2004) Nat Med , vol.10 , pp. 1088-1094
    • Seo, S.K.1
  • 106
    • 33749507677 scopus 로고    scopus 로고
    • Amelioration of mercury-induced autoimmunity by 4-1BB
    • Vinay DS, Kim JD, Kwon BS. Amelioration of mercury-induced autoimmunity by 4-1BB. J Immunol 2006 177 : 5708 5717.
    • (2006) J Immunol , vol.177 , pp. 5708-5717
    • Vinay, D.S.1    Kim, J.D.2    Kwon, B.S.3
  • 107
    • 33845975948 scopus 로고    scopus 로고
    • Targeting the activation-induced antigen CD137 can selectively deplete alloreactive T cells from antileukemic and antitumor donor T-cell lines
    • Wehler TC, et al. Targeting the activation-induced antigen CD137 can selectively deplete alloreactive T cells from antileukemic and antitumor donor T-cell lines. Blood 2007 109 : 365 373.
    • (2007) Blood , vol.109 , pp. 365-373
    • Wehler, T.C.1
  • 108
    • 85069422995 scopus 로고    scopus 로고
    • Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses [Erratum in: Blood 2004;104:1605]
    • Amrolia PJ, et al. Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses [Erratum in: Blood 2004;104:1605]. Blood 2003 102 : 2292 2299.
    • (2003) Blood , vol.102 , pp. 2292-2299
    • Amrolia, P.J.1
  • 109
    • 34249655080 scopus 로고    scopus 로고
    • 4-1BB triggers IL-13 production from T cells to limit the polarized, Th1-mediated inflammation
    • Shin SM, Kim YH, Choi BK, Kwon PM, Lee HW, Kwon BS. 4-1BB triggers IL-13 production from T cells to limit the polarized, Th1-mediated inflammation. J Leukoc Biol 2007 81 : 1455 1465.
    • (2007) J Leukoc Biol , vol.81 , pp. 1455-1465
    • Shin, S.M.1    Kim, Y.H.2    Choi, B.K.3    Kwon, P.M.4    Lee, H.W.5    Kwon, B.S.6
  • 110
    • 33747119866 scopus 로고    scopus 로고
    • 4-1BB-mediated amelioration of experimental autoimmune uveoretinitis is caused by indoleamine 2,3-dioxygenase-dependent mechanisms
    • Choi BK, Asai T, Vinay DS, Kim YH, Kwon BS. 4-1BB-mediated amelioration of experimental autoimmune uveoretinitis is caused by indoleamine 2,3-dioxygenase-dependent mechanisms. Cytokine 2006 34 : 233 242.
    • (2006) Cytokine , vol.34 , pp. 233-242
    • Choi, B.K.1    Asai, T.2    Vinay, D.S.3    Kim, Y.H.4    Kwon, B.S.5
  • 111
    • 4344718859 scopus 로고    scopus 로고
    • 4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function
    • Myers L, Takahashi C, Mittler RS, Rossi RJ, Vella AT. 4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function. J Immunol 2004 173 : 3002 3012.
    • (2004) J Immunol , vol.173 , pp. 3002-3012
    • Myers, L.1    Takahashi, C.2    Mittler, R.S.3    Rossi, R.J.4    Vella, A.T.5
  • 112
    • 20444403047 scopus 로고    scopus 로고
    • Peptide-specific CD8 T regulatory cells use IFN-gamma to elaborate TGF-beta-based suppression
    • Myers L, Croft M, Kwon BS, Mittler RS, Vella AT. Peptide-specific CD8 T regulatory cells use IFN-gamma to elaborate TGF-beta-based suppression. J Immunol 2005 174 : 7625 7632.
    • (2005) J Immunol , vol.174 , pp. 7625-7632
    • Myers, L.1    Croft, M.2    Kwon, B.S.3    Mittler, R.S.4    Vella, A.T.5


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