CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling

Journal of Immunology

Volumn 160, Issue 5, 1998, Pages 2488-2494

  Langstein, Joachim ^a   Michel, Jan ^a   Fritsche, Jana ^a   Kreutz, Marina ^a   Andreesen, Reinhard ^a   Schwarz, Herbert ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; FC RECEPTOR; HLA DR ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR RELATED PROTEIN CD 137; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN IMMOBILIZATION; SIGNAL TRANSDUCTION;

ANTIGENS, CD; ANTIGENS, CD137; BINDING, COMPETITIVE; CELL ADHESION; CELLS, CULTURED; DOWN-REGULATION; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; MONOCYTES; POLYMERASE CHAIN REACTION; RECEPTORS, IGG; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032032236     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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33. 6 cells/ml. Fc and CD137-Fc proteins (2 μg/ml) were added and cross-linked by anti-Fc Ab (4 μg/ml). Concentrations of IL-8 were determined after 16 h. Identical results were obtained with monocytes from two different donors in two independent experiments.