CD137: Costimulator turns suppressor?

Immunology

Volumn 113, Issue 1, 2004, Pages 23-25

  Al Shamkhani, Aymen ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

CD137; Costimulator; Immunotherapy; Suppressor

Indexed keywords

CD134 ANTIGEN; CD137 ANTIGEN; CD27 ANTIGEN; CD30 ANTIGEN; CD40 ANTIGEN; MONOCLONAL ANTIBODY; TUMOR NECROSIS FACTOR RECEPTOR;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANTIBODY PRODUCTION; ANTIGEN RECOGNITION; AUTOIMMUNE DISEASE; CANCER IMMUNOTHERAPY; CELL SURVIVAL; HUMAN; IMMUNOGENICITY; IMMUNOSTIMULATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; NOTE; PRIORITY JOURNAL; RECEPTOR AFFINITY; SUPPRESSOR CELL;

ANTIGENS, CD; ANTIGENS, CD137; AUTOIMMUNE DISEASES; HUMANS; IMMUNE TOLERANCE; IMMUNOTHERAPY; LYMPHOCYTE ACTIVATION; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; T-LYMPHOCYTE SUBSETS;

EID: 4444345650     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2004.01963.x     Document Type: Note

References (32)

1. Jenkins MK, Schwartz RH. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med 1987; 165:302.
2. Bretscher PA. A two-step, two-signal model for the primary activation of precursor helper T cells. Proc Natl Acad Sci USA 1999; 96:185.
3. van der Merwe PA, Davis SJ. Molecular interactions mediating T cell antigen recognition. Annu Rev Immunol 2003; 21:659.
4. Sharpe AH, Freeman GJ. The B7-CD28 superfamily. Nat Rev Immunol 2002; 2:116.
5. Croft M. Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? Nat Rev Immunol 2003; 3:609.
6. Schwartz RH. T cell anergy. Annu Rev Immunol 2003; 21:305.
7. Foell JL, Diez-Mendiondo BI, Diez OH et al. Engagement of the CD137 (4-1BB) costimulatory molecule inhibits and reverses the autoimmune process in collagen-induced athritis and establishes lasting disease resistance. Immunology 2004; 113:89-98.
8. Zheng L, Fisher G, Miller RE, Peschon J, Lynch DH, Lenardo MJ. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature 1995; 377:348.
9. Banner DW, D'Arcy A, Janes W et al. Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. Cell 1993; 73:431.
10. Bertram EM, Lau P, Watts TH. Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection. J Immunol 2002; 168:3777.
11. Hendriks J, Xiao Y, Borst J. CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool. J Exp Med 2003; 198:1369.
12. + cytotoxic T cell responses in vivo. J Immunol 2004; 172:6039.
13. Liang L, Sha WC. The right place at the right time: novel B7 family members regulate effector T cell responses. Curr Opin Immunol 2002; 14:384.
14. Rogers PR, Song J, Gramaglia I, Killeen N, Croft M. OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity 2001; 15:445.
15. Salek-Ardakani S, Song J, Halteman BS et al. OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation. J Exp Med 2003; 198:315.
16. Bertram EM, Dawicki W, Sedgmen B, Bramson JL, Lynch DH, Watts TH. A switch in costimulation from CD28-4-1BB during primary versus secondary CD8 T cell response to influenza in vivo. J Immunol 2004; 172:981.
17. + T cell responses by ICOS/B7h costimulation. J Immunol 2001; 167:132.
18. Tan JT, Whitmire JK, Ahmed R, Pearson TC, Larsen CP. 4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses. J Immunol 1999; 163:4859.
19. Kopf M, Ruedl C, Schmitz N et al. OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL responses after virus infection. Immunity 1999; 11:699.
20. Takahashi C, Mittler RS, Vella AT. Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal. J Immunol 1999; 162:5037.
21. Taraban VY, Rowley TF, O'Brien L et al. Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses. Eur J Immunol 2002; 32:3617.
22. Melero I, Shuford WW, Newby SA et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med 1997; 3:682.
23. Wilcox RA, Flies DB, Zhu G et al. Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. J Clin Invest 2002; 109:651.
24. + T cell responses. Nat Immunol 2002; 3:536.
25. + cytolytic T cells and responsiveness to IL-2 but not cytolytic activity. J Immunol 2002; 169:4230.
26. Wilcox RA, Chapoval AI, Gorski KS et al. Cutting edge: expression of functional CD137 receptor by dendritic cells. J Immunol 2002; 168:4262.
27. Futagawa T, Akiba H, Kodama T et al. Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells. Int Immunol 2002; 14:275.
28. Sun Y, Chen HM, Subudhi SK et al. Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease. Nat Med 2002; 8:1405.
29. Foell J, Strahotin S, O'Neil SP et al. CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB x NZW F1 mice. J Clin Invest 2003; 111:1505.
30. Sun Y, Lin X, Chen HM et al. Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis. J Immunol 2002; 168:1457.
31. Mittler RS, Bailey TS, Klussman K, Trailsmith MD, Hoffmann MK. Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy. J Exp Med 1999; 190:1535.
32. Dawicki W, Watts TH. Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivo. Eur J Immunol 2004; 34:743.