Chapter 5 Rab Proteins and Their Interaction Partners

International Review of Cell and Molecular Biology

Volumn 274, Issue C, 2009, Pages 235-274

  Barnekow, Angelika ^a   Thyrock, Anika ^a   Kessler, Daniel ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; RAB PROTEIN; RAS PROTEIN;

AMINO ACID SEQUENCE; APOPTOSIS; BRAIN; BREAST CANCER; CELL GROWTH; CELL MEMBRANE; CELL MIGRATION; CELL VACUOLE; CHOROIDEREMIA; COLON ADENOCARCINOMA; GRISCELLI SYNDROME; HUMAN; INTRACELLULAR SPACE; LIVER CELL CARCINOMA; MODULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OCULAR ALBINISM; OVARY CANCER; PHYLOGENY; PHYSIOLOGY; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TUMOR CELL;

AMINO ACID SEQUENCE; ANIMALS; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN INTERACTION DOMAINS AND MOTIFS; RAB GTP-BINDING PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 63449135882     PISSN: 19376448     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1937-6448(08)02005-4     Document Type: Review

References (166)

1. Ali B.R., and Seabra M.C. Targeting of Rab GTPases to cellular membranes. Biochem. Soc. Trans. 33 (2005) 652-656
2. Allan B.B., Moyer B.D., and Balch W.E. Rab1 recruitment of p115 into a cis-SNARE complex: Programming budding COPII vesicles for fusion. Science 289 (2000) 444-448
3. Alory C., and Balch W.E. Organization of the Rab-GDI/CHM superfamily: The functional basis for choroideremia disease. Traffic 2 (2001) 532-543
4. Alory C., and Balch W.E. Molecular evolution of the Rab-escort-protein/guanine-nucleotide-dissociation-inhibitor superfamily. Mol. Biol. Cell 14 (2003) 3857-3867
5. Alvarez-Dominguez C., and Stahl P.D. Increased expression of Rab5a correlates directly with accelerated maturation of Listeria monocytogenes phagosomes. J. Biol. Chem. 274 (1999) 11459-11462
6. Barral D.C., Ramalho J.S., Anders R., Hume A.N., Knapton H.J., Tolmachova T., Collinson L.M., Goulding D., Authi K.S., and Seabra M.C. Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. J. Clin. Invest. 110 (2002) 247-257
7. Baskys A., Bayazitov I., Zhu E., Fang L., and Wang R. Rab-mediated endocytosis: Linking neurodegeneration, neuroprotection, and synaptic plasticity?. Ann. N. Y. Acad. Sci. 1122 (2007) 313-329
8. Batista D.G., Silva C.F., Mota R.A., Costa L.C., Meirelles M.N., Meuser-Batista M., and Soeiro M.N. Trypanosoma cruzi modulates the expression of Rabs and alters the endocytosis in mouse cardiomyocytes in vitro. J. Histochem. Cytochem. 54 (2006) 605-614
9. Bayer M., Fischer J., Kremerskothen J., Ossendorf E., Matanis T., Konczal M., Weide T., and Barnekow A. Identification and characterization of Iporin as a novel interaction partner of rab1. BMC Cell Biol. 6 (2005) 15
10. Beard M., Satoh A., Shorter J., and Warren G. A cryptic Rab1-binding site in the p115 tethering protein. J. Biol. Chem. 280 (2005) 25840-25848
11. Biou V., and Cherfils J. Structural principles for the multispecificity of small GTP-binding proteins. Biochemistry 43 (2004) 6833-6840
12. Blott E.J., and Griffiths G.M. Secretory lysosomes. Nat. Rev. Mol. Cell Biol. 3 (2002) 122-131
13. Bock J.B., Matern H.T., Peden A.A., and Scheller R.H. A genomic perspective on membrane compartment organization. Nature 409 (2001) 839-841
14. Boldogh I.R., and Pon L.A. Mitochondria on the move. Trends Cell Biol. 17 (2007) 502-510
15. Borg J.P., Ooi J., Levy E., and Margolis B. The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein. Mol. Cell. Biol. 16 (1996) 6229-6241
16. Brass A.L., Dykxhoorn D.M., Benita Y., Yan N., Engelman A., Xavier R.J., Lieberman J., and Elledge S.J. Identification of host proteins required for HIV infection through a functional genomic screen. Science 319 (2008) 921-926
17. Bucci C., Thomsen P., Nicoziani P., McCarthy J., and van Deurs B. Rab7: A key to lysosome biogenesis. Mol. Biol. Cell 11 (2000) 467-480
18. Burton J., Roberts D., Montaldi M., Novick P., and De Camilli P. A mammalian guanine-nucleotide-releasing protein enhances function of yeast secretory protein Sec4. Nature 361 (1993) 464-467
19. Calvo A., Xiao N., Kang J., Best C.J., Leiva I., Emmert-Buck M.R., Jorcyk C., and Green J.E. Alterations in gene expression profiles during prostate cancer progression: Functional correlations to tumorigenicity and down-regulation of selenoprotein-P in mouse and human tumors. Cancer Res. 62 (2002) 5325-5335
20. Cao X., Ballew N., and Barlowe C. Initial docking of ER-derived vesicles requires Uso1p and Ypt1p but is independent of SNARE proteins. EMBO J. 17 (1998) 2156-2165
21. Casanova J.E., Wang X., Kumar R., Bhartur S.G., Navarre J., Woodrum J.E., Altschuler Y., Ray G.S., and Goldenring J.R. Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells. Mol. Biol. Cell 10 (1999) 47-61
22. Casey P.J., and Seabra M.C. Protein prenyltransferases. J. Biol. Chem. 71 (1996) 5289-5292
23. Catz S.D. Characterization of Rab27a and JFC1 as constituents of the secretory machinery of prostate-specific antigen in prostate carcinoma cells. Methods Enzymol. 438 (2008) 25-40
24. Chavrier P., Gorvel J.P., Stelzer E., Simons K., Gruenberg J., and Zerial M. Hypervariable C-terminal domain of rab proteins acts as a targeting signal. Nature 353 (1991) 769-772
25. Chavrier P., and Goud B. The role of ARF and Rab GTPases in membrane transport. Curr. Opin. Cell Biol. 11 (1999) 466-475
26. Cheng K.W., Lahad J.P., Kuo W.L., Lapuk A., Yamada K., Auersperg N., Liu J., Smith-McCune K., Lu K.H., Fishman D., Gray J.W., and Mills G.B. The Rab25 small GTPase determines aggressiveness of ovarian and breast cancers. Nat. Med. 10 (2004) 1251-1256
27. Cheng K.W., Lahad J.P., Gray J.W., and Mills G.B. Emerging role of Rab GTPases in cancer and human disease. Cancer Res. 65 (2005) 2516-2519
28. Chua C.E., and Tang B.L. α-Synuclein and Parkinson's disease: The first roadblock. J. Cell. Mol. Med. 10 (2006) 837-846
29. Clabecq A., Henry J.P., and Darchen F. Biochemical characterization of Rab3-GTPase-activating protein reveals a mechanism similar to that of Ras-GAP. J. Biol. Chem. 275 (2000) 31786-31791
30. Correll R.N., Pang C., Niedowicz D.M., Finlin B.S., and Andres D.S. The RGK family of GTP-binding proteins: Regulators of voltage-dependent calcium channels and cytoskeleton remodelling. Cell. Signal. 20 (2008) 292-300
31. Coutelis J.B., and Ephrussi A. Rab6 mediates membrane organization and determinant localization during Drosophila oogenesis. Development 134 (2007) 1419-1430
32. Cuif M.H., Possmayer F., Zander H., Bordes N., Jollivet F., Couedel-Courteille A., Janoueix-Lerosey I., Langsley G., Bornens M., and Goud B. Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome. EMBO J. 18 (1999) 1772-1782
33. D'Adamo P., Menegon A., Lo Nigro C., Grasso M., Gulisano M., Tamanimi F., Bienvenu T., Gedeon A.K., Oostra B., Wu S.K., Tandon A., Valtorta F., et al. Mutations in GDI1 are responsible for X-linked non-specific mental retardation. Nat. Genet. 19 (1998) 134-139
34. Del Nery E., Miserey-Lenkei S., Falguieres T., Nizak C., Johannes L., Perez F., and Goud B. Rab6A and Rab6A′ GTPases play non-overlapping roles in membrane trafficking. Traffic 7 (2006) 394-407
35. Deneka M., Neeft M., and van der Sluijs P. Regulation of membrane transport by rab GTPases. Crit. Rev. Biochem. Mol. Biol. 38 (2003) 121-142
36. DerMardirossian C., and Bokoch G.M. GDIs: Central regulatory molecules in Rho GTPase activation. Trends Cell Biol. 15 (2005) 356-363
37. Devon R.S., Orban P.C., Gerrow K., Barbieri M.A., Schwab C., Cao L.P., Helm J.R., Bissada N., Cruz-Aguado R., Davidson T.L., Witmer J., Metzler M., et al. Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities. Proc. Natl. Acad. Sci. USA 103 (2006) 9595-9600
38. Diao A., Rahmann D., Pappin D.J., Lucocq J., and Lowe M. The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation. J. Cell Biol. 160 (2003) 2001-2212
39. Di Petro S.M., and Dell'Angelica E.C. The cell biology of Hermansky-Pudlak syndrome: Recent advances. Traffic 6 (2005) 525-533
40. Echard A., Jollivet F., Martinez O., Lacapere J.J., Rousselet A., Janoueix-Lerosey I., and Goud B. Interaction of a Golgi-associated kinesin-like protein with Rab6. Science 279 (1998) 580-585
41. Echard A., Opdam F.J.M., de Leeuw H.J.P.C., Jollivet F., Savelkoul P., Hendriks W., Voorberg J., Goud B., and Fransen J.A. Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms. Mol. Biol. Cell. 11 (2000) 3819-3833
42. Etienne-Manneville S., and Hall A. Rho GTPases in cell biology. Nature 420 (2002) 629-635
43. Feng Y., Press B., and Wandinger-Ness A. Rab 7: An important regulator of late endocytic membrane traffic. J. Cell Biol. 131 (1995) 1435-1452
44. Finlin B.S., Shao H., Kadini-Okunda K., Guo N., and Andres D.A. Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases. Biochem. J. 347 (2000) 223-231
45. Fischer J., Weide T., and Barnekow A. The MICAL proteins and rab1: A possible link to the cytoskeleton?. Biochem. Biophys. Res. Commun. 328 (2005) 415-423
46. Fontijn R.D., Goud B., Echard A., Jollivet F., van Marle J., Pannekoek H., and Horrevoets A.J. The human kinesin-like protein RB6K is under tight cell cycle control and is essential for cytogenesis. Mol. Cell. Biol. 21 (2001) 2944-2955
47. Fridmann-Sirkis Y., Siniossoglou S., and Pelham H.R.B. TMF is a golgin that binds Rab6 and influences Golgi morphology. BMC Cell Biol. 5 (2004) 18
48. Garrett M.D., Zahner J.E., Cheney C.M., and Novick P.J. GDI1 encodes a GDP dissociation inhibitor that plays an essential role in the yeast secretory pathway. EMBO J. 13 (1994) 1718-1728
49. Gorvel J., Chavrier P., Zerial M., and Gruenberg J. Rab5 controls early endosome fusion in vitro. Cell 64 (1991) 915-925
50. Goud B., Zahraoui A., Tavitian A., and Saraste J. Small GTP-binding protein associated with Golgi cisternae. Nature 345 (1990) 553-556
51. Grigoriev I., Splinter D., Keijzer N., Wulf P.S., Demmers J., Ohtsuka T., Modesti M., Maly I.V., Grosveld F., Hoogenraad C.C., and Akhmanova A. Rab6 regulates transport and targeting of exocytotic carriers. Dev. Cell 13 (2007) 305-314
52. Guggino W.B., and Stanton B.A. New insights into cystic fibrosis: Molecular switches that regulate CFTR. Nat. Rev. Mol. Cell Biol. 7 (2006) 426-436
53. Haas A.K., Fuchs E., Kopajtich R., and Barr F.A. GTPase-activating protein controls Rab5 function in endocytotic trafficking. Nat. Cell Biol. 7 (2005) 887-893
54. Haubruck H., Prange R., Vorgias C., and Gallwitz D. The ras-related mouse ypt1 protein can functionally replace the YPT1 gene product in yeast. EMBO J. 8 (1989) 1427-1432
55. He H., Dai F., Yu L., She X., Zhao Y., Jiang J., Chen X., and Zhao S. Identification and characterization of nine novel human small GTPases showing variable expressions in liver cancer tissues. Gene Expr. 10 (2002) 231-242
56. Hermansky F., and Pudlak P. Albinism associated with hemorrhagic diathesis and unusual reticular cells in the bone marrow: Report of two cases with histochemical studies. Blood 14 (1959) 162-169
57. Hill E., Clarke M., and Barr F.A. The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis. EMBO J. 19 (2000) 5711-5719
58. Hoogenraad C.C., Akhmanova A., Howell S.A., Dortland B.R., De Zeeuw C.I., Willemsen R., Visser P., Grosveld F., and Galjart N. Mammalian Golgi-associated Bicaudal D2 functions in the dynein-dynactin pathway by interacting with these complexes. EMBO J. 20 (2001) 4041-4054
59. Horiuchi H., Lippé R., McBride H.M., Rubino M., Woodman P., Stenmark H., Rybin V., Wilm M., Ashman K., Mann M., and Zerial M. A novel Rab5 GDP/GTP exchange factor complexed to Rapaptin-5 links nucleotide exchange to effector recruitment and function. Cell 90 (1997) 1149-1159
60. Hyvola N., Diao A., McKenzie E., Skippen A., Cockcroft S., and Lowe M. Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases. EMBO J. 25 (2006) 3750-3761
61. Izumi T., Gomi H., Kasai K., Mizutani S., and Torii S. The roles of Rab27 and its effectors in the regulated secretory pathways. Cell Struct. Funct. 28 (2003) 465-474
62. Jacobsen M., Repsilber D., Gutschmidt A., Neher A., Feldmann K., Mollenkopf H.J., Ziegler A., and Kaufmann S.H. Ras-associated small GTPase 33A, a novel T cell factor, is down-regulated in patients with tuberculosis. J. Infect. Dis. 192 (2005) 1211-1218
63. Jäger D., Stockerte E., Jäger E., Güre A.O., Scanlan M.J., Knuth A., Old L.J., and Chen Y.-T. Serological cloning of a melanocyte rab guanosine 5′-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library. Cancer Res. 60 (2000) 3584-3591
64. Januschke J., Nicolas E., Compagnon J., Formstecher E., Goud B., and Guichet A. Rab6 and the secretory pathway affect oocyte polarity in Drosophila. Development 134 (2007) 3419-3425
65. Jiang J., Yu L., Huang X., Chen X., Li D., Zhang Y., Tang L., and Zhao S. Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients. Gene 281 (2001) 103-113
66. Jones S., Newman C., Liu F., and Segev N. The TRAPP complex is a nucleotide exchanger for Ypt1 and Ypt31/32. Mol. Biol. Cell 11 (2000) 4403-4411
67. Jordens I., Marsman M., Kuijl C., and Neefjes J. Rab proteins, connecting transport and vesicle fusion. Traffic 6 (2005) 1070-1077
68. Kail M., and Barnekow A. Identification and characterization of interacting partners of Rab GTPases by yeast two-hybrid analyses. Methods Mol. Biol. 440 (2008) 111-125
69. Kail M., Hollinshead M., Kaufmann M., Boettcher J., Vaux D., and Barnekow A. Yeast Ypt11 is targeted to recycling endosomes in mammalian cells. Biol. Cell 97 (2005) 651-658
70. Karnoub E.A., and Weinberg R.A. Ras oncogenes: Split personalities. Nat. Rev. Mol. Cell Biol. 9 (2008) 517-531
71. Kaufmann M., Kail M., Bilbilis K., and Barnekow A. Dynein light chain 2A-A link between the small GTPase Rab6A and the motor protein Dynein. Eur. J. Cell Biol. 84 (2005) 49
72. Kauppi M., Simonsen A., Bremnes B., Vieira A., Callaghan J., Stenmark H., and Olkkonen V.M. The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking. J. Cell Sci. 115 (2002) 899-911
73. King G.D., and Turner R.S. Adaptor protein interactions: Modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?. Exp. Neurol. 185 (2004) 208-219
74. Klein C., Philippe N., Le Dreist F., Fraitag S., Prost C., Durandy A., Fischer A., and Griscelli C. Partial albinism with immunodeficiency (Griscelli syndrome). J. Pediatr. 125 (1994) 886-895
75. Kotsch M., Sieuwerts A.M., Grosser M., Meye A., Fuessel S., Meijer-van Gelder M.E., Smid M., Schmitt M., Baretton G., Luther T., Magdolen V., and Foekens J.A. Urokinase receptor splice variant uPAR-del4/5-associated gene expression in breast cancer: Identification of rab31 as an independent prognostic factor. Breast Cancer Res. Treat. 111 (2008) 229-240
76. Krishnan M.N., Sukumaran B., Pal U., Agaisse H., Murray J.L., Hodge T.W., and Fikrig E. Rab5 is required for the cellular entry of dengue and West Nile viruses. J. Virol. 81 (2007) 4881-4885
77. Lazar T., Goette M., and Gallwitz D. Vesicular transport: How many Ypt/Rab-GTPases make a eukaryotic cell?. Trends Biochem. Sci. 12 (1997) 468-472
78. Lombardi D., Soldati T., Riederer M.A., Goda Y., Zerial M., and Pfeffer S.R. Rab9 functions in transport between late endosomes and the trans Golgi network. EMBO J. 12 (1993) 677-682
79. Luo Z., and Gallwitz D. Biochemical and genetic evidence for the involvement of yeast Ypt6-GTPase in protein retrieval to different Golgi compartments. J. Biol. Chem. 278 (2003) 791-799
80. Macara I.G., Lounsbury K.M., Richards S.A., McKiernan C., and Bar-Sagi D. The Ras superfamily of GTPases. FASEB J. 10 (1996) 625-630
81. Mallard F., Tang B.L., Galli T., Tenza D., Saint-Pol A., Yue X., Antony C., Hong W., Goud B., and Johannes L. Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform. J. Cell Biol. 156 (2002) 653-664
82. Martinez O., Schmidt A., Salaméro J., Hoflack B., Roa M., and Goud B. The small GTP-binding protein rab6 functions in intra-Golgi transport. J. Cell Biol. 127 (1994) 1575-1588
83. Martinez O., Antony C., Pehau-Arnaudet G., Berger E.G., Salamero J., and Goud B. GTP-bound forms of rab6 induce the redistribution of Golgi proteins into the endoplasmic reticulum. Proc. Natl. Acad. Sci. USA 94 (1997) 1828-1833
84. Matanis T., Akhmanova A., Wulf P., Del Nery E., Weide T., Stepanova T., Galjart N., Grosveld F., Goud B., De Zeeuw C., Barnekow A., and Hoogenraad C. Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. Nat. Cell Biol. 4 (2002) 986-992
85. Matthijs G., Schollen E., Pirard M., Budarf M.L., Van Schaftingen E., and Cassiman J.J. PMM (PMM1), the human homologue of SRC53 or yeast phosphomannomutase, is localized on chromosome 22q13. Genomics 40 (1997) 41-47
86. McConlogue L., Castellano F., deWit C., Schenk D., and Maltese W.A. Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's β-amyloid precursor protein. J. Biol. Chem. 271 (1996) 1343-1348
87. McLoughlin D.M., and Miller C.C. The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system. FEBS Lett. 397 (1996) 197-200
88. Merithew E., Hatherly S., Dumas J.J., Lawe D.C., Heller-Harrison R., and Lambright D.G. Structural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognition. J. Biol. Chem. 276 (2001) 13982-13988
89. Miserey-Lenkei S., Couedel-Courteille A., Del Nery E., Bardin S., Piel M., Racine V., Sibarita J.-B., Perez F., Bornens M., and Goud B. A role for the Rab6A′ GTPase in the inactivation of the Mad2-spindle checkpoint. EMBO J. 25 (2006) 278-289
90. Miserey-Lenkei S., Waharte F., Boulet A., Cuif M.-H., Tenza D., El Marjou A., Raposo G., Salamero J., Héliot L., Goud B., and Nonier S. Rab6-interacting protein 1 links Rab6 and Rab11 function. Traffic 8 (2007) 1385-1403
91. Monier S., and Goud B. Purification and properties of rab6 interacting proteins. Methods Enzymol. 403 (2005) 593-599
92. Monier S., Jollivet J., Janoueix-Lerosey I., Johannes L., and Goud B. Traffic 3 (2002) 289-297
93. Moyer B.D., Allan B.B., and Balch W.E. Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis-Golgi tethering. Traffic 2 (2001) 268-276
94. Mukhopadhyay A., Funato K., and Stahl P.D. Rab7 regulates transport from early to late endocytic compartments in Xenopus oocytes. J. Biol. Chem. 272 (1997) 13055-13059
95. Munafó D.B., and Colombo M.I. Induction of autophagy causes dramatic changes in the subcellular distribution of GFP-Rab24. Traffic 3 (2002) 472-482
96. Neef R., Preisinger C., Sutcliff J., Kopajtich R., Nigg E.A., Mayer T.U., and Barr F.A. Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis. J. Cell Biol. 162 (2003) 863-875
97. Neuhaus J., Schulze U., Barnekow A., and Kail M. Identification of a novel small GTPase in yeast. Eur. J. Cell Biol. 86 (2007) 58
98. Ni X., Ma Y., Cheng H., Jiang M., Guo L., Ji C., Gu S., Cao Y., Xie Y., and Mao Y. Molecular cloning and characterization of a novel human Rab (Rab2B) gene. J. Hum. Genet. 47 (2002) 548-551
99. Nielsen E., Severin F., Backer J.M., Hyman A.A., and Zerial M. Rab5 regulates motility of early endosomes on microtubules. Nat. Cell Biol. 1 (1999) 376-382
100. Novick P., and Zerial M. The diversity of Rab proteins in vesicle transport. Curr. Opin. Cell Biol. 9 (1997) 496-504
101. Nuoffer C., Davidson H.W., Matteson J., Meinkoth J., and Balch W.E. A GDP-bound form of rab1 inhibits protein export from the endoplasmic reticulum and transport between Golgi compartments. J. Cell Biol. 125 (1994) 225-237
102. Okamoto M., and Südhof T.C. Mint 3: A ubiquitous mint isoform that does not bind to munc18-1 or -2. Eur. J. Cell Biol. 77 (1998) 161-165
103. Opdam F.J., Echard A., Croes H.J., van den Hurk J.A., van de Vorstenbosch R.A., Ginsel L.A., Goud B., and Fransen J.A. The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus. J. Cell Sci. 113 (2000) 2725-2735
104. Osanai K., and Voelker D.R. Analysis and expression of Rab38 in oculocutaneous lung disease. Methods Enzymol. 438 (2008) 203-215
105. Ostermeier C., and Brunger A.T. Structural basis of Rab effector specificity: Crystal structure of the small G protein Rab3A complexed with the effector domain of Rabphilin-3A. Cell 96 (1999) 363-374
106. Pal A., Severin F., Lommer B., Shevchenko A., and Zerial M. Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease. J. Cell Biol. 172 (2006) 605-618
107. Pal A., Severin F., Höpfner S., and Zerial M. Regulation of endosome dynamics by Rab5 and Huntingtin-HAP40 effector complex in physiological versus pathological conditions. Methods Enzymol. 438 (2008) 239-257
108. +-ATPase inhibitor bafilomycin A1. Mol. Biol. Cell 9 (1998) 3561-3578
109. Pasqualato S., Renault L., and Cherfils J. Arf, Arl, Arp and Sar proteins: A family of GTP-binding proteins with a structural device for 'front-back' communication. EMBO Rep. 3 (2002) 3605-3612
110. Pereira-Leal J.B., and Seabra M.C. The mammalian Rab family of small GTPases: Definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily. J. Mol. Biol. 301 (2000) 1077-1087
111. Pereira-Leal J.B., and Seabra M.C. Evolution of the Rab family of small GTP-binding proteins. J. Mol. Biol. 313 (2001) 889-901
112. Pereira-Leal J.B., Hume A.N., and Seabra M.C. Prenylation of Rab GTPases: Molecular mechanisms and involvement in genetic disease. FEBS Lett. 498 (2001) 197-200
113. Pereira-Leal J.B., Strom M., Godfrey R.F., and Seabra M.C. Structural determinants of Rab and Rab escort protein interaction: Rab family motifs define a conserved binding surface. Biochem. Biophys. Res. Commun. 301 (2003) 92-97
114. Pfeffer S.R. Structural clues to Rab GTPase functional diversity. J. Biol. Chem. 280 (2005) 15485-15488
115. Pfeffer S.R. Unsolved mysteries in membrane traffic. Annu. Rev. Biochem. 76 (2007) 629-645
116. Pfeffer S., and Aivazian D. Targeting Rab GTPases to distinct membrane compartments. Nat. Rev. Mol. Cell Biol. 5 (2004) 5886-5896
117. Plutner H., Cox A.D., Pind S., Khosravi-Far R., Bourne J.R., Schwaninger R., Der C.J., and Balch W.E. Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. J. Cell Biol. 115 (1991) 31-43
118. Press B., Feng Y., Hoflack B., and Wandinger-Ness A. Mutant Rab7 causes the accumulation of cathepsin D and cation-independent mannose 6-phosphate receptor in an early endocytic compartment. J. Cell Biol. 140 (1998) 1075-1089
119. Rak A., Pylypenko O., Durek T., Watzke A., Kushnir S., Brunsveld L., Waldmann H., Goody R.S., and Alexandrov K. Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase. Science 302 (2003) 646-650
120. Rak A., Pylypenko O., Niculae A., Pyatkov K., Goody R.S., and Alexandrov K. Structure of the Rab7: REP-1 Complex: Insights into the mechanism of Rab prenylation and Choroiderma disease. Cell 117 (2004) 749-760
121. Ren M., Xu G., Zeng J., De Lemos-Chiarandini C., Adesnik M., and Sabatini D.D. Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes. Proc. Natl. Acad. Sci. USA 95 (1998) 6187-6192
122. Ridley A.J. The GTP-binding protein Rho. Int. J. Biochem. Cell Biol. 29 (2004) 1225-1229
123. Rosing M., Ossendorf E., Rak A., and Barnekow A. Giantin interacts with both, the small GTPase Rab6 and Rab1. Exp. Cell Res. 313 (2007) 2318-2325
124. Rzomp K.A., Moorhead A.R., and Scidmore M.A. The GTPase Rab4 interacts with Chlamydia trachomatis inclusion membrane protein CT229. Infect. Immun. 74 (2006) 5362-5372
125. Sakane A., Miyoshi J., Takai Y., and Sasaki T. Analysis on the emerging role of Rab3 GTPase-activating protein in Warburg Micro and Martsolf syndrome. Methods Enzymol. 438 (2008) 131-139
126. Sannerud R., Saraste J., and Goud B. Retrograde traffic in the biosynthetic-secretory route: Pathways and machinery. Curr. Opin. Cell Biol. 15 (2003) 438-445
127. Sannerud R., Marie M., Nizak C., Dale H.A., Pernet-Gallay K., Perez F., Goud B., and Saraste J. Rab1 defines a novel pathway connecting the pre-Golgi intermediate compartment with the cell periphery. Mol. Biol. Cell 17 (2006) 1514-1526
128. Saraste J., and Goud B. Functional symmetry of endomembranes. Mol. Biol. Cell 18 (2007) 1430-1436
129. Saraste J., Lahtinen U., and Goud B. Localization of the small GTP-binding protein rab1p to early compartments of the secretory pathway. J. Cell Sci. 108 (1995) 1541-1552
130. Scheper W., Hoozemans J.J., Hoogenraad C.C., Rozemuller A.J., Eikelenboom P., and Baas F. Rab6 is increased in Alzheimer's disease brain and correlates with endoplasmic reticulum stress. Neuropathol. Appl. Neurobiol. 33 (2007) 523-532
131. Schroer T. Dynactin. Annu. Rev. Cell Dev. Biol. 20 (2004) 759-779
132. Schwartz S.L., Cao C., Pylypenko O., Rak A., and Wandinger-Ness A. Rab GTPases at a glance. J. Cell Sci. 15 (2007) 3905-3910
133. Schweizer Burguete A., Fenn T.D., Brunger A.T., and Pfeffer S.R. Rab and Arl GTPase family members cooperate in the localization of the Golgin GCC185. Cell 132 (2008) 286-298
134. Seabra M.C., and Wasmeier C. Controlling the location and activation of Rab GTPases. Curr. Opin. Cell Biol. 16 (2004) 451-457
135. Seabra M.C., Mules E.H., and Hume A.N. Rab GTPases, intracellular traffic and disease. Trends Mol. Med. 8 (2002) 23-30
136. Selkoe D.J. Alzheimer's disease: Genes, proteins, and therapy. Physiol. Rev. 81 (2001) 741-766
137. Shimada K., Uzawa K., Kato M., Endo Y., Shiiba M., Bukawa H., Yokoe H., Seki N., and Tanzawa H. Aberrant expression of Rab1A in human tongue cancer. Br. J. Cancer 92 (2005) 1915-1921
138. Short B., Preisinger C., Schaletzky J., Kopajtich R., and Barr F.A. The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membrane. Curr. Biol. 12 (2002) 1792-1795
139. Short B., Haas A., and Barr F.A. Golgins and GTPases, giving identity and structure to the Golgi apparatus. Biochim. Biophys. Acta 1744 (2005) 383-395
140. Sklan E.H., Staschke K., Oakes T.M., Elazar M., Winters M., Aroeti B., Danieli T., and Glenn J.S. A Rab-GAP TBC domain protein binds hepatitis C virus NS5A and mediates viral replication. J. Virol. 81 (2007) 11096-11105
141. Sklan E.H., Serrano R.L., Einav S., Pfeffer S.R., Lambright D.G., and Glenn J.S. TBC1D20 is a Rab1 GTPase-activating protein that mediates Hepatitis C Virus replication. J. Biol. Chem. 282 (2007) 36354-36361
142. Stenmark H., Parton R.G., Steele-Mortimer O., Lütcke A., Gruenberg J., and Zerial M. Inhibition of Rab5 GTPase activity stimulates membrane fusion in endocytosis. EMBO J. 13 (1994) 1287-1296
143. Stone M., Jia S., Heo W.D., Meyer T., and Konan K.V. Participation of rab5, an early endosome protein, in hepatitis C virus RNA replication machinery. J. Virol. 81 (2007) 4551-4563
144. Strom M., Vollmer P., Tan T.J., and Gallwitz D. A yeast GTPase-activating protein that interacts specifically with a member of the Ypt/Rab family. Nature 361 (1993) 736-739
145. Tanahashi H., and Tabira T. X11L2, a new member of the X11 protein family, interacts with Alzheimer's β-amyloid precursor protein. Biochem. Biophys. Res. Commun. 255 (1999) 663-667
146. Teber I., Nagano F., Kremerskothen J., Bilbilis K., Goud B., and Barnekow A. Rab6 interacts with the Mint3 adaptor protein. Biol. Chem. 386 (2005) 671-677
147. Tisdale E.J., Bourne J.R., Khosravi-Far R., Der C.J., and Balch W.E. GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex. J. Cell Biol. 119 (1992) 749-761
148. Valsdottir R., Hashimoto H., Ashman K., Koda T., Storrie B., and Nilsson T. Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER. FEBS Lett. 508 (2001) 201-209
149. van der Sluijs P., Hull M., Webster P., Male P., Goud B., and Mellman I. The small GTP-binding protein rab4 controls an early sorting event on the endocytic pathway. Cell 70 (1992) 729-740
150. Vetter I.R., and Wittinghofer A. The guanine nucleotide-binding switch in three dimensions. Science 294 (2001) 1299-1304
151. Vonderheit A., and Helenius A. Rab7 associates with early endosomes to mediate sorting and transport of Semliki forest virus to late endosomes. PLoS Biol. 3 (2005) 1225-1238
152. Wanschers B., van de Vorstenbosch R., Wijers M., Wieringa B., King S.M., and Fransen J. Rab6 family proteins interact with the dynein light chain protein DYNLRB1. Cell Motil. Cytoskeleton 65 (2008) 183-196
153. Wanschers B.F., van de Vorstenbosch R., Schlager M.A., Splinter D., Akhmanova A., Hoogenraad C.C., Wieringa B., and Fransen J.A. A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells. Exp. Cell Res. 313 (2007) 3408-3420
154. Wasmeier C., Romao M., Plowright L., Bennett D.C., Raposo G., and Seabra M.C. Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes. J. Cell Biol. 175 (2006) 271-281
155. Weide T., Bayer M., Köster M., Siebrasse J.-P., Peters R., and Barnekow A. The golgi matrix protein GM130: A specific interacting partner of the small GTPase rab1b. EMBO Rep. 21 (2001) 336-341
156. Weide T., Teuber J., Bayer M., and Barnekow A. MICAL-1 isoforms, novel rab1 interacting proteins. Biochem. Biophys. Res. Commun. 306 (2003) 79-86
157. Weis K. Regulating access to the genome: Nucleocytoplasmic transport throughout the cell cycle. Cell 112 (2003) 441-451
158. Wennerberg K., and Der C.J. Rho-family GTPases: It's not only Rac and Rho (and I like it). J. Cell Sci. 117 (2004) 1301-1312
159. Wennerberg K., Rossman K.L., and Der C.J. The Ras superfamily at a glance. J. Cell Sci. 118 (2005) 843-846
160. White J., Johannes L., Mallard F., Girod A., Grill S., Reinsch S., Keller P., Tzschaschel B., Echard A., Goud B., and Stelzer E.H. Rab6 coordinates a novel Golgi to ER retrograde transport pathway in live cells. J. Cell Biol. 147 (1999) 743-760
161. Will E., and Gallwitz D. Biochemical characterization of Gyp6p, a Ypt/Rab-specific GTPase-activating protein from yeast. J. Biol. Chem. 276 (2001) 12135-12139
162. Wu G., Yussmann M.G., Barrett T.J., Hahn H.S., Osinska H., Hilliard G.M., Wang X., Toyokawa T., Yatani A., Lynch R.A., Robbins J., and Dorn II G.W. Increased myocardial Rab GTPase expression: A consequence and cause of cardiomyopathy. Circ. Res. 89 (2001) 1130-1137 **
163. Yamane J., Kubo A., Nakayama K., Yuba-Kubo A., Katsuno T., Tsukita S., and Tsukita S. Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic. Exp. Cell Res. 313 (2007) 3472-3485
164. Yao R., Wang Y., Lubet R.A., and You M. Differential gene expression in chemically induced mouse lung adenomas. Neoplasia 5 (2003) 41-52
165. Young J., Stauber T., Del Nery E., Vernos I., Pepperkok R., and Nilsson T. Regulation of microtubule-dependent recycling at the trans-Golgi network by Rab6A and Rab6A′. Mol. Biol. Cell 16 (2005) 162-177
166. Zerial M., and McBride H. Rab proteins as membrane organizers. Nat. Rev. Mol. Cell Biol. 2 (2001) 107-117