The Ras superfamily of GTPases

FASEB Journal

Volumn 10, Issue 5, 1996, Pages 625-630

  Macara, Ian G ^a   Lounsbury, Karen M ^a   Richards, Stephanie A ^a   Mckiernan, Colleen ^a   Bar Sagi, Dafna ^b  

^a UNIVERSITY OF VERMONT   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

cytoskeleton; GTP binding proteins; nuclear transplant; secretion; signal transduction

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; PROTEIN KINASE;

CELL FUNCTION; CYTOSKELETON; ENZYME REGULATION; MITOGENESIS; ONCOGENE RAS; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

EID: 0029985757     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.10.5.8621061     Document Type: Review

References (45)

1. Boguski, M. S., and McCormick, F. (1993) Proteins regulating Ras and its relatives. Nature (London) 366, 643-653
2. Chardin, P., Camonis, J. H., Gale, N. W., Van Aelst, L., Schlessinger, J., Wigler, M. H., and Bar-Sagi, D. (1993) Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science 260, 1338-1343
3. Vojtek, A. B., Hollenberg, S. M., and Cooper, J. A. (1993) Mammalian Ras interacts with the serine/threonine kinase Raf. Cell 74, 205-214
4. White, M. A, Nicolette C., Minen A., Polverino A., Van Aelst, L., Karin, M., and Wigler, M. H. (1995) Multiple Ras functions can contribute to mammalian cell transformation. Cell 80, 533-541
5. Van Blesen, T., Hawes, B. E., Luttrell, D. K., Krueger, K. M., Touhara, K., Porfiri, E., Sakaue, M., Luttrell, L. M., and Lefkowitz, R. J. (1995) Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway. Nature (London) 376, 781-784
6. 2+-induced regulation of ion channel and MAP kinase functions. Nature (London) 376, 737-745
7. Farnsworth, C. L., Freshney, N. W., Rosen, L. B., Ghosh, A., Greenberg, M. E., and Feig, L. A. (1995) Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF. Nature (London) 376, 524-526.
8. Rodriguez-Viciana, P., Warne, P. H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M. J., Waterfield, M. D., and Downward, J. (1994) Phosphatidylinositol-3 -OH kinase as a direct target of Ras. Nature (London) 370, 527-532
9. Kikuchi, A., Demo, S. D., Ye, Z.-H., Chen, Y.-W., and Williams, L. T. (1994) RalGDS family members interact with the effector loop of ras p21.Mol. Cell. Biol. 14, 7483-7491
10. Han, L., and Colicelli, J. (1995) A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1. Mol. Cell. Biol. 15, 1318-1323.
11. Chang, E. C., Barr, M., Wang, Y., Jung, V., Xu, H. P., and Wigler M. H. (1994) Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell 79, 131-141
12. Hu, Q., Klippel, A., Muslin, A. J., Fantl, W. J., and Williams, L. T. (1995) Ras-dependent induction of cellular responses by constitutively active phosphatidylinosilol-3 kinase. Science 268, 100-102
13. Qiu, R.-G., Chen, J., Kirn, D., McCormick, F., and Symons, M. (1995) An essential role for Rac in Ras transformation. Nature (London) 374, 457-459
14. Khosravi-far, R., Solski, P. A., Clark, G. J., Kinch, M. S., and Der, C. J. (1995) Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol. Cell. Biol. 15, 6443-6453
15. Stokoe, D., Macdonald, S. G., Cadwallader, K., Symons, M., and Hancock, J. F. (1994) Activation of Raf as a result of recruitment of the plasma membrane. Science 264, 1463-1467
16. Nassar, N., Horn, G., Scherer, A., McCormick, F., and Wittinghofer, A. (1995) The 2.2Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue. Nature (London) 375, 554-560
17. Cullen, P. J., Hsuan, J. J., Truong, O., Letcher, A. J., Jackson, T. R., Dawson, A. P., and Irvine, R. F. (1995) Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family. Nature (London) 376, 527-510
18. Henkemeyer, M., Rossi, D. J., Holmyard, D. P., Puri, M. C., Mbamalu, G., Harpal, K., Shih, T. S., Jacks, T., and Pawson, T. (1995) Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein. Nature (London) 377, 695-701
19. Nobes, C. D., and Hall, A. (1995) Rho, Rac and Cdc42p GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia and filopodia. Cell 81, 53-62
20. Cantor, S. B., Urano, T., and Feig, L. A. (1995) Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases. Mol. Cell. Biol. 15, 4578-4584
21. Peppelenboasch, M. P., Qiu, R. G., de Vries-Smits, A. M., Tertoolen L. G., de Laat, S. W., McCormick, F., Hall, A., Symons, M. H., and Bos, J. L. (1995) Rac mediates growth factor-induced arachidonic acid release. Cell 81, 849-856
22. Michiels, F., Habets, G. G., Stam, J. C., van der Kammen, R. A., and Collard, J. G. (1995) A role for Rac in Tiam1-induced membrane ruffling and invasion. Nature (London) 375, 338-340
23. Lamarche, N., and Hall, A. (1994) GAPs for the Rho-related GTPases. Trends Genet. 10, 436-440
24. Homma, Y., and Emori, Y. (1995) A dual functional signal mediator showing RhoGAP and phospholipase D-stimulating activities. EMBO J. 14, 286-291
25. Reinhard, J., Scheel, A. A., Diekmann, D., Hall, A., Ruppert, C., and Bahler, M. (1995) A novel type of myosin implicated in signalling by rho family GTPases. EMBO J. 14, 697-704
26. Manser, E., Leung, T., Salihudden, H., Zhao, Z.-s., and Lim, L. (1994) A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature (London) 367, 40-46
27. Simon, M.-N., De Virgilio C., Souza, B., Pringle, J. R., Abo, A., and Reed, S. I. (1995) Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway. Nature (London) 376, 702-705
28. Watanabe, G., Saito, Y., Madaule, P., Ishizaki, T., Fujisawa, Morii, N., Mucai, H., Ono, Y., Kakizuka, A., and Narumiya, S. (1996) Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase rho. Science 171, 645-648
29. Amano, M., Mukai, H., Ono, Y., Chihara, K., Matsui, T., Hamajima, Y., Okawa, K., Iwamatsu, A., and Kaibuchi, K. (1996) Identification of a putative target for rho as the serine-threonine kinase protein kinase N. Science 271, 648-650
30. Zheng, Y., Bagrodia S., and Cerione, R. A. (1994) Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85. J. Biol. Chem. 269, 18727-18730
31. Ferro-Novick, S., and Jahn, R. (1994) Vesicle fusion from yeast to man. Nature (London) 370, 191-193
32. Cockcroft, S., Thomas, G.M., Fensome, A., Geny, B., Cunningham, E., Grout, I., Hiles, I., Totty, N. F., Truong, O., and Hsuan, J. J. (1994) Phospholipase D: a downstream effector of ARF in granulocytes. Science 263, 523-526
33. Randazzo, P. A., and Kahn, R. A. (1994) GTP hydrolysis by ARF is dependent on both an ARF GTPase-activating protein and acid phospholipids. J. Biol. Chem. 269, 10758-10763
34. Brennwald, P., and Novick, P. (1993) Interactions of three domains distinguishing theRas-related GTP-binding proteins Ypt1 and Sec4. Nature (London) 362, 560-565
35. Ullrich, O., Bucci, H. H., and Zerial, M. (1994) Membrane association of Rab5 mediated by GDP-dissociation inhibitor and accompanied by GDP/GTP exchange. Nature (London) 368, 157-160
36. Sodati, T., Shapiro, A. D., Svejstrup, A. B. D., and Pfeffer, S. R. (1994) Membrane targeting of the small GTPase Rab9 is accompanied by nucleotide exchange. Nature (London) 369, 76-78
37. Shirataki, H., Kaibuchi, K., Sakoda, T., Kishida, S., Yamaguchi, T., Wada, K., Miyazaki, M., and Takai, Y. (1993) Rabphilin-3A, a putative target protein for smg p25A/Rab3A small CTP-binding protein related to synaptogagmin. Mol. Cell. Biol. 13, 2061-2068
38. Stenmark, H., Vitale, G., Ullrich, O., and Zerial, M. (1995) Rababtin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion. Cell 83, 423-432
39. 2+-dependent exocytosis from adrenal chromaffin cells. J. Biol. Chem. 269, 10229-10234
40. Melchior, F., and Gerace, L. (1995) Mechanisms of nuclear protein import. Curr. Opin. Biol. 1, 310-318
41. Coutavas, E., Ren, M., Oppenheim, J. D., D'Eustachio, P., and Rush, M. (1993) Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4. Nature (London) 366, 585-587
42. Wu, J., Matunis, J., Kraemer D., Blobel, G., and Coutavas, E. (1995) Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-CTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region. J. Biol. Chem. 270, 14209-14213
43. Yokoyama, N., Hayashi, N., Seki, T., Pante, N., Ohba, T., Nishii, K., Kuma, K., Hayashida, T., Miyata, T., Aebi, U., Fukui, M., and Nishimoto, T. (1995) A giant nucleopore ptotein that binds Ran/TC4. Nature (London) 376, 184-188
44. Beddow, A. L., Richards, S. A., Orem, N. R., and Macara, I. G. (1995) The Rar/TC4 GTPase-binding domain: identification by expression cloning and characterization of a conserved sequence motif. Proc. Natl. Acad. Sci. USA 92, 3328-3332
45. Lounsbury, K. M., Richards, S. A., Perlungher, R. R., and Macara, I. G. (1996) Ran binding domains promote the interaction of Ran with p97/β-karyopherin, linking the docking and translocation steps of nuclear import. J. Biol. Chem. 271, 2357-2360