-
1
-
-
0035135929
-
Small GTP-binding proteins
-
Takai, Y., Sasaki, T., and Matozaki, T. (2001) Small GTP-binding proteins, Physiol. Rev. 81, 153-208.
-
(2001)
Physiol. Rev.
, vol.81
, pp. 153-208
-
-
Takai, Y.1
Sasaki, T.2
Matozaki, T.3
-
2
-
-
0035834388
-
The guanine nucleotide-binding switch in three dimensions
-
Vetter, I. R., and Wittinghofer, A. (2001) The guanine nucleotide-binding switch in three dimensions, Science 294, 1299-1304.
-
(2001)
Science
, vol.294
, pp. 1299-1304
-
-
Vetter, I.R.1
Wittinghofer, A.2
-
3
-
-
0035659985
-
The many faces of Ras: Recognition of small GTP-binding proteins
-
Corbett, K. D., and Alber, T. (2001) The many faces of Ras: recognition of small GTP-binding proteins, Trends Biochem. Sci. 26, 710-716.
-
(2001)
Trends Biochem. Sci.
, vol.26
, pp. 710-716
-
-
Corbett, K.D.1
Alber, T.2
-
4
-
-
0034686987
-
Conformational display: A role for switch polymorphism in the superfamily of regulatory GTPases
-
Sprang, S. R. (2000) Conformational display: a role for switch polymorphism in the superfamily of regulatory GTPases, Sci. STKE 2000, E1.
-
(2000)
Sci. STKE
, vol.2000
-
-
Sprang, S.R.1
-
5
-
-
0033231561
-
The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1
-
Maesaki, R., Ihara, K., Shimizu, T., Kuroda, S., Kaibuchi, K., and Hakoshima, T. (1999) The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1, Mol. Cell 4, 793-803.
-
(1999)
Mol. Cell
, vol.4
, pp. 793-803
-
-
Maesaki, R.1
Ihara, K.2
Shimizu, T.3
Kuroda, S.4
Kaibuchi, K.5
Hakoshima, T.6
-
6
-
-
0028103275
-
The CCP4 suite: Programs for protein crystallography
-
Collaborative Computational Project, No. 4 (1994) The CCP4 suite: programs for protein crystallography, Acta Crystallogr. D50, 760-763.
-
(1994)
Acta Crystallogr.
, vol.D50
, pp. 760-763
-
-
-
7
-
-
2642538234
-
-
Roussel, A., and Cambillau, C. (2003) afmb.cnrs-mrs.fr/TURBO_FRODO/main.html
-
Roussel, A., and Cambillau, C. (2003) afmb.cnrs-mrs.fr/TURBO_FRODO/main.html.
-
-
-
-
8
-
-
1842301722
-
Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPγS
-
Cherfils, J., Menetrey, J., Le Bras, G., Janoueix-Lerosey, I., de Gunzburg, J., Garel, J. R., and Auzat, I. (1997) Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPγS, EMBO J. 16, 5582-5591.
-
(1997)
EMBO J.
, vol.16
, pp. 5582-5591
-
-
Cherfils, J.1
Menetrey, J.2
Le Bras, G.3
Janoueix-Lerosey, I.4
De Gunzburg, J.5
Garel, J.R.6
Auzat, I.7
-
9
-
-
0025908897
-
The ras protein family: Evolutionary tree and role of conserved amino acids
-
Valencia, A., Chardin, P., Wittinghofer, A., and Sander, C. (1991) The ras protein family: evolutionary tree and role of conserved amino acids, Biochemistry 30, 4637-4648.
-
(1991)
Biochemistry
, vol.30
, pp. 4637-4648
-
-
Valencia, A.1
Chardin, P.2
Wittinghofer, A.3
Sander, C.4
-
10
-
-
0028556994
-
Structure of the human ADP-ribosylation factor 1 complexed with GDP
-
Amor, J. C., Harrison, D. H., Kahn, R. A., and Ringe, D. (1994) Structure of the human ADP-ribosylation factor 1 complexed with GDP, Nature 372, 704-708.
-
(1994)
Nature
, vol.372
, pp. 704-708
-
-
Amor, J.C.1
Harrison, D.H.2
Kahn, R.A.3
Ringe, D.4
-
11
-
-
0346243924
-
Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor
-
Renault, L., Guibert, B., and Cherfils, J. (2003) Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor, Nature 426, 525-530.
-
(2003)
Nature
, vol.426
, pp. 525-530
-
-
Renault, L.1
Guibert, B.2
Cherfils, J.3
-
12
-
-
0032538317
-
Structural basis for activation of ARF GTPase: Mechanisms of guanine nucleotide exchange and GTP-myristoyl switching
-
Goldberg, J. (1998) Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching, Cell 95, 237-248.
-
(1998)
Cell
, vol.95
, pp. 237-248
-
-
Goldberg, J.1
-
13
-
-
0028289241
-
Anatomy of the antibody molecule
-
Padlan, E. A. (1994) Anatomy of the antibody molecule, Mol. Immunol. 31, 169-217.
-
(1994)
Mol. Immunol.
, vol.31
, pp. 169-217
-
-
Padlan, E.A.1
-
14
-
-
0003187567
-
The atomic structure of protein-protein recognition sites
-
Lo Conte, L., Chothia, C., and Janin, J. (1999) The atomic structure of protein-protein recognition sites, J. Mol. Biol. 285, 2177-2198.
-
(1999)
J. Mol. Biol.
, vol.285
, pp. 2177-2198
-
-
Lo Conte, L.1
Chothia, C.2
Janin, J.3
-
15
-
-
0035917523
-
Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)
-
Renault, L., Kuhlmann, J., Henkel, A., and Wittinghofer, A. (2001) Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1), Cell 105, 245-255.
-
(2001)
Cell
, vol.105
, pp. 245-255
-
-
Renault, L.1
Kuhlmann, J.2
Henkel, A.3
Wittinghofer, A.4
-
16
-
-
0031570337
-
A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm
-
Keep, N. H., Barnes, M., Barsukov, I., Badii, R., Lian, L. Y., Segal, A. W., Moody, P. C., and Roberts, G. C. (1997) A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm, Structure 5, 623-633.
-
(1997)
Structure
, vol.5
, pp. 623-633
-
-
Keep, N.H.1
Barnes, M.2
Barsukov, I.3
Badii, R.4
Lian, L.Y.5
Segal, A.W.6
Moody, P.C.7
Roberts, G.C.8
-
17
-
-
0035964281
-
Crystal structure of the Rac1-RhoGDI complex involved in NADPH oxidase activation
-
Grizot, S., Faure, J., Fieschi, F., Vignais, P. V., Dagher, M. C., and Pebay-Peyroula, E. (2001) Crystal structure of the Rac1-RhoGDI complex involved in NADPH oxidase activation, Biochemistry 40, 10007-10013.
-
(2001)
Biochemistry
, vol.40
, pp. 10007-10013
-
-
Grizot, S.1
Faure, J.2
Fieschi, F.3
Vignais, P.V.4
Dagher, M.C.5
Pebay-Peyroula, E.6
-
18
-
-
0034603198
-
Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI
-
Hoffman, G. R., Nassar, N., and Cerione, R. A. (2000) Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI, Cell 100, 345-356.
-
(2000)
Cell
, vol.100
, pp. 345-356
-
-
Hoffman, G.R.1
Nassar, N.2
Cerione, R.A.3
-
19
-
-
0035185551
-
Molecular basis for Rac1 recognition by guanine nucleotide exchange factors
-
Karnoub, A. E., Worthylake, D. K., Rossman, K. L., Pruitt, W. M., Campbell, S. L., Sondek, J., and Der, C. J. (2001) Molecular basis for Rac1 recognition by guanine nucleotide exchange factors, Nat. Struct. Biol. 8, 1037-1041.
-
(2001)
Nat. Struct. Biol.
, vol.8
, pp. 1037-1041
-
-
Karnoub, A.E.1
Worthylake, D.K.2
Rossman, K.L.3
Pruitt, W.M.4
Campbell, S.L.5
Sondek, J.6
Der, C.J.7
-
20
-
-
0034681465
-
Convergent solutions to binding at a protein-protein interface
-
DeLano, W. L., Ultsch, M. H., de Vos, A. M., and Wells, J. A. (2000) Convergent solutions to binding at a protein-protein interface, Science 287, 1279-1283.
-
(2000)
Science
, vol.287
, pp. 1279-1283
-
-
DeLano, W.L.1
Ultsch, M.H.2
De Vos, A.M.3
Wells, J.A.4
-
21
-
-
0035799582
-
Protein interactions. Unspinning the web
-
Hasty, J., and Collins, J. J. (2001) Protein interactions. Unspinning the web, Nature 411, 30-31.
-
(2001)
Nature
, vol.411
, pp. 30-31
-
-
Hasty, J.1
Collins, J.J.2
-
22
-
-
0035799707
-
Lethality and centrality in protein networks
-
Jeong, H., Mason, S. P., Barabasi, A. L., and Oltvai, Z. N. (2001) Lethality and centrality in protein networks, Nature 411, 41-42.
-
(2001)
Nature
, vol.411
, pp. 41-42
-
-
Jeong, H.1
Mason, S.P.2
Barabasi, A.L.3
Oltvai, Z.N.4
-
23
-
-
0034502457
-
Modulation of host signaling by a bacterial mimic: Structure of the Salmonella effector SptP bound to Rac1
-
Stebbins, C. E., and Galan, J. E. (2000) Modulation of host signaling by a bacterial mimic: structure of the Salmonella effector SptP bound to Rac1, Mol. Cell 6, 1449-1460.
-
(2000)
Mol. Cell
, vol.6
, pp. 1449-1460
-
-
Stebbins, C.E.1
Galan, J.E.2
-
24
-
-
0035171524
-
How the Pseudomonas aeruginosa ExoS toxin downregulates Rac
-
Wurtele, M., Wolf, E., Pederson, K. J., Buchwald, G., Ahmadian, M. R., Barbieri, J. T., and Wittinghofer, A. (2001) How the Pseudomonas aeruginosa ExoS toxin downregulates Rac, Nat. Struct. Biol. 8, 23-26.
-
(2001)
Nat. Struct. Biol.
, vol.8
, pp. 23-26
-
-
Wurtele, M.1
Wolf, E.2
Pederson, K.J.3
Buchwald, G.4
Ahmadian, M.R.5
Barbieri, J.T.6
Wittinghofer, A.7
-
25
-
-
0036646473
-
Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE
-
Buchwald, G., Friebel, A., Galan, J. E., Hardt, W. D., Wittinghofer, A., and Scheffzek, K. (2002) Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE, EMBO J. 21, 3286-3295.
-
(2002)
EMBO J.
, vol.21
, pp. 3286-3295
-
-
Buchwald, G.1
Friebel, A.2
Galan, J.E.3
Hardt, W.D.4
Wittinghofer, A.5
Scheffzek, K.6
-
26
-
-
0344885558
-
Structural evidence for feedback activation by Ras·GTP of the Ras-specific nucleotide exchange factor SOS
-
Margarit, S. M., Sondermann, H., Hall, B. E., Nagar, B., Hoelz, A., Pirruccello, M., Bar-Sagi, D., and Kuriyan, J. (2003) Structural evidence for feedback activation by Ras·GTP of the Ras-specific nucleotide exchange factor SOS, Cell 112, 685-695.
-
(2003)
Cell
, vol.112
, pp. 685-695
-
-
Margarit, S.M.1
Sondermann, H.2
Hall, B.E.3
Nagar, B.4
Hoelz, A.5
Pirruccello, M.6
Bar-Sagi, D.7
Kuriyan, J.8
-
27
-
-
0033635157
-
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase γ
-
Pacold, M. E., Suire, S., Perisic, O., Lara-Gonzalez, S., Davis, C. T., Walker, E. H., Hawkins, P. T., Stephens, L., Eccleston, J. F., and Williams, R. L. (2000) Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase γ, Cell 103, 931-943.
-
(2000)
Cell
, vol.103
, pp. 931-943
-
-
Pacold, M.E.1
Suire, S.2
Perisic, O.3
Lara-Gonzalez, S.4
Davis, C.T.5
Walker, E.H.6
Hawkins, P.T.7
Stephens, L.8
Eccleston, J.F.9
Williams, R.L.10
-
28
-
-
0032898066
-
Structural and biochemical analysis of Ras-effector signaling via RAlGDS
-
Verter, I. R., Linnemann, T., Wohlgemuth, S., Geyer, M., Kalbitzer, H. R., Herrmann, C., and Wittinghofer, A. (1999) Structural and biochemical analysis of Ras-effector signaling via RAlGDS, FEBS Lett. 451, 175-180.
-
(1999)
FEBS Lett.
, vol.451
, pp. 175-180
-
-
Verter, I.R.1
Linnemann, T.2
Wohlgemuth, S.3
Geyer, M.4
Kalbitzer, H.R.5
Herrmann, C.6
Wittinghofer, A.7
-
29
-
-
0030772378
-
The Ras-RasGAP complex: Structural basis for GTPase activation and its loss in oncogenic Ras mutants
-
Scheffzek, K., Ahmadian, M. R., Kabsch, W., Wiesmuller, L., Lautwein, A., Schmitz, F., and Wittinghofer, A. (1997) The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants, Science 277, 333-338.
-
(1997)
Science
, vol.277
, pp. 333-338
-
-
Scheffzek, K.1
Ahmadian, M.R.2
Kabsch, W.3
Wiesmuller, L.4
Lautwein, A.5
Schmitz, F.6
Wittinghofer, A.7
-
30
-
-
0032478537
-
Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran
-
Stewart, M., Kent, H. M., and McCoy, A. J. (1998) Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran, J. Mol. Biol. 277, 635-646.
-
(1998)
J. Mol. Biol.
, vol.277
, pp. 635-646
-
-
Stewart, M.1
Kent, H.M.2
McCoy, A.J.3
-
31
-
-
0001506297
-
Structure of the nuclear transport complex karyopherin-β2-Ran × GppNHp
-
Chook, Y. M., and Blobel, G. (1999) Structure of the nuclear transport complex karyopherin-β2-Ran × GppNHp, Nature 399, 230-237.
-
(1999)
Nature
, vol.399
, pp. 230-237
-
-
Chook, Y.M.1
Blobel, G.2
-
32
-
-
0033612390
-
Structural view of the Ran-Importin β interaction at 2.3 Å resolution
-
Vetter, I. R., Arndt, A., Kutay, U., Gorlich, D., and Wittinghofer, A. (1999) Structural view of the Ran-Importin β interaction at 2.3 Å resolution, Cell 97, 635-646.
-
(1999)
Cell
, vol.97
, pp. 635-646
-
-
Vetter, I.R.1
Arndt, A.2
Kutay, U.3
Gorlich, D.4
Wittinghofer, A.5
-
33
-
-
0033522118
-
Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: Implications for nuclear transport
-
Vetter, I. R., Nowak, C., Nishimoto, T., Kuhlmann, J., and Wittinghofer, A. (1999) Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport, Nature 398, 39-46.
-
(1999)
Nature
, vol.398
, pp. 39-46
-
-
Vetter, I.R.1
Nowak, C.2
Nishimoto, T.3
Kuhlmann, J.4
Wittinghofer, A.5
-
34
-
-
0037033983
-
RanGAP mediates GTP hydrolysis without an arginine finger
-
Seewald, M. J., Korner, C., Wittinghofer, A., and Vetter, I. R. (2002) RanGAP mediates GTP hydrolysis without an arginine finger, Nature 415, 662-666.
-
(2002)
Nature
, vol.415
, pp. 662-666
-
-
Seewald, M.J.1
Korner, C.2
Wittinghofer, A.3
Vetter, I.R.4
-
35
-
-
0037407395
-
Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport
-
Shiba, T., Kawasaki, M., Takatsu, H., Nogi, T., Matsugaki, N., Igarashi, N., Suzuki, M., Kato, R., Nakayama, K., and Wakatsuki, S. (2003) Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport, Nat. Struct. Biol. 10, 386-393.
-
(2003)
Nat. Struct. Biol.
, vol.10
, pp. 386-393
-
-
Shiba, T.1
Kawasaki, M.2
Takatsu, H.3
Nogi, T.4
Matsugaki, N.5
Igarashi, N.6
Suzuki, M.7
Kato, R.8
Nakayama, K.9
Wakatsuki, S.10
-
36
-
-
0034619877
-
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
-
Worthylake, D. K., Rossman, K. L., and Sondek, J. (2000) Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1, Nature 408, 682-688.
-
(2000)
Nature
, vol.408
, pp. 682-688
-
-
Worthylake, D.K.1
Rossman, K.L.2
Sondek, J.3
-
37
-
-
0033635228
-
Structure of the TPR domain of p67phox in complex with Rac·GTP
-
Lapouge, K., Smith, S. J., Walker, P. A., Gamblin, S. J., Smerdon, S. J., and Rittinger, K. (2000) Structure of the TPR domain of p67phox in complex with Rac·GTP, Mol. Cell 6, 899-907.
-
(2000)
Mol. Cell
, vol.6
, pp. 899-907
-
-
Lapouge, K.1
Smith, S.J.2
Walker, P.A.3
Gamblin, S.J.4
Smerdon, S.J.5
Rittinger, K.6
-
38
-
-
0035837426
-
The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways
-
Tarricone, C., Xiao, B., Justin, N., Walker, P. A., Rittinger, K., Gamblin, S. J., and Smerdon, S. J. (2001) The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways, Nature 411, 215-219.
-
(2001)
Nature
, vol.411
, pp. 215-219
-
-
Tarricone, C.1
Xiao, B.2
Justin, N.3
Walker, P.A.4
Rittinger, K.5
Gamblin, S.J.6
Smerdon, S.J.7
-
39
-
-
0037086652
-
A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange
-
Rossman, K. L., Worthylake, D. K., Snyder, J. T., Siderovski, D. P., Campbell, S. L., and Sondek, J. (2002) A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange, EMBO J. 21, 1315-1326.
-
(2002)
EMBO J.
, vol.21
, pp. 1315-1326
-
-
Rossman, K.L.1
Worthylake, D.K.2
Snyder, J.T.3
Siderovski, D.P.4
Campbell, S.L.5
Sondek, J.6
-
40
-
-
0036646473
-
Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE
-
Buchwald, G., Friebel, A., Galan, J. E., Hardt, W.-D., Wittinghofer, A., and Scheffzek, K. (2002) Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE, EMBO J. 21, 3286-3295.
-
(2002)
EMBO J.
, vol.21
, pp. 3286-3295
-
-
Buchwald, G.1
Friebel, A.2
Galan, J.E.3
Hardt, W.-D.4
Wittinghofer, A.5
Scheffzek, K.6
-
41
-
-
0037416217
-
Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6
-
Garrard, S. M., Capaldo, C. T., Gao, L., Rosen, M. K., Macara, I. G., and Tomchick, D. R. (2003) Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6, EMBO J. 22, 1125-1133.
-
(2003)
EMBO J.
, vol.22
, pp. 1125-1133
-
-
Garrard, S.M.1
Capaldo, C.T.2
Gao, L.3
Rosen, M.K.4
Macara, I.G.5
Tomchick, D.R.6
-
42
-
-
0031762533
-
Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP
-
Nassar, N., Hoffman, G. R., Manor, D., Clardy, J. C., and Cerione, R. A. (1998) Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP, Nat. Struct. Biol. 5, 1047-1052.
-
(1998)
Nat. Struct. Biol.
, vol.5
, pp. 1047-1052
-
-
Nassar, N.1
Hoffman, G.R.2
Manor, D.3
Clardy, J.C.4
Cerione, R.A.5
-
43
-
-
0036263915
-
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors
-
Snyder, J. T., Worthylake, D. K., Rossman, K. L., Betts, L., Pruitt, W. M., Siderovski, D. P., Der, C. J., and Sondek, J. (2002) Structural basis for the selective activation of Rho GTPases by Dbl exchange factors, Nat. Struct. Biol. 9, 468-475.
-
(2002)
Nat. Struct. Biol.
, vol.9
, pp. 468-475
-
-
Snyder, J.T.1
Worthylake, D.K.2
Rossman, K.L.3
Betts, L.4
Pruitt, W.M.5
Siderovski, D.P.6
Der, C.J.7
Sondek, J.8
-
44
-
-
0030716497
-
Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue
-
Rittinger, K., Walker, P. A., Eccleston J. F., Smerdon, S. J., and Gamblin, S. J. (1997) Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue, Nature 389, 758-762.
-
(1997)
Nature
, vol.389
, pp. 758-762
-
-
Rittinger, K.1
Walker, P.A.2
Eccleston, J.F.3
Smerdon, S.J.4
Gamblin, S.J.5
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