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Volumn 39, Issue 5, 2004, Pages 320-328

Experimental ageing research: From false knowledge to true ignorance;Investigación experimental sobre envejecimiento: Del falso conocimiento a la verdadera ignorancia

Author keywords

Current gerontology; Longevity genes; Oxidative stress ageing

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; BETA CAROTENE; CATALASE; COLLAGEN; COPPER ZINC SUPEROXIDE DISMUTASE; FREE RADICAL; GLUTATHIONE TRANSFERASE; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P66; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; TELOMERASE; THIOREDOXIN; URIC ACID; XANTHINE DEHYDROGENASE;

EID: 6344261850     PISSN: 0211139X     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0211-139x(04)74981-1     Document Type: Review
Times cited : (1)

References (91)
  • 3
    • 0037470542 scopus 로고    scopus 로고
    • Aging and genome maintenance: Lessons from the mouse?
    • Hasty P, Campisi J, Hoeijmakers J, et al. Aging and genome maintenance: lessons from the mouse? Science 2003;299:1355-9.
    • (2003) Science , vol.299 , pp. 1355-1359
    • Hasty, P.1    Campisi, J.2    Hoeijmakers, J.3
  • 4
    • 4344605785 scopus 로고    scopus 로고
    • Aging and cancer in transgenic and mutant mice
    • Anisimov VN. Aging and cancer in transgenic and mutant mice. Front Biosci 2003;8:S883-902.
    • (2003) Front Biosci , vol.8
    • Anisimov, V.N.1
  • 5
    • 0347416781 scopus 로고    scopus 로고
    • Genetic mouse models of extended lifespan
    • Liang H, Masoro EJ, Nelson JF, et al. Genetic mouse models of extended lifespan. Exp Gerontol 2003;38:1353-64.
    • (2003) Exp Gerontol , vol.38 , pp. 1353-1364
    • Liang, H.1    Masoro, E.J.2    Nelson, J.F.3
  • 7
    • 0037333520 scopus 로고    scopus 로고
    • The relationship between aging and carcinogenesis
    • Anisimov VN. The relationship between aging and carcinogenesis. Crit Rev Oncol Hematol 2003;45:277-304.
    • (2003) Crit Rev Oncol Hematol , vol.45 , pp. 277-304
    • Anisimov, V.N.1
  • 8
    • 0027171266 scopus 로고
    • Oxidants, antioxidants, and the degenerative diseases of aging
    • Ames BN, Shigenaga MB, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 1993;90:7915-22.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7915-7922
    • Ames, B.N.1    Shigenaga, M.B.2    Hagen, T.M.3
  • 9
    • 0031984218 scopus 로고    scopus 로고
    • Extending functional life span
    • Harman D. Extending functional life span. Exp Gerontol 1998;33:95-112.
    • (1998) Exp Gerontol , vol.33 , pp. 95-112
    • Harman, D.1
  • 10
    • 0034985743 scopus 로고    scopus 로고
    • The programmed death phenomena, aging, and the Samurai law of biology
    • Skulachev VP. The programmed death phenomena, aging, and the Samurai law of biology. Exp Gerontol 2001;36:995-1024.
    • (2001) Exp Gerontol , vol.36 , pp. 995-1024
    • Skulachev, V.P.1
  • 11
    • 0029548239 scopus 로고
    • Oxidative stress: Its potential relevance to human disease and longevity determinants
    • Cutler R. Oxidative stress: its potential relevance to human disease and longevity determinants. Age 1995;18:91-6.
    • (1995) Age , vol.18 , pp. 91-96
    • Cutler, R.1
  • 12
    • 0030297512 scopus 로고    scopus 로고
    • Factors contributing to the plasticity of the extended longevity phenotypes of Drosophila
    • Arking R, Force AG, Dugas SP, et al. Factors contributing to the plasticity of the extended longevity phenotypes of Drosophila. Exp Gerontol 1996;31:623-43.
    • (1996) Exp Gerontol , vol.31 , pp. 623-643
    • Arking, R.1    Force, A.G.2    Dugas, S.P.3
  • 13
    • 0028220114 scopus 로고
    • Extension of life-span by overexpresion of superoxide dismutase and catalase in Drosophila melanogaster
    • Orr WC, Sohal RS. Extension of life-span by overexpresion of superoxide dismutase and catalase in Drosophila melanogaster. Science 1994;263:1128-30.
    • (1994) Science , vol.263 , pp. 1128-1130
    • Orr, W.C.1    Sohal, R.S.2
  • 14
    • 0031864164 scopus 로고    scopus 로고
    • Extension of Drosophila lifespan by overexpression of human SOD1 in motoneurons
    • Parkes TL, Elia AJ, Dickinson D, et al. Extension of Drosophila lifespan by overexpression of human SOD1 in motoneurons. Nature Genetics 1998;19:171-4.
    • (1998) Nature Genetics , vol.19 , pp. 171-174
    • Parkes, T.L.1    Elia, A.J.2    Dickinson, D.3
  • 15
    • 0034284973 scopus 로고    scopus 로고
    • Extension of life-span with superoxide dismutase/catalase mimetics
    • Melov S, Ravenscroft J, Malik S, et al. Extension of life-span with superoxide dismutase/catalase mimetics. Science 2000;289:1567-9.
    • (2000) Science , vol.289 , pp. 1567-1569
    • Melov, S.1    Ravenscroft, J.2    Malik, S.3
  • 16
    • 0034006162 scopus 로고    scopus 로고
    • Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice
    • Huang TT, Carlson EJ, Gillespie AM, et al. Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice. J Gerontol A Biol Sci Med Sci 2000;55:B5-9.
    • (2000) J Gerontol A Biol Sci Med Sci , vol.55
    • Huang, T.T.1    Carlson, E.J.2    Gillespie, A.M.3
  • 17
    • 0020413493 scopus 로고
    • Butylated hydroxytoluene (BHT): A review
    • Babich H. Butylated hydroxytoluene (BHT): a review. Environ Res 1982;29:1-29.
    • (1982) Environ Res , vol.29 , pp. 1-29
    • Babich, H.1
  • 18
    • 0023500803 scopus 로고
    • The role of antioxidants in chemical carcinogenesis
    • Ito N, Hirose M. The role of antioxidants in chemical carcinogenesis. Jpn J Cancer Res 1987;78:1011-26.
    • (1987) Jpn J Cancer Res , vol.78 , pp. 1011-1026
    • Ito, N.1    Hirose, M.2
  • 19
    • 0023224628 scopus 로고
    • Ethoxyquin alone inducespreneoplastic changes in rat kidney whilst preventing induction of such lesions in liver by aflatoxin B(1)
    • Manson MM, Green JA, Driver HE. Ethoxyquin alone inducespreneoplastic changes in rat kidney whilst preventing induction of such lesions in liver by aflatoxin B(1). Carcinogenesis 1987;8:723-8.
    • (1987) Carcinogenesis , vol.8 , pp. 723-728
    • Manson, M.M.1    Green, J.A.2    Driver, H.E.3
  • 20
    • 0019314628 scopus 로고
    • Effect of the type of dietary fat at two levels of vitamin E in Wistar male rats during development and aging. I. Life span, serum biochemical parameters and pathological changes
    • Porta EA, Joun NS, Nitta RT. Effect of the type of dietary fat at two levels of vitamin E in Wistar male rats during development and aging. I. Life span, serum biochemical parameters and pathological changes. Mech Ageing Dev 1980;13:1-39.
    • (1980) Mech Ageing Dev , vol.13 , pp. 1-39
    • Porta, E.A.1    Joun, N.S.2    Nitta, R.T.3
  • 21
    • 0020571045 scopus 로고
    • Enhancing effect of vitamin E on murine intestinal tumorigenesis by 1,2-dimethylhydrazine dihydrochloride
    • Toth B, Patil K. Enhancing effect of vitamin E on murine intestinal tumorigenesis by 1,2-dimethylhydrazine dihydrochloride. J Natl Cancer Inst 1983;70:1107-11.
    • (1983) J Natl Cancer Inst , vol.70 , pp. 1107-1111
    • Toth, B.1    Patil, K.2
  • 22
    • 0022001260 scopus 로고
    • Preventive and enhancing effects of retinoids on the development of naturally occuring tumors of skin, prostate gland, and endocrine pancreas in aged male ACI/segHapBR rats
    • Ohshima M, Ward JM, Wenk ML. Preventive and enhancing effects of retinoids on the development of naturally occuring tumors of skin, prostate gland, and endocrine pancreas in aged male ACI/segHapBR rats. J Natl Cancer Inst 1985;74:517-24.
    • (1985) J Natl Cancer Inst , vol.74 , pp. 517-524
    • Ohshima, M.1    Ward, J.M.2    Wenk, M.L.3
  • 23
    • 0015156628 scopus 로고
    • Selenium and tellurium in rats: Effect on growth, survival and tumors
    • Schroeder HA, Mitchener M. Selenium and tellurium in rats: effect on growth, survival and tumors. J Nutr 1971;101:1531-40.
    • (1971) J Nutr , vol.101 , pp. 1531-1540
    • Schroeder, H.A.1    Mitchener, M.2
  • 25
    • 0032921559 scopus 로고    scopus 로고
    • Can antioxidant vitamins meterially reduce oxidative damage in humans?
    • McCall MR, Frei B. Can antioxidant vitamins meterially reduce oxidative damage in humans? Free Radical Biol Med 1999;26:1034-53.
    • (1999) Free Radical Biol Med , vol.26 , pp. 1034-1053
    • McCall, M.R.1    Frei, B.2
  • 26
    • 0037231580 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 (IGF01) and aging: Controvrses and new insights
    • Bartke A, Chandrashekar V, Dominici F, et al. Insulin-like growth factor 1 (IGF01) and aging: controvrses and new insights. Biogerontology 2003;4:1-8.
    • (2003) Biogerontology , vol.4 , pp. 1-8
    • Bartke, A.1    Chandrashekar, V.2    Dominici, F.3
  • 27
    • 0037470501 scopus 로고    scopus 로고
    • The endocrine regulation of afging by insulin-like signals
    • Tatar M, Bartke A, Antebi A. The endocrine regulation of afging by insulin-like signals. Science 2003;299:1346-51.
    • (2003) Science , vol.299 , pp. 1346-1351
    • Tatar, M.1    Bartke, A.2    Antebi, A.3
  • 28
    • 0034672599 scopus 로고    scopus 로고
    • Hyperinsulinemia: The missing link among oxidative stress and age-related diseases?
    • Facchini FS, Hua NW, Reaven GM, Stoohs RA. Hyperinsulinemia: the missing link among oxidative stress and age-related diseases? Free Radicals Biol Med 2000;29:1302-6.
    • (2000) Free Radicals Biol Med , vol.29 , pp. 1302-1306
    • Facchini, F.S.1    Hua, N.W.2    Reaven, G.M.3    Stoohs, R.A.4
  • 30
    • 0037237370 scopus 로고    scopus 로고
    • Glucose regulation and oxidative stress in healthy centenarians
    • Barbieri M, Rizzo MR, Manzella D, et al. Glucose regulation and oxidative stress in healthy centenarians. Exp Gerontol 2003;38:137-43.
    • (2003) Exp Gerontol , vol.38 , pp. 137-143
    • Barbieri, M.1    Rizzo, M.R.2    Manzella, D.3
  • 31
    • 0036123618 scopus 로고    scopus 로고
    • Colorectal cancer mortality and factors related to the insulin resistance syndrome
    • Colangelo LA, Gapstur SM, Gann PH. Colorectal cancer mortality and factors related to the insulin resistance syndrome. Cancer Epidemiol Biomarkers Prev 2002;11:385-91.
    • (2002) Cancer Epidemiol Biomarkers Prev , vol.11 , pp. 385-391
    • Colangelo, L.A.1    Gapstur, S.M.2    Gann, P.H.3
  • 33
    • 0037470488 scopus 로고    scopus 로고
    • Evolutionary medicine: From dwarf model systems to healthy centenarians?
    • Longo VD, Finch CE. Evolutionary medicine: from dwarf model systems to healthy centenarians? Science 2003;299:1342-6.
    • (2003) Science , vol.299 , pp. 1342-1346
    • Longo, V.D.1    Finch, C.E.2
  • 35
    • 0002158748 scopus 로고    scopus 로고
    • Human implications of caloric restriction's effect on laboratory animals: An overview of opportunities for research
    • Hadley EC, Dutta C, Finkelstein J, et al. Human implications of caloric restriction's effect on laboratory animals: an overview of opportunities for research. J Gerontol Ser A 2001;56A(Special issue 1):5-6.
    • (2001) J Gerontol Ser A , vol.56 A , Issue.SPEC. ISSUE 1 , pp. 5-6
    • Hadley, E.C.1    Dutta, C.2    Finkelstein, J.3
  • 36
    • 19244371274 scopus 로고    scopus 로고
    • Caloric restriction mimetics: Metabolic intervention
    • Weindruch R, Keenan KP, Carney JM, et al. Caloric restriction mimetics: metabolic intervention. J Gerontol Biol Sci 2001;56A(Special Issue 1):20-33.
    • (2001) J Gerontol Biol Sci , vol.56 A , Issue.SPEC. ISSUE 1 , pp. 20-33
    • Weindruch, R.1    Keenan, K.P.2    Carney, J.M.3
  • 37
    • 0032904778 scopus 로고    scopus 로고
    • Metformin and fatty acids
    • Muntoni S. Metformin and fatty acids. Diabetes Care 1999;22:179-80.
    • (1999) Diabetes Care , vol.22 , pp. 179-180
    • Muntoni, S.1
  • 38
    • 0142138599 scopus 로고
    • Comparative study of 5- and 10-year-long results of the metabolic rehabilitation of cancer patients
    • Hanson KP, Dilman VM, editors. St. Petersburg: NN Petrov Research Institute of Oncology Publ
    • Berstein LM, Evtushenko TP, Tsyrlina EV, et al. Comparative study of 5- and 10-year-long results of the metabolic rehabilitation of cancer patients. En: Hanson KP, Dilman VM, editors. Neuroendocrine system, metabolism, immunity and cancer (clinical aspects). St. Petersburg: NN Petrov Research Institute of Oncology Publ, 1992; p. 102-12.
    • (1992) Neuroendocrine System, Metabolism, Immunity and Cancer (Clinical Aspects) , pp. 102-112
    • Berstein, L.M.1    Evtushenko, T.P.2    Tsyrlina, E.V.3
  • 39
    • 0012712289 scopus 로고    scopus 로고
    • Effect of 1-butylbiguanide hydrochloride on the longevity in the nematoda Caenorhabditis elegans
    • Bakaev W. Effect of 1-butylbiguanide hydrochloride on the longevity in the nematoda Caenorhabditis elegans. Biogerontology 2002;3(Suppl 1):23-4.
    • (2002) Biogerontology , vol.3 , Issue.SUPPL. 1 , pp. 23-24
    • Bakaev, W.1
  • 40
    • 0344394514 scopus 로고    scopus 로고
    • Insulin and longevity: Antidiobetic biguanides as geroprotectors
    • Anisimov VN, Semenchenko AV, Yashin AI. Insulin and longevity: antidiobetic biguanides as geroprotectors. Biogerontology 2003;4:297-307.
    • (2003) Biogerontology , vol.4 , pp. 297-307
    • Anisimov, V.N.1    Semenchenko, A.V.2    Yashin, A.I.3
  • 41
    • 0036562394 scopus 로고    scopus 로고
    • Metformin and polycystic ovary syndrome: A literature review
    • Awortani KA, Cheung AP. Metformin and polycystic ovary syndrome: a literature review. J Obstet Gynecol Can 2002;24:393-401.
    • (2002) J Obstet Gynecol Can , vol.24 , pp. 393-401
    • Awortani, K.A.1    Cheung, A.P.2
  • 42
    • 0035574487 scopus 로고    scopus 로고
    • Effect of age on elements of insulin-signaling pathway in central nervous system of rats
    • Fernandes ML, Saad MJ, Velloso LA. Effect of age on elements of insulin-signaling pathway in central nervous system of rats. Endocrine 2001;16:227-34.
    • (2001) Endocrine , vol.16 , pp. 227-234
    • Fernandes, M.L.1    Saad, M.J.2    Velloso, L.A.3
  • 43
    • 0036376131 scopus 로고    scopus 로고
    • Novel signaling pathways that control ovarian follicular development, ovulation, and luteinization
    • Richards JS, Russell DL, Ochsner S, et al. Novel signaling pathways that control ovarian follicular development, ovulation, and luteinization. Recent Prog Horm Res 2002;57:195-220.
    • (2002) Recent Prog Horm Res , vol.57 , pp. 195-220
    • Richards, J.S.1    Russell, D.L.2    Ochsner, S.3
  • 44
    • 0037112250 scopus 로고    scopus 로고
    • Anti-aging effects of caloric restriction: Involvement of neuroendocrine adaptation by peripheral signaling
    • Chiba T, Yamaza H, Higami Y, Shimokawa I. Anti-aging effects of caloric restriction: Involvement of neuroendocrine adaptation by peripheral signaling. Microsc Res Tech 2002;59:317-24.
    • (2002) Microsc Res Tech , vol.59 , pp. 317-324
    • Chiba, T.1    Yamaza, H.2    Higami, Y.3    Shimokawa, I.4
  • 46
    • 0142186132 scopus 로고    scopus 로고
    • Insulin: IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention
    • Anisimov VN. Insulin: IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention. Exp Gerontol 2003;38:1041-9.
    • (2003) Exp Gerontol , vol.38 , pp. 1041-1049
    • Anisimov, V.N.1
  • 47
    • 0036255463 scopus 로고    scopus 로고
    • Metformin decreases platelet superoxide anion production in diabetic patients
    • Gargiulo P, Caccese D, Pignatelli P, et al. Metformin decreases platelet superoxide anion production in diabetic patients. Diabetes Metab Res Rev 2002;18:156-9.
    • (2002) Diabetes Metab Res Rev , vol.18 , pp. 156-159
    • Gargiulo, P.1    Caccese, D.2    Pignatelli, P.3
  • 48
    • 0037238101 scopus 로고    scopus 로고
    • Cellular senescence and apoptosis: How cellular responses might influence aging phenotypes
    • Campisi J. Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes. Exp Gerontol 2003;38:5-11.
    • (2003) Exp Gerontol , vol.38 , pp. 5-11
    • Campisi, J.1
  • 49
    • 0034855887 scopus 로고    scopus 로고
    • Neoplastic disease through the human life span
    • Maciera-Coelho A. Neoplastic disease through the human life span. Biogerontology 2001;2:179-92.
    • (2001) Biogerontology , vol.2 , pp. 179-192
    • Maciera-Coelho, A.1
  • 50
    • 0028289884 scopus 로고
    • Genome reorganization through cell division, implications for aging of the organism and cancer development
    • Maciera-Coelho A. Genome reorganization through cell division, implications for aging of the organism and cancer development. Ann NY Acad Sci 1994;719:108-28.
    • (1994) Ann NY Acad Sci , vol.719 , pp. 108-128
    • Maciera-Coelho, A.1
  • 51
    • 0031060331 scopus 로고    scopus 로고
    • Cellular aging is a critical determinant of primary cell resistance to v-src transformation
    • Tavoloni N, Inoue H. Cellular aging is a critical determinant of primary cell resistance to v-src transformation. J Virol 1997;71:237-47.
    • (1997) J Virol , vol.71 , pp. 237-247
    • Tavoloni, N.1    Inoue, H.2
  • 52
    • 0025345812 scopus 로고
    • Incerased susceptibility to SV40 transformation with development and in vitro aging
    • Kunisada T, Danner D, Friedman V, Schneider EL. Incerased susceptibility to SV40 transformation with development and in vitro aging. Exp Cell Res 1990;189:222-6.
    • (1990) Exp Cell Res , vol.189 , pp. 222-226
    • Kunisada, T.1    Danner, D.2    Friedman, V.3    Schneider, E.L.4
  • 53
    • 0034028836 scopus 로고    scopus 로고
    • Tumor supressors and oncogenes in cellular senescence
    • Bringold F, Serrano M. Tumor supressors and oncogenes in cellular senescence. Exp Gerontol 2000;35:317-29.
    • (2000) Exp Gerontol , vol.35 , pp. 317-329
    • Bringold, F.1    Serrano, M.2
  • 54
    • 0027484484 scopus 로고
    • Loss of telomeric DMA during aging may predispose cells to cancer
    • Shay JW, Wright WE, Werbin H. Loss of telomeric DMA during aging may predispose cells to cancer. Int J Oncology 1993;3:559-63.
    • (1993) Int J Oncology , vol.3 , pp. 559-563
    • Shay, J.W.1    Wright, W.E.2    Werbin, H.3
  • 55
    • 0032407917 scopus 로고    scopus 로고
    • A reassessment of the telomere hypothesis of senescence
    • Reddel RR. A reassessment of the telomere hypothesis of senescence. Bioessays 1998;20:977-84.
    • (1998) Bioessays , vol.20 , pp. 977-984
    • Reddel, R.R.1
  • 56
    • 0035850870 scopus 로고    scopus 로고
    • How carcinogens (or telomere dysfunction) induce genetic instability: Associated-selection model
    • Blagosklonny MV. How carcinogens (or telomere dysfunction) induce genetic instability: associated-selection model. FEBS Lett 2001;506:169-72.
    • (2001) FEBS Lett , vol.506 , pp. 169-172
    • Blagosklonny, M.V.1
  • 57
  • 58
    • 0035834121 scopus 로고    scopus 로고
    • Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
    • Krtolica A, Parinello S, Locckett S, et al. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci USA 2001;98:12072-7.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12072-12077
    • Krtolica, A.1    Parinello, S.2    Locckett, S.3
  • 59
    • 0030929127 scopus 로고    scopus 로고
    • Aging and cancer: The role of stromal interactions with epithelial cells
    • Rinehart CA, Torti VR. Aging and cancer: the role of stromal interactions with epithelial cells. Mol Carcinogenesis 1997;18:187-92.
    • (1997) Mol Carcinogenesis , vol.18 , pp. 187-192
    • Rinehart, C.A.1    Torti, V.R.2
  • 60
    • 0035793381 scopus 로고    scopus 로고
    • Lack of replicative senescence in normal rodent glia
    • Mathon NF, Malcolm DS, Harrisingh MC, et al. Lack of replicative senescence in normal rodent glia. Science 2001;291:872-5.
    • (2001) Science , vol.291 , pp. 872-875
    • Mathon, N.F.1    Malcolm, D.S.2    Harrisingh, M.C.3
  • 61
    • 0035793380 scopus 로고    scopus 로고
    • Lack of replicative senescence in cultured rat oligodendrocyte precursor cell
    • Tang DG, Tokumoto YM, Apperly JA, et al. Lack of replicative senescence in cultured rat oligodendrocyte precursor cell. Science 2001;291:868-71.
    • (2001) Science , vol.291 , pp. 868-871
    • Tang, D.G.1    Tokumoto, Y.M.2    Apperly, J.A.3
  • 62
    • 0035252089 scopus 로고    scopus 로고
    • Normal human mammary epithelial cells spontaneously escape senescence and aquire genomic changes
    • Romanov SR, Kozakiewicz BK, Holst CR, et al. Normal human mammary epithelial cells spontaneously escape senescence and aquire genomic changes. Nature 2001;409:633-7.
    • (2001) Nature , vol.409 , pp. 633-637
    • Romanov, S.R.1    Kozakiewicz, B.K.2    Holst, C.R.3
  • 63
    • 0035403274 scopus 로고    scopus 로고
    • A old epithelial cell never dies, it just agonesces away
    • Clevenger CV. A old epithelial cell never dies, it just agonesces away. Trends Endocrinol Metab 2001;12:183-4.
    • (2001) Trends Endocrinol Metab , vol.12 , pp. 183-184
    • Clevenger, C.V.1
  • 64
    • 0033208626 scopus 로고    scopus 로고
    • Changes of telomerase and telomere length in paried normal and cancer tissues of breast
    • Rha SY. Changes of telomerase and telomere length in paried normal and cancer tissues of breast. Int J Oncol 1999;15:839-45.
    • (1999) Int J Oncol , vol.15 , pp. 839-845
    • Rha, S.Y.1
  • 65
    • 0023884584 scopus 로고
    • Influence of host age on lung colony forming capacity of injected rat rhabdomyosarcoma cells
    • Anisimov VN, Zhukovskaya NV, Loktionov AS, et al. Influence of host age on lung colony forming capacity of injected rat rhabdomyosarcoma cells. Cancer Lett 1988;40:77-82.
    • (1988) Cancer Lett , vol.40 , pp. 77-82
    • Anisimov, V.N.1    Zhukovskaya, N.V.2    Loktionov, A.S.3
  • 66
    • 0027998414 scopus 로고
    • Age-dependent regulation of the tumorigenic potential of neoplastically transformed rat liver epithelial cells by the liver microenvironment
    • McCullough KD, Coleman WB, Smith GJ, Grisham JW. Age-dependent regulation of the tumorigenic potential of neoplastically transformed rat liver epithelial cells by the liver microenvironment. Cancer Res 1994;54:3668-71.
    • (1994) Cancer Res , vol.54 , pp. 3668-3671
    • McCullough, K.D.1    Coleman, W.B.2    Smith, G.J.3    Grisham, J.W.4
  • 69
    • 0034987074 scopus 로고    scopus 로고
    • Human aging and melotonin. Clinical relevance
    • Touitou Y. Human aging and melotonin. Clinical relevance. Exp Gerontol 2001;36:1083-100.
    • (2001) Exp Gerontol , vol.36 , pp. 1083-1100
    • Touitou, Y.1
  • 71
    • 0032876501 scopus 로고    scopus 로고
    • Augmentation of indices of oxidative damage in life-long melatonin-deficient rats
    • Reiter RJ, Tan DX, Kim SJ, et al. Augmentation of indices of oxidative damage in life-long melatonin-deficient rats. Mech Ageing Dev 1999;110:157-73.
    • (1999) Mech Ageing Dev , vol.110 , pp. 157-173
    • Reiter, R.J.1    Tan, D.X.2    Kim, S.J.3
  • 72
    • 0027952777 scopus 로고
    • Pineal control of aging: Effect of melatonin and pineal grafting on aging mice
    • Pierpaoli W, Regelson W. Pineal control of aging: effect of melatonin and pineal grafting on aging mice. Proc Natl Acad Sci USA 1994;91:787-91.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 787-791
    • Pierpaoli, W.1    Regelson, W.2
  • 73
    • 0028286713 scopus 로고
    • Pineal cross-transplantation (old-to-young and vice versa) as evidence for an endogenous «aging clock»
    • Lesnikov VA, Pierpaoli W. Pineal cross-transplantation (old-to-young and vice versa) as evidence for an endogenous «aging clock». Ann NY Acad Sci 1994;719:461-73.
    • (1994) Ann NY Acad Sci , vol.719 , pp. 461-473
    • Lesnikov, V.A.1    Pierpaoli, W.2
  • 74
    • 0242552333 scopus 로고    scopus 로고
    • Effects of exogenous melatonin: A review
    • Anisimov VN. Effects of exogenous melatonin: a review. Toxicol Pathol 2003b;31:589-603.
    • (2003) Toxicol Pathol , vol.31 , pp. 589-603
    • Anisimov, V.N.1
  • 76
    • 0001366611 scopus 로고    scopus 로고
    • Effect of melatonin and physiological epiphysectomy on the developmet of spontaneous endometrial carcinoma in BDII/HAN rats
    • Deerberg F, Bartsch C, Pohlmeyer G, Bartsch H. Effect of melatonin and physiological epiphysectomy on the developmet of spontaneous endometrial carcinoma in BDII/HAN rats. Cancer Biother Radiopharmacol 1997;12:420.
    • (1997) Cancer Biother Radiopharmacol , vol.12 , pp. 420
    • Deerberg, F.1    Bartsch, C.2    Pohlmeyer, G.3    Bartsch, H.4
  • 77
    • 0031428105 scopus 로고    scopus 로고
    • Melatonin and colon carcinogenesis: I. Inhibitory effects of melatonin on development of intestinal tumors induced by 1,2-dimethylhydrazine in rats
    • Anisimov VN, Popovich IG, Zabezhinski MA. Melatonin and colon carcinogenesis: I. Inhibitory effects of melatonin on development of intestinal tumors induced by 1,2-dimethylhydrazine in rats. Carcinogenesis 1997;18:1549-53.
    • (1997) Carcinogenesis , vol.18 , pp. 1549-1553
    • Anisimov, V.N.1    Popovich, I.G.2    Zabezhinski, M.A.3
  • 78
    • 0034637710 scopus 로고    scopus 로고
    • Inhibitory effect of melatonin on 7,12-dimethylbenz[a]anthracene-induced carcinogenesis of the uterine cervix and vagina in mice and mutagenesis in vitro
    • Anisimov VN, Zabezhinski MA, Popovich IG, et al. Inhibitory effect of melatonin on 7,12-dimethylbenz[a]anthracene-induced carcinogenesis of the uterine cervix and vagina in mice and mutagenesis in vitro. Cancer Lett 2000;156:199-205.
    • (2000) Cancer Lett , vol.156 , pp. 199-205
    • Anisimov, V.N.1    Zabezhinski, M.A.2    Popovich, I.G.3
  • 79
    • 0034601171 scopus 로고    scopus 로고
    • Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: Relation to the influence of electromagnetic near field exposure
    • Imaida K, Hagiwara A, Yoshino H, et al. Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure. Cancer Lett 2000;155:105-14.
    • (2000) Cancer Lett , vol.155 , pp. 105-114
    • Imaida, K.1    Hagiwara, A.2    Yoshino, H.3
  • 80
    • 0036936925 scopus 로고    scopus 로고
    • Is there a role for melatonin in supportive care?
    • Lissoni P. Is there a role for melatonin in supportive care? Support Care Cancer 2002;10:110-6.
    • (2002) Support Care Cancer , vol.10 , pp. 110-116
    • Lissoni, P.1
  • 81
    • 0035131845 scopus 로고    scopus 로고
    • Effects of melatonin in perimenopausal and menopousal women: A randomized and placebo controlled study
    • Bellipanni G, Bianchi P, Pierpaoli W, et al. Effects of melatonin in perimenopausal and menopousal women: a randomized and placebo controlled study. Exp Gerontol 2001;36:297-310.
    • (2001) Exp Gerontol , vol.36 , pp. 297-310
    • Bellipanni, G.1    Bianchi, P.2    Pierpaoli, W.3
  • 82
    • 0004002410 scopus 로고    scopus 로고
    • Special Committee on Aging, GAO-01-1129, September
    • US General Accounting Office. Anti-aging products pose potential for physical and economic harm. Special Committee on Aging, GAO-01-1129, September 2001. Disponible en: htip://aging.senate.gov/hr73gao.pdf
    • (2001) Anti-aging Products Pose Potential for Physical and Economic Harm
  • 83
    • 0034993181 scopus 로고    scopus 로고
    • Life span extension and cancer risk: Myths and reality
    • Anisimov VN. Life span extension and cancer risk: myths and reality. Exp Geront 2001;36:1101-36.
    • (2001) Exp Geront , vol.36 , pp. 1101-1136
    • Anisimov, V.N.1
  • 84
    • 0025650442 scopus 로고
    • Prolongation of the yeast life span by the v-Ha-RAS oncogene
    • Chen JB, Sun J, Jazwinski SM. Prolongation of the yeast life span by the v-Ha-RAS oncogene. Mol Microbiol 1990;4:2081-6.
    • (1990) Mol Microbiol , vol.4 , pp. 2081-2086
    • Chen, J.B.1    Sun, J.2    Jazwinski, S.M.3
  • 85
    • 0032582489 scopus 로고    scopus 로고
    • Extended life-span and stress resistance in the Drosophila mutant methuselah
    • Lin YJ, Seroude L, Benzer S. Extended life-span and stress resistance in the Drosophila mutant methuselah. Science 1998;282:943-6.
    • (1998) Science , vol.282 , pp. 943-946
    • Lin, Y.J.1    Seroude, L.2    Benzer, S.3
  • 86
    • 0029768753 scopus 로고    scopus 로고
    • A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
    • Morris JZ, Tissenbaum HA, Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 1996;382:536-9.
    • (1996) Nature , vol.382 , pp. 536-539
    • Morris, J.Z.1    Tissenbaum, H.A.2    Ruvkun, G.3
  • 87
    • 0030813398 scopus 로고    scopus 로고
    • daf-2, an insulin receptor-like gene that regulated longevity and diapause in Caenorhabditis elegans
    • Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulated longevity and diapause in Caenorhabditis elegans. Science 1997;277:942-6.
    • (1997) Science , vol.277 , pp. 942-946
    • Kimura, K.D.1    Tissenbaum, H.A.2    Liu, Y.3    Ruvkun, G.4
  • 88
    • 0036671827 scopus 로고    scopus 로고
    • Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span
    • Mitsui A, Hamuro J, Nakamura R, et al. Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span. Antioxid Redox Signal 2002;4:693-6.
    • (2002) Antioxid Redox Signal , vol.4 , pp. 693-696
    • Mitsui, A.1    Hamuro, J.2    Nakamura, R.3
  • 89
    • 0033581704 scopus 로고    scopus 로고
    • The p66shr adaptor protein controls oxidative stress response and life span in mammals
    • Migliaccio E, Giorgio M, Mele S, et al. The p66shr adaptor protein controls oxidative stress response and life span in mammals. Nature 1999;402:309-13.
    • (1999) Nature , vol.402 , pp. 309-313
    • Migliaccio, E.1    Giorgio, M.2    Mele, S.3
  • 90
    • 0347664057 scopus 로고    scopus 로고
    • IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
    • Holzenberger M, Dupond J, Ducos B, et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 2003;421: 182-7.
    • (2003) Nature , vol.421 , pp. 182-187
    • Holzenberger, M.1    Dupond, J.2    Ducos, B.3
  • 91
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life span by introduction of telomerase into normal human cells
    • Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life span by introduction of telomerase into normal human cells. Sciences 1998; 279:349-52.
    • (1998) Sciences , vol.279 , pp. 349-352
    • Bodnar, A.G.1    Ouellette, M.2    Frolkis, M.3


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