Anti-aging effects of caloric restriction: Involvement of neuroendocrine adaptation by peripheral signaling

Microscopy Research and Technique

Volumn 59, Issue 4, 2002, Pages 317-324

  Chiba, Takuya ^a   Yamaza, Haruyoshi ^a   Higami, Yoshikazu ^a   Shimokawa, Isao ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Adipocytokine; Ghrelin; IGF I; Insulin; Leptin

Indexed keywords

HISTOLOGY; TISSUE;

ADAPTIVE RESPONSE; ADIPOCYTOKINES; ADIPOSE TISSUE; AGEING EFFECTS; ANTI-AGING; CALORIC RESTRICTION; GHRELIN; HORMONAL SIGNALS; IGF-I; LEPTINS;

INSULIN;

ADIPONECTIN; ADIPSIN; ANOREXIGENIC AGENT; APPETITE STIMULANT; CYTOKINE; GHRELIN; INSULIN; INTERLEUKIN 6; LEPTIN; NEUROPEPTIDE; PLASMINOGEN ACTIVATOR INHIBITOR 1; RESISTIN; SOMATOMEDIN C; TUMOR NECROSIS FACTOR ALPHA;

ADAPTATION; ADIPOCYTE; ADIPOSE TISSUE; AGING; APPETITE; ARTICLE; CALORIC RESTRICTION; ENERGY; EVOLUTION; FOOD INTAKE; HOMEOSTASIS; HUMAN; HYPOTHALAMUS; LONGEVITY; NEUROENDOCRINE SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; SURVIVAL;

EID: 0037112250     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jemt.10211     Document Type: Article

References (95)

1. Adam CL, Findlay PA, Kyle CE, Young P, Mercer JG. 1997. Effect of chronic food restriction on pulsatile luteinizing hormone secretion and hypothalamic neuropeptide Y gene expression in castrate male sheep. J Endocrinol 152:329-337.
2. Ahima RS. 2000. Leptin and the neuroendocrinology of fasting. Front Horm Res 26:42-56.
3. Ahima RS, Flier JS. 2000a. Adipose tissue as an endocrine organ. Trends Endocrinol Metab 11:327-332.
4. Ahima RS, Flier JS. 2000b. Leptin. Annu Rev Physiol 62:413-437.
5. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS. 1996. Role of leptin in the neuroendocrine response to fasting. Nature 382:250-252.
6. Alessi MC, Peiretti F, Morange P, Henry M, Nalbone G, Juhan-Vague I. 1997. Production of plasminogen activator inhibitor 1 by human adipose tissue: Possible link between visceral fat accumulation and vascular disease. Diabetes 46:860-867.
7. Anfosso F, Alessi MC, Nalbone G, Chomiki N, Henry M, Juhan-Vague I. 1995. Up-regulated expression of plasminogen activator inhibitor-1 in Hep G2 cells: Interrelationship between insulin and insulin-like growth factor 1. Thromb Haemost 73:268-274.
8. Araki E, Lipes MA, Patti ME, Bruning JC, Haag B, 3rd, Johnson RS, Kahn CR. 1994. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 372:186-190.
9. Barker-Gibb ML, Clarke IJ. 1996. Increased galanin and neuropeptide-Y immunoreactivity within the hypothalamus of ovariectomised ewes following a prolonged period of reduced body weight is associated with changes in plasma growth hormone but not gonadotropin levels. Neuroendocrinology 64:194-207.
10. Bartke A, Wright JC, Mattison JA, Ingram DK, Miller RA, Roth GS. 2001. Extending the lifespan of long-lived mice. Nature 414:412.
11. Barzilai N, Gupta G. 1999. Revisiting the role of fat mass in the life extension induced by caloric restriction. J Gerontol A Biol Sci Med Sci 54:B89-96.
12. Barzilai N, Banerjee S, Hawkins M, Chen W, Rossetti L. 1998. Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat. J Clin Invest 101:1353-1361.
13. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. 2001. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7:947-953.
14. Brady LS, Smith MA, Gold PW, Herkenham M. 1990. Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats. Neuroendocrinology 52:441-447.
15. Breese CR, Ingram RL, Sonntag WE. 1991. Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins. J Gerontol 46:B180-187.
16. Brown-Borg HM, Borg KE, Meliska CJ, Bartke A. 1996. Dwarf mice and the ageing process. Nature 384:33.
17. Bruning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR. 1997. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 88:561-572.
18. Bruning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, Klein R, Krone W, Muller-Wieland D, Kahn CR. 2000. Role of brain insulin receptor in control of body weight and reproduction. Science 289:2122-2125.
19. Carpenter LR, Farruggella TJ, Symes A, Karow ML, Yancopoulos GD, Stahl N. 1998. Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor. Proc Natl Acad Sci USA 95:6061-6066.
20. Carvalheira JB, Siloto RM, Ignacchitti I, Brenelli SL, Carvalho CR, Leite A, Velloso LA, Gontijo JA, Saad MJ. 2001. Insulin modulates leptin-induced STAT3 activation in rat hypothalamus. FEBS Lett 500:119-124.
21. Cianflone K, Maslowska M, Sniderman AD. 1999. Acylation stimulating protein (ASP), an adipocyte autocrine: New directions. Semin Cell Dev Biol 10:31-41.
22. Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E, Leevers SJ, Partridge L. 2001. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292:104-106.
23. Coschigano KT, Clemmons D, Bellush LL, Kopchick JJ. 2000. Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology 141:2608-2613.
24. Date Y, Murakami N, Kojima M, Kuroiwa T, Matsukura S, Kangawa K, Nakazato M. 2000. Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rats. Biochem Biophys Res Commun 275:477-480.
25. Doglio A, Dani C, Fredrikson G, Grimaldi P, Ailhaud G. 1987. Acute regulation of insulin-like growth factor-I gene expression by growth hormone during adipose cell differentiation. Embo J 6:4011-4016.
26. Figlewicz DP, Dorsa DM, Stein LJ, Baskin DG, Paquette T, Greenwood MR, Woods SC, Porte D, Jr. 1985. Brain and liver insulin binding is decreased in Zucker rats carrying the 'fa' gene. Endocrinology 117:1537-1543.
27. Flier JS, Cook KS, Usher P, Spiegelman BM. 1987. Severely impaired adipsin expression in genetic and acquired obesity. Science 237:405-408.
28. Flier JS, Lowell B, Napolitano A, Usher P, Rosen B, Cook KS, Spiegelman B. 1989. Adipsin: Regulation and dysregulation in obesity and other metabolic states. Recent Prog Horm Res 45:567-580; discussion 580-561.
29. Flurkey K, Papaconstantinou J, Miller RA, Harrison DE. 2001. Life-span extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci U S A 98:6736-6741.
30. Friedman JM, Halaas JL. 1998. Leptin and the regulation of body weight in mammals. Nature 395:763-770.
31. Fruhbeck G, Gomez-Ambrosi J, Muruzabal FJ, Burrell MA .2001. The adipocyte: A model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am J Physiol Endocrinol Metab 280:E827-847.
32. Grunfeld C, Feingold KR. 1996. Regulation of lipid metabolism by cytokines during host defense. Nutrition 12:S24-26.
33. Guan XM, Yu H, Palyha OC, McKee KK, Feighner SD, Sirinathsinghji DJ, Smith RG, Van der Ploeg LH, Howard AD. 1997. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res Mol Brain Res 48:23-29.
34. Guarente L, Kenyon C. 2000. Genetic pathways that regulate ageing in model organisms. Nature 408:255-262.
35. Harrison DE, Archer JR, Astle CM. 1984. Effects of food restriction on aging: Separation of food intake and adiposity. Proc Natl Acad Sci USA 81:1835-1838.
36. Havel PJ. 2001. Peripheral signals conveying metabolic information to the brain: Short-term and long-term regulation of food intake and energy homeostasis. Exp Biol Med (Maywood) 226:963-977.
37. Hekimi S, Burgess J, Bussiere F, Meng Y, Benard C. 2001. Genetics of lifespan in C. elegans: Molecular diversity, physiological complexity, mechanistic simplicity. Trends Genet 17:712-718.
38. Holliday R. 1989. Food, reproduction and longevity: Is the extended lifespan of calorie-restricted animals an evolutionary adaptation? Bioessays 10:125-127.
39. Hotamisligil GS, Shargill NS, Spiegelman BM. 1993. Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science 259:87-91.
40. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K, Nishida M, Kihara S, Sakai N, Nakajima T, Hasegawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Hanafusa T, Matsuzawa Y. 2000. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 20:1595-1599.
41. Hu E, Liang P, Spiegelman BM. 1996. AdipoQ is a novel adiposespecific gene dysregulated in obesity. J Biol Chem 271:10697-10703.
42. Imura H, Fukata J, Mori T. 1991. Cytokines and endocrine function: An interaction between the immune and neuroendocrine systems. Clin Endocrinol (Oxf) 35:107-115.
43. Juhan-Vague I, Alessi MC. 1997. PAI-1, obesity, insulin resistance and risk of cardiovascular events. Thromb Haemost 78:656-660.
44. Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW, Neifing JL, Ward WK, Beard JC, Palmer JP, Porte D, Jr. 1993. Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 42:1663-1672.
45. Kalra SP, Dube MG, Pu S, Xu B, Horvath TL, Kalra PS. 1999. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev 20:68-100.
46. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. 1993. A C. elegans mutant that lives twice as long as wild type. Nature 366:461-464.
47. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. 1999. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660.
48. Li C, Friedman JM. 1999. Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. Proc Natl Acad Sci U S A 96:9677-9682.
49. Masoro EJ. 1988. Food restriction in rodents: An evaluation of its role in the study of aging. J Gerontol 43:B59-64.
50. Matsuzawa Y, Funahashi T, Nakamura T. 1999. Molecular mechanism of metabolic syndrome X: Contribution of adipocytokines adipocyte-derived bioactive substances. Ann N Y Acad Sci 892:146-154.
51. McShane TM, Wilson ME, Wise PM. 1999. Effects of lifelong moderate caloric restriction on levels of neuropeptide Y, proopiomelanocortin, and galanin mRNA. J Gerontol A Biol Sci Med Sci 54:B14-21.
52. Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lanfrancone L, Pelicci PG. 1999. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402:309-313.
53. Miskin R, Masos T. 1997. Transgenic mice overexpressing urokinase-type plasminogen activator in the brain exhibit reduced food consumption, body weight and size, and increased longevity. J Gerontol A Biol Sci Med Sci 52:B118-124.
54. Mohamed-Ali V, Pinkney JH, Coppack SW. 1998. Adipose tissue as an endocrine and paracrine organ. Int J Obes Relat Metab Disord 22:1145-1158.
55. Morris JZ, Tissenbaum HA, Ruvkun G. 1996. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382:536-539.
56. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S. 2001. A role for ghrelin in the central regulation of feeding. Nature 409:194-198.
57. Napolitano A, Lowell BB, Damm D, Leibel RL, Ravussin E, Jimerson DC, Lesem MD, Van Dyke DC, Daly PA, Chatis P, White RT, Spiegelman BM, Flier JS. 1994. Concentrations of adipsin in blood and rates of adipsin secretion by adipose tissue in humans with normal, elevated and diminished adipose tissue mass. Int J Obes Relat Metab Disord 18:213-218.
58. Nelson JF. 1994. Neuroendocrine involvement in the retardation of aging by dietary restriction: A hypothesis. In: Yu BP, editor. Modulation of Aging Processes by Dietary Restriction. Boca Raton: CRC Press. p 37-55.
59. Polonsky KS, Given BD, Hirsch L, Shapiro ET, Tillil H, Beebe C, Galloway JA, Frank BH, Karrison T, Van Cauter E. 1988. Quantitative study of insulin secretion and clearance in normal and obese subjects. J Clin Invest 81:435-441.
60. Saltiel AR, Kahn CR. 2001. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414:799-806.
61. Scacchi M, Pincelli AI, Cavagnini F. 1999. Growth hormone in obesity. Int J Obes Relat Metab Disord 23:260-271.
62. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. 1995. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270:26746-26749.
63. Schwartz MW, Baskin DG, Kaiyala KJ, Woods SC. 1999. Model for the regulation of energy balance and adiposity by the central nervous system. Am J Clin Nutr 69:584-596.
64. Schwartz MW, Woods SC, Porte D, Jr, Seeley RJ, Baskin DG. 2000. Central nervous system control of food intake. Nature 404:661-671.
65. Seoane LM, Tovar S, Baldelli R, Arvat E, Ghigo E, Casanueva FF, Dieguez C. 2000. Ghrelin elicits a marked stimulatory effect on GH secretion in freely-moving rats. Eur J Endocrinol 143:R7-9.
66. Shimokawa I, Higami Y. 1999. A role for leptin in the antiaging action of dietary restriction: A hypothesis. Aging (Milano) 11:380-382.
67. Shimokawa I, Higami Y. 2001a. Leptin and anti-aging action of caloric restriction. J Nutr Health Aging 5:43-48.
68. Shimokawa I, Higami Y. 2001b. Leptin signaling and aging: Insight from caloric restriction. Mech Ageing Dev 122:1511-1519.
69. Shimokawa I, Higami Y. 2001c. A role for suppression of growth hormone in the anti-aging action of caloric restriction. Gerontology 47:582.
70. Shimokawa I, Higami T, Utsuyama M, Tuchiya T, Komatsu T, Chiba T, Yamaza H. 2002. Life span extension by reduction in growth hormone-insulin-like growth factor-1 axis in a transgenic rat model. Am J Pathol. 160:2259-2265.
71. Shimomura I, Funahashi T, Takahashi M, Maeda K, Kotani K, Nakamura T, Yamashita S, Miura M, Fukuda Y, Takemura K, Tokunaga K, Matsuzawa Y. 1996. Enhanced expression of PAI-1 in visceral fat: Possible contributor to vascular disease in obesity. Nat Med 2:800-803.
72. Sniderman AD, Cianflone KM, Eckel RH. 1991. Levels of acylation stimulating protein in obese women before and after moderate weight loss. Int J Obes 15:333-336.
73. Sonntag WE, Xu X, Ingram RL, D'Costa A. 1995. Moderate caloric restriction alters the subcellular distribution of somatostatin mRNA and increases growth hormone pulse amplitude in aged animals. Neuroendocrinology 61:601-608.
74. Spanswick D, Smith MA, Groppi VE, Logan SD, Ashford ML. 1997. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390:521-525.
75. Spanswick D, Smith MA, Mirshamsi S, Routh VH, Ashford ML. 2000. Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats. Nat Neurosci 3:757-758.
76. Spaulding CC, Walford RL, Effros RB. 1997. Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-alpha and IL-6 in C3B10RF1 mice. Mech Ageing Dev 93:87-94.
77. Spiegelman BM, Flier JS. 1996. Adipogenesis and obesity: Rounding out the big picture. Cell 87:377-389.
78. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA. 2001. The hormone resistin links obesity to diabetes. Nature 409:307-312.
79. Stouthard JM, Romijn JA, Van der Poll T, Endert E, Klein S, Bakker PJ, Veenhof CH, Sauerwein HP. 1995. Endocrinologic and metabolic effects of interleukin-6 in humans. Am J Physiol 268:E813819.
80. Sze JY, Victor M, Loer C, Shi Y, Ruvkun G. 2000. Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature 403:560-564.
81. Tamemoto H, Kadowaki T, Tobe K, Yagi T, Sakura H, Hayakawa T, Terauchi Y, Ueki K, Kaburagi Y, Satoh S, Sekihara H, Yoshioka S, Horikoshi H, Furuta Y, Ikawa Y, Kasuga M, Yazaki Y, Aizawa S. 1994. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372:182-186.
82. Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS. 2001. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292:107-110.
83. Tolle V, Zizzari P, Tomasetto C, Rio MC, Epelbaum J, Bluet-Pajot MT. 2001. In vivo and in vitro effects of ghrelin/motilin-related peptide on growth hormone secretion in the rat. Neuroendocrinology 73:5461.
84. Tschöp M, Smiley DL, Heiman ML. 2000. Ghrelin induces adiposity in rodents. Nature 407:908-913.
85. Tsigos C, Papanicolaou DA, Defensor R, Mitsiadis CS, Kyrou I, Chrousos GP. 1997. Dose effects of recombinant human interleukin-6 on pituitary hormone secretion and energy expenditure. Neuroendocrinology 66:54-62.
86. Vgontzas AN, Papanicolaou DA, Bixler EO, Kales A, Tyson K, Chrousos GP. 1997. Elevation of plasma cytokines in disorders of excessive daytime sleepiness: Role of sleep disturbance and obesity. J Clin Endocrinol Metab 82:1313-1316.
87. Way JM, Gorgun CZ, Tong Q, Uysal KT, Brown KK, Harrington WW, Oliver WR, Jr., Willson TM, Kliewer SA, Hotamisligil GS. 2001. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. J Biol Chem 276:25651-25653.
88. Weindruch R, Wolford RL. 1988. The Retardation of Aging and Disease by Dietary Restriction. Springfield: Charles C Thomas Publisher.
89. White DW, Kuropatwinski KK, Devos R, Baumann H, Tartaglia LA. 1997. Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization. J Biol Chem 272:4065-4071.
90. Wolkow CA, Kimura KD, Lee MS, Ruvkun G. 2000. Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science 290:147-150.
91. Woods SC, Seeley RJ. 2000. Adiposity signals and the control of energy homeostasis. Nutrition 16:894-902.
92. Xu B, Kalra PS, Farmerie WG, Kalra SP. 1999. Daily changes in hypothalamic gene expression of neuropeptide Y, galanin, proopiomelanocortin, and adipocyte leptin gene expression and secretion: Effects of food restriction. Endocrinology 140:2868-2875.
93. Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T. 2001. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7:941-946.
94. Yasruel Z, Cianflone K, Sniderman AD, Rosenbloom M, Walsh M, Rodriguez MA. 1991. Effect of acylation stimulating protein on the triacylglycerol synthetic pathway of human adipose tissue. Lipids 26:495-499.
95. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432.