Extending functional life span

Experimental Gerontology

Volumn 33, Issue 1-2, 1998, Pages 95-112

  Harman, Denham ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA AT OMAHA   (United States)

Author keywords

Aging; Antioxidants; Free radicals; Longevity; Phytochemicals

Indexed keywords

FREE RADICAL;

AGING; DEVELOPED COUNTRY; DEVELOPMENT; ENVIRONMENT; GENETIC DISORDER; HUMAN; LIFE EXPECTANCY; LIFESPAN; LONGEVITY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; RISK FACTOR;

EID: 0031984218     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(97)00059-4     Document Type: Article

References (101)

1. AMES, B.N., PROFET, M., and GOLD, L. S. Dietary pesticides (99.99% all natural). Proc. Natl. Acad. Sci. USA 87, 7777-7781, 1990.
2. ARUOMA, O.I., BOMFORD, A., POISON, J.J., and HALLIWELL, B. Nontransferrin-bound iron in plasma from hemochromatosis patients: Effect of phlebotomy therapy. Blood 72, 1416-1419, 1988.
3. BANDY, B. and DAVISON, A.J. Mitochondrial mutations may increase oxidative stress: Implications for carcinogenesis and aging? Free Radic. Biol. Med. 8, 523-539, 1990.
4. 2 consumption can explain the simultaneous presence of high longevity and high aerobic metabolic rate in birds. Free Radic. Res. 21, 317-328, 1994.
5. BENSON, A.M., BATZINGER, R.P., OU, S.-Y.L., BUEDING. E., CHA, Y.-N., and TALALAY, P. Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants. Cancer Res. 38, 4486-4495, 1978.
6. BENSON, A.M., HUNKELER, M.J., and TALALAY, P. Increase of NAD(P)H:quinone reductase by dietary antioxidants: Possible role in protection against carcinogenesis and toxicity. Proc. Natl. Acad. Sci. USA 77, 5216-5230, 1980.
7. BENSON, A.M., BARRETTO, P., and STANLEY, J.S. Induction of DT-diaphorase by anticarcinogenic sulfur compounds in mice. J. Natl. Cancer Inst. 76, 467-473, 1986.
8. BLOCK, G., PATTERSON, B., and SUBAR, A. Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence. Nutr. Cancer 18, 1-29, 1992.
9. BOURLIERE, F. Symposium of the European Biology Section of the International Association of Gerontology. Experientia 18, 470-478, 1962.
10. CAREY, J.R., LIEDO, P. OROZCO, D., and VAUPEL, J.W. Slowing of mortality rates at older ages in large medfly cohorts. Science 258, 457-463, 1992.
11. CARNEY, J.M., STARKE-REED, P.E., OLIVER, C.N., LANDUM, R.W., CHENG, M.S., WU, J.F., and FLOYD, R.A. Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-α-phenylnitrone. Proc. Natl. Acad. Sci. USA 88, 3633-3636, 1991.
12. CLAPP, N.K., SATTERFIELD, L.C., and BOWLES, N.D. Effects of the antioxidant butylated hydroxytoluene (BHT) on mortality in BALB/c mice. J. Gerontol. 34, 497-501, 1979.
13. COMFORT, A. Effect of ethoxyquin on the longevity of C3H mice. Nature, 229, 254-255, 1971.
14. COMFORT, A. The Biology of Senescence, 3rd ed., pp. 81-86, Elsevier, New York, 1979.
15. CURTSINGER, J.W., FUKUI, H.H., TOWNSEND, D.R., and VAUPEL, J.W. Demography of genotypes: Failure of the limited life-span paradigm in Drosophila melanogaster. Science 258, 461-463, 1992.
16. DIPLOCK, A.T. Antioxidant nutrients and disease prevention: An overview. Am. J. Clin. Nutr. 53(Suppl 1), 189S-193S, 1991.
17. DWYER. S., BERRIOS, A., and ARKING, R. Extended longevity and enhanced antioxidant defenses in Drosophila. Gerontology 29, 186a, 1989.
18. EDAMATSU, R., MORI, A., and PACKER, L. The spin-trap N-tert-α-butylnitrone prolongs the life span of the senescence accelerated mouse. Biochem. Biophys. Res. Commun. 211, 847-849, 1995.
19. EMANUEL, N.M. Free radicals and the action of inhibitors of radical processes under pathological states and aging in living organisms and man. Q. Rev. Biophys. 9, 283-308, 1976.
20. EMANUEL, N.M., DUBURS, G., OBUKHOV, L.K., and ULDRIKIS, J. Drug for prophylaxis of aging and prolongation of lifetime. Chem. Abstr. 94, 9632a, 1981.
21. EPSTEIN, J. and GERSHON, D. Studies on aging in nematodes, IV. The effect of antioxidants on cellular damage and life span. Mech. Ageing Dev. 1, 257-264, 1972.
22. FLEMING, J.E., MIQUEL, J., COTTRELL, S. F., YENGOYAN, L.S., and ECONOMOS. A.C. Is cell aging caused by respiratory-dependent injury to the mitochondrial genome? Gerontology 28, 44-53, 1982.
23. FLOYD, R.A. Oxidative damage to behavior during aging. Science 254, 1597, 1991.
24. FOTSIS, T., PEPPER, M., ADLERCREUTZ, H., FLEISCHMANN, G., HASE, T., MONTESANO, R., and SCHWEIGERER, L. Genistein, a dietary-derived inhibitor of in vitro angiogenesis. Proc. Natl. Acad. Sci. USA 90, 2690-2694, 1993.
25. FRANKEL, E.N., KANNER, J., GERMAN, J.B., PARKS, E., and KINSELLA, J.E. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341, 454-457, 1993.
26. GLAGOV, S., ZARINS, C., GIDDENS, D. P., and KU, D.N. Hemodynamics and atherosclerosis. Arch. Pathol. Lab. Med. 112, 1018-1031, 1988.
27. GRAF, E., EMPSON, K.L., and EATON, J.W. Phytic acid: A natural antioxidant. J. Biol. Chem. 262, 11647-11650, 1987.
28. HALLIWELL, B. and GUTTERIDGE, J.M.C. Free Radicals in Biology and Medicine, 2nd ed., Clarendon Press, Oxford, England, 1989.
29. HARMAN, D. Atherosclerosis: A hypothesis concerning initiating steps in pathogenesis. J. Gerontol. 12, 199-202, 1957.
30. HARMAN, D. Atherosclerosis: Inhibiting effect of an antihistaminic drug, chlorpheniramine. Circ. Res. 11, 277-282, 1962.
31. 1 mice. J. Gerontol. 23, 476-482, 1968.
32. HARMAN, D. The biological clock: The mitochondria? J. Am. Geriatr. 20, 145-147, 1972.
33. HARMAN, D. Free radical theory of aging: nutritional implications. Age 1, 145-152, 1978.
34. HARMAN, D. Free radical theory of aging: Consequences of mitochondrial aging. Age 6, 86-94, 1983.
35. HARMAN, D. Free radical theory of aging: The "free radical" diseases. Age 7, 111-131, 1984.
36. HARMAN, D. Free radical theory of aging: Role of free radicals in the origination and evolution of life, aging, and disease processes, In: Free Radicals, Aging, and Degenerative Diseases, Johnson, J.E., Jr., Walford, R., Harman, D., and MIQUEL, J. (Editors), pp. 3-49, Alan R. Liss, New York, 1986.
37. HARMAN, D. Free radical theory of aging: History. In: Free Radicals and Aging, Emerit, I. and Chance, B. (Editors), pp. 1-10, Birkhauser, Basel, Switzerland, 1992.
38. HARMAN, D. Free radical involvement inaging: Pathophysiology and therapeutic implications. Drugs Aging 3, 60-80, 1993.
39. HARMAN, D. Aging: Prospects for further increases in the functional life span. Age 17, 119-146, 1994.
40. HARMAN, D. and EDDY, D.E. Free radical theory of aging: beneficial effect of adding antioxidants to the maternal mouse diet on life span of offspring: Possible explanation of the sex difference in longevity. Age 2, 109-122, 1979.
41. 1 mice. Mech. Ageing Dev. 27, 341-358, 1984.
42. HORRUM, M.A., HARMAN, D., and TOBIN, R.B. Free radical theory of aging: Effects of antioxidants on mitochondrial function. Age 10, 58-61, 1987.
43. HUANG, M.-T., HO, C.-T., and LEE, C.Y. (Editors). American Chemical Society Series 507. Phenolic Compounds in Food and their Effects on Health, Vol. II, Amer. Chem. Soc., Washington, DC, 1992.
44. INGRAM, D.K., CUTLER, R.G., WEINDRUCH, R., RENQUIST, D.M., KNAPKA, J.J., APRIL, M., BELCHER, C.T., CLARK., M.A., HATCHERSON, C.D., MARRIOTT, B.M., and ROTH, G.S. Dietary restriction and aging: The initiation of a primate study. J. Gerontol Biol. Sci. 45, B148-B163, 1990.
45. JAKOBY, W.B. and ZIEGLER, D.M. Minireview: The enzymes of detoxication. J. Biol. Chem. 265, 20715-20718, 1990.
46. JANZEN, E.G. A critical review of spin trapping in biological systems. In: Free Radicals in Biology, Pryor, W.A. (Editor), pp. 115-154, Academic Press, New York, 1984.
47. JOHNSON, T.E., and LITHGOW, G.J. The search for the genetic basis of aging: The identification of gerontogenes in the nematode Caenorhabditis elegans. J. Am. Geriatr. Soc. 40, 936-945, 1992.
48. JONES, H.R. The relation of human health to age, place and time. In: Handbook of Aging and the Individual, Birren, J.E. (Editor), pp. 333-363, Chicago University Press, Chicago, IL, 1955.
49. KOHN, R.R. Aging and age-related diseases: Normal processes. In: Relation Between Normal Aging and Disease, Johnson, H.A. (Editor), pp. 1-44, Raven Press, New York, 1985.
50. KU, H.-H., BRUNK, U.T., and SOHAL, R.S. Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species. Free Radic. Biol. Med. 15, 621-627, 1993.
51. KU, H.-H. and SOHAL, R.S. Comparison of mitochondrial pro-oxidant generation and anti-oxidant defenses between rat and pigeon: Possible basis of variation in longevity and metabolic potential. Mech. Ageing Dev. 72, 67-76, 1993.
52. LIU, J. and MORI, A. Age-associated changes in superoxide dismutase activity, thiobarbituric acid reactivity and reduced glutathione level in the brain and liver in senescence accelerated mice (SAM): A comparison with ddY mice. Mech. Ageing Dev. 71, 23-30, 1993.
53. MAXWELL, S., CRUICKSHANK, A., and THROPE, G. Red wine and antioxidant activity in serum. Lancet 344, 193-104, 1994.
54. MEDVEDEV, Z.A. An attempt at a rational classification of theories of aging. Biol. Rev. 65, 375-398, 1990.
55. MEHLHORN, R. J. and COLE, G. The free radical theory of aging: A critical review. Adv. Free Radic. Biol. Med. 1, 165-223, 1985.
56. MELVILLE, C.A.S. Red wine, tea, and antioxidants. Lancet 344, 626, 1994.
57. MIQUEL, J. and JOHNSON, J.E., JR. Effects of various antioxidants and radiation protectants on the life span and lipofuscin of Drosophila and C57BL/6J mice. Gerontologist 15, 25, 1975.
58. MIQUEL, J., ECONOMOS, A.C., BENSCH, K.G., ATLAM, H., and JOHNSON, J.E., JR. Review of cell aging in Drosophila and mouse. Age 2, 78-88, 1979.
59. MIQUEL, J., ECONOMOS, A.C., FLEMING, J., and JOHNSON, J.E., JR. Mitochondiral role in cell aging. Exp. Gerontol. 15, 575-591, 1980.
60. MIQUEL, J., FLEMING, J., and ECONOMOS, A.C. Antioxidants, metabolic rate and aging in Drosophila. Arch. Gerontol. Geriatr. 1, 159-165, 1982.
61. MITCHELL, J.B., SAMUNI, A., KRISHNA, M.C., DEGRAFF, W.G., AHN, M.S., SAMURI, U., and RUSSO, A. Biologically active metal-independent superoxide dismutase mimics. Biochemistry 29, 2802-2807, 1990.
62. MUNKERS, K.D., RANA, R.S., and GOLDSTEIN, E. Genetically determined conidial longevity is positively correlated with superoxide dismutase, catalase, glutathione peroxidase, cytochrome c peroxidase, and ascorbate free radical reductase activities in Neumspora crassa. Mech. Ageing Dev. 24, 83-100, 1984.
63. NAKAZONO, K., WATANABE, N., MATSUNO, K., SASAKI, J., SATO, T., and INOUE, M. Does superoxide underlie the pathogenesis of hypertension? Proc. Natl. Acad. Sci. USA 88, 10045-10049, 1991.
64. NOHL, H., and HEGNER, D. Do mitochondria produce oxygen radicals in vivo? Eur. J. Biochcm. 82, 863-867, 1978.
65. NONHEBEL, D.C. and WALTON, J.C. Free Radical Chemistry, Univ. Press, Cambridge, MA, 1974.
66. ORR, W.C. and SOHAL, R.S. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophilia melanogaster. Science 263, 1128-1130, 1994.
67. PACKER, L., and CADENAS, E. (Editors) Biothiols in Health and Disease, Marcel Dekker, New York, 1995.
68. PACKER, L., WITT, E.H., and TRITSCHLER, E.H. Alpha-lipoic acid as a biological antioxidant. Free Radic. Biol. Med. 19, 227-250, 1995.
69. PARDINI, R.S., HEIDKER, J.C., and FLETCHER, D.C. Inhibition of mitochondrial electron transport by nordihydroguaiaretic acid (NDGA). Biochem. Pharmacol. 19, 2695-2699, 1970.
70. PIERPAOLI, W. and REGELSON, W. Pineal control of aging: Effect of melatonin and pineal grafting on aging mice. Proc. Natl. Acad. Sci. USA 91, 787-791, 1994.
71. PRYOR, W.A. Free Radicals, Raven Press, New York, 1966.
72. QUINTANILHA, A.T. and PACKER, L. Surface localization of sites of reduction of nitroxide spin-labeled molecules in mitochondria. Proc. Natl. Acad. Sci. USA 74, 570-574, 1977.
73. REITER, R.J. The Pineal Gland and Melatonin: Regulation and Role in Oxidative Defense, Cancer, and Aging, CRC Press, Boca Raton, FL, 1994.
74. RIMM, E.B., STAMPFER, M.J., ASCHERIO, A., GIOVANNUCCI, E., COLDITZ, G.A., and WILLETT, W.C. Vitamin E consumption and the risk of coronary heart disease in men. N. Engl. J. Med. 328, 1450-1456, 1993.
75. ROCKSTEIN, M., SUSSMAN, M.L., and CHESKY, J. (Editors). Theoretical Aspects of Aging, Academic Press, New-York, 1974.
76. ROSEN, D.R., SIDDIQUE, T., PATTERSON, D., FIGLEWICZ, D.A., SAPP, P., HENTATI, A., DONALDSON, A., GOTO, J., O'REGAN, J.P., DENG, H.-X., RAHMANI, Z., KRIZUS, A., MCKENNA-YASEK, D., CAYABYAB, A., GASTON, S.M., BERGER, R., TANZI, R.E., HALPERIN, J.J., HERZFELDT, B., VAN DEN BERGH, R., HUNG, W.-Y., BIRD, T., DENG, G., MULDER, D.W., SMYTH, C., LAING, N.G., SORIANO, E., PERICAKVANCE, M.A., HAINES, J., ROULEAU, G.A., GUSELLA, G.S., HORVITZ, H.R., and BROWN, R.H., JR. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362, 59-62, 1993.
77. ROTHSTEIN, M. Biochemical studies of aging. Chem. Eng. News 64, 26, 1986.
78. SACHER, G.A. Life table modification and life prolongation. In: Handbook of the Biology of Aging, Finch, C.E. and Hayflick, L. (Editors), pp. 582-638, Van Nostrand Reinhold, New York, 1977.
79. SALONEN, J.T., NYYSSONEN, K., KORPELA, H., TUOMILEHTO J., SEPPANEN, R., and SALONEN, R. High stored iron levels are associated with excess risk of myocardial infarction in Eastern Finnish men. Circulation 86, 803-811, 1992.
80. SCHNEIDER, E.L. Theories of aging: A perspective. In: Modern Biologic Theories of Aging, Warner, H.R., Butler, R.N., Sprott, R.L., and Schneider, E.L. (Editors), pp. 1-4, Raven Press, New York, 1987.
81. SOHAL, R.S. and SOHAL, B.H. Hydrogen peroxide release by mitochondria increases during aging. Mech. Ageing Dev. 57, 187-202, 1991.
82. SOHAL, R.S. The free radical hypothesis of aging: An appraisal of the current status. Aging Clin. Exp. Res. 5, 3-17, 1993.
83. SOHAL, R.S., KU, H.-H., AGARWAL, S., FORSTER, M.J., and LAL, H. Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mech. Ageing Dev. 74, 121-133, 1994.
84. SPARNINS, V.L., VENEGAS, P.L., and WATTENBERG, L.W. Glutathione S-transferase activity: Enhancement by compounds inhibiting chemical carcinogenesis and by dietary constituents. J. Natl. Cancer Inst. 68, 493-496, 1982.
85. STAMPFER, M.J., HENNEKENS, C.H., MASON. J.E., COLDITZ, G.A., ROSNER, B., and WILLETT, W.C. Vitamin E consumption and the risk of coronary disease in women. N. Engl. J. Med. 328, 1444-1449, 1993.
86. STEINBERG, D. Lipoproteins and atherogenesis: Current concepts. JAMA 264, 3047-3052, 1990.
87. STEVENS, R.G., JONES, D.Y., MICOZZI, M.S., and TAYLOR, P.R. Body iron stores and the risk of cancer. N. Engl. J. Med. 319, 1047-1052, 1988.
88. STOHS, S., LAWSON, T.A., ANDERSON, L., and BUEDING, E. Effect of oltipraz, BHA, ADT, and cabbage on glutathione metabolism, DNA damage and lipid peroxidation in old mice. Mech. Ageing Dev. 37, 137-145, 1986.
89. SULLIVAN, J.L. Iron and the sex difference in heart disease rate. Lancet 1, 1293-1294, 1981.
90. SVERIGES OFFICIELLA STATISTIK. Befolknings-forandringar. Livslangstabeller, 1951-1993, pp. 114-115, Statistiska centralbyran, Stockholm, Sweden, 1993.
91. TAN, D.-X., CHEN, L.-D., POEGGELER, B., MANCHESTER, L.C., and REITER, R.J. Melatonin: A potent, endogenous hydroxyl radical scavenger. Endocr. J. 1, 57-60, 1993.
92. THOMAS, P.D., MAO, G.D., RABINOVITCH, A., and POZNANSKY, M.J. Inhibition of superoxide-generating NADPH oxidase of human neutrophils by lazaroids (21-aminosteroids and 2-methylaminochromans). Biochem. Pharmacol. 45, 241-251, 1993.
93. UPTON, A.C. Pathobiology. In: The Biology of Aging, Finch, C.E. and Hayflick, L. (Editors), pp. 513-535, Van Nostrand, New York, 1977.
94. VIIG, J. Searching for the molecular basis of aging: The need for life extension models. Aging 2, 227-229, 1990.
95. VOEST. E.E., VAN FAASSEN, E., and MARX. J.J.M. An electron paramagnetic resonance study of the antioxidant properties of the nitroxide free radical tempo. Free Radic. Biol. Med. 15, 589-595, 1993.
96. WARNER, H.R., BUTLER, R.N., SPROTT, R.L., and SCHNEIDER, E.L. (Editors). Modern Biological Theories of Aging, Raven Press, New York, 1987.
97. WEINDRUCH. R., WARNER, H.R., and STARKE-REED, P.E. Future directions of free radical research in aging. In: Free Radicals in Aging, Yu, B.P. (Editor), pp. 269-295, CRC Press, Boca Raton, FL, 1993.
98. WIGGLESWORTH, V.B. The Principles of Insect Physiology, 6th ed., pp. 317-368, Methuen, London, UK, 1965.
99. WILLIAMS, R.T. Comparative patterns of drug metabolism. Fed. Proc. 26, 1029-1039, 1967.
100. YU, B.P., MASORO, E.J., MURATA, E.J., BERTRAND, H.A., and LYND, F.T. Life span study of SPF Fischer 344 male rats fed ad libitum or restricted diets: Longevity, growth, lean body mass and disease. J. Gerontol. 37, 130-141, 1982.
101. ZHANG, Y., TALALAY, P., CHO, C.-G., and POSNER, G.H. A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure. Proc. Natl. Acad. Sci. USA 89, 2399-2403, 1992.