-
1
-
-
0031003468
-
Learning versus confirming in clinical drug development
-
L. B. Sheiner. 1997 Learning versus confirming in clinical drug development Clin. Pharmacol. Ther. 61 275 291
-
(1997)
Clin. Pharmacol. Ther.
, vol.61
, pp. 275-291
-
-
Sheiner., L.B.1
-
2
-
-
0030429755
-
Characterization of four basic models of indirect pharmacodynamic responses
-
A. Sharma W. J. Jusko. 1996 Characterization of four basic models of indirect pharmacodynamic responses J. Pharmacokinet. Biopharm. 24 611 635
-
(1996)
J. Pharmacokinet. Biopharm.
, vol.24
, pp. 611-635
-
-
Sharma, A.1
Jusko., W.J.2
-
3
-
-
0035658567
-
A set-point model with oscillatory behavior predicts the time course of 8-OH-DPAT-induced hypothermia
-
K. P. Zuideveld H. J. Maas N. Treijtel J. Hulshof P. H. van der Graaf L. A. Peletier M. Danhof. 2001 A set-point model with oscillatory behavior predicts the time course of 8-OH-DPAT-induced hypothermia Am. J. Physiol., Regul. Integr. Comp. Physiol. 281 R2059 R2071
-
(2001)
Am. J. Physiol., Regul. Integr. Comp. Physiol.
, vol.281
-
-
Zuideveld, K.P.1
Maas, H.J.2
Treijtel, N.3
Hulshof, J.4
Van Der Graaf, P.H.5
Peletier, L.A.6
Danhof., M.7
-
4
-
-
0027769745
-
Comparison of four basic models of indirect pharmacodynamic responses
-
N. L. Dayneka V. Garg W. J. Jusko. 1993 Comparison of four basic models of indirect pharmacodynamic responses J. Pharmacokinet. Biopharm. 21 457 478
-
(1993)
J. Pharmacokinet. Biopharm.
, vol.21
, pp. 457-478
-
-
Dayneka, N.L.1
Garg, V.2
Jusko., W.J.3
-
5
-
-
0027943266
-
Physiologic indirect response models characterize diverse types of pharmacodynamic effects
-
W. J. Jusko H. C. Ko. 1994 Physiologic indirect response models characterize diverse types of pharmacodynamic effects Clin. Pharmacol. Ther. 56 406 419
-
(1994)
Clin. Pharmacol. Ther.
, vol.56
, pp. 406-419
-
-
Jusko, W.J.1
Ko., H.C.2
-
6
-
-
0030842321
-
Analysis of drug-receptor interactions in vivo: A new approach in pharmacokinetic-pharmacodynamic modelling
-
P. H. Van der Graaf M. Danhof. 1997 Analysis of drug-receptor interactions in vivo: a new approach in pharmacokinetic-pharmacodynamic modelling Int. J. Clin. Pharmacol. Ther. 35 442 446
-
(1997)
Int. J. Clin. Pharmacol. Ther.
, vol.35
, pp. 442-446
-
-
Van Der Graaf, P.H.1
Danhof., M.2
-
7
-
-
0030830382
-
Mechanism-based pharmacokinetic-pharmacodynamic modeling of the effects of N6-cyclopentyladenosine analogs on heart rate in rat: Estimation of in vivo operational affinity and efficacy at adenosine A1 receptors
-
P. H. Van Der Graaf E. A. Van Schaick R. A. Math-ot A. P. Ijzerman M. Danhof. 1997 Mechanism-based pharmacokinetic-pharmacodynamic modeling of the effects of N6-cyclopentyladenosine analogs on heart rate in rat: estimation of in vivo operational affinity and efficacy at adenosine A1 receptors J.Pharmacol. Exp. Ther. 283 809 816
-
(1997)
J.Pharmacol. Exp. Ther.
, vol.283
, pp. 809-816
-
-
Van Der Graaf, P.H.1
Van Schaick, E.A.2
Math-Ot, R.A.3
Ijzerman, A.P.4
Danhof., M.5
-
8
-
-
0032789519
-
Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: Prediction of tissue-dependent efficacy in vivo
-
P. H. Van der Graaf E. A. Van Schaick S. A. Visser H. J. De De Greef A. P. Ijzerman M. Danhof. 1999 Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo J. Pharmacol. Exp. Ther. 290 702 709
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.290
, pp. 702-709
-
-
Van Der Graaf, P.H.1
Van Schaick, E.A.2
Visser, S.A.3
De De Greef, H.J.4
Ijzerman, A.P.5
Danhof., M.6
-
10
-
-
0036721222
-
Mechanism-based pharmacokinetic-pharmacodynamic modeling of concentration-dependent hysteresis and biphasic electroencephalogram effects of alphaxalone in rats
-
S. A. Visser C. J. Smulders B. P. Reijers P. H. Van der Graaf L. A. Peletier M. Danhof. 2002 Mechanism-based pharmacokinetic-pharmacodynamic modeling of concentration-dependent hysteresis and biphasic electroencephalogram effects of alphaxalone in rats J. Pharmacol. Exp. Ther. 302 1158 1167
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.302
, pp. 1158-1167
-
-
Visser, S.A.1
Smulders, C.J.2
Reijers, B.P.3
Van Der Graaf, P.H.4
Peletier, L.A.5
Danhof., M.6
-
12
-
-
0036137066
-
A competitive interaction model predicts the effect of WAY-100,635 on the time course of R-(+)-8-hydroxy-2-(di-n-propylamino)tetralin-induced hypothermia
-
K. P. Zuideveld N. Treijtel H. J. Maas J. M. Gubbens-Stibbe L. A. Peletier P. H. van Der Graaf M. Danhof. 2002 A competitive interaction model predicts the effect of WAY-100,635 on the time course of R-(+)-8-hydroxy-2-(di- n-propylamino)tetralin-induced hypothermia J. Pharmacol. Exp. Ther. 300 330 338
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.300
, pp. 330-338
-
-
Zuideveld, K.P.1
Treijtel, N.2
Maas, H.J.3
Gubbens-Stibbe, J.M.4
Peletier, L.A.5
Van Der Graaf, P.H.6
Danhof., M.7
-
14
-
-
0028141439
-
The effect of tacrine and lecithin in Alzheimer's disease. a population pharmacodynamic analysis of five clinical trials
-
N. H. Holford K. Peace. 1994 The effect of tacrine and lecithin in Alzheimer's disease. A population pharmacodynamic analysis of five clinical trials Eur. J. Clin. Pharmacol. 47 17 23
-
(1994)
Eur. J. Clin. Pharmacol.
, vol.47
, pp. 17-23
-
-
Holford, N.H.1
Peace., K.2
-
15
-
-
0026452038
-
Methodologic aspects of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine
-
N. H. Holford K. Peace. 1992 Methodologic aspects of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine Proc. Natl. Acad. Sci. USA 89 11466 11470
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 11466-11470
-
-
Holford, N.H.1
Peace., K.2
-
16
-
-
0026471544
-
Results and validation of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine
-
N. H. Holford K. E. Peace. 1992 Results and validation of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine Proc. Natl. Acad. Sci. USA 89 11471 11475
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 11471-11475
-
-
Holford, N.H.1
Peace., K.E.2
-
17
-
-
33645182348
-
Understanding disease progression using clinical pharmacology
-
M. Danhof, M. Karlsson, and R. J. Powell (eds.) Leiden/Amsterdam Center for Drug Research, Leiden. Advances in Simultaneous Pharmacokinetic/ Pharmacodynamic Modelling, 4th International Symposium, 24-27 April, Noordwijkerhout
-
N. H. G. Holford. Understanding disease progression using clinical pharmacology. In M. Danhof, M. Karlsson, and R. J. Powell (eds.), Measurement and Kinetics of in vivo Drug Effects, Leiden/Amsterdam Center for Drug Research, Leiden. Advances in Simultaneous Pharmacokinetic/Pharmacodynamic Modelling, 4th International Symposium, 24-27 April, Noordwijkerhout, 2002.
-
(2002)
Measurement and Kinetics of in Vivo Drug Effects
-
-
Holford, N.H.G.1
-
19
-
-
0035037328
-
Use of biomarkers and surrogate endpoints in drug development and regulatory decision making: Criteria, validation, strategies
-
L. J. Lesko A. J. Atkinson Jr. Jr 2001 Use of biomarkers and surrogate endpoints in drug development and regulatory decision making: criteria, validation, strategies Annu. Rev. Pharmacol. Toxicol. 41 347 366
-
(2001)
Annu. Rev. Pharmacol. Toxicol.
, vol.41
, pp. 347-366
-
-
Lesko, L.J.1
Atkinson Jr., A.J.2
-
20
-
-
0037380673
-
Biomarkers in drug discovery and development: From target identification through drug marketing
-
W. A. Colburn. 2003 Biomarkers in drug discovery and development: from target identification through drug marketing J. Clin. Pharmacol. 43 329 341
-
(2003)
J. Clin. Pharmacol.
, vol.43
, pp. 329-341
-
-
Colburn., W.A.1
-
21
-
-
0141762330
-
Biomarkers, validation and pharmacokinetic-pharmacodynamic modelling
-
W. A. Colburn J. W. Lee. 2003 Biomarkers, validation and pharmacokinetic-pharmacodynamic modelling Clin. Pharmacokinet. 42 997 1022
-
(2003)
Clin. Pharmacokinet.
, vol.42
, pp. 997-1022
-
-
Colburn, W.A.1
Lee., J.W.2
-
22
-
-
0035100888
-
Biomarkers and surrogate endpoints in clinical trials: Preferred definitions and conceptual framework
-
A. J. Atkinson W. A. Colburn V. DeGruttola D. L. DeMets G. J. Downing D. F. Hoth J. A. Oates C. C. Peck R. T. Schooley B. A. Spilker J. Woodcock S. L. Zeger. 2001 Biomarkers and surrogate endpoints in clinical trials: preferred definitions and conceptual framework Clin. Pharmacol. Ther. 69 89 95
-
(2001)
Clin. Pharmacol. Ther.
, vol.69
, pp. 89-95
-
-
Atkinson, A.J.1
Colburn, W.A.2
Degruttola, V.3
Demets, D.L.4
Downing, G.J.5
Hoth, D.F.6
Oates, J.A.7
Peck, C.C.8
Schooley, R.T.9
Spilker, B.A.10
Woodcock, J.11
Zeger., S.L.12
-
23
-
-
3342964033
-
Biomarker discovery and validation: Technologies and integrative approaches
-
S. E. Ilyin S. M. Belkowski C. R. Plata-Salaman. 2004 Biomarker discovery and validation: technologies and integrative approaches Trends Biotechnol. 22 411 416
-
(2004)
Trends Biotechnol.
, vol.22
, pp. 411-416
-
-
Ilyin, S.E.1
Belkowski, S.M.2
Plata-Salaman., C.R.3
-
24
-
-
0034491130
-
Optimizing the science of drug development: Opportunities for better candidate selection and accelerated evaluation in humans
-
L. J. Lesko M. Rowland C. C. Peck T. F. Blaschke. 2000 Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans Pharm. Res. 17 1335 1344
-
(2000)
Pharm. Res.
, vol.17
, pp. 1335-1344
-
-
Lesko, L.J.1
Rowland, M.2
Peck, C.C.3
Blaschke., T.F.4
-
25
-
-
0032898755
-
Prospective six year follow up of patients withdrawn from a randomised study comparing parenteral gold salt and methotrexate
-
O. Sander G. Herborn E. Bock R. Rau. 1999 Prospective six year follow up of patients withdrawn from a randomised study comparing parenteral gold salt and methotrexate Ann. Rheum. Dis. 58 281 287
-
(1999)
Ann. Rheum. Dis.
, vol.58
, pp. 281-287
-
-
Sander, O.1
Herborn, G.2
Bock, E.3
Rau., R.4
-
26
-
-
10744225301
-
Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: A randomized controlled trial
-
S. E. Nissen E. M. Tuzcu P. Schoenhagen B. G. Brown P. Ganz R. A. Vogel T. Crowe G. Howard C. J. Cooper B. Brodie C. L. Grines A. N. DeMaria. 2004 Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial JAMA 291 1071 1080
-
(2004)
JAMA
, vol.291
, pp. 1071-1080
-
-
Nissen, S.E.1
Tuzcu, E.M.2
Schoenhagen, P.3
Brown, B.G.4
Ganz, P.5
Vogel, R.A.6
Crowe, T.7
Howard, G.8
Cooper, C.J.9
Brodie, B.10
Grines, C.L.11
Demaria., A.N.12
-
27
-
-
0242335593
-
Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanercept
-
M. Crnkic B. Mansson L. Larsson P. Geborek D. Heinegard T. Saxne. 2003 Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanercept Arthritis Res. Ther. 5 R181 R185
-
(2003)
Arthritis Res. Ther.
, vol.5
-
-
Crnkic, M.1
Mansson, B.2
Larsson, L.3
Geborek, P.4
Heinegard, D.5
Saxne., T.6
-
28
-
-
9144264155
-
Infliximab in active early rheumatoid arthritis
-
F. C. Breedveld P. Emery E. Keystone K. Patel D. E. Furst J.R. Kalden E. W. St Clair M. Weisman J. Smolen P. E. Lipsky R. N. Maini. 2004 Infliximab in active early rheumatoid arthritis Ann. Rheum. Dis. 63 149 155
-
(2004)
Ann. Rheum. Dis.
, vol.63
, pp. 149-155
-
-
Breedveld, F.C.1
Emery, P.2
Keystone, E.3
Patel, K.4
Furst, D.E.5
Kalden, J.R.6
St Clair, E.W.7
Weisman, M.8
Smolen, J.9
Lipsky, P.E.10
Maini., R.N.11
-
29
-
-
33645180424
-
Disease progression in Parkinson's disease - Evidence for protective effects of drug treatment
-
Uppsala, Sweden
-
N. H. Holford, P. L. Chan, and J. Nutt. Disease progression in Parkinson's disease-evidence for protective effects of drug treatment. 13th Population Approach Group Conference, Uppsala, Sweden, http://www.page-meeting. org, 2004.
-
(2004)
13th Population Approach Group Conference
-
-
Holford, N.H.1
Chan, P.L.2
Nutt, J.3
-
30
-
-
0030696346
-
Combination of sulphasalazine and methotrexate versus the single components in early rheumatoid arthritis: A randomized, controlled, double-blind, 52 week clinical trial
-
C. J. Haagsma P. L. van Riel A. J. de Jong L. B. van de Putte 1997 Combination of sulphasalazine and methotrexate versus the single components in early rheumatoid arthritis: a randomized, controlled, double-blind, 52 week clinical trial Br. J. Rheumatol. 36 1082 1088
-
(1997)
Br. J. Rheumatol.
, vol.36
, pp. 1082-1088
-
-
Haagsma, C.J.1
Van Riel, P.L.2
De Jong, A.J.3
Van De Putte, L.B.4
-
31
-
-
0036913449
-
More efficient clinical trials through use of scientific model-based statistical tests
-
E. N. Jonsson L. B. Sheiner. 2002 More efficient clinical trials through use of scientific model-based statistical tests Clin. Pharmacol. Ther. 72 603 614
-
(2002)
Clin. Pharmacol. Ther.
, vol.72
, pp. 603-614
-
-
Jonsson, E.N.1
Sheiner., L.B.2
-
32
-
-
0036039781
-
Is intent-to-treat analysis always (ever) enough?
-
L. B. Sheiner. 2002 Is intent-to-treat analysis always (ever) enough? Br. J. Clin. Pharmacol. 54 203 211
-
(2002)
Br. J. Clin. Pharmacol.
, vol.54
, pp. 203-211
-
-
Sheiner., L.B.1
-
33
-
-
0028817457
-
Intention-to-treat analysis and the goals of clinical trials
-
L. B. Sheiner D. B. Rubin. 1995 Intention-to-treat analysis and the goals of clinical trials Clin. Pharmacol. Ther. 57 6 15
-
(1995)
Clin. Pharmacol. Ther.
, vol.57
, pp. 6-15
-
-
Sheiner, L.B.1
Rubin., D.B.2
-
34
-
-
0037036227
-
Pharmacokinetic-pharmacodynamic modelling of the hypothermic and corticosterone effects of the 5-HT1A receptor agonist flesinoxan
-
K. P. Zuideveld A. van Gestel L. A. Peletier P. H. Van der Graaf M. Danhof. 2002 Pharmacokinetic-pharmacodynamic modelling of the hypothermic and corticosterone effects of the 5-HT1A receptor agonist flesinoxan Eur. J. Pharmacol. 445 43 54
-
(2002)
Eur. J. Pharmacol.
, vol.445
, pp. 43-54
-
-
Zuideveld, K.P.1
Van Gestel, A.2
Peletier, L.A.3
Van Der Graaf, P.H.4
Danhof., M.5
-
35
-
-
0037327319
-
Population PKPD modelling of the long-term hypoglycaemic effect of gliclazide given as a once-a-day modified release (MR) formulation
-
N. Frey C. Laveille M. Paraire M. Francillard N. H. Holford R. Jochemsen. 2003 Population PKPD modelling of the long-term hypoglycaemic effect of gliclazide given as a once-a-day modified release (MR) formulation Br. J. Clin. Pharmacol. 55 147 157
-
(2003)
Br. J. Clin. Pharmacol.
, vol.55
, pp. 147-157
-
-
Frey, N.1
Laveille, C.2
Paraire, M.3
Francillard, M.4
Holford, N.H.5
Jochemsen., R.6
-
36
-
-
1542327580
-
Dopamine agonists, receptor selectivity and dyskinesia induction in Parkinson's disease
-
P. Jenner. 2003 Dopamine agonists, receptor selectivity and dyskinesia induction in Parkinson's disease Curr. Opin. Neurol. 16 S3 S7
-
(2003)
Curr. Opin. Neurol.
, vol.16
-
-
Jenner., P.1
-
37
-
-
1842856723
-
Pharmacology of dopamine agonists in the treatment of Parkinson's disease
-
P. Jenner. 2002 Pharmacology of dopamine agonists in the treatment of Parkinson's disease Neurology 58 S1 S8
-
(2002)
Neurology
, vol.58
-
-
Jenner., P.1
-
38
-
-
0037202792
-
Dopamine agonist monotherapy in Parkinson's disease
-
C. E. Clarke M. Guttman. 2002 Dopamine agonist monotherapy in Parkinson's disease Lancet 360 1767 1769
-
(2002)
Lancet
, vol.360
, pp. 1767-1769
-
-
Clarke, C.E.1
Guttman., M.2
-
39
-
-
2442570592
-
Disease modification in Parkinson's disease
-
A. H. Schapira. 2004 Disease modification in Parkinson's disease Lancet Neurol. 3 362 368
-
(2004)
Lancet Neurol.
, vol.3
, pp. 362-368
-
-
Schapira., A.H.1
-
42
-
-
1542269162
-
The scientific basis for the current treatment of Parkinson's disease
-
C. W. Olanow. 2004 The scientific basis for the current treatment of Parkinson's disease Annu. Rev. Med. 55 41 60
-
(2004)
Annu. Rev. Med.
, vol.55
, pp. 41-60
-
-
Olanow., C.W.1
-
44
-
-
10844265575
-
A semimechanistic and mechanistic population PK-PD model for biomarker response to ibandronate, a new bisphosphonate for the treatment of osteoporosis
-
G. Pillai R. Gieschke T. Goggin P. Jacqmin R. C. Schimmer J. L. Steimer. 2004 A semimechanistic and mechanistic population PK-PD model for biomarker response to ibandronate, a new bisphosphonate for the treatment of osteoporosis Br. J. Clin. Pharmacol. 58 618 631
-
(2004)
Br. J. Clin. Pharmacol.
, vol.58
, pp. 618-631
-
-
Pillai, G.1
Gieschke, R.2
Goggin, T.3
Jacqmin, P.4
Schimmer, R.C.5
Steimer., J.L.6
-
45
-
-
11144357578
-
Recommendations for the use of new methods to assess the efficacy of disease-modifying drugs in the treatment of osteoarthritis
-
E. Abadie D. Ethgen B. Avouac G. Bouvenot J. Branco O. Bruyere G. Calvo J. P. Devogelaer R. L. Dreiser G. Herrero-Beaumont A. Kahan G. Kreutz A. Laslop E. M. Lemmel G. Nuki L. Van De Putte L. Vanhaelst J. Y. Reginster. 2004 Recommendations for the use of new methods to assess the efficacy of disease-modifying drugs in the treatment of osteoarthritis Osteoarthr. Cartil. 12 263 268
-
(2004)
Osteoarthr. Cartil.
, vol.12
, pp. 263-268
-
-
Abadie, E.1
Ethgen, D.2
Avouac, B.3
Bouvenot, G.4
Branco, J.5
Bruyere, O.6
Calvo, G.7
Devogelaer, J.P.8
Dreiser, R.L.9
Herrero-Beaumont, G.10
Kahan, A.11
Kreutz, G.12
Laslop, A.13
Lemmel, E.M.14
Nuki, G.15
Van De Putte, L.16
Vanhaelst, L.17
Reginster., J.Y.18
-
46
-
-
0842267170
-
Structure-modifying agents for osteoarthritis: An update
-
P. Richette T. Bardin. 2004 Structure-modifying agents for osteoarthritis: an update Jt. Bone Spine 71 18 23
-
(2004)
Jt. Bone Spine
, vol.71
, pp. 18-23
-
-
Richette, P.1
Bardin., T.2
-
47
-
-
33645180987
-
Pioglitazone efficacy in NIDDM (diabetes type II) therapy: Unification of two glycemic control markers by a cascading disease progression model
-
M. Danhof, M. Karlsson, and R. J. Powell (eds.) Leiden/Amsterdam Center for Drug Research, Leiden. Advances in Simultaneous Pharmacokinetic/ Pharmacodynamic Modelling, 4th International Symposium, 24-27 April, Noordwijkerhout
-
J. DeJongh, D. Eckland, R. J. Heine, and M. Danhof. Pioglitazone efficacy in NIDDM (diabetes type II) therapy: unification of two glycemic control markers by a cascading disease progression model. In M. Danhof, M. Karlsson, and R. J. Powell (eds.), Measurement and Kinetics of in vivo Drug Effects, Leiden/Amsterdam Center for Drug Research, Leiden. Advances in Simultaneous Pharmacokinetic/Pharmacodynamic Modelling, 4th International Symposium, 24-27 April, Noordwijkerhout, 2002.
-
(2002)
Measurement and Kinetics of in Vivo Drug Effects
-
-
Dejongh, J.1
Eckland, D.2
Heine, R.J.3
Danhof, M.4
-
48
-
-
33645175426
-
A mechanistic disease progression model for type 2 diabetes mellitus and pioglitazone treatment effects
-
Uppsala, Sweden
-
W. DeWinter, T. M. Post, J. DeJongh, R. Urquhart, I. Moules, D. Eckland, and M. Danhof. A mechanistic disease progression model for type 2 diabetes mellitus and pioglitazone treatment effects. 13th Population Approach Group Conference, Uppsala, Sweden, http://www.page-meeting.org, 2004.
-
(2004)
13th Population Approach Group Conference
-
-
Dewinter, W.1
Post, T.M.2
Dejongh, J.3
Urquhart, R.4
Moules, I.5
Eckland, D.6
Danhof, M.7
-
49
-
-
33645181101
-
Disease progression modelling; Application of population analysis to distinguish between symptomatic and protective treatment effects
-
Verona, Italy
-
W. DeWinter, J. DeJongh, B. Ploeger, R. Urquhart, I. Moules, D. Eckland, and M. Danhof. Disease progression modelling; application of population analysis to distinguish between symptomatic and protective treatment effects. 12th Population Approach Group Conference, Verona, Italy, http://www.page-meeting. org, 2003.
-
(2003)
12th Population Approach Group Conference
-
-
Dewinter, W.1
Dejongh, J.2
Ploeger, B.3
Urquhart, R.4
Moules, I.5
Eckland, D.6
Danhof, M.7
-
51
-
-
0037403960
-
Diversity of mechanism-based pharmacodynamic models
-
D. E. Mager E. Wyska W. J. Jusko. 2003 Diversity of mechanism-based pharmacodynamic models Drug Metab. Dispos. 31 510 518
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 510-518
-
-
Mager, D.E.1
Wyska, E.2
Jusko., W.J.3
-
52
-
-
0031890386
-
Characteristics of indirect pharmacodynamic models and applications to clinical drug responses
-
A. Sharma W. J. Jusko. 1998 Characteristics of indirect pharmacodynamic models and applications to clinical drug responses Br. J. Clin. Pharmacol. 45 229 239
-
(1998)
Br. J. Clin. Pharmacol.
, vol.45
, pp. 229-239
-
-
Sharma, A.1
Jusko., W.J.2
|