Fifth-generation model for corticosteroid pharmacodynamics: Application to steady-state receptor down-regulation and enzyme induction patterns during seven-day continuous infusion of methylprednisolone in rats

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 29, Issue 1, 2002, Pages 1-24

  Ramakrishnan, R ^a   Dubois, D C ^a   Almon, R R ^a   Pyszczynski, N A ^a   Jusko, W J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Methylprednisolone; Pharmacodynamics; Pharmacogenomics; Tyrosine aminotransferase

Indexed keywords

CORTICOSTEROID; MESSENGER RNA; METHYLPREDNISOLONE SODIUM SUCCINATE; TYROSINE AMINOTRANSFERASE; METHYLPREDNISOLONE;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTINUOUS INFUSION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG MECHANISM; ENZYME INDUCTION; EXPERIMENTAL MODEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; LYMPHOCYTE COUNT; MALE; NONHUMAN; ORGAN WEIGHT; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; STEADY STATE; THEORETICAL MODEL; WEIGHT REDUCTION; ADRENALECTOMY; ANIMAL; BIOLOGICAL MODEL; BLOOD; DOWN REGULATION; GENE EXPRESSION REGULATION; INFUSION PUMP; LYMPHOCYTE; PHYSIOLOGY; WISTAR RAT;

ADRENAL CORTEX HORMONES; ADRENALECTOMY; ANIMAL; DOWN-REGULATION; ENZYME INDUCTION; GENE EXPRESSION REGULATION; INFUSION PUMPS, IMPLANTABLE; LYMPHOCYTES; MALE; METHYLPREDNISOLONE; MODELS, BIOLOGICAL; RATS; RATS, WISTAR; SUPPORT, U.S. GOV'T, P.H.S.; ANIMALS;

EID: 0036021823     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015765201129     Document Type: Article

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