Modulation of mouse endotoxin shock by inhibition of phosphatidylcholine-specific phospholipase C

Journal of Pharmacology and Experimental Therapeutics

Volumn 285, Issue 2, 1998, Pages 800-804

  Tschaikowsky, Klaus ^a   Schmidt, J ^a   Meisner, M ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; INTERLEUKIN 1; INTERLEUKIN 6; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHOLIPASE; TRICYCLO[4.3.0.1]DECAN 9 YL XANTHOGENATE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; GRAM NEGATIVE INFECTION; INFLAMMATION; LETHALITY; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SEPTIC SHOCK; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; BRIDGED COMPOUNDS; FEMALE; INTERLEUKIN-1; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHATIDYLCHOLINES; PHOSPHODIESTERASE INHIBITORS; PHOSPHOLIPASE C; SHOCK, SEPTIC; THIONES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031862348     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Buscher D, Hipskind RA, Krautwald S, Reimann T and Baccarini M (1995) Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages. Mol Cell Biol 15:466-475.
2. Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, Gallagher TF, Young PR and Lee JC (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEES Lett 364:229-233.
3. Dinarello CA, Gelfand JA and Wolff SM (1993) Anticytokine strategies in the treatment of the systemic inflammatory response syndrome. JAMA 269:1829-1835.
4. Fisher CJ, Agosti JM, Opal SM, Lowry SF, Balk RA, Sadoff JC, Abraham E, Schein RM and Benjamin E (1996) Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein: The Soluble TNF- Receptor Sepsis Study Group. N Engl J Med 334:1697-1702.
5. Han J, Lee JD, Bibbs L and Ulevitch RJ (1994) A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265:808-811.
6. Han J, Lee JD, Tobias PS and Ulevitch RJ (1993) Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14. J Biol Chem 268:25009-25014.
7. Kelly NM and Cross AS (1992) Interleukin-6 is a better marker of lethality than tumor necrosis factor in endotoxin treated mice. Fems Microbiol Immunol 4:317-322.
8. G-methyl-L-arginine, an inhibitor of nitric oxide synthesis. Biochem Biophys Res Commun 172:1132-1138.
9. Kolesnick R and Golde DW (1994) The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell 77:325-328.
10. Machleidt T, Kramer B, Adam D, Neumann B, Schütze S, Wiegmann K and Krönke M (1996) Function of the p55 tumor necrosis factor receptor 'death domain' mediated by phosphatidylcholine-specific phospholipase C. J Exp Med 184:725-733.
11. Marletta MA, Yoon PS, Iyengar R, Leaf CD and Wishnok JS (1988) Macrophage oxidation of L-arginine to nitrite and nitrate: Nitric oxide is an intermediate. Biochemistry 27:8706-8711.
12. Moncada SR, Palmer MJ and Higgs EA (1991) Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109-142.
13. Müller DK (1989) Interruption of TPA-induced signals by an antiviral and antitumoral xanthate compound: Inhibition of a phospholipase C-type reaction. Biochem Biophys Res. Commun 162:198-205.
14. Novogrodsky A, Vanichkin A, Patya M, Gazit A, Osherov N and Levitzki A (1994) Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science 264:1319-1322.
15. Opal SM, Fisher CJ, Dhainaut JF, Vincent JL, Erase R, Lowry SF, Sadoff JC, Slotman GJ, Levy H, Balk RA, Shelly MP, Pribble JP, LaBrecque JF, Lookabaugh J, Donovan H, Dubin H, Baughman R, Norman J, DeMaria E, Matzel K, Abraham E and Seneff M (1997) Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: A phase III, randomized, double-blind, placebo-controlled, multi-center trial: The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. Crit Care Med 25:1115-1124.
16. Pfeffer K, Matsuyama T, Kundig TM, Wakeham A, Kishihara K, Shahinian A, Wiegmann K, Ohashi PS, Krönke M and Mak TW (1993) Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L monocytogenes infection. Cell 73:457-467.
17. Pripic V, Weiel J, Sommers S, DiGuiseppe J, Gonias S, Pizzo S, Hamilton T, Herman B and Adams D (1987) Effects of bacterial lipopolysaccharide on the hydrolysis of phosphatidyl-4,5-biphosphonate in murine peritoneal macrophages. J Immunol 139:526-533.
18. Redmond HP, Chavin KD, Bromberg JS and Daly JM (1991) Inhibition of macrophage-activating cytokines is beneficial in the acute septic response. Ann Surg 214:502-508.
19. Schütze S and Krönke M (1994) Activation of phosphatidylcholine-specific phospholipase c by cytokines. In Signal-activated Phospholipases, ed. by Liscovitch M, pp. 101-124, R. G. Landes Company, Georgetown, Texas.
20. Schütze S, Potthoff K, Machleidt T, Berkovic D, Wiegmann K and Krönke M (1992) TNF- activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced 'acidic' sphingomyelin breakdown. Cell 71:765-776.
21. Shalaby MR, Halgunset J, Haugen OA, Aarset H, Aarden L, Waage A, Matsushima K, Kvithyll H, Boraschi D, Lamvik J, et al (1991) Cytokine-associated tissue injury and lethality in mice: A comparative study. Clin Immunol Immunopathol 61:69-82.
22. Tateda K, Matsumoto T, Miyazaki S and Yamaguchi K (1996) Lipopolysaccharide-induced lethality and cytokine production in aged mice. Infect Immunol 64:769-774.
23. Tracey KJ, Beutler B, Lowry SF, Merryweather J, Wolpe S, Milsark IW, Hariri RJ, Fahey TJ, Zentell A, Albert JD, Shires GT and Cerami A (1986) Shock and tissue injury induced by recombinant human cachectin. Science 1986 234:470-474.
24. Tschaikowsky K and Brain JD (1994) Staurosporine encapsulated into pH-sensitive liposomes reduces TNF- production and increases survival in rat endotoxin shock. Shock 1:401-407.
25. Tschaikowsky K, Meisner M, Schönhuber F and Rügheimer E (1994) Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609). Br J Pharmacol 113:664-668.
26. Weber C, Erl W, Pietsch A, Danesch U and Weber PC (1995) Docosahexaenoic acid selectively attenuates induction of vascular cell adhesion molecule-1 and subsequent monocytic cell adhesion to human endothelial cells stimulated by tumor necrosis factor-α. Arterioscler Thromb Vase Biol 15:622-628.
27. Wiegmann K, Schütze S, Machleidt T, Witte D and Krönke M (1994) Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Cell 78:1005-1015.