Inflammation suppressor genes: Please switch out all the lights

Journal of Leukocyte Biology

Volumn 78, Issue 1, 2005, Pages 9-13

  Wells, Christine A ^a   Ravasi, Timothy ^b   Hume, David A ^b  

^a GRIFFITH UNIVERSITY   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Lipopolysaccharide; Macrophage; Toll like receptor

Indexed keywords

LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR 4;

CELL POPULATION; CHRONIC INFLAMMATION; GENE; GENE INDUCTION; GRAM NEGATIVE BACTERIUM; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; IMMUNOSTIMULATION; INFLAMMATION; INFLAMMATION SUPPRESSOR GENE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; GENE EXPRESSION REGULATION; GENES, SUPPRESSOR; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MEMBRANE GLYCOPROTEINS; RECEPTORS, CELL SURFACE; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

NEGIBACTERIA;

EID: 22144464423     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1204710     Document Type: Review

References (25)

1. Knudson Jr., A. G. (1971) Mutation and cancer: statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA 68, 820-823.
2. Nathan, C. (2002) Points of control in inflammation. Nature 420, 846-852.
3. Dandona, P., Aljada, A., Bandyopadhyay, A. (2004) Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol. 25, 4-7.
4. OMIM, Online Mendelian Inheritance in Man (2004) McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University, Baltimore, MD, and National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD. http://www.ncbi.nlm.nih.gov/omim/
5. Sweet, M. J., Hume, D. A. (1996) Endotoxin signal transduction in macrophages. J. Leukoc. Biol. 60, 8-26.
6. Wells, C., Ravasi, T., Faulkner, G., Carinci, P., Okazaki, Y., Hayashizaki, Y., Sweet, M. J., Wainwright, B. J., Hume, D. A. (2003) Genetic control of the innate immune response. BMC Immunol. 4, 5.
7. van de Loo, F. A. J., Bennink, M. B., Arntz, O. J., Smeets, R. L., Lubberts, E., Joosten, L. A. B., van Lent, P. L. E. M., Coenen-de Roo, C. J. J., Cuzzocrea, S., Segal, B. H., Holland, S. M., van den Berg, W. B. (2003) Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models. Am. J. Pathol. 163, 1525-1537.
8. Ravetch, J. V., Lanier, L. L. (2000) Immune inhibitory receptors. Science 290, 84-89.
9. Long, E. O. (1999) Regulation of immune responses through inhibitory receptors. Annu. Rev. Immunol. 17, 875-904.
10. Harder, K. W., Parsons, L. M., Armes, J., Evans, N., Kountouri, N., Clark, R., Quilici, C., Grail, D., Hodgson, G. S., Dunn, A. R., Hibbs, M. L. (2001) Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage. Immunity 15, 603-615.
11. Phillips, K., Kedersha, N., Shen, L., Blackshear, P. J., Anderson, P. (2004) Arthritis suppressor genes TIA-I and TTP dampen the expression of tumor necrosis factor α, cyclooxygenase 2, and inflammatory arthritis. Proc. Natl. Acad. Sci. USA 101, 2011-2016.
12. Blouin, C. C., Page, E. L., Soucy, C. M., Richard, D. E. (2004) Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1α. Blood 103, 1124-1130.
13. Netea, M. G., Kullberg, B. J., de Jong, D. J., Kranke, B., Sprong, T., Naber, T. H., Drenth, J. P., Van der Meer, J. W. (2004) NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease. Eur. J. Immunol. 34, 2052-2059.
14. Watanabe, T., Kitani, A., Murray, P. J., Strober, W. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat. Immunol. 5, 800-808.
15. O'Connor Jr., W., Harton, J. A., Zhu, X., Linhoff, M. W., Ting, J. P-Y. (2003) Cutting edge: CIASI/cryopyrin/PYPAFI/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NK-κ B suppressive properties. J. Immunol. 171, 6329-6333.
16. Xing, Y., Xu, Q., Lee, C. (2003) Widespread production of novel soluble protein isoforms by alternative splicing removal of transmembrane anchoring domains. FEBS Lett. 555, 572-578.
17. Janssens, S., Burns, K., Tschopp, J., Beyaert, R. (2002) Regulation of interleukin-1- and lipopolysaccharide-induced NF-κB activation by alternative splicing of MyD88. Curr. Biol. 12, 467-471.
18. Kobayashi, K., Hernandez, L. D., Galan, J. E., Janeway Jr., C. A., Medzhitov, R., Flavell, R. A. (2002) IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 110, 191-202.
19. Hardy, M. P., O'Neill, L. A. J. (2004) The murine Irak2 gene encodes four alternatively spliced isoforms, two of which are inhibitory. J. Biol. Chem. 279, 27699-27708.
20. Valledor, A. F., Xaus, J., Comalada, M., Soler, C., Celada, A. (2000) Protein kinase C ε is required for the induction of mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages. J. Immunol. 164, 29-37.
21. Krappmann, D., Wegener, E., Sunami, Y., Esen, M., Thiel, A., Mordmuller, B., Scheidereit, C. (2004) The IκB kinase complex and NF-κB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1. Mol. Cell Biol. 24, 6488-6500.
22. Lazarus, R., Vercelli, D., Palmer, L. J., Klimecki, W. J., Silverman, E. K., Richter, B., Riva, A., Ramoni, M., Martinez, F. D., Weiss, S. T., Kwiatkowski, D. J. (2002) Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease. Immunol. Rev. 190, 9-25.
23. Ogura, Y., Saab, L., Chen, F. F., Benito, A., Inohara, N., Nunez, G. (2003) Genetic variation and activity of mouse Nod2, a susceptibility gene for Crohn's disease. Genomics 81, 369-377.
24. Pereira, J. P., Girard, R., Chaby, R., Cumano, A., Vieira, P. (2003) Monoallelic expression of the murine gene encoding Toll-like receptor 4. Nat. Immunol. 4, 464-470.
25. Ravasi, T., Wells, C. A., Forest, A., Underhill, D. M., Wainwright, B. J., Aderem, A., Grimmond, S., Hume, D. A. (2002) Generation of diversity in the innate immune system: macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes. J. Immunol. 168, 44-50.