Pharmacogenomic responses of rat liver to methylprednisolone: An approach to mining a rich microarray time series

AAPS Journal

Volumn 7, Issue 1, 2005, Pages

  Almon, Richard R ^a   Dubois, Debra C ^a   Jin, Jin Y ^a   Jusko, William J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Data mining; Gene arrays; Glucocorticoids; Mathematical modeling; Pharmacogenomics

Indexed keywords

METHYLPREDNISOLONE SODIUM SUCCINATE; RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CLUSTER ANALYSIS; CONTROLLED STUDY; DATA ANALYSIS; FILTER; GENE EXPRESSION; GENE PROBE; GENETIC REGULATION; LIVER; MALE; MATHEMATICAL MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PHARMACOGENOMICS; QUALITY CONTROL; RAT; RNA HYBRIDIZATION; SEQUENTIAL ANALYSIS; SINGLE DRUG DOSE; STANDARDIZATION; TIME SERIES ANALYSIS; TISSUE MICROARRAY; UNINDEXED SEQUENCE;

ADRENALECTOMY; ALGORITHMS; ANIMALS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LIVER; MALE; METHYLPREDNISOLONE; MUSCLE, SKELETAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OLIGONUCLEOTIDE PROBES; RATS; RATS, WISTAR; RECEPTORS, GLUCOCORTICOID; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; SUBTRACTION TECHNIQUE; TIME FACTORS;

EID: 27144451563     PISSN: 15221059     EISSN: 15221059     Source Type: Journal    
DOI: 10.1208/aapsj070117     Document Type: Article

References (18)

1. Bialis M, Routledge P. Adverse effects of corticosteroids. Adverse Drug React Toxicol Rev. 1998;17:227-235.
2. Frauman A. An overview of the adverse reactions to adrenal corticosteroids. Adverse Drug React Toxicol Rev. 1996;15:203-206.
3. Reynolds RM, Walker BR. Human insulin resistance: the role of glucocorticoids. Diabetes Obes Metab. 2003;5:5-12.
4. Eisenstein A. Effects of adrenal cortical hormones on carbohydrate, protein, and fat metabolism. Am J Clin Nutr. 1973;26:113-120.
5. Jin JY, Almon RR, DuBois DC, Jusko WJ. Modeling of corticosteroid pharmacogenomics in rat liver using gene microarrays. J Pharmacol Exp Ther. 2003;307:93-109.
6. Friedman N, Kaminski N. Statistical Methods for Analyzing Gene Expression Data for Cancer Research. Ernst Schering Research Foundation Workshop. Springer-Verlag: Berlin, Germany; 2002;38:109-131.
7. Kaminski N. Microarray analysis of idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol. 2003;29:S32-S36.
8. Lock C, Hermans G, Pedotti R, et al. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med. 2002;8:500-508.
9. Sun YN, DuBois DC, Almon RR, Jusko WJ. Fourth-generation model for corticosteroid pharmacodynamics: a model for methylprednisolone effects on receptor/gene-mediated glucocorticoid receptor down-regulation and tyrosine aminotransferase induction in rat liver. J Pharmacokinet Biopharm. 1998;26:289-317.
10. Sun YN, DuBois DC, Almon RR, Pyszczynski NA, Jusko WJ. Dose-dependence and repeated-dose studies for receptor/gene-mediated pharmacodynamics of methylprednisolone on glucocorticoid receptor down-regulation and tyrosine aminotransferase induction in rat liver. J Pharmacokinet Biopharm. 1998;26:619-648.
11. Sun YN, McKay LI, DuBois DC, Jusko WJ, Almon RR. Pharmacokinetic/Pharmacodynamic models for corticosteroid receptor down-regulation and glutamine synthetase induction in rat skeletal muscle by a Receptor/Gene-mediated mechanism. J Pharmacol Exp Ther. 1999;288:720-728.
12. Almon RR, DuBois DC, Brandenburg EH, et al. Pharmacodynamics and pharmacogenomics of diverse receptor-mediated effects of methylprednisolone in rats using microarray analysis. J Pharmacokinet Pharmacodyn. 2002;29:103-129.
13. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A. 1998;95:14863-14868.
14. Takiguchi M, Mori M. Transcriptional regulation of genes for ornithine cycle enzymes. Biochem J. 1985;312:649-659.
15. McKay LI, DuBois DC, Sun YN, Almon RR, Jusko WJ. Corticosteroid effects in skeletal muscle: gene induction/receptor autoregulation. Muscle Nerve. 1997;20:1318-1320.
16. Ramakrishnan R, DuBois DC, Almon RR, Pyszczynski NA, Jusko WJ. Fifth-generation model for corticosteroid pharmacodynamics: application to steady-state receptor down-regulation and enzyme induction patterns during seven-day continuous infusion of methylprednisolone in rats. J Pharmacokinet Pharmacodyn. 2002;29:1-24.
17. Ramakrishnan R, DuBois DC, Almon RR, Pyszczynski NA Jusko WJ. Pharmacodynamics and pharmacogenomics of methylprednisolone during 7-day infusions in rats. J Pharmacol Exp Ther. 2002;300:245-256.
18. Almon RR, Chen J, Snyder G, DuBois DC, Jusko WJ Hoffman EP. In vivo multi-tissue corticosteroid microarray time series available online at Public Expression Profile Resource (PEPR). Pharmacogenomics. 2003;4:791-799.