Mathematical formalism for the properties of four basic models of indirect pharmacodynamic responses

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 25, Issue 1, 1997, Pages 107-123

  Krzyzanski, Wojciech ^a   Jusko, William J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Differential equations; Drug; Indirect response models; Pharmacodynamic responses; Pharmacokinetics

Indexed keywords

ARTICLE; CONCENTRATION RESPONSE; DRUG DISPOSITION; DRUG RESPONSE; MATHEMATICAL MODEL; PHARMACODYNAMICS; PHARMACOKINETICS; PRIORITY JOURNAL; SIMULATION;

MATHEMATICS; MODELS, BIOLOGICAL; PHARMACOKINETICS; PHARMACOLOGY;

EID: 0030662187     PISSN: 0090466X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025723927981     Document Type: Article

References (5)

1. N. L. Dayneka, V. Garg, and W. J. Jusko. Comparison of four basic models of indirect pharmacodynamic responses. J. Pharmacokin. Biopharm. 21:457-478 (1993).
2. W. J. Jusko and H. C. Ko. Physiologic indirect response models characterize diverse types of pharmacodynamic effects. Clin. Pharmacol. Ther. 56:406-419 (1994).
3. C. H. Edwards and D. E. Penney. Elementary Differential Equations with Applications, 3rd ed., Prentice-Hall, Englewood Cliffs, NJ, 1994, chap. 1.
4. A. Sharma and W. J. Jusko. Characterization of four basic models of indirect pharmacodynamic responses. J. Pharmacokin. Biopharm. 24:611-634 (1996).
5. W. J. Jusko, H. C. Ko, and W. F. Ebling. Convergence of direct and indirect pharmacodynamic response models, J. Pharmacokin. Biopharm. 23:5-8 (1995).