-
1
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, et al. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391: 806-811.
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
-
2
-
-
0035863097
-
RNA interference is mediated by 21- and 22-nucleotide RNAs
-
Elbashir SM, Lendeckel W, Tuschl T (2001) RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev 15: 188-200.
-
(2001)
Genes Dev
, vol.15
, pp. 188-200
-
-
Elbashir, S.M.1
Lendeckel, W.2
Tuschl, T.3
-
3
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, et al. (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498.
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
-
4
-
-
0035859929
-
Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
-
Caplen NJ, Parrish S, Imani F, Fire A, Morgan RA (2001) Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc Natl Acad Sci U S A 98: 9742-9747.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 9742-9747
-
-
Caplen, N.J.1
Parrish, S.2
Imani, F.3
Fire, A.4
Morgan, R.A.5
-
5
-
-
0036251639
-
Effective expression of small interfering RNA in human cells
-
Paul CP, Good PD, Winer I, Engelke DR (2002) Effective expression of small interfering RNA in human cells. Nat Biotechnol 20: 505-508.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 505-508
-
-
Paul, C.P.1
Good, P.D.2
Winer, I.3
Engelke, D.R.4
-
6
-
-
0037134020
-
A system for stable expression of short interfering RNAs in mammalian cells
-
Brummelkamp TR, Bernards R, Agami R (2002) A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550-553.
-
(2002)
Science
, vol.296
, pp. 550-553
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
7
-
-
0036245628
-
U6 promoter-driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells
-
Miyagishi M, Taira K (2002) U6 promoter-driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells. Nat Biotechnol 20: 497-500.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 497-500
-
-
Miyagishi, M.1
Taira, K.2
-
8
-
-
0034704084
-
Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters
-
Wang Z, Morris JC, Drew ME, Englund PT (2000) Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters. J Biol Chem 275: 40174-40179.
-
(2000)
J Biol Chem
, vol.275
, pp. 40174-40179
-
-
Wang, Z.1
Morris, J.C.2
Drew, M.E.3
Englund, P.T.4
-
9
-
-
0036185054
-
RNAi triggered by symmetrically transcribed transgenes in Drosophila melanogaster
-
Giordano E, Rendina R, Peluso I, Furia M (2002) RNAi triggered by symmetrically transcribed transgenes in Drosophila melanogaster. Genetics 160: 637-648.
-
(2002)
Genetics
, vol.160
, pp. 637-648
-
-
Giordano, E.1
Rendina, R.2
Peluso, I.3
Furia, M.4
-
10
-
-
3042561450
-
Expressing functional siRNAs in mammalian cells using convergent transcription
-
Tran N, Cairns MJ, Dawes IW, Arndt GM (2003) Expressing functional siRNAs in mammalian cells using convergent transcription. BMC Biotechnol 3: 21.
-
(2003)
BMC Biotechnol
, vol.3
, pp. 21
-
-
Tran, N.1
Cairns, M.J.2
Dawes, I.W.3
Arndt, G.M.4
-
11
-
-
10444240021
-
A plasmid-based system for expressing small interfering RNA libraries in mammalian cells
-
Kaykas A, Moon RT (2004) A plasmid-based system for expressing small interfering RNA libraries in mammalian cells. BMC Cell Biol 5: 16.
-
(2004)
BMC Cell Biol
, vol.5
, pp. 16
-
-
Kaykas, A.1
Moon, R.T.2
-
12
-
-
45549089565
-
The art and design of genetic screens: RNA interference
-
Boutros M, Ahringer J (2008) The art and design of genetic screens: RNA interference. Nat Rev Genet 9: 554-566.
-
(2008)
Nat Rev Genet
, vol.9
, pp. 554-566
-
-
Boutros, M.1
Ahringer, J.2
-
13
-
-
42149146685
-
From sequence to function: Using RNAi to elucidate mechanisms of human disease
-
Wolters NM, MacKeigan JP (2008) From sequence to function: using RNAi to elucidate mechanisms of human disease. Cell Death Differ 15: 809-819.
-
(2008)
Cell Death Differ
, vol.15
, pp. 809-819
-
-
Wolters, N.M.1
MacKeigan, J.P.2
-
14
-
-
0034676457
-
Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
-
Fraser AG, Kamath RS, Zipperlen P, Martinez-Campos M, Sohrmann M, et al. (2000) Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408: 325-330.
-
(2000)
Nature
, vol.408
, pp. 325-330
-
-
Fraser, A.G.1
Kamath, R.S.2
Zipperlen, P.3
Martinez-Campos, M.4
Sohrmann, M.5
-
15
-
-
0242361514
-
A functional genomic analysis of cell morphology using RNA interference
-
Kiger AA, Baum B, Jones S, Jones MR, Coulson A, et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J Biol 2: 27.
-
(2003)
J Biol
, vol.2
, pp. 27
-
-
Kiger, A.A.1
Baum, B.2
Jones, S.3
Jones, M.R.4
Coulson, A.5
-
16
-
-
12144289681
-
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
-
Berns K, Hijmans EM, Mullenders J, Brummelkamp TR, Velds A, et al. (2004) A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature 428: 431-437.
-
(2004)
Nature
, vol.428
, pp. 431-437
-
-
Berns, K.1
Hijmans, E.M.2
Mullenders, J.3
Brummelkamp, T.R.4
Velds, A.5
-
17
-
-
12144288006
-
A resource for large-scale RNA-interference-based screens in mammals
-
Paddison PJ, Silva JM, Conklin DS, Schlabach M, Li M, et al. (2004) A resource for large-scale RNA-interference-based screens in mammals. Nature 428: 427-431.
-
(2004)
Nature
, vol.428
, pp. 427-431
-
-
Paddison, P.J.1
Silva, J.M.2
Conklin, D.S.3
Schlabach, M.4
Li, M.5
-
18
-
-
27644436787
-
Second-generation shRNA libraries covering the mouse and human genomes
-
Silva JM, Li MZ, Chang K, Ge W, Golding MC, et al. (2005) Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet 37: 1281-1288.
-
(2005)
Nat Genet
, vol.37
, pp. 1281-1288
-
-
Silva, J.M.1
Li, M.Z.2
Chang, K.3
Ge, W.4
Golding, M.C.5
-
19
-
-
1842631431
-
Small interfering RNA production by enzymatic engineering of DNA (SPEED)
-
Luo B, Heard AD, Lodish HF (2004) Small interfering RNA production by enzymatic engineering of DNA (SPEED). Proc Natl Acad Sci U S A 101: 5494-5499.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 5494-5499
-
-
Luo, B.1
Heard, A.D.2
Lodish, H.F.3
-
20
-
-
0842332405
-
Enzymatic production of RNAi libraries from cDNAs
-
Shirane D, Sugao K, Namiki S, Tanabe M, Iino M, et al. (2004) Enzymatic production of RNAi libraries from cDNAs. Nat Genet 36: 190-196.
-
(2004)
Nat Genet
, vol.36
, pp. 190-196
-
-
Shirane, D.1
Sugao, K.2
Namiki, S.3
Tanabe, M.4
Iino, M.5
-
21
-
-
0842310832
-
Restriction enzyme-generated siRNA (REGS) vectors and libraries
-
Sen G, Wehrman TS, Myers JW, Blau HM (2004) Restriction enzyme-generated siRNA (REGS) vectors and libraries. Nat Genet 36: 183-189.
-
(2004)
Nat Genet
, vol.36
, pp. 183-189
-
-
Sen, G.1
Wehrman, T.S.2
Myers, J.W.3
Blau, H.M.4
-
22
-
-
0347089019
-
An approach to genomewide screens of expressed small interfering RNAs in mammalian cells
-
Zheng L, Liu J, Batalov S, Zhou D, Orth A, et al. (2004) An approach to genomewide screens of expressed small interfering RNAs in mammalian cells. Proc Natl Acad Sci U S A 101: 135-140.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 135-140
-
-
Zheng, L.1
Liu, J.2
Batalov, S.3
Zhou, D.4
Orth, A.5
-
23
-
-
33845977975
-
Screening for genes essential for mouse embryonic stem cell self-renewal using a subtractive RNA interference library
-
Zhang JZ, Gao W, Yang HB, Zhang B, Zhu ZY, et al. (2006) Screening for genes essential for mouse embryonic stem cell self-renewal using a subtractive RNA interference library. Stem Cells 24: 2661-2668.
-
(2006)
Stem Cells
, vol.24
, pp. 2661-2668
-
-
Zhang, J.Z.1
Gao, W.2
Yang, H.B.3
Zhang, B.4
Zhu, Z.Y.5
-
24
-
-
34547893850
-
A cDNA-based random RNA interference library for functional genetic screens in embryonic stem cells
-
Jian R, Cheng X, Jiang J, Deng S, Hu F, et al. (2007) A cDNA-based random RNA interference library for functional genetic screens in embryonic stem cells. Stem Cells 25: 1904-1912.
-
(2007)
Stem Cells
, vol.25
, pp. 1904-1912
-
-
Jian, R.1
Cheng, X.2
Jiang, J.3
Deng, S.4
Hu, F.5
-
25
-
-
37249065240
-
Generation of shRNAs from randomized oligonucleotides
-
Wu H, Dinh A, Mo YY (2007) Generation of shRNAs from randomized oligonucleotides. Biol Proced Online 9: 9-17.
-
(2007)
Biol Proced Online
, vol.9
, pp. 9-17
-
-
Wu, H.1
Dinh, A.2
Mo, Y.Y.3
-
26
-
-
34248390904
-
A randomized lentivirus shRNA library construction
-
Guo Q, Kong Y, Fu L, Yu T, Xu J, et al. (2007) A randomized lentivirus shRNA library construction. Biochem Biophys Res Commun 358: 272-276.
-
(2007)
Biochem Biophys Res Commun
, vol.358
, pp. 272-276
-
-
Guo, Q.1
Kong, Y.2
Fu, L.3
Yu, T.4
Xu, J.5
-
27
-
-
36248979862
-
Primer extension-based method for the generation of a siRNA/miRNA expression vector
-
Gou D, Zhang H, Baviskar PS, Liu L (2007) Primer extension-based method for the generation of a siRNA/miRNA expression vector. Physiol Genomics 31: 554-562.
-
(2007)
Physiol Genomics
, vol.31
, pp. 554-562
-
-
Gou, D.1
Zhang, H.2
Baviskar, P.S.3
Liu, L.4
-
29
-
-
14044272863
-
A universal plasmid library encoding all permutations of small interfering RNA
-
Chen M, Zhang L, Zhang HY, Xiong X, Wang B, et al. (2005) A universal plasmid library encoding all permutations of small interfering RNA. Proc Natl Acad Sci U S A 102: 2356-2361.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 2356-2361
-
-
Chen, M.1
Zhang, L.2
Zhang, H.Y.3
Xiong, X.4
Wang, B.5
-
30
-
-
0035800521
-
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
-
Hutvagner G, McLachlan J, Pasquinelli AE, Balint E, Tuschl T, et al. (2001) A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293: 834-838.
-
(2001)
Science
, vol.293
, pp. 834-838
-
-
Hutvagner, G.1
McLachlan, J.2
Pasquinelli, A.E.3
Balint, E.4
Tuschl, T.5
-
31
-
-
0035879501
-
Cloning of random oligonucleotides to create single-insert plasmid libraries
-
Worthington MT, Pelo J, Lo RQ (2001) Cloning of random oligonucleotides to create single-insert plasmid libraries. Anal Biochem 294: 169-175.
-
(2001)
Anal Biochem
, vol.294
, pp. 169-175
-
-
Worthington, M.T.1
Pelo, J.2
Lo, R.Q.3
-
32
-
-
54149095553
-
Biological principles of microRNA-mediated regulation: Shared themes amid diversity
-
Flynt AS, Lai EC (2008) Biological principles of microRNA-mediated regulation: shared themes amid diversity. Nat Rev Genet 9: 831-842.
-
(2008)
Nat Rev Genet
, vol.9
, pp. 831-842
-
-
Flynt, A.S.1
Lai, E.C.2
-
33
-
-
40449110935
-
The enigmatic world of mRNA-like ncRNAs: Their role in human evolution and in human diseases
-
Szell M, Bata-Csorgo Z, Kemeny L (2008) The enigmatic world of mRNA-like ncRNAs: their role in human evolution and in human diseases. Semin Cancer Biol 18: 141-148.
-
(2008)
Semin Cancer Biol
, vol.18
, pp. 141-148
-
-
Szell, M.1
Bata-Csorgo, Z.2
Kemeny, L.3
-
34
-
-
0037685280
-
Expression profiling reveals off-target gene regulation by RNAi
-
Jackson AL, Bartz SR, Schelter J, Kobayashi SV, Burchard J, et al. (2003) Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol 21: 635-637.
-
(2003)
Nat Biotechnol
, vol.21
, pp. 635-637
-
-
Jackson, A.L.1
Bartz, S.R.2
Schelter, J.3
Kobayashi, S.V.4
Burchard, J.5
-
35
-
-
13944282215
-
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
-
Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, et al. (2005) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433: 769-773.
-
(2005)
Nature
, vol.433
, pp. 769-773
-
-
Lim, L.P.1
Lau, N.C.2
Garrett-Engele, P.3
Grimson, A.4
Schelter, J.M.5
-
36
-
-
0142173075
-
Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells
-
Saxena S, Jonsson ZO, Dutta A (2003) Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells. J Biol Chem 278: 44312-44319.
-
(2003)
J Biol Chem
, vol.278
, pp. 44312-44319
-
-
Saxena, S.1
Jonsson, Z.O.2
Dutta, A.3
-
37
-
-
15044358407
-
A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites
-
Du Q, Thonberg H, Wang J, Wahlestedt C, Liang Z (2005) A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites. Nucleic Acids Res 33: 1671-1677.
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 1671-1677
-
-
Du, Q.1
Thonberg, H.2
Wang, J.3
Wahlestedt, C.4
Liang, Z.5
-
38
-
-
44449149276
-
Analysis of siRNA specificity on targets with double-nucleotide mismatches
-
Dahlgren C, Zhang HY, Du Q, Grahn M, Norstedt G, et al. (2008) Analysis of siRNA specificity on targets with double-nucleotide mismatches. Nucleic Acids Res 36: e53.
-
(2008)
Nucleic Acids Res
, vol.36
-
-
Dahlgren, C.1
Zhang2
HY, D.Q.3
Grahn, M.4
Norstedt, G.5
-
40
-
-
34250805982
-
MicroRNA targeting specificity in mammals: Determinants beyond seed pairing
-
Grimson A, Farh KK, Johnston WK, Garrett-Engele P, Lim LP, et al. (2007) MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell 27: 91-105.
-
(2007)
Mol Cell
, vol.27
, pp. 91-105
-
-
Grimson, A.1
Farh, K.K.2
Johnston, W.K.3
Garrett-Engele, P.4
Lim, L.P.5
-
41
-
-
33745612464
-
Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity
-
Jackson AL, Burchard J, Schelter J, Chau BN, Cleary M, et al. (2006) Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity. Rna 12: 1179-1187.
-
(2006)
Rna
, vol.12
, pp. 1179-1187
-
-
Jackson, A.L.1
Burchard, J.2
Schelter, J.3
Chau, B.N.4
Cleary, M.5
-
42
-
-
42449152837
-
Experimental validation of the importance of seed complement frequency to siRNA specificity
-
Anderson EM, Birmingham A, Baskerville S, Reynolds A, Maksimova E, et al. (2008) Experimental validation of the importance of seed complement frequency to siRNA specificity. Rna 14: 853-861.
-
(2008)
Rna
, vol.14
, pp. 853-861
-
-
Anderson, E.M.1
Birmingham, A.2
Baskerville, S.3
Reynolds, A.4
Maksimova, E.5
-
43
-
-
4544240870
-
Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling
-
Schmidt WM, Kalipciyan M, Dornstauder E, Rizovski B, Steger GG, et al. (2004) Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling. Int J Cancer 112: 200-212.
-
(2004)
Int J Cancer
, vol.112
, pp. 200-212
-
-
Schmidt, W.M.1
Kalipciyan, M.2
Dornstauder, E.3
Rizovski, B.4
Steger, G.G.5
-
44
-
-
33746620404
-
Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery
-
De Angelis PM, Svendsrud DH, Kravik KL, Stokke T (2006) Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. Mol Cancer 5: 20.
-
(2006)
Mol Cancer
, vol.5
, pp. 20
-
-
De Angelis, P.M.1
Svendsrud, D.H.2
Kravik, K.L.3
Stokke, T.4
-
45
-
-
40549090546
-
Cell cycle perturbation and acquired 5-fluorouracil resistance
-
Guo X, Goessl E, Jin G, Collie-Duguid ES, Cassidy J, et al. (2008) Cell cycle perturbation and acquired 5-fluorouracil resistance. Anticancer Res 28: 9-14.
-
(2008)
Anticancer Res
, vol.28
, pp. 9-14
-
-
Guo, X.1
Goessl, E.2
Jin, G.3
Collie-Duguid, E.S.4
Cassidy, J.5
-
46
-
-
0345830383
-
Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis
-
Di Stefano V, Rinaldo C, Sacchi A, Soddu S, D'Orazi G (2004) Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis. Exp Cell Res 293: 311-320.
-
(2004)
Exp Cell Res
, vol.293
, pp. 311-320
-
-
Di Stefano, V.1
Rinaldo, C.2
Sacchi, A.3
Soddu, S.4
D'Orazi, G.5
-
47
-
-
44549085662
-
Overexpression of HIPK2 circumvents the blockade of apoptosis in chemoresistant ovarian cancer cells
-
Puca R, Nardinocchi L, Pistritto G, D'Orazi G (2008) Overexpression of HIPK2 circumvents the blockade of apoptosis in chemoresistant ovarian cancer cells. Gynecol Oncol 109: 403-410.
-
(2008)
Gynecol Oncol
, vol.109
, pp. 403-410
-
-
Puca, R.1
Nardinocchi, L.2
Pistritto, G.3
D'Orazi, G.4
-
48
-
-
61349121467
-
Inhibition of HIF-1α activity by homoeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis
-
Nardinocchi L, Puca R, Sacchi A, D'Orazi G (2009) Inhibition of HIF-1α activity by homoeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis. Mol Cancer 8: 1.
-
(2009)
Mol Cancer
, vol.8
, pp. 1
-
-
Nardinocchi, L.1
Puca, R.2
Sacchi, A.3
D'Orazi, G.4
-
49
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
50
-
-
0033870281
-
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers and tumor-associated macrophages
-
Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, et al. (2000) The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers and tumor-associated macrophages. Am J Pathol 157: 411-421.
-
(2000)
Am J Pathol
, vol.157
, pp. 411-421
-
-
Talks, K.L.1
Turley, H.2
Gatter, K.C.3
Maxwell, P.H.4
Pugh, C.W.5
|