-
1
-
-
33646759590
-
Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase
-
Ahn, J. Y., X. Liu, Z. Liu, L. Pereira, D. Cheng, J. Peng, P. A. Wade, A. W. Hamburger, and K. Ye. 2006. Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase. EMBO J. 25:2083-2095.
-
(2006)
EMBO J
, vol.25
, pp. 2083-2095
-
-
Ahn, J.Y.1
Liu, X.2
Liu, Z.3
Pereira, L.4
Cheng, D.5
Peng, J.6
Wade, P.A.7
Hamburger, A.W.8
Ye, K.9
-
2
-
-
0346753579
-
Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2
-
Aki, T., K. Yamaguchi, T. Fujimiya, and Y. Mizukami. 2003. Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2. Oncogene 22:8529-8535.
-
(2003)
Oncogene
, vol.22
, pp. 8529-8535
-
-
Aki, T.1
Yamaguchi, K.2
Fujimiya, T.3
Mizukami, Y.4
-
3
-
-
41149161290
-
Apoptin: Therapeutic potential of an early sensor of carcinogenic transformation
-
Backendorf, C., A. E. Visser, A. G. de Boer, R. Zimmerman, M. Visser, P. Voskamp, Y. H. Zhang, and M. H. Noteborn. 2008. Apoptin: therapeutic potential of an early sensor of carcinogenic transformation. Annu. Rev. Pharmacol. Toxicol. 48:143-169.
-
(2008)
Annu. Rev. Pharmacol. Toxicol
, vol.48
, pp. 143-169
-
-
Backendorf, C.1
Visser, A.E.2
de Boer, A.G.3
Zimmerman, R.4
Visser, M.5
Voskamp, P.6
Zhang, Y.H.7
Noteborn, M.H.8
-
4
-
-
0033596127
-
Control of apoptosis by Rel/NF-kappaB transcription factors
-
Barkett, M., and T. D. Gilmore 1999. Control of apoptosis by Rel/NF-kappaB transcription factors. Oncogene 18:6910-6924.
-
(1999)
Oncogene
, vol.18
, pp. 6910-6924
-
-
Barkett, M.1
Gilmore, T.D.2
-
5
-
-
1642378661
-
Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase
-
Bashir, T., N. V. Dorrello, V. Amador, D. Guardavaccaro, and M. Pagano. 2004. Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase. Nature 428:190-193.
-
(2004)
Nature
, vol.428
, pp. 190-193
-
-
Bashir, T.1
Dorrello, N.V.2
Amador, V.3
Guardavaccaro, D.4
Pagano, M.5
-
6
-
-
0142116249
-
Cdk2 knockout mice are viable
-
Berthet, C., E. Aleem, V. Coppola, L. Tessarollo, and P. Kaldis. 2003. Cdk2 knockout mice are viable. Curr. Biol. 13:1775-1785.
-
(2003)
Curr. Biol
, vol.13
, pp. 1775-1785
-
-
Berthet, C.1
Aleem, E.2
Coppola, V.3
Tessarollo, L.4
Kaldis, P.5
-
7
-
-
33747465510
-
Monoclonal and bispecific antibodies as novel therapeutics
-
Booy, E. P., D. Johar, S. Maddika, H. Pirzada, M. M. Sahib, I. Gehrke, S. D. Loewen, S. D. Louis, K. Kadkhoda, M. Mowat, and M. Los. 2006. Monoclonal and bispecific antibodies as novel therapeutics. Arch. Immunol. Ther. Exp. 54:1-17.
-
(2006)
Arch. Immunol. Ther. Exp
, vol.54
, pp. 1-17
-
-
Booy, E.P.1
Johar, D.2
Maddika, S.3
Pirzada, H.4
Sahib, M.M.5
Gehrke, I.6
Loewen, S.D.7
Louis, S.D.8
Kadkhoda, K.9
Mowat, M.10
Los, M.11
-
8
-
-
32544433725
-
Apoptin-induced cell death is modulated by Bcl-2 family members and is Apaf-1 dependent
-
Burek, M., S. Maddika, C. J. Burek, P. T. Daniel, K. Schulze-Osthoff, and M. Los. 2006. Apoptin-induced cell death is modulated by Bcl-2 family members and is Apaf-1 dependent. Oncogene 25:2213-2222.
-
(2006)
Oncogene
, vol.25
, pp. 2213-2222
-
-
Burek, M.1
Maddika, S.2
Burek, C.J.3
Daniel, P.T.4
Schulze-Osthoff, K.5
Los, M.6
-
9
-
-
0033176887
-
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
-
Carrano, A. C., E. Eytan, A. Hershko, and M. Pagano. 1999. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat. Cell Biol. 1:193-199.
-
(1999)
Nat. Cell Biol
, vol.1
, pp. 193-199
-
-
Carrano, A.C.1
Eytan, E.2
Hershko, A.3
Pagano, M.4
-
10
-
-
46449136003
-
Deregulation of Cdk2 causes Bim-mediated apoptosis in p53-deficient tumors following actin damage
-
Chae, H. D., B. M. Kim, U. J. Yun, and D. Y. Shin. 2008. Deregulation of Cdk2 causes Bim-mediated apoptosis in p53-deficient tumors following actin damage. Oncogene 27:4115-4121.
-
(2008)
Oncogene
, vol.27
, pp. 4115-4121
-
-
Chae, H.D.1
Kim, B.M.2
Yun, U.J.3
Shin, D.Y.4
-
11
-
-
27844598284
-
The Akt/PKB pathway: Molecular target for cancer drug discovery
-
Cheng, J. Q., C. W. Lindsley, G. Z. Cheng, H. Yang, and S. V. Nicosia. 2005. The Akt/PKB pathway: molecular target for cancer drug discovery. Oncogene 24:7482-7492.
-
(2005)
Oncogene
, vol.24
, pp. 7482-7492
-
-
Cheng, J.Q.1
Lindsley, C.W.2
Cheng, G.Z.3
Yang, H.4
Nicosia, S.V.5
-
12
-
-
0032189381
-
Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
-
Coffer, P. J., J. Jin, and J. R. Woodgett. 1998. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem. J. 335:1-13.
-
(1998)
Biochem. J
, vol.335
, pp. 1-13
-
-
Coffer, P.J.1
Jin, J.2
Woodgett, J.R.3
-
13
-
-
12644313241
-
Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells
-
Danen-Van Oorschot, A. A., D. F. Fischer, J. M. Grimbergen, B. Klein, S. Zhuang, J. H. Falkenburg, C. Backendorf, P. H. Quax, A. J. Van der Eb, and M. H. Noteborn. 1997. Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells. Proc. Natl. Acad. Sci. USA 94:5843-5847.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 5843-5847
-
-
Danen-Van Oorschot, A.A.1
Fischer, D.F.2
Grimbergen, J.M.3
Klein, B.4
Zhuang, S.5
Falkenburg, J.H.6
Backendorf, C.7
Quax, P.H.8
Van der Eb, A.J.9
Noteborn, M.H.10
-
14
-
-
0033912936
-
The chicken anemia virus-derived protein apoptin requires activation of caspases for induction of apoptosis in human tumor cells
-
Danen-van Oorschot, A. A., A. J. van der Eb, and M. H. Noteborn. 2000. The chicken anemia virus-derived protein apoptin requires activation of caspases for induction of apoptosis in human tumor cells. J. Virol. 74:7072-7078.
-
(2000)
J. Virol
, vol.74
, pp. 7072-7078
-
-
Danen-van Oorschot, A.A.1
van der Eb, A.J.2
Noteborn, M.H.3
-
15
-
-
1342321750
-
PI 3-kinase, Akt and cell survival
-
Downward, J. 2004. PI 3-kinase, Akt and cell survival. Semin. Cell. Dev. Biol. 15:177-182.
-
(2004)
Semin. Cell. Dev. Biol
, vol.15
, pp. 177-182
-
-
Downward, J.1
-
16
-
-
27844601539
-
Regulation of the Akt kinase by interacting proteins
-
Du, K., and P. N. Tsichlis. 2005. Regulation of the Akt kinase by interacting proteins. Oncogene 24:7401-7409.
-
(2005)
Oncogene
, vol.24
, pp. 7401-7409
-
-
Du, K.1
Tsichlis, P.N.2
-
17
-
-
0344394175
-
Retinoids in cancer therapy and chemoprevention: Promise meets resistance
-
Freemantle, S. J., M. J. Spinella, and E. Dmitrovsky. 2003. Retinoids in cancer therapy and chemoprevention: promise meets resistance. Oncogene 22:7305-7315.
-
(2003)
Oncogene
, vol.22
, pp. 7305-7315
-
-
Freemantle, S.J.1
Spinella, M.J.2
Dmitrovsky, E.3
-
18
-
-
0033001501
-
Cell cycle withdrawal promotes myogenic induction of Akt, a positive modulator of myocyte survival
-
Fujio, Y., K. Guo, T. Mano, Y. Mitsuuchi, J. R. Testa, and K. Walsh. 1999. Cell cycle withdrawal promotes myogenic induction of Akt, a positive modulator of myocyte survival. Mol. Cell. Biol. 19:5073-5082.
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 5073-5082
-
-
Fujio, Y.1
Guo, K.2
Mano, T.3
Mitsuuchi, Y.4
Testa, J.R.5
Walsh, K.6
-
19
-
-
14944384245
-
Apoptosis signaling in tumor therapy
-
Fulda, S., and K. M. Debatin. 2004. Apoptosis signaling in tumor therapy. Ann. N. Y. Acad. Sci. 1028:150-156.
-
(2004)
Ann. N. Y. Acad. Sci
, vol.1028
, pp. 150-156
-
-
Fulda, S.1
Debatin, K.M.2
-
20
-
-
0035092687
-
The cell-cycle regulatory protein Cks1 is required for SCF-Skp2-mediated ubiquitinylation of p27
-
Ganoth, D., G. Bornstein, T. K. Ko, B. Larsen, M. Tyers, M. Pagano, and A. Hershko. 2001. The cell-cycle regulatory protein Cks1 is required for SCF-Skp2-mediated ubiquitinylation of p27. Nat. Cell Biol. 3:321-324.
-
(2001)
Nat. Cell Biol
, vol.3
, pp. 321-324
-
-
Ganoth, D.1
Bornstein, G.2
Ko, T.K.3
Larsen, B.4
Tyers, M.5
Pagano, M.6
Hershko, A.7
-
21
-
-
0032535140
-
A link between cell cycle and cell death: Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis
-
Gil-Gomez, G., A. Berns, and H. J. Brady. 1998. A link between cell cycle and cell death: Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis. EMBO J. 17:7209-7218.
-
(1998)
EMBO J
, vol.17
, pp. 7209-7218
-
-
Gil-Gomez, G.1
Berns, A.2
Brady, H.J.3
-
22
-
-
11144352722
-
Cdk1 and Cdk2 complexes (cyclin dependent kinases) in apoptosis: A role beyond the cell cycle
-
Golsteyn, R. M. 2005. Cdk1 and Cdk2 complexes (cyclin dependent kinases) in apoptosis: a role beyond the cell cycle. Cancer Lett. 217:129-138.
-
(2005)
Cancer Lett
, vol.217
, pp. 129-138
-
-
Golsteyn, R.M.1
-
23
-
-
0026713875
-
Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15
-
Gu, Y., J. Rosenblatt, and D. O. Morgan. 1992. Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J. 11:3995-4005.
-
(1992)
EMBO J
, vol.11
, pp. 3995-4005
-
-
Gu, Y.1
Rosenblatt, J.2
Morgan, D.O.3
-
24
-
-
1442327629
-
TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells
-
Guelen, L., H. Paterson, J. Gaken, M. Meyers, F. Farzaneh, and M. Tavassoli. 2004. TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells. Oncogene 23:1153-1165.
-
(2004)
Oncogene
, vol.23
, pp. 1153-1165
-
-
Guelen, L.1
Paterson, H.2
Gaken, J.3
Meyers, M.4
Farzaneh, F.5
Tavassoli, M.6
-
25
-
-
0036604448
-
Contribution of death receptor and mitochondrial pathways to Fas-mediated apoptosis in the prostatic carcinoma cell line PC3
-
Guseva, N. V., A. F. Taghiyev, O. W. Rokhlin, and M. B. Cohen. 2002. Contribution of death receptor and mitochondrial pathways to Fas-mediated apoptosis in the prostatic carcinoma cell line PC3. Prostate 51:231-240.
-
(2002)
Prostate
, vol.51
, pp. 231-240
-
-
Guseva, N.V.1
Taghiyev, A.F.2
Rokhlin, O.W.3
Cohen, M.B.4
-
26
-
-
0033559980
-
The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis
-
Hakem, A., T. Sasaki, I. Kozieradzki, and J. M. Penninger. 1999. The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis. J. Exp. Med. 189:957-968.
-
(1999)
J. Exp. Med
, vol.189
, pp. 957-968
-
-
Hakem, A.1
Sasaki, T.2
Kozieradzki, I.3
Penninger, J.M.4
-
27
-
-
0028234519
-
Participation of cyclin A in Myc-induced apoptosis
-
Hoang, A. T., K. J. Cohen, J. F. Barrett, D. A. Bergstrom, and C. V. Dang. 1994. Participation of cyclin A in Myc-induced apoptosis. Proc. Natl. Acad. Sci. USA 91:6875-6879.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 6875-6879
-
-
Hoang, A.T.1
Cohen, K.J.2
Barrett, J.F.3
Bergstrom, D.A.4
Dang, C.V.5
-
28
-
-
33847780136
-
The multiple battles fought by anti-apoptotic p21
-
Jänicke, R. U., D. Sohn, F. Essmann, and K. Schulze-Osthoff. 2007. The multiple battles fought by anti-apoptotic p21. Cell Cycle 6:407-413.
-
(2007)
Cell Cycle
, vol.6
, pp. 407-413
-
-
Jänicke, R.U.1
Sohn, D.2
Essmann, F.3
Schulze-Osthoff, K.4
-
29
-
-
33947155885
-
Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies
-
Janssen, K., T. G. Hofmann, D. A. Jans, R. T. Hay, K. Schulze-Osthoff, and U. Fischer. 2007. Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies. Oncogene 26:1557-1566.
-
(2007)
Oncogene
, vol.26
, pp. 1557-1566
-
-
Janssen, K.1
Hofmann, T.G.2
Jans, D.A.3
Hay, R.T.4
Schulze-Osthoff, K.5
Fischer, U.6
-
30
-
-
40549120602
-
Specific isoforms of p73 control the induction of cell death induced by the viral proteins, E1A or apoptin
-
Klanrit, P., M. B. Flinterman, E. W. Odell, G. Melino, R. Killick, J. S. Norris, and M. Tavassoli. 2008. Specific isoforms of p73 control the induction of cell death induced by the viral proteins, E1A or apoptin. Cell Cycle 7:205-215.
-
(2008)
Cell Cycle
, vol.7
, pp. 205-215
-
-
Klanrit, P.1
Flinterman, M.B.2
Odell, E.W.3
Melino, G.4
Killick, R.5
Norris, J.S.6
Tavassoli, M.7
-
31
-
-
0036170836
-
Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1
-
Kunstle, G., J. Laine, G. Pierron, S. Kagami Si, H. Nakajima, F. Hoh, C. Roumestand, M. H. Stern, and M. Noguchi. 2002. Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1. Mol. Cell. Biol. 22:1513-1525.
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 1513-1525
-
-
Kunstle, G.1
Laine, J.2
Pierron, G.3
Kagami Si, S.4
Nakajima, H.5
Hoh, F.6
Roumestand, C.7
Stern, M.H.8
Noguchi, M.9
-
32
-
-
0032012062
-
Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: Role of a caspase cascade
-
Levkau, B., H. Koyama, E. W. Raines, B. E. Clurman, B. Herren, K. Orth, J. M. Roberts, and R. Ross. 1998. Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade. Mol. Cell 1:553-563.
-
(1998)
Mol. Cell
, vol.1
, pp. 553-563
-
-
Levkau, B.1
Koyama, H.2
Raines, E.W.3
Clurman, B.E.4
Herren, B.5
Orth, K.6
Roberts, J.M.7
Ross, R.8
-
33
-
-
2342618936
-
Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression
-
Liang, J., and J. M. Slingerland. 2003. Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle 2:339-345.
-
(2003)
Cell Cycle
, vol.2
, pp. 339-345
-
-
Liang, J.1
Slingerland, J.M.2
-
34
-
-
18644376449
-
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
-
Liang, J., J. Zubovitz, T. Petrocelli, R. Kotchetkov, M. K. Connor, K. Han, J. H. Lee, S. Ciarallo, C. Catzavelos, R. Beniston, E. Franssen, and J. M. Slingerland. 2002. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat. Med. 8:1153-1160.
-
(2002)
Nat. Med
, vol.8
, pp. 1153-1160
-
-
Liang, J.1
Zubovitz, J.2
Petrocelli, T.3
Kotchetkov, R.4
Connor, M.K.5
Han, K.6
Lee, J.H.7
Ciarallo, S.8
Catzavelos, C.9
Beniston, R.10
Franssen, E.11
Slingerland, J.M.12
-
35
-
-
1342306819
-
Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3
-
Lin, B., S. K. Kolluri, F. Lin, W. Liu, Y. H. Han, X. Cao, M. I. Dawson, J. C. Reed, and X. K. Zhang. 2004. Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell 116:527-540.
-
(2004)
Cell
, vol.116
, pp. 527-540
-
-
Lin, B.1
Kolluri, S.K.2
Lin, F.3
Liu, W.4
Han, Y.H.5
Cao, X.6
Dawson, M.I.7
Reed, J.C.8
Zhang, X.K.9
-
36
-
-
0034912853
-
Caspases: More than just killers?
-
Los, M., C. Stroh, R. U. Janicke, I. H. Engels, and K. Schulze-Osthoff. 2001. Caspases: more than just killers? Trends Immunol. 22:31-34.
-
(2001)
Trends Immunol
, vol.22
, pp. 31-34
-
-
Los, M.1
Stroh, C.2
Janicke, R.U.3
Engels, I.H.4
Schulze-Osthoff, K.5
-
37
-
-
33646857103
-
Phosphatidylinositol 3-kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in epidermal Cl41 cells
-
Lu, B., L. Wang, C. Stehlik, D. Medan, C. Huang, S. Hu, F. Chen, X. Shi, and Y. Rojanasakul. 2006. Phosphatidylinositol 3-kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in epidermal Cl41 cells. J. Immunol. 176:6785-6793.
-
(2006)
J. Immunol
, vol.176
, pp. 6785-6793
-
-
Lu, B.1
Wang, L.2
Stehlik, C.3
Medan, D.4
Huang, C.5
Hu, S.6
Chen, F.7
Shi, X.8
Rojanasakul, Y.9
-
38
-
-
34247385065
-
Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma
-
Luciano, F., M. Krajewska, P. Ortiz-Rubio, S. Krajewski, D. Zhai, B. Faustin, J. M. Bruey, B. Bailly-Maitre, A. Lichtenstein, S. K. Kolluri, A. C. Satterthwait, X. K. Zhang, and J. C. Reed. 2007. Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma. Blood 109:3849-3855.
-
(2007)
Blood
, vol.109
, pp. 3849-3855
-
-
Luciano, F.1
Krajewska, M.2
Ortiz-Rubio, P.3
Krajewski, S.4
Zhai, D.5
Faustin, B.6
Bruey, J.M.7
Bailly-Maitre, B.8
Lichtenstein, A.9
Kolluri, S.K.10
Satterthwait, A.C.11
Zhang, X.K.12
Reed, J.C.13
-
39
-
-
43149102480
-
Akt mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis
-
Maddika, S., S. R. Ande, E. Wiechec, L. L. Hansen, S. Wesselborg, and M. Los. 2008. Akt mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis. J. Cell Sci. 121:979-988.
-
(2008)
J. Cell Sci
, vol.121
, pp. 979-988
-
-
Maddika, S.1
Ande, S.R.2
Wiechec, E.3
Hansen, L.L.4
Wesselborg, S.5
Los, M.6
-
40
-
-
36248987708
-
Akt is transferred to the nucleus of cells treated with apoptin, and it participates in apoptin-induced cell death
-
Maddika, S., G. H. Bay, T. J. Kroczak, S. R. Ande, S. Maddika, E. Wiechec, S. B. Gibson, and M. Los. 2007. Akt is transferred to the nucleus of cells treated with apoptin, and it participates in apoptin-induced cell death. Cell. Prolif. 40:835-848.
-
(2007)
Cell. Prolif
, vol.40
, pp. 835-848
-
-
Maddika, S.1
Bay, G.H.2
Kroczak, T.J.3
Ande, S.R.4
Maddika, S.5
Wiechec, E.6
Gibson, S.B.7
Los, M.8
-
41
-
-
27644584179
-
Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell-death mediators by a Nur77-dependent pathway
-
Maddika, S., E. P. Booy, D. Johar, S. B. Gibson, S. Ghavami, and M. Los. 2005. Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell-death mediators by a Nur77-dependent pathway. J. Cell Sci. 118:4485-4493.
-
(2005)
J. Cell Sci
, vol.118
, pp. 4485-4493
-
-
Maddika, S.1
Booy, E.P.2
Johar, D.3
Gibson, S.B.4
Ghavami, S.5
Los, M.6
-
42
-
-
43449130891
-
Interaction with PI3-kinase contributes to the cytotoxic activity of apoptin
-
Maddika, S., E. Wiechec, S. R. Ande, I. K. Poon, U. Fischer, S. Wesselborg, D. A. Jans, K. Schulze-Osthoff, and M. Los. 2008. Interaction with PI3-kinase contributes to the cytotoxic activity of apoptin. Oncogene 27:3060-3065.
-
(2008)
Oncogene
, vol.27
, pp. 3060-3065
-
-
Maddika, S.1
Wiechec, E.2
Ande, S.R.3
Poon, I.K.4
Fischer, U.5
Wesselborg, S.6
Jans, D.A.7
Schulze-Osthoff, K.8
Los, M.9
-
43
-
-
34250788809
-
AKT/PKB signaling: Navigating downstream
-
Manning, B. D., and L. C. Cantley. 2007. AKT/PKB signaling: navigating downstream. Cell 129:1261-1274.
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
44
-
-
0034643331
-
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
-
Medema, R. H., G. J. Kops, J. L. Bos, and B. M. Burgering. 2000. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404:782-787.
-
(2000)
Nature
, vol.404
, pp. 782-787
-
-
Medema, R.H.1
Kops, G.J.2
Bos, J.L.3
Burgering, B.M.4
-
45
-
-
33646712747
-
Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer
-
Nahta, R., D. Yu, M. C. Hung, G. N. Hortobagyi, and F. J. Esteva. 2006. Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat. Clin. Pract. Oncol. 3:269-280.
-
(2006)
Nat. Clin. Pract. Oncol
, vol.3
, pp. 269-280
-
-
Nahta, R.1
Yu, D.2
Hung, M.C.3
Hortobagyi, G.N.4
Esteva, F.J.5
-
46
-
-
0034595292
-
Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication
-
Nakayama, K., H. Nagahama, Y. A. Minamishima, M. Matsumoto, I. Nakamichi, K. Kitagawa, M. Shirane, R. Tsunematsu, T. Tsukiyama, N. Ishida, M. Kitagawa, K. Nakayama, and S. Hatakeyama. 2000. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J. 19:2069-2081.
-
(2000)
EMBO J
, vol.19
, pp. 2069-2081
-
-
Nakayama, K.1
Nagahama, H.2
Minamishima, Y.A.3
Matsumoto, M.4
Nakamichi, I.5
Kitagawa, K.6
Shirane, M.7
Tsunematsu, R.8
Tsukiyama, T.9
Ishida, N.10
Kitagawa, M.11
Nakayama, K.12
Hatakeyama, S.13
-
47
-
-
0037374597
-
Cytokine activation of phosphoinositide 3-kinase sensitizes hematopoietic cells to cisplatin-induced death
-
Nimbalkar, D., M. K. Henry, and F. W. Quelle. 2003. Cytokine activation of phosphoinositide 3-kinase sensitizes hematopoietic cells to cisplatin-induced death. Cancer Res. 63:1034-1039.
-
(2003)
Cancer Res
, vol.63
, pp. 1034-1039
-
-
Nimbalkar, D.1
Henry, M.K.2
Quelle, F.W.3
-
48
-
-
1442351169
-
The tumour specific pro-apoptotic factor apoptin (Vp3) from chicken anaemia virus
-
Oro, C., and D. A. Jans. 2004. The tumour specific pro-apoptotic factor apoptin (Vp3) from chicken anaemia virus. Curr. Drug Targets 5:179-190.
-
(2004)
Curr. Drug Targets
, vol.5
, pp. 179-190
-
-
Oro, C.1
Jans, D.A.2
-
49
-
-
0034724199
-
Tcl1 enhances Akt kinase activity and mediates its nuclear translocation
-
Pekarsky, Y., A. Koval, C. Hallas, R. Bichi, M. Tresini, S. Malstrom, G. Russo, P. Tsichlis, and C. M. Croce. 2000. Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. Proc. Natl. Acad. Sci. USA 97:3028-3033.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 3028-3033
-
-
Pekarsky, Y.1
Koval, A.2
Hallas, C.3
Bichi, R.4
Tresini, M.5
Malstrom, S.6
Russo, G.7
Tsichlis, P.8
Croce, C.M.9
-
50
-
-
35348815504
-
Imatinib mesylate in the treatment of hematologic malignancies
-
Piccaluga, P. P., M. Rondoni, S. Paolini, G. Rosti, G. Martinelli, and M. Baccarani. 2007. Imatinib mesylate in the treatment of hematologic malignancies. Expert Opin. Biol. Ther. 7:1597-1611.
-
(2007)
Expert Opin. Biol. Ther
, vol.7
, pp. 1597-1611
-
-
Piccaluga, P.P.1
Rondoni, M.2
Paolini, S.3
Rosti, G.4
Martinelli, G.5
Baccarani, M.6
-
51
-
-
6544245050
-
Specific tumor-cell killing with adenovirus vectors containing the apoptin gene
-
Pietersen, A. M., M. M. van der Eb, H. J. Rademaker, D. J. van den Wollenberg, M. J. Rabelink, P. J. Kuppen, J. H. van Dierendonck, H. van Ormondt, D. Masman, C. J. van de Velde, A. J. van der Eb, R. C. Hoeben, and M. H. Noteborn. 1999. Specific tumor-cell killing with adenovirus vectors containing the apoptin gene. Gene Ther. 6:882-892.
-
(1999)
Gene Ther
, vol.6
, pp. 882-892
-
-
Pietersen, A.M.1
van der Eb, M.M.2
Rademaker, H.J.3
van den Wollenberg, D.J.4
Rabelink, M.J.5
Kuppen, P.J.6
van Dierendonck, J.H.7
van Ormondt, H.8
Masman, D.9
van de Velde, C.J.10
van der Eb, A.J.11
Hoeben, R.C.12
Noteborn, M.H.13
-
52
-
-
23844445433
-
Apoptin nuclear accumulation is modulated by a CRM1-recognized nuclear export signal that is active in normal but not in tumor cells
-
Poon, I. K., C. Oro, M. M. Dias, J. Zhang, and D. A. Jans. 2005. Apoptin nuclear accumulation is modulated by a CRM1-recognized nuclear export signal that is active in normal but not in tumor cells. Cancer Res. 65:7059-7064.
-
(2005)
Cancer Res
, vol.65
, pp. 7059-7064
-
-
Poon, I.K.1
Oro, C.2
Dias, M.M.3
Zhang, J.4
Jans, D.A.5
-
53
-
-
0031058048
-
Identification of functional domains in the neuronal Cdk5 activator protein
-
Poon, R. Y., J. Lew, and T. Hunter. 1997. Identification of functional domains in the neuronal Cdk5 activator protein. J. Biol. Chem. 272:5703-5708.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 5703-5708
-
-
Poon, R.Y.1
Lew, J.2
Hunter, T.3
-
54
-
-
34347215518
-
Analysis of apoptosis by propidium iodide staining and flow cytometry
-
Riccardi, C., and I. Nicoletti. 2006. Analysis of apoptosis by propidium iodide staining and flow cytometry. Nat. Protoc. 1:1458-1461.
-
(2006)
Nat. Protoc
, vol.1
, pp. 1458-1461
-
-
Riccardi, C.1
Nicoletti, I.2
-
55
-
-
0037184913
-
A tumor-specific kinase activity regulates the viral death protein apoptin
-
Rohn, J. L., Y. H. Zhang, R. I. Aalbers, N. Otto, J. Den Hertog, N. V. Henriquez, C. J. Van De Velde, P. J. Kuppen, D. Mumberg, P. Donner, and M. J. Noteborn. 2002. A tumor-specific kinase activity regulates the viral death protein apoptin. J. Biol. Chem. 277:50820-50827.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 50820-50827
-
-
Rohn, J.L.1
Zhang, Y.H.2
Aalbers, R.I.3
Otto, N.4
Den Hertog, J.5
Henriquez, N.V.6
Van De Velde, C.J.7
Kuppen, P.J.8
Mumberg, D.9
Donner, P.10
Noteborn, M.J.11
-
56
-
-
3142512358
-
14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1)
-
Sekimoto, T., M. Fukumoto, and Y. Yoneda. 2004. 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1). EMBO J. 23:1934-1942.
-
(2004)
EMBO J
, vol.23
, pp. 1934-1942
-
-
Sekimoto, T.1
Fukumoto, M.2
Yoneda, Y.3
-
57
-
-
0037379438
-
Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity
-
Shack, S., X. T. Wang, G. C. Kokkonen, M. Gorospe, D. L. Longo, and N. J. Holbrook. 2003. Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity. Mol. Cell. Biol. 23:2407-2414.
-
(2003)
Mol. Cell. Biol
, vol.23
, pp. 2407-2414
-
-
Shack, S.1
Wang, X.T.2
Kokkonen, G.C.3
Gorospe, M.4
Longo, D.L.5
Holbrook, N.J.6
-
58
-
-
0035265829
-
A CDK-independent function of mammalian Cks1: Targeting of SCF(Skp2) to the CDK inhibitor p27Kip1
-
Spruck, C., H. Strohmaier, M. Watson, A. P. Smith, A. Ryan, T. W. Krek, and S. I. Reed. 2001. A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. Mol. Cell 7:639-650.
-
(2001)
Mol. Cell
, vol.7
, pp. 639-650
-
-
Spruck, C.1
Strohmaier, H.2
Watson, M.3
Smith, A.P.4
Ryan, A.5
Krek, T.W.6
Reed, S.I.7
-
59
-
-
23944504820
-
Apoptin: Specific killer of tumor cells?
-
Tavassoli, M., L. Guelen, B. A. Luxon, and J. Gaken. 2005. Apoptin: specific killer of tumor cells? Apoptosis 10:717-724.
-
(2005)
Apoptosis
, vol.10
, pp. 717-724
-
-
Tavassoli, M.1
Guelen, L.2
Luxon, B.A.3
Gaken, J.4
-
60
-
-
4043178615
-
The viral protein apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53
-
Teodoro, J. G., D. W. Heilman, A. E. Parker, and M. R. Green. 2004. The viral protein apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53. Genes Dev. 18:1952-1957.
-
(2004)
Genes Dev
, vol.18
, pp. 1952-1957
-
-
Teodoro, J.G.1
Heilman, D.W.2
Parker, A.E.3
Green, M.R.4
-
61
-
-
33745316089
-
Identification of a tumour suppressor network opposing nuclear Akt function
-
Trotman, L. C., A. Alimonti, P. P. Scaglioni, J. A. Koutcher, C. Cordon-Cardo, and P. P. Pandolfi. 2006. Identification of a tumour suppressor network opposing nuclear Akt function. Nature 441:523-527.
-
(2006)
Nature
, vol.441
, pp. 523-527
-
-
Trotman, L.C.1
Alimonti, A.2
Scaglioni, P.P.3
Koutcher, J.A.4
Cordon-Cardo, C.5
Pandolfi, P.P.6
-
62
-
-
0033578073
-
p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27
-
Tsvetkov, L. M., K. H. Yeh, S. J. Lee, H. Sun, and H. Zhang. 1999. p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr. Biol. 9:661-664.
-
(1999)
Curr. Biol
, vol.9
, pp. 661-664
-
-
Tsvetkov, L.M.1
Yeh, K.H.2
Lee, S.J.3
Sun, H.4
Zhang, H.5
-
63
-
-
33845340834
-
Chronic protein kinase B (PKB/c-akt) activation leads to apoptosis induced by oxidative stress-mediated Foxo3a transcriptional up-regulation
-
Van Gorp, A. G., K. M. Pomeranz, K. U. Birkenkamp, R. C. Hui, E. W. Lam, and P. J. Coffer. 2006. Chronic protein kinase B (PKB/c-akt) activation leads to apoptosis induced by oxidative stress-mediated Foxo3a transcriptional up-regulation. Cancer Res. 66:10760-10769.
-
(2006)
Cancer Res
, vol.66
, pp. 10760-10769
-
-
Van Gorp, A.G.1
Pomeranz, K.M.2
Birkenkamp, K.U.3
Hui, R.C.4
Lam, E.W.5
Coffer, P.J.6
-
64
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathway in human cancer
-
Vivanco, I., and C. L. Sawyers. 2002. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat. Rev. Cancer 2:489-501.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
65
-
-
2342562556
-
Mitogen-activated protein kinases in apoptosis regulation
-
Wada, T., and J. M. Penninger. 2004. Mitogen-activated protein kinases in apoptosis regulation. Oncogene 23:2838-2849.
-
(2004)
Oncogene
, vol.23
, pp. 2838-2849
-
-
Wada, T.1
Penninger, J.M.2
-
66
-
-
1642399624
-
-
Wei, W., N. G. Ayad, Y. Wan, G. J. Zhang, M. W. Kirschner, and W. G. Kaelin, Jr. 2004. Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature 428:194-198.
-
Wei, W., N. G. Ayad, Y. Wan, G. J. Zhang, M. W. Kirschner, and W. G. Kaelin, Jr. 2004. Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature 428:194-198.
-
-
-
-
67
-
-
42949105096
-
Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A
-
Wolthuis, R., L. Clay-Farrace, W. van Zon, M. Yekezare, L. Koop, J. Ogink, R. Medema, and J. Pines. 2008. Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A. Mol. Cell 30:290-302.
-
(2008)
Mol. Cell
, vol.30
, pp. 290-302
-
-
Wolthuis, R.1
Clay-Farrace, L.2
van Zon, W.3
Yekezare, M.4
Koop, L.5
Ogink, J.6
Medema, R.7
Pines, J.8
-
68
-
-
0036692835
-
Cyclin A in cell cycle control and cancer
-
Yam, C. H., T. K. Fung, and R. Y. Poon. 2002. Cyclin A in cell cycle control and cancer. Cell. Mol. Life Sci. 59:1317-1326.
-
(2002)
Cell. Mol. Life Sci
, vol.59
, pp. 1317-1326
-
-
Yam, C.H.1
Fung, T.K.2
Poon, R.Y.3
|