Deregulation of Cdk2 causes Bim-mediated apoptosis in p53-deficient tumors following actin damage

Oncogene

Volumn 27, Issue 29, 2008, Pages 4115-4121

  Chae, H D ^a,b   Kim, B M ^a,b   Yun, U J ^a,b   Shin, D Y ^a,b  

^a Dankook University College of Medicine   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Actin; Apoptosis; Bim; Cdk2; Polyploidy

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; ACTIN; BIM PROTEIN; CASPASE 3; CASPASE 9; CYCLIN A; CYCLIN B; CYCLIN D; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 2 INHIBITOR; CYCLIN E; CYCLINE; CYTOCHALASIN D; CYTOCHROME C; HEAT SHOCK PROTEIN 60; OLOMOUCINE; PECTENOTOXIN 2; PROTEIN BCL XL; PROTEIN MCL 1; PROTEIN P21; PROTEIN P53; PSYCHOSINE; RETINOBLASTOMA PROTEIN; ROSCOVITINE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; TUBULIN;

APOPTOSIS; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; ENZYME INACTIVATION; HUMAN; HUMAN CELL; MULTINUCLEAR CELL; POLYPLOIDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION;

ACTINS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-X PROTEIN; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; CYCLIN B; CYCLIN-DEPENDENT KINASE 2; FURANS; GENE EXPRESSION; GENES, DOMINANT; HUMANS; MEMBRANE PROTEINS; MUTATION; POLYPLOIDY; PROTO-ONCOGENE PROTEINS; PYRANS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 46449136003     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2008.46     Document Type: Article

References (26)

1. Amon A. (1999). The spindle checkpoint. Curr Opin Genet Dev 9: 69-75.
2. Andreassen PR, Lohez OD, Lacroix FB, Margolis RL. (2001). Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1. Mol Biol Cell 12: 1315-1328.
3. Antignani A, Youle RJ. (2006). How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane? Curr Opin Cell Biol 18: 685-689.
4. Barreyro FJ, Kobayashi S, Bronk SF, Werneburg NW, Malhi H, Gores GJ. (2007). Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis. J Biol Chem 282: 27141-27154.
5. Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP et al. (1998). Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282: 1497-1501.
6. Castedo M, Coquelle A, Vivet S, Vitale I, Kauffmann A, Dessen P et al. (2006). Apoptosis regulation in tetraploid cancer cells. EMBO J 25: 2584-2595.
7. Chae HD, Choi TS, Kim BM, Jung JH, Bang YJ, Shin DY. (2005). Oocyte-based screening of cytokinesis inhibitors and identification of pectenotoxin-2 that induces Bim/Bax-mediated apoptosis in p53-deficient tumors. Oncogene 24: 4813-4819.
8. Chae HD, Yun J, Bang YJ, Shin DY. (2004). Cdk2-dependent phosphorylation of the NF-Y transcription factor is essential for the expression of the cell cycle-regulatory genes and cell cycle G1/S and G2/M transitions. Oncogene 23: 4084-4088.
9. Di Leonardo A, Khan S, Linke S, Greco V, Seidita G, Wahl G. (1997). DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function. Cancer Res 57: 1013-1019.
10. Gilley J, Coffer PJ, Ham J. (2003). FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol 162: 613-622.
11. Graham FL, van der Eb AJ. (1973). Transformation of rat cells by DNA of human adenovirus 5. Virology 54: 536-539.
12. Hartwell LH, Weinert TA. (1989). Checkpoints: controls that ensure the order of cell cycle events. Science 246: 629-634.
13. Hollstein M, Sidransky D, Vogelstein B, Harris CC. (1991). p53 mutations in human cancers. Science 253: 49-53.
14. Jordan M, Thrower D, Wilson L. (1991). Mechanism of inhibition of cell proliferation by Vinca alkaloids. Cancer Res 51: 2212-2222.
15. Jordan M, Wendell K, Gardiner S, Derry W, Copp H, Wilson L. (1996). Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res 56: 816-825.
16. Jung MS, Yun J, Chae HD, Kim JM, Kim SC, Choi TS et al. (2001). p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor. Oncogene 20: 5818-5825.
17. Khan S, Wahl G. (1998). p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest. Cancer Res 58: 396-401.
18. Kuerbitz SJ, Plunkett BS, Walsh WV, Kastan MB. (1992). Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad Sci USA 89: 7491-7495.
19. Lanni JS, Jacks T. (1998). Characteriz ation of the p53-dependent postmitotic checkpoint following spindle disruption. Mol Cell Biol 18: 1055-1064.
20. Minn AJ, Boise LH, Thompson CB. (1996). Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage. Genes Dev 10: 2621-2631.
21. Puthalakath H, O'Reilly LA, Gunn P, Lee L, Kelly PN, Huntington ND et al. (2007). ER stress triggers apoptosis by activating BH3-only protein bim. Cell 129: 1337-1349.
22. Rudner AD, Murray AW. (1996). The spindle assembly checkpoint. Curr Opin Cell Biol 8: 773-780.
23. Sedlak TW, Oltvai ZN, Yang E, Wang K, Boise LH, Thompson CB et al. (1995). Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc Natl Acad Sci USA 92: 7834-7838.
24. Stahl M, Dijkers PF, Kops GJ, Lens SM, Coffer PJ, Burgering BM et al. (2002). The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J Immunol 168: 5024-5031.
25. Torres K, Horwitz S. (1998). Mechanisms of taxol-induced cell death are concentration dependent. Cancer Res 58: 3620-3626.
26. Yun J, Chae HD, Choi TS, Kim EH, Bang YJ, Chung J et al. (2003). Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway. J Biol Chem 278: 36966-36972.