The viral protein apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53

Genes and Development

Volumn 18, Issue 16, 2004, Pages 1952-1957

  Teodoro, Jose G ^a   Heilman, Destin W ^a   Parker, Albert E ^a   Green, Michael R ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Anaphase promoting complex cyclosome; Apoptin; Apoptosis; G2 M arrest; P53 independent; RNA interference

Indexed keywords

ANAPHASE PROMOTING COMPLEX; ANAPHASE PROMOTING COMPLEX 1; ANTINEOPLASTIC AGENT; APOPTIN; PROTEIN P53; UNCLASSIFIED DRUG;

ANAPHASE; APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL LINE; CELL MUTANT; CELL TRANSFORMATION; CIRCOVIRIDAE; CONTROLLED STUDY; DRUG TARGETING; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE;

APOPTOSIS; BASE SEQUENCE; CAPSID PROTEINS; DNA PRIMERS; FLUORESCENT ANTIBODY TECHNIQUE; G2 PHASE; HUMANS; MITOSIS; PRECIPITIN TESTS; PROTEIN BINDING; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASE COMPLEXES;

CHICKEN ANEMIA VIRUS; CIRCOVIRIDAE; GALLUS GALLUS;

EID: 4043178615     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1198404     Document Type: Article

References (24)

1. Bacchetti, S. and Graham, F.L. 1993. Inhibition of cell proliferation by an adenovirus vector expressing the human wild type p53 protein. Int. J. Onc. 3: 781-788.
2. Beroud, C. and Soussi, T. 2003. The UMD-p53 database: New mutations and analysis tools. Hum. Mutat. 21: 176-181.
3. Danen-Van Oorschot, A.A., Fischer, D.F., Grimbergen, J.M., Klein, B., Zhuang, S., Falkenburg, J.H., Backendorf, C., Quax, P.H., Van der Eb, A.J., and Noteborn, M.H. 1997. Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells. Proc. Natl. Acad. Sci. 94: 5843-5847.
4. Danen-Van Oorschot, A.A., van der Eb, A.J., and Noteborn, M.H. 1999. BCL-2 stimulates Apoptin-induced apoptosis. Adv. Exp. Med. Biol. 457: 245-249.
5. Danen-van Oorschot, A.A., van Der Eb, A.J., and Noteborn, M.H. 2000. The chicken anemia virus-derived protein apoptin requires activation of caspases for induction of apoptosis in human tumor cells. J. Virol. 74: 7072-7078.
6. Danen-Van Oorschot, A.A., Zhang, Y.H., Leliveld, S.R., Rohn, J.L., Seelen, M.C., Bolk, M.W., Van Zon, A., Erkeland, S.J., Abrahams, J.P., Mumberg, D., et al. 2003. Importance of nuclear localization of apoptin for tumor-specific induction of apoptosis. J. Biol. Chem. 278: 27729-27736.
7. Debernardis, D., Sire, E.G., De Feudis, P., Vikhanskaya, F., Valenti, M., Russo, P., Parodi, S., D'Incalci, M., and Broggini, M. 1997. p53 status does not affect sensitivity of human ovarian cancer cell lines to paclitaxel. Cancer Res. 57: 870-874.
8. Elbashir, S.M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., and Tuschl, T. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498.
9. Guelen, L., Paterson, H., Gaken, J., Meyers, M., Farzaneh, F., and Tavassoli, M. 2004. TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells. Oncogene 23: 1153-1165.
10. Hussain, S.P. and Harris, C.C. 1998. Molecular epidemiology of human cancer: Contribution of mutation spectra studies of tumor suppressor genes. Cancer Res. 58: 4023-4037.
11. Kirn, D., Martuza, R.L., and Zwiebel, J. 2001. Replication-selective virotherapy for cancer: Biological principles, risk management and future directions. Nat. Med. 7: 781-787.
12. Kornitzer, D., Sharf, R., and Kleinberger, T. 2001. Adenovirus E4orf4 protein induces PP2A-dependent growth arrest in Saccharomyces cerevisiae and interacts with the anaphase-promoting complex/cyclosome. J. Cell Biol. 154: 331-344.
13. Kraft, C., Herzog, F., Gieffers, C., Mechtler, K., Hagting, A., Pines, J., and Peters, J.M. 2003. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. EMBO J. 22: 6598-6609.
14. Marcellus, R.C., Lavoie, J.N., Boivin, D., Shore, G.C., Ketner, G., and Branton, P.E. 1998. The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis. J. Virol. 72: 7144-7153.
15. Roulston, A., Marcellus, R.C., and Branton, P.E. 1999. Viruses and apoptosis. Annu. Rev. Microbiol. 53: 577-628.
16. Saffery, R., Irvine, D.V., Griffiths, B., Kalitsis, P., and Choo, K.H. 2000. Components of the human spindle checkpoint control mechanism localize specifically to the active centromere on dicentric chromosomes. Hum. Genet. 107: 376-384.
17. Teodoro, J.G. and Branton, P.E. 1997. Regulation of apoptosis by viral gene products. J. Virol. 71: 1739-1746.
18. van der Eb, M.M., Pietersen, A.M., Speetjens, F.M., Kuppen, P.J., van de Velde, C.J., Noteborn, M.H., and Hoeben, R.C. 2002. Gene therapy with apoptin induces regression of xenografted human hepatomas. Cancer Gene Ther. 9: 53-61.
19. Vikhanskaya, F., Vignati, S., Beccaglia, P., Ottoboni, C., Russo, P., D'Incalci, M., and Broggini, M. 1998. Inactivation of p53 in a human ovarian cancer cell line increases the sensitivity to paclitaxel by inducing G2/M arrest and apoptosis. Exp. Cell Res. 241: 96-101.
20. Vodermaier, H.C., Gieffers, C., Maurer-Stroh, S., Eisenhaber, F., and Peters, J.M. 2003. TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. Curr. Biol. 13: 1459-1468.
21. Wahl, A.F., Donaldson, K.L., Fairchild, C., Lee, F.Y., Foster, S.A., Demers, G.W., and Galloway, D.A. 1996. Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis. Nat. Med. 2: 72-79.
22. Wirth, K.G., Ricci, R., Gimenez-Abian, J.F., Taghybeeglu, S., Kudo, N.R., Jochum, W., Vasseur-Cognet, M., and Nasmyth, K. 2004. Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation. Genes & Dev. 18: 88-98.
23. Yu, J., Tiwari, S., Steiner, P., and Zhang, L. 2003. Differential apoptotic response to the proteasome inhibitor Bortezomib (VELCADE™, PS-341) in Bax-deficient and p21-deficient colon cancer cells. Cancer Biol. Ther. 2: 694-699.
24. Zhuang, S.M., Shvarts, A., van Ormondt, H., Jochemsen, A.G., van der Eb, A.J., and Noteborn, M.H. 1995. Apoptin, a protein derived from chicken anemia virus, induces p53-independent apoptosis in human osteosarcoma cells. Cancer Res. 55: 486-489.