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Volumn 54, Issue 2, 2006, Pages 85-101

Monoclonal and bispecific antibodies as novel therapeutics

Author keywords

Bexxar; Gleevec; Imantib; Mitumomab; Tositumomab; Trastuzumab

Indexed keywords

[4 [2 CYCLOPENTYL 9 (3 HYDROXYPHENETHYL)PURIN 6 YLAMINO]PHENYL]DIMETHYLPHOSPHINE OXIDE; ALEMTUZUMAB; AZD 0530; BEC 2; BEVACIZUMAB; BISPECIFIC ANTIBODY; BOSUTINIB; CEA VAC; CETUXIMAB; CG 76030; DACLIZUMAB; DASATINIB; EDRECOLOMAB; EPIDERMAL GROWTH FACTOR; EPRATUZUMAB; GEMTUZUMAB OZOGAMICIN; GROWTH FACTOR; GROWTH FACTOR RECEPTOR; IBRITUMOMAB TIUXETAN; IMATINIB; MASTUZUMAB; MATUZUMAB; MDX 210; MITUMOMAB; MONOCLONAL ANTIBODY; OREGOVOMAB; PANITUMUMAB; PEMTUMOMAB; PHOSPHOTRANSFERASE; RITUXIMAB; TOSITUMOMAB I 131; TRASTUZUMAB; TRIAB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 33747465510     PISSN: 0004069X     EISSN: 16614917     Source Type: Journal    
DOI: 10.1007/s00005-006-0011-5     Document Type: Review
Times cited : (33)

References (167)
  • 1
    • 0033735278 scopus 로고    scopus 로고
    • Technology evaluation: Edrecolomab, Centocor Inc.
    • Abicht A. and Lochmuller H. (2000): Technology evaluation: edrecolomab, Centocor Inc. Curr. Opin. Mol. Ther., 2, 593-600.
    • (2000) Curr. Opin. Mol. Ther. , vol.2 , pp. 593-600
    • Abicht, A.1    Lochmuller, H.2
  • 2
    • 0022647432 scopus 로고
    • The product of the human c-erbB-2 gene: A 185-kilodalton glycoprotein with tyrosine kinase activity
    • Akiyama T., Sudo C., Ogawara H., Toyoshima K.and Yamamoto T. (1986): The product of the human c-erbB-2 gene: a 185-kilodalton glycoprotein with tyrosine kinase activity. Science, 232, 1644-1646.
    • (1986) Science , vol.232 , pp. 1644-1646
    • Akiyama, T.1    Sudo, C.2    Ogawara, H.3    Toyoshima, K.4    Yamamoto, T.5
  • 6
    • 27644497588 scopus 로고    scopus 로고
    • Strategies of protection of normal cells during chemo- and radio-therapy based on modulation of cell cycle and apoptotic pathways
    • Los M. and Gibson S. B. (eds.) Springer Science+Business Media, Inc., New York
    • Blagosklonny M. V. and Darzynkiewicz Z. (2005): Strategies of protection of normal cells during chemo- and radio-therapy based on modulation of cell cycle and apoptotic pathways. In: Los M. and Gibson S. B. (eds.): Apoptotic pathways as target for novel therapies in cancer and other diseases. Springer Science+Business Media, Inc., New York, 357-391.
    • (2005) Apoptotic Pathways As Target for Novel Therapies in Cancer and Other Diseases , pp. 357-391
    • Blagosklonny, M.V.1    Darzynkiewicz, Z.2
  • 7
    • 0035991907 scopus 로고    scopus 로고
    • Plasma membrane components of adherens junctions
    • Blaschuk O. W. and Rowlands T. M. (2002): Plasma membrane components of adherens junctions. Mol. Membr. Biol., 19, 75-80.
    • (2002) Mol. Membr. Biol. , vol.19 , pp. 75-80
    • Blaschuk, O.W.1    Rowlands, T.M.2
  • 9
    • 0036566540 scopus 로고    scopus 로고
    • High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
    • Branford S., Rudzki Z., Walsh S., Grigg A., Arthur C., Taylor K., Herrmann R., Lynch K. P. and Hughes T. P. (2002): High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood, 99, 3472-3475.
    • (2002) Blood , vol.99 , pp. 3472-3475
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3    Grigg, A.4    Arthur, C.5    Taylor, K.6    Herrmann, R.7    Lynch, K.P.8    Hughes, T.P.9
  • 11
    • 14944382647 scopus 로고    scopus 로고
    • Growth factors, receptors, and kinases: Their exploration to target cancer
    • Los M. and Gibson S. B. (eds.) Springer Science + Business Media, Inc., New York
    • Brown J. G. and Gibson S. B. (2005): Growth factors, receptors, and kinases: their exploration to target cancer. In: Los M. and Gibson S. B. (eds.): Apoptotic pathways as target for novel therapies in cancer and other diseases: Springer Science + Business Media, Inc., New York, 173-196.
    • (2005) Apoptotic Pathways As Target for Novel Therapies in Cancer and Other Diseases , pp. 173-196
    • Brown, J.G.1    Gibson, S.B.2
  • 14
    • 13944282937 scopus 로고    scopus 로고
    • Identification of Src-specific phosphorylation site on focal adhesion kinase: Dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior
    • Brunton V. G., Avizienyte E., Fincham V. J., Serrels B., Metcalf C. A. 3rd, Sawyer T. K. and Frame M. C. (2005): Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior. Cancer Res., 65, 1335-1342.
    • (2005) Cancer Res. , vol.65 , pp. 1335-1342
    • Brunton, V.G.1    Avizienyte, E.2    Fincham, V.J.3    Serrels, B.4    Metcalf III, C.A.5    Sawyer, T.K.6    Frame, M.C.7
  • 16
    • 0037010087 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression, signal pathway, and inhibitors in non-small cell lung cancer
    • Bunn P. A. Jr. and Franklin W. (2002): Epidermal growth factor receptor expression, signal pathway, and inhibitors in non-small cell lung cancer. Semin. Oncol., 29, 38-44.
    • (2002) Semin. Oncol. , vol.29 , pp. 38-44
    • Bunn Jr., P.A.1    Franklin, W.2
  • 17
    • 3543106366 scopus 로고    scopus 로고
    • Phase III randomized trial of cisplatin plus placebo versus cisplatin+C225, a monoclonal antibody directed to the epidermal growth factor-receptor: An Eastern Cooperative Oncology Group trial
    • Burtness B. A., Li Y., Flood W., Mattar B. I. and Forastiere A. (2003): Phase III randomized trial of cisplatin plus placebo versus cisplatin+C225, a monoclonal antibody directed to the epidermal growth factor-receptor: An Eastern Cooperative Oncology Group trial. Clin. Cancer Res., 9, 6088S.
    • (2003) Clin. Cancer Res. , vol.9
    • Burtness, B.A.1    Li, Y.2    Flood, W.3    Mattar, B.I.4    Forastiere, A.5
  • 19
    • 17844386569 scopus 로고    scopus 로고
    • Monoclonal antibodies targeting epidermal growth factor receptor and vascular endothelial growth factor with a focus on head and neck tumors
    • Caponigro F., Formato R., Caraglia M., Normanno N. and Iaffaioli R. V. (2005): Monoclonal antibodies targeting epidermal growth factor receptor and vascular endothelial growth factor with a focus on head and neck tumors. Curr. Opin. Oncol., 17, 212-217.
    • (2005) Curr. Opin. Oncol. , vol.17 , pp. 212-217
    • Caponigro, F.1    Formato, R.2    Caraglia, M.3    Normanno, N.4    Iaffaioli, R.V.5
  • 20
    • 0035524114 scopus 로고    scopus 로고
    • Improving the efficacy of antibody-based cancer therapies
    • Carter P. (2001): Improving the efficacy of antibody-based cancer therapies. Nat. Rev. Cancer, 1, 118-129.
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 118-129
    • Carter, P.1
  • 23
    • 0033227592 scopus 로고    scopus 로고
    • Preclinical evaluation of 90Y-labeled anti-CD20 monoclonal antibody for treatment of non-Hodgkin's lymphoma
    • Chinn P. C., Leonard J. E., Rosenberg J., Hanna N. and Anderson D. R. (1999): Preclinical evaluation of 90Y-labeled anti-CD20 monoclonal antibody for treatment of non-Hodgkin's lymphoma. Int. J. Oncol., 15, 1017-1025.
    • (1999) Int. J. Oncol. , vol.15 , pp. 1017-1025
    • Chinn, P.C.1    Leonard, J.E.2    Rosenberg, J.3    Hanna, N.4    Anderson, D.R.5
  • 26
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
    • Clynes R. A., Towers T. L., Presta L. G. and Ravetch J. V. (2000): Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat. Med., 6, 443-446.
    • (2000) Nat. Med. , vol.6 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3    Ravetch, J.V.4
  • 31
    • 0038518619 scopus 로고    scopus 로고
    • Practical management of patients with chronic myeloid leukemia receiving imatinib
    • Deininger M. W., O'Brien S. G., Ford J. M. and Druker B. J. (2003): Practical management of patients with chronic myeloid leukemia receiving imatinib. J. Clin. Oncol., 21, 1637-1647.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 1637-1647
    • Deininger, M.W.1    O'Brien, S.G.2    Ford, J.M.3    Druker, B.J.4
  • 32
  • 33
    • 0037254419 scopus 로고    scopus 로고
    • Imatinib alone and in combination for chronic myeloid leukemia
    • Druker B. J. (2003): Imatinib alone and in combination for chronic myeloid leukemia. Semin. Hematol., 40, 50-58.
    • (2003) Semin. Hematol. , vol.40 , pp. 50-58
    • Druker, B.J.1
  • 34
    • 0033987746 scopus 로고    scopus 로고
    • Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia
    • Druker B. J. and Lydon N. B. (2000): Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia. J. Clin. Invest., 105, 3-7.
    • (2000) J. Clin. Invest. , vol.105 , pp. 3-7
    • Druker, B.J.1    Lydon, N.B.2
  • 36
    • 0036080953 scopus 로고    scopus 로고
    • CAMPATH (alemtuzumab) for the treatment of chronic lymphocytic leukemia and beyond
    • Dumont F. J. (2002): CAMPATH (alemtuzumab) for the treatment of chronic lymphocytic leukemia and beyond. Expert Rev. Anticancer Ther., 2, 23-35.
    • (2002) Expert Rev. Anticancer Ther. , vol.2 , pp. 23-35
    • Dumont, F.J.1
  • 37
    • 0017653321 scopus 로고
    • Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage
    • Fialkow P. J., Jacobson R. J. and Papayannopoulou T. (1977): Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. Am. J. Med., 63, 125-130.
    • (1977) Am. J. Med. , vol.63 , pp. 125-130
    • Fialkow, P.J.1    Jacobson, R.J.2    Papayannopoulou, T.3
  • 38
    • 0032529438 scopus 로고    scopus 로고
    • Src stimulates insulin-like growth factor I (IGF-I)-dependent cell proliferation by increasing IGF-I receptor number in human pancreatic carcinoma cells
    • Flossmann-Kast B. B., Jehle P. M., Hoeflich A., Adler G. and Lutz M. P. (1998): Src stimulates insulin-like growth factor I (IGF-I)-dependent cell proliferation by increasing IGF-I receptor number in human pancreatic carcinoma cells. Cancer Res., 58, 3551-3554.
    • (1998) Cancer Res. , vol.58 , pp. 3551-3554
    • Flossmann-Kast, B.B.1    Jehle, P.M.2    Hoeflich, A.3    Adler, G.4    Lutz, M.P.5
  • 39
    • 0032877667 scopus 로고    scopus 로고
    • Clinical and immune responses in resected colon cancer patients treated with anti-idiotype monoclonal antibody vaccine that mimics the carcinoembryonic antigen
    • Foon K. A., John W. J., Chakraborty M., Das R., Teitelbaum A., Garrison J., Kashala O., Chatterjee S. K. and Bhattacharya-Chatterjee M. (1999): Clinical and immune responses in resected colon cancer patients treated with anti-idiotype monoclonal antibody vaccine that mimics the carcinoembryonic antigen. J. Clin. Oncol., 17, 2889-2885.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 2889-12885
    • Foon, K.A.1    John, W.J.2    Chakraborty, M.3    Das, R.4    Teitelbaum, A.5    Garrison, J.6    Kashala, O.7    Chatterjee, S.K.8    Bhattacharya-Chatterjee, M.9
  • 40
    • 0028909393 scopus 로고
    • Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules
    • Freeman S. D., Kelm S., Barber E. K. and Crocker P. R. (1995): Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules. Blood, 85, 2005-2012.
    • (1995) Blood , vol.85 , pp. 2005-2012
    • Freeman, S.D.1    Kelm, S.2    Barber, E.K.3    Crocker, P.R.4
  • 42
    • 4444325508 scopus 로고    scopus 로고
    • Monoclonal antibodies in cancer therapy
    • Gatto B. (2004): Monoclonal antibodies in cancer therapy. Curr. Med. Chem. Anti-Cane. Agents, 4, 411-414.
    • (2004) Curr. Med. Chem. Anti-Cane. Agents , vol.4 , pp. 411-414
    • Gatto, B.1
  • 44
    • 3042740431 scopus 로고    scopus 로고
    • Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines: The role of ROS and the effect of metal ions
    • Ghavami S., Kerkhoff C., Los M., Hashemi M., Sorg C. and Karami-Tehrani F. (2004): Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines: the role of ROS and the effect of metal ions. J. Leukoc. Biol., 76, 169-175.
    • (2004) J. Leukoc. Biol. , vol.76 , pp. 169-175
    • Ghavami, S.1    Kerkhoff, C.2    Los, M.3    Hashemi, M.4    Sorg, C.5    Karami-Tehrani, F.6
  • 45
    • 0034042660 scopus 로고    scopus 로고
    • Multiple roles for the major histocompatibility complex class I- related receptor FcRn
    • Ghetie V. and Ward E. S. (2000): Multiple roles for the major histocompatibility complex class I- related receptor FcRn. Annu. Rev. Immunol., 18, 739-766.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 739-766
    • Ghetie, V.1    Ward, E.S.2
  • 46
    • 0242695736 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin in the treatment of acute myeloid leukemia
    • Giles F., Estey E. and O'Brien S. (2003): Gemtuzumab ozogamicin in the treatment of acute myeloid leukemia. Cancer, 98, 2095-2104.
    • (2003) Cancer , vol.98 , pp. 2095-2104
    • Giles, F.1    Estey, E.2    O'Brien, S.3
  • 47
    • 0033855859 scopus 로고    scopus 로고
    • Clinical trials of antibody therapy
    • Glennie M. J. and Johnson P. W. (2000): Clinical trials of antibody therapy. Immunol. Today, 21, 403-410.
    • (2000) Immunol. Today , vol.21 , pp. 403-410
    • Glennie, M.J.1    Johnson, P.W.2
  • 48
    • 0037439689 scopus 로고    scopus 로고
    • SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice
    • Golas J. M., Arndt K., Etienne C., Lucas J., Nardin D., Gibbons J., Frost P., Ye F., Boschelli D. H. and Boschelli F. (2003): SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Cancer Res., 63, 375-381.
    • (2003) Cancer Res. , vol.63 , pp. 375-381
    • Golas, J.M.1    Arndt, K.2    Etienne, C.3    Lucas, J.4    Nardin, D.5    Gibbons, J.6    Frost, P.7    Ye, F.8    Boschelli, D.H.9    Boschelli, F.10
  • 49
    • 0034468346 scopus 로고    scopus 로고
    • Rituximab: An insider's historical perspective
    • Grillo-Lopez A. J. (2000): Rituximab: an insider's historical perspective. Semin. Oncol., 27, 9-16.
    • (2000) Semin. Oncol. , vol.27 , pp. 9-16
    • Grillo-Lopez, A.J.1
  • 51
    • 0021346853 scopus 로고
    • Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
    • Groffen J., Stephenson J. R., Heisterkamp N., de Klein A., Bartram C. R. and Grosveld G. (1984): Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell, 36, 93-99.
    • (1984) Cell , vol.36 , pp. 93-99
    • Groffen, J.1    Stephenson, J.R.2    Heisterkamp, N.3    De Klein, A.4    Bartram, C.R.5    Grosveld, G.6
  • 52
    • 0035496616 scopus 로고    scopus 로고
    • Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2
    • Gupta R. A. and Dubois R. N. (2001): Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nat. Rev. Cancer, 1, 11-21.
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 11-21
    • Gupta, R.A.1    Dubois, R.N.2
  • 53
    • 0029928384 scopus 로고    scopus 로고
    • Recent results using CAMPATH-1 antibodies to control GVHD and graft rejection
    • Hale G. and Waldmann H. (1996): Recent results using CAMPATH-1 antibodies to control GVHD and graft rejection. Bone Marrow Transplant., 17, 305-308.
    • (1996) Bone Marrow Transplant. , vol.17 , pp. 305-308
    • Hale, G.1    Waldmann, H.2
  • 54
    • 0035104782 scopus 로고    scopus 로고
    • Update of clinical trials with edrecolomab: A monoclonal antibody therapy for colorectal cancer
    • Haller D. G. (2001): Update of clinical trials with edrecolomab: a monoclonal antibody therapy for colorectal cancer. Semin. Oncol., 28, 25-30.
    • (2001) Semin. Oncol. , vol.28 , pp. 25-30
    • Haller, D.G.1
  • 55
    • 15244352751 scopus 로고    scopus 로고
    • A calicheamicin conjugate with a fully humanized anti-MUC1 antibody shows potent antitumor effects in breast and ovarian tumor xenografts
    • Hamann P. R., Hinman L. M., Beyer C. F., Lindh D., Upeslacis J., Shochat D. and Mountain A. (2005): A calicheamicin conjugate with a fully humanized anti-MUC1 antibody shows potent antitumor effects in breast and ovarian tumor xenografts. Bioconjug. Chem., 16, 354-360.
    • (2005) Bioconjug. Chem. , vol.16 , pp. 354-360
    • Hamann, P.R.1    Hinman, L.M.2    Beyer, C.F.3    Lindh, D.4    Upeslacis, J.5    Shochat, D.6    Mountain, A.7
  • 57
    • 27144519159 scopus 로고    scopus 로고
    • Adenosine and deoxyadenosine induces apoptosis in estrogen receptor positive and negative human breast cancer cells via the intrinsic pathway
    • Hashemi M., Karami-Tehrani F., Ghavami S., Maddika S. and Los M. (2005): Adenosine and deoxyadenosine induces apoptosis in estrogen receptor positive and negative human breast cancer cells via the intrinsic pathway. Cell Prolif., 38, 269-285.
    • (2005) Cell Prolif. , vol.38 , pp. 269-285
    • Hashemi, M.1    Karami-Tehrani, F.2    Ghavami, S.3    Maddika, S.4    Los, M.5
  • 58
    • 27144453624 scopus 로고    scopus 로고
    • Peptide-based approaches to treat asthma, arthritis, other autoimmune diseases and pathologies of the central nervous system
    • Hauff K., Zamzow C., Law W. J., de Melo J., Kennedy K. and Los M. (2005): Peptide-based approaches to treat asthma, arthritis, other autoimmune diseases and pathologies of the central nervous system. Arch. Immunol. Ther. Exp., 53, 308-320.
    • (2005) Arch. Immunol. Ther. Exp. , vol.53 , pp. 308-320
    • Hauff, K.1    Zamzow, C.2    Law, W.J.3    De Melo, J.4    Kennedy, K.5    Los, M.6
  • 59
    • 0020972979 scopus 로고
    • Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia
    • Heisterkamp N., Stephenson J. R., Groffen J., Hansen P. F., de Klein A., Bartram C. R. and Grosveld G. (1983): Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia. Nature, 306, 239-242.
    • (1983) Nature , vol.306 , pp. 239-242
    • Heisterkamp, N.1    Stephenson, J.R.2    Groffen, J.3    Hansen, P.F.4    De Klein, A.5    Bartram, C.R.6    Grosveld, G.7
  • 60
    • 0028838012 scopus 로고
    • Dimerization of cell surface receptors in signal transduction
    • Heldin C. H. (1995): Dimerization of cell surface receptors in signal transduction. Cell, 80, 213-223.
    • (1995) Cell , vol.80 , pp. 213-223
    • Heldin, C.H.1
  • 61
    • 0036500831 scopus 로고    scopus 로고
    • Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: A new paradigm for cancer therapy
    • Herbst R. S. and Shin D. M. (2002): Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy. Cancer, 94, 1593-1611.
    • (2002) Cancer , vol.94 , pp. 1593-1611
    • Herbst, R.S.1    Shin, D.M.2
  • 64
    • 0346690258 scopus 로고    scopus 로고
    • Beta-glucan functions as an adjuvant for monoclonal antibody immunotherapy by recruiting tumoricidal granulocytes as killer cells
    • Hong F., Hansen R. D., Yan J., Allendorf D. J., Baran J. T., Ostroff G. R. and Ross G. D. (2003): Beta-glucan functions as an adjuvant for monoclonal antibody immunotherapy by recruiting tumoricidal granulocytes as killer cells. Cancer Res., 63, 9023-9031.
    • (2003) Cancer Res. , vol.63 , pp. 9023-9031
    • Hong, F.1    Hansen, R.D.2    Yan, J.3    Allendorf, D.J.4    Baran, J.T.5    Ostroff, G.R.6    Ross, G.D.7
  • 65
    • 2442465000 scopus 로고    scopus 로고
    • Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia
    • Hu Y., Liu Y., Pelletier S., Buchdunger E., Warmuth M., Fabbro D., Hallek M., Van Etten R. A. and Li S. (2004): Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia. Nat. Genet., 36, 453-461.
    • (2004) Nat. Genet. , vol.36 , pp. 453-461
    • Hu, Y.1    Liu, Y.2    Pelletier, S.3    Buchdunger, E.4    Warmuth, M.5    Fabbro, D.6    Hallek, M.7    Van Etten, R.A.8    Li, S.9
  • 66
    • 3442891161 scopus 로고    scopus 로고
    • Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): Combining anti-EGFR antibody with tyrosine kinase inhibitor
    • Huang S., Armstrong E. A., Benavente S., Chinnaiyan P. and Harari P. M. (2004): Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor. Cancer Res., 64, 5355-5362.
    • (2004) Cancer Res. , vol.64 , pp. 5355-5362
    • Huang, S.1    Armstrong, E.A.2    Benavente, S.3    Chinnaiyan, P.4    Harari, P.M.5
  • 67
    • 0012907461 scopus 로고    scopus 로고
    • A novel pyridopyrimidine inhibitor of abl kinase is a picomolar inhibitor of Bcr-abl-driven K562 cells and is effective against STI571-resistant Bcr-abl mutants
    • Huron D. R., Gorre M. E., Kraker A. J., Sawyers C. L., Rosen N. and Moasser M. M. (2003): A novel pyridopyrimidine inhibitor of abl kinase is a picomolar inhibitor of Bcr-abl-driven K562 cells and is effective against STI571-resistant Bcr-abl mutants. Clin. Cancer Res., 9, 1267-1273.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 1267-1273
    • Huron, D.R.1    Gorre, M.E.2    Kraker, A.J.3    Sawyers, C.L.4    Rosen, N.5    Moasser, M.M.6
  • 73
    • 1242352458 scopus 로고    scopus 로고
    • Internalization and cell cycle-dependent killing of leukemic cells by Gemtuzumab Ozogamicin: Rationale for efficacy in CD33-negative malignancies with endocytic capacity
    • Jedema I., Barge R. M., van der Velden V. H., Nijmeijer B. A., van Dongen J. J., Willemze R. and Falkenburg J. H. (2004): Internalization and cell cycle-dependent killing of leukemic cells by Gemtuzumab Ozogamicin: rationale for efficacy in CD33-negative malignancies with endocytic capacity. Leukemia, 18, 316-325.
    • (2004) Leukemia , vol.18 , pp. 316-325
    • Jedema, I.1    Barge, R.M.2    Van Der Velden, V.H.3    Nijmeijer, B.A.4    Van Dongen, J.J.5    Willemze, R.6    Falkenburg, J.H.7
  • 74
    • 14944360395 scopus 로고    scopus 로고
    • Inflammatory response, reactive oxygen species, programmed (necrotic-like and apoptotic) cell death and cancer
    • Johar D., Roth J. C., Bay G. H., Walker J. N., Kroczak T. J. and Los M. (2004): Inflammatory response, reactive oxygen species, programmed (necrotic-like and apoptotic) cell death and cancer. Rocz. Akad. Med. Bialymst., 49, 31-39.
    • (2004) Rocz. Akad. Med. Bialymst. , vol.49 , pp. 31-39
    • Johar, D.1    Roth, J.C.2    Bay, G.H.3    Walker, J.N.4    Kroczak, T.J.5    Los, M.6
  • 75
    • 0035863587 scopus 로고    scopus 로고
    • Local immunotherapy of glioma patients with a combination of 2 bispecific antibody fragments and resting autologous lymphocytes: Evidence for in situ t-cell activation and therapeutic efficacy
    • Jung G., Brandl M., Eisner W., Fraunberger P., Reifenberger G., Schlegel U., Wiestler O. D., Reulen H. J. and Wilmanns W. (2001): Local immunotherapy of glioma patients with a combination of 2 bispecific antibody fragments and resting autologous lymphocytes: evidence for in situ t-cell activation and therapeutic efficacy. Int. J. Cancer, 91, 225-230.
    • (2001) Int. J. Cancer , vol.91 , pp. 225-230
    • Jung, G.1    Brandl, M.2    Eisner, W.3    Fraunberger, P.4    Reifenberger, G.5    Schlegel, U.6    Wiestler, O.D.7    Reulen, H.J.8    Wilmanns, W.9
  • 76
    • 0035266408 scopus 로고    scopus 로고
    • Target cell-restricted triggering of the CD95 (APO-1/Fas) death receptor with bispecific antibody fragments
    • Jung G., Grosse-Hovest L., Krammer P. H. and Rammensee H. G. (2001): Target cell-restricted triggering of the CD95 (APO-1/Fas) death receptor with bispecific antibody fragments. Cancer Res., 61, 1846-1848.
    • (2001) Cancer Res. , vol.61 , pp. 1846-1848
    • Jung, G.1    Grosse-Hovest, L.2    Krammer, P.H.3    Rammensee, H.G.4
  • 77
    • 1542409979 scopus 로고    scopus 로고
    • Changes in the apoptotic and survival signaling in cancer cells and their potential therapeutic implications
    • Kabore A. F., Johnston J. B. and Gibson S. B. (2004): Changes in the apoptotic and survival signaling in cancer cells and their potential therapeutic implications. Curr. Cancer Drug Targets, 4, 147-163.
    • (2004) Curr. Cancer Drug Targets , vol.4 , pp. 147-163
    • Kabore, A.F.1    Johnston, J.B.2    Gibson, S.B.3
  • 79
    • 22944472086 scopus 로고    scopus 로고
    • Induction of apoptotic cell death in tumor cells by s100a8/a9 released from inflammatory cells upon cellular activation
    • Kerkhoff C. and Ghavami S. (2005): Induction of apoptotic cell death in tumor cells by s100a8/a9 released from inflammatory cells upon cellular activation. Curr. Med. Chem.-Anti-Inflammatory Anti-Allergy Agents, 4, 383-392.
    • (2005) Curr. Med. Chem.-Anti-Inflammatory Anti-Allergy Agents , vol.4 , pp. 383-392
    • Kerkhoff, C.1    Ghavami, S.2
  • 82
    • 0034830739 scopus 로고    scopus 로고
    • Dimeric and trimeric antibodies: High avidity scFvs for cancer targeting
    • Kortt A. A., Dolezal O., Power B. E. and Hudson P. J. (2001): Dimeric and trimeric antibodies: high avidity scFvs for cancer targeting. Biomol. Eng., 18, 95-108.
    • (2001) Biomol. Eng. , vol.18 , pp. 95-108
    • Kortt, A.A.1    Dolezal, O.2    Power, B.E.3    Hudson, P.J.4
  • 83
    • 14944362115 scopus 로고    scopus 로고
    • Stroke, myocardial infarction, acute and chronic inflammatory diseases: Caspases and other apoptotic molecules as targets for drug development
    • Kreuter M., Langer C., Kerkhoff C., Reddanna P., Kania A. L., Maddika S., Chlichlia K., Bui T. N. and Los M. (2004): Stroke, myocardial infarction, acute and chronic inflammatory diseases: caspases and other apoptotic molecules as targets for drug development. Arch. Immunol. Ther. Exp., 52, 141-155.
    • (2004) Arch. Immunol. Ther. Exp. , vol.52 , pp. 141-155
    • Kreuter, M.1    Langer, C.2    Kerkhoff, C.3    Reddanna, P.4    Kania, A.L.5    Maddika, S.6    Chlichlia, K.7    Bui, T.N.8    Los, M.9
  • 84
    • 17844366575 scopus 로고    scopus 로고
    • Development of 131I-tositumomab
    • Lewington V. (2005): Development of 131I-tositumomab. Semin. Oncol., 32, S50-6.
    • (2005) Semin. Oncol. , vol.32
    • Lewington, V.1
  • 86
    • 5444227027 scopus 로고    scopus 로고
    • Production of neutralizing monoclonal antibody against human vascular endothelial growth factor receptor II
    • Li R., Xiong D. S., Shao X. F., Liu J., Xu Y. F., Xu Y. S., Liu H. Z., Zhu Z. P. and Yang C. Z. (2004): Production of neutralizing monoclonal antibody against human vascular endothelial growth factor receptor II. Acta Pharmacol. Sin., 25, 1292-1298.
    • (2004) Acta Pharmacol. Sin. , vol.25 , pp. 1292-1298
    • Li, R.1    Xiong, D.S.2    Shao, X.F.3    Liu, J.4    Xu, Y.F.5    Xu, Y.S.6    Liu, H.Z.7    Zhu, Z.P.8    Yang, C.Z.9
  • 87
    • 85047699075 scopus 로고    scopus 로고
    • In vitro and preclinical targeted alpha therapy of human prostate cancer with Bi-213 labeled J591 antibody against the prostate specific membrane antigen
    • Li Y., Tian Z., Rizvi S. M., Bander N. H. and Allen B. J. (2002): In vitro and preclinical targeted alpha therapy of human prostate cancer with Bi-213 labeled J591 antibody against the prostate specific membrane antigen. Prostate Cancer Prostatic Dis., 5, 36-46.
    • (2002) Prostate Cancer Prostatic Dis. , vol.5 , pp. 36-46
    • Li, Y.1    Tian, Z.2    Rizvi, S.M.3    Bander, N.H.4    Allen, B.J.5
  • 88
    • 0034630187 scopus 로고    scopus 로고
    • The mitochondrion in cell death control: Certainties and incognita
    • Loeffler M. and Kroemer G. (2000): The mitochondrion in cell death control: certainties and incognita. Exp. Cell Res., 256, 19-26.
    • (2000) Exp. Cell Res. , vol.256 , pp. 19-26
    • Loeffler, M.1    Kroemer, G.2
  • 90
    • 0032531092 scopus 로고    scopus 로고
    • Human T cell leukemia virus-I (HTLV-I) Tax-mediated apoptosis in activated T cells requires an enhanced intracellular prooxidant state
    • Los M., Khazaie K., Schulze Osthoff K., Baeuerle P. A., Schirrmacher V. and Chlichlia K. (1998): Human T cell leukemia virus-I (HTLV-I) Tax-mediated apoptosis in activated T cells requires an enhanced intracellular prooxidant state. J. Immunol., 161, 3050-3055.
    • (1998) J. Immunol. , vol.161 , pp. 3050-3055
    • Los, M.1    Khazaie, K.2    Schulze Osthoff, K.3    Baeuerle, P.A.4    Schirrmacher, V.5    Chlichlia, K.6
  • 92
    • 0033153086 scopus 로고    scopus 로고
    • The role of caspases in development, immunity, and apoptotic signal transduction: Lessons from knockout mice
    • Los M., Wesselborg S. and Schulze Osthoff K. (1999): The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice. Immunity, 10, 629-639.
    • (1999) Immunity , vol.10 , pp. 629-639
    • Los, M.1    Wesselborg, S.2    Schulze Osthoff, K.3
  • 94
    • 27644584179 scopus 로고    scopus 로고
    • Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell death mediators by a Nur77-dependent pathway
    • Maddika S., Booy E. P., Johar D., Gibson S. B., Ghavami S. and Los M. (2005): Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell death mediators by a Nur77-dependent pathway. J. Cell Sci., 118, 4485-4493.
    • (2005) J. Cell Sci. , vol.118 , pp. 4485-4493
    • Maddika, S.1    Booy, E.P.2    Johar, D.3    Gibson, S.B.4    Ghavami, S.5    Los, M.6
  • 96
    • 0030856803 scopus 로고    scopus 로고
    • CD3xCD19 bispecific antibodies and CD28 costimulation for locoregional treatment of low-malignancy non-Hodgkin's lymphoma
    • Manzke O., Titzer S., Tesch H., Diehl V. and Bohlen H. (1997): CD3xCD19 bispecific antibodies and CD28 costimulation for locoregional treatment of low-malignancy non-Hodgkin's lymphoma. Cancer Immunol. Immunother., 45, 198-202.
    • (1997) Cancer Immunol. Immunother. , vol.45 , pp. 198-202
    • Manzke, O.1    Titzer, S.2    Tesch, H.3    Diehl, V.4    Bohlen, H.5
  • 98
    • 5144229336 scopus 로고    scopus 로고
    • Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): Superiority over singleagent receptor targeting
    • Matar P., Rojo F., Cassia R., Moreno-Bueno G., Di Cosimo S., Tabernero J., Guzman M., Rodriguez S., Arribas J., Palacios J. and Baselga J. (2004): Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over singleagent receptor targeting. Clin. Cancer Res., 10, 6487-6501.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 6487-6501
    • Matar, P.1    Rojo, F.2    Cassia, R.3    Moreno-Bueno, G.4    Di Cosimo, S.5    Tabernero, J.6    Guzman, M.7    Rodriguez, S.8    Arribas, J.9    Palacios, J.10    Baselga, J.11
  • 99
    • 21844454101 scopus 로고    scopus 로고
    • Phase I study of epidermal growth factor receptor (EGFR) inhibitor, erlotinib, and vascular endothelial growth factor monoclonal antibody, bevacizumab, in recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN)
    • Mauer A. M., Cohen E. E. W., Wong S. J., Kozloff M., Winegarden J., Gustin D. M. and Vokes E. E. (2004): Phase I study of epidermal growth factor receptor (EGFR) inhibitor, erlotinib, and vascular endothelial growth factor monoclonal antibody, bevacizumab, in recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN). Proc. Am. Soc. Clin. Oncol., 23, 497S-497S.
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23
    • Mauer, A.M.1    Cohen, E.E.W.2    Wong, S.J.3    Kozloff, M.4    Winegarden, J.5    Gustin, D.M.6    Vokes, E.E.7
  • 100
    • 14944340997 scopus 로고    scopus 로고
    • Anti-tumor chemotherapy utilizing peptide-based approaches-apoptotic pathways, kinases, and proteasome as targets
    • Mendoza F. J., Espino P. S., Cann K. L., Bristow N., McCrea K. and Los M. (2005): Anti-tumor chemotherapy utilizing peptide-based approaches-apoptotic pathways, kinases, and proteasome as targets. Arch. Immunol. Ther. Exp., 53, 47-60.
    • (2005) Arch. Immunol. Ther. Exp. , vol.53 , pp. 47-60
    • Mendoza, F.J.1    Espino, P.S.2    Cann, K.L.3    Bristow, N.4    McCrea, K.5    Los, M.6
  • 101
    • 4344618391 scopus 로고    scopus 로고
    • Phase I trial of yttrium-90-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for androgen-independent prostate cancer
    • Milowsky M. I., Nanus D. M., Kostakoglu L., Vallabhajosula S., Goldsmith S. J. and Bander N. H. (2004): Phase I trial of yttrium-90-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for androgen-independent prostate cancer. J. Clin. Oncol., 22, 2522-2531.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 2522-2531
    • Milowsky, M.I.1    Nanus, D.M.2    Kostakoglu, L.3    Vallabhajosula, S.4    Goldsmith, S.J.5    Bander, N.H.6
  • 103
    • 0028897269 scopus 로고
    • The binding of HB-EGF to tumour cells is blocked by mAbs which act as EGF and TGF alpha antagonists
    • Modjtahedi H. and Dean C. (1995): The binding of HB-EGF to tumour cells is blocked by mAbs which act as EGF and TGF alpha antagonists. Biochem. Biophys. Res. Commun., 207, 389-397.
    • (1995) Biochem. Biophys. Res. Commun. , vol.207 , pp. 389-397
    • Modjtahedi, H.1    Dean, C.2
  • 104
    • 0033985054 scopus 로고    scopus 로고
    • CD3 directed bispecific antibodies induce increased lymphocyte- endothelial cell interactions in vitro
    • Molema G., Tervaert J. W., Kroesen B. J., Helfrich W., Meijer D. K. and de Leij L. F. (2000): CD3 directed bispecific antibodies induce increased lymphocyte-endothelial cell interactions in vitro. Br. J. Cancer, 82, 472-479.
    • (2000) Br. J. Cancer , vol.82 , pp. 472-479
    • Molema, G.1    Tervaert, J.W.2    Kroesen, B.J.3    Helfrich, W.4    Meijer, D.K.5    De Leij, L.F.6
  • 105
    • 0036682301 scopus 로고    scopus 로고
    • Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)
    • Nagar B., Bornmann W. G., Pellicena P., Schindler T., Veach D. R., Miller W. T., Clarkson B. AND Kuriyan J. (2002): Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Res., 62, 4236-4243.
    • (2002) Cancer Res. , vol.62 , pp. 4236-4243
    • Nagar, B.1    Bornmann, W.G.2    Pellicena, P.3    Schindler, T.4    Veach, D.R.5    Miller, W.T.6    Clarkson, B.7    Kuriyan, J.8
  • 106
    • 0037285971 scopus 로고    scopus 로고
    • Growth factor receptors in breast cancer: Potential for therapeutic intervention
    • Nahta R., Hortobagyi G. N. and Esteva F. J. (2003): Growth factor receptors in breast cancer: potential for therapeutic intervention. Oncologist, 8, 5-17.
    • (2003) Oncologist , vol.8 , pp. 5-17
    • Nahta, R.1    Hortobagyi, G.N.2    Esteva, F.J.3
  • 109
    • 0029147737 scopus 로고
    • The nonreceptor protein-tyrosine kinase CSK complexes directly with the GTPase-activating protein-associated p62 protein in cells expressing v-Src or activated c-Src
    • Neet K. and Hunter T. (1995): The nonreceptor protein-tyrosine kinase CSK complexes directly with the GTPase-activating protein-associated p62 protein in cells expressing v-Src or activated c-Src. Mol. Cell Biol., 15, 4908-4920.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 4908-4920
    • Neet, K.1    Hunter, T.2
  • 110
    • 0025161953 scopus 로고
    • Preliminary trial of specific targeting therapy against malignant glioma
    • Nitta T., Sato K., Yagita H., Okumura K. and Ishii S. (1990): Preliminary trial of specific targeting therapy against malignant glioma. Lancet, 335, 368-371.
    • (1990) Lancet , vol.335 , pp. 368-371
    • Nitta, T.1    Sato, K.2    Yagita, H.3    Okumura, K.4    Ishii, S.5
  • 117
    • 0023712557 scopus 로고
    • Molecular cloning, expression, and chromosomal localization of a human gene encoding the CD33 myeloid differentiation antigen
    • Peiper S. C., Ashmun R. A. and Look A. T. (1988): Molecular cloning, expression, and chromosomal localization of a human gene encoding the CD33 myeloid differentiation antigen. Blood, 72, 314-321.
    • (1988) Blood , vol.72 , pp. 314-321
    • Peiper, S.C.1    Ashmun, R.A.2    Look, A.T.3
  • 118
    • 0023267261 scopus 로고
    • CD19 monoclonal antibody HD37 inhibits anti-immunoglobulin-induced B cell activation and proliferation
    • Pezzutto A., Dorken B., Rabinovitch P. S., Ledbetter J. A., Moldenhauer G. and Clark E. A. (1987): CD19 monoclonal antibody HD37 inhibits anti-immunoglobulin-induced B cell activation and proliferation. J. Immunol., 138, 2793-2799.
    • (1987) J. Immunol. , vol.138 , pp. 2793-2799
    • Pezzutto, A.1    Dorken, B.2    Rabinovitch, P.S.3    Ledbetter, J.A.4    Moldenhauer, G.5    Clark, E.A.6
  • 119
    • 3242806104 scopus 로고    scopus 로고
    • Caspases and cancer: Mechanisms of inactivation and new treatment modalities
    • Philchenkov A., Zavelevich M., Kroczak T. J. and Los M. (2004): Caspases and cancer: mechanisms of inactivation and new treatment modalities. Exp. Oncol., 26, 82-97.
    • (2004) Exp. Oncol. , vol.26 , pp. 82-97
    • Philchenkov, A.1    Zavelevich, M.2    Kroczak, T.J.3    Los, M.4
  • 120
    • 0026504147 scopus 로고
    • Social controls on cell survival and cell death
    • Raff M. C. (1992): Social controls on cell survival and cell death. Nature, 356, 397-400.
    • (1992) Nature , vol.356 , pp. 397-400
    • Raff, M.C.1
  • 121
    • 0035469830 scopus 로고    scopus 로고
    • Rapid extracellular release of cytochrome c is specific for apoptosis and marks cell death in vivo
    • Renz A., Berdel W. E., Kreuter M., Belka C., Schulze-Osthoff K. and Los M. (2001): Rapid extracellular release of cytochrome c is specific for apoptosis and marks cell death in vivo. Blood, 98, 1542-1548.
    • (2001) Blood , vol.98 , pp. 1542-1548
    • Renz, A.1    Berdel, W.E.2    Kreuter, M.3    Belka, C.4    Schulze-Osthoff, K.5    Los, M.6
  • 122
    • 3843135029 scopus 로고    scopus 로고
    • Improving monoclonal antibodies for cancer therapy
    • Robinson M. K., Weiner L. M. and Adams G. P. (2004): Improving monoclonal antibodies for cancer therapy. Drug Dev. Res., 61, 172-187.
    • (2004) Drug Dev. Res. , vol.61 , pp. 172-187
    • Robinson, M.K.1    Weiner, L.M.2    Adams, G.P.3
  • 123
    • 0036682481 scopus 로고    scopus 로고
    • Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment
    • Roche-Lestienne C., Soenen-Cornu V., Grardel-Duflos N., Lai J. L., Philippe N., Facon T., Fenaux P. and Preudhomme C. (2002): Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment. Blood, 100, 1014-1018.
    • (2002) Blood , vol.100 , pp. 1014-1018
    • Roche-Lestienne, C.1    Soenen-Cornu, V.2    Grardel-Duflos, N.3    Lai, J.L.4    Philippe, N.5    Facon, T.6    Fenaux, P.7    Preudhomme, C.8
  • 126
    • 0036678472 scopus 로고    scopus 로고
    • Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop
    • USA
    • Roumiantsev S., Shah N. P., Gorre M. E., Nicoll J., Brasher B. B., Sawyers C. L. and Van Etten R. A. (2002): Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop. Proc. Natl. Acad. Sci. USA, 99, 10700-10705.
    • (2002) Proc. Natl. Acad. Sci. , vol.99 , pp. 10700-10705
    • Roumiantsev, S.1    Shah, N.P.2    Gorre, M.E.3    Nicoll, J.4    Brasher, B.B.5    Sawyers, C.L.6    Van Etten, R.A.7
  • 128
    • 0015936643 scopus 로고
    • Chromosomal patterns in myelocytic leukemia
    • Rowley J. D. (1973): Chromosomal patterns in myelocytic leukemia. N. Engl. J. Med., 289, 220-221.
    • (1973) N. Engl. J. Med. , vol.289 , pp. 220-221
    • Rowley, J.D.1
  • 129
    • 0015694748 scopus 로고
    • Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
    • Rowley J. D. (1973): Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature, 243, 290-293.
    • (1973) Nature , vol.243 , pp. 290-293
    • Rowley, J.D.1
  • 130
    • 0036372121 scopus 로고    scopus 로고
    • Caspases - Their role in apoptosis and other physiological processes as revealed by knock-out studies
    • Sadowski-Debbing K., Coy J. F., Mier W., Hug H. and Los M. (2002): Caspases - their role in apoptosis and other physiological processes as revealed by knock-out studies. Arch. Immunol. Ther. Exp., 50, 19-34.
    • (2002) Arch. Immunol. Ther. Exp. , vol.50 , pp. 19-34
    • Sadowski-Debbing, K.1    Coy, J.F.2    Mier, W.3    Hug, H.4    Los, M.5
  • 131
    • 0041856115 scopus 로고    scopus 로고
    • Generation of a FasL-based proapoptotic fusion protein devoid of systemic toxicity due to cell-surface antigen-restricted Activation
    • Samel D., Muller D., Gerspach J., Assohou-Luty C., Sass G., Tiegs G., Pfizenmaier K. and Wajant H. (2003): Generation of a FasL-based proapoptotic fusion protein devoid of systemic toxicity due to cell-surface antigen-restricted Activation. J. Biol. Chem., 278, 32077-32082.
    • (2003) J. Biol. Chem. , vol.278 , pp. 32077-32082
    • Samel, D.1    Muller, D.2    Gerspach, J.3    Assohou-Luty, C.4    Sass, G.5    Tiegs, G.6    Pfizenmaier, K.7    Wajant, H.8
  • 132
    • 4444220447 scopus 로고    scopus 로고
    • Novel oncogenic protein kinase inhibitors for cancer therapy
    • Sawyer T. K. (2004): Novel oncogenic protein kinase inhibitors for cancer therapy. Curr. Med. Chem. Anti-Canc. Agents, 4, 449-455.
    • (2004) Curr. Med. Chem. Anti-Canc. Agents , vol.4 , pp. 449-455
    • Sawyer, T.K.1
  • 135
    • 0033028510 scopus 로고    scopus 로고
    • Signal perception and transduction: The role of protein kinases
    • Schenk P. W. and Snaar-Jagalska B. E. (1999): Signal perception and transduction: the role of protein kinases. Biochim. Biophys. Acta, 1449, 1-24.
    • (1999) Biochim. Biophys. Acta , vol.1449 , pp. 1-24
    • Schenk, P.W.1    Snaar-Jagalska, B.E.2
  • 136
    • 0034603197 scopus 로고    scopus 로고
    • New roles for Src kinases in control of cell survival and angiogenesis
    • Schlessinger J. (2000): New roles for Src kinases in control of cell survival and angiogenesis. Cell, 100, 293-296.
    • (2000) Cell , vol.100 , pp. 293-296
    • Schlessinger, J.1
  • 137
    • 0034812866 scopus 로고    scopus 로고
    • Clinical experience with edrecolomab: A monoclonal antibody therapy for colorectal carcinoma
    • Schwartzberg L. S. (2001): Clinical experience with edrecolomab: a monoclonal antibody therapy for colorectal carcinoma. Crit. Rev. Oncol. Hematol., 40, 17-24.
    • (2001) Crit. Rev. Oncol. Hematol. , vol.40 , pp. 17-24
    • Schwartzberg, L.S.1
  • 139
    • 3142676436 scopus 로고    scopus 로고
    • Overriding imatinib resistance with a novel ABL kinase inhibitor
    • Shah N. P., Tran C., Lee F. Y., Chen P., Norris D. and Sawyers C. L. (2004): Overriding imatinib resistance with a novel ABL kinase inhibitor. Science, 305, 399-401.
    • (2004) Science , vol.305 , pp. 399-401
    • Shah, N.P.1    Tran, C.2    Lee, F.Y.3    Chen, P.4    Norris, D.5    Sawyers, C.L.6
  • 140
    • 0032030699 scopus 로고    scopus 로고
    • Apoptosis of malignant human B cells by ligation of CD20 with monoclonal antibodies
    • Shan D., Ledbetter J. A. and Press O. W. (1998): Apoptosis of malignant human B cells by ligation of CD20 with monoclonal antibodies. Blood, 91, 1644-1652.
    • (1998) Blood , vol.91 , pp. 1644-1652
    • Shan, D.1    Ledbetter, J.A.2    Press, O.W.3
  • 141
    • 3242719825 scopus 로고    scopus 로고
    • Activated T killer cells induce apoptosis in lung epithelial cells and the release of pro-inflammatory cytokine TNF-alpha
    • Shinbori T., Walczak H. and Krammer P. H. (2004): Activated T killer cells induce apoptosis in lung epithelial cells and the release of pro-inflammatory cytokine TNF-alpha. Eur. J. Immunol., 34, 1762-1770.
    • (2004) Eur. J. Immunol. , vol.34 , pp. 1762-1770
    • Shinbori, T.1    Walczak, H.2    Krammer, P.H.3
  • 142
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon D. J., Clark G. M., Wong S. G., Levin W. J., Ullrich A. and McGuire W. L. (1987): Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science, 235, 177-182.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 143
    • 0022588291 scopus 로고
    • p185, a product of the neu proto-oncogene, is a receptor -like protein associated with tyrosine kinase activity
    • Stern D. F., Heffernan P. A. and Weinberg R. A. (1986): p185, a product of the neu proto-oncogene, is a receptor -like protein associated with tyrosine kinase activity. Mol. Cell Biol., 6, 1729-1740.
    • (1986) Mol. Cell Biol. , vol.6 , pp. 1729-1740
    • Stern, D.F.1    Heffernan, P.A.2    Weinberg, R.A.3
  • 144
    • 15244351004 scopus 로고    scopus 로고
    • Overview of monoclonal antibodies in cancer therapy: Present and promise
    • Stern M. and Herrmann R. (2005): Overview of monoclonal antibodies in cancer therapy: present and promise. Crit. Rev. Oncol. Hematol., 54, 11-29.
    • (2005) Crit. Rev. Oncol. Hematol. , vol.54 , pp. 11-29
    • Stern, M.1    Herrmann, R.2
  • 145
    • 0036796781 scopus 로고    scopus 로고
    • Get a ligand, get a life: Integrins, signaling and cell survival
    • Stupack D. G. and Cheresh D. A. (2002): Get a ligand, get a life: integrins, signaling and cell survival. J. Cell Sci., 115, 3729-3738.
    • (2002) J. Cell Sci. , vol.115 , pp. 3729-3738
    • Stupack, D.G.1    Cheresh, D.A.2
  • 146
    • 0242624594 scopus 로고    scopus 로고
    • Growth factor receptors as therapeutic targets: Strategies to inhibit the insulin-like growth factor I receptor
    • Surmacz E. (2003): Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor. Oncogene, 22, 6589-6597.
    • (2003) Oncogene , vol.22 , pp. 6589-6597
    • Surmacz, E.1
  • 149
    • 0028818886 scopus 로고
    • How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein-tyrosine kinase
    • Taylor S. S., Radzio-Andzelm E. and Hunter T. (1995): How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein-tyrosine kinase. FASEB J., 9, 1255-1266.
    • (1995) FASEB J. , vol.9 , pp. 1255-1266
    • Taylor, S.S.1    Radzio-Andzelm, E.2    Hunter, T.3
  • 150
    • 0029991804 scopus 로고    scopus 로고
    • Pharmacokinetics, biodistribution and biological effects of intravenously administered bispecific monoclonal antibody OC/TR F(ab')2 in ovarian carcinoma patients
    • Tibben J. G., Boerman O. C., Massuger L. F., Schijf C. P., Claessens R. A. and Corstens F. H. (1996): Pharmacokinetics, biodistribution and biological effects of intravenously administered bispecific monoclonal antibody OC/TR F(ab')2 in ovarian carcinoma patients. Int. J. Cancer, 66, 477-483.
    • (1996) Int. J. Cancer , vol.66 , pp. 477-483
    • Tibben, J.G.1    Boerman, O.C.2    Massuger, L.F.3    Schijf, C.P.4    Claessens, R.A.5    Corstens, F.H.6
  • 155
    • 0035811587 scopus 로고    scopus 로고
    • Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative
    • Wajant H., Moosmayer D., Wuest T., Bartke T., Gerlach E., Schonherr U., Peters N., Scheurich P. and Pfizenmaier K. (2001): Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative. Oncogene, 20, 4101-4106.
    • (2001) Oncogene , vol.20 , pp. 4101-4106
    • Wajant, H.1    Moosmayer, D.2    Wuest, T.3    Bartke, T.4    Gerlach, E.5    Schonherr, U.6    Peters, N.7    Scheurich, P.8    Pfizenmaier, K.9
  • 156
    • 0037350545 scopus 로고    scopus 로고
    • Immunotherapy: Past, present and future
    • Waldmann T. A. (2003): Immunotherapy: past, present and future. Nat. Med., 9, 269-277.
    • (2003) Nat. Med. , vol.9 , pp. 269-277
    • Waldmann, T.A.1
  • 157
    • 2442696260 scopus 로고    scopus 로고
    • A new recombinant single chain trispecific antibody recruits T lymphocytes to kill CEA (carcinoma embryonic antigen) positive tumor cells in vitro efficiently
    • Wang X. B., Zhao B. F., Zhao Q., Piao J. H., Liu J., Lin Q. and Huang H. L. (2004): A new recombinant single chain trispecific antibody recruits T lymphocytes to kill CEA (carcinoma embryonic antigen) positive tumor cells in vitro efficiently. J. Biochem., 135, 555-565.
    • (2004) J. Biochem. , vol.135 , pp. 555-565
    • Wang, X.B.1    Zhao, B.F.2    Zhao, Q.3    Piao, J.H.4    Liu, J.5    Lin, Q.6    Huang, H.L.7
  • 158
    • 0032944540 scopus 로고    scopus 로고
    • Antibody dependent cellular phagocytosis (ADCP) and antibody dependent cellular cytotoxicity (ADCC) of breast cancer cells mediated by bispecific antibody, MDX-210
    • Watanabe M., Wallace P. K., Keler T., Deo Y. M., Akewanlop C. and Hayes D. F. (1999): Antibody dependent cellular phagocytosis (ADCP) and antibody dependent cellular cytotoxicity (ADCC) of breast cancer cells mediated by bispecific antibody, MDX-210. Breast Cancer Res. Treat., 53, 199-207.
    • (1999) Breast Cancer Res. Treat. , vol.53 , pp. 199-207
    • Watanabe, M.1    Wallace, P.K.2    Keler, T.3    Deo, Y.M.4    Akewanlop, C.5    Hayes, D.F.6
  • 159
    • 0034638918 scopus 로고    scopus 로고
    • New approaches to antibody therapy
    • Weiner L. M. and Adams G. P. (2000): New approaches to antibody therapy. Oncogene, 19, 6144-6151.
    • (2000) Oncogene , vol.19 , pp. 6144-6151
    • Weiner, L.M.1    Adams, G.P.2
  • 161
    • 0035091343 scopus 로고    scopus 로고
    • Antibody-targeted immunotherapy for treatment of malignancy
    • White C. A., Weaver R. L. and Grillo-Lopez A. J. (2001): Antibody-targeted immunotherapy for treatment of malignancy. Annu. Rev. Med., 52, 125-145.
    • (2001) Annu. Rev. Med. , vol.52 , pp. 125-145
    • White, C.A.1    Weaver, R.L.2    Grillo-Lopez, A.J.3
  • 162
    • 0031866665 scopus 로고    scopus 로고
    • Sensitivity to Fas-mediated apoptosis is null or weak in B-cell non-Hodgkin's lymphomas and is moderately increased by CD40 ligation
    • Xerri L., Bouabdallah R., Devilard E., Hassoun J., Stoppa A. M. and Birg F. (1998): Sensitivity to Fas-mediated apoptosis is null or weak in B-cell non-Hodgkin's lymphomas and is moderately increased by CD40 ligation. Br. J. Cancer, 78, 225-232.
    • (1998) Br. J. Cancer , vol.78 , pp. 225-232
    • Xerri, L.1    Bouabdallah, R.2    Devilard, E.3    Hassoun, J.4    Stoppa, A.M.5    Birg, F.6
  • 163
    • 4344590997 scopus 로고    scopus 로고
    • Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II Trial
    • Xiong H. Q., Rosenberg A., LoBuglio A., Schmidt W., Wolff R. A., Deutsch J., Needle M. and Abbruzzese J. L. (2004): Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II Trial. J. Clin. Oncol., 22, 2610-2616.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 2610-2616
    • Xiong, H.Q.1    Rosenberg, A.2    Lobuglio, A.3    Schmidt, W.4    Wolff, R.A.5    Deutsch, J.6    Needle, M.7    Abbruzzese, J.L.8
  • 164
    • 0033559606 scopus 로고    scopus 로고
    • Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy
    • Yang X. D., Jia X. C., Corvalan J. R., Wang P., Davis C. G. and Jakobovits A. (1999): Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy. Cancer Res., 59, 1236-1243.
    • (1999) Cancer Res. , vol.59 , pp. 1236-1243
    • Yang, X.D.1    Jia, X.C.2    Corvalan, J.R.3    Wang, P.4    Davis, C.G.5    Jakobovits, A.6
  • 165
    • 0024596722 scopus 로고
    • A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor
    • Yonehara S., Ishii A. and Yonehara M. (1989): A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J. Exp. Med., 169, 1747-1756.
    • (1989) J. Exp. Med. , vol.169 , pp. 1747-1756
    • Yonehara, S.1    Ishii, A.2    Yonehara, M.3
  • 166
    • 0034964611 scopus 로고    scopus 로고
    • Opportunities for up to date treatment of the colorectal cancer
    • Yovtchev Y. and Nilolov S. (2001): Opportunities for up to date treatment of the colorectal cancer. Radiol. Oncol., 35, 111-115.
    • (2001) Radiol. Oncol. , vol.35 , pp. 111-115
    • Yovtchev, Y.1    Nilolov, S.2
  • 167
    • 0023820894 scopus 로고
    • Calicheamicin gamma II: An antitumor antibiotic that cleaves double-stranded DNA site specifically
    • Zein N., Sinha A. M., McGahren W. J. and Ellestad G. A. (1988): Calicheamicin gamma II: an antitumor antibiotic that cleaves double-stranded DNA site specifically. Science, 240, 1198-1201.
    • (1988) Science , vol.240 , pp. 1198-1201
    • Zein, N.1    Sinha, A.M.2    McGahren, W.J.3    Ellestad, G.A.4


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