메뉴 건너뛰기




Volumn 6, Issue 4, 2008, Pages 142-148

Targeting the Wnt signaling pathway to augment bone formation

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; DICKKOPF 1 PROTEIN; GLUCOCORTICOID; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM CHLORIDE; PARATHYROID HORMONE; PROTEIN WIF1; SCLEROSTIN; SECRETED FRIZZLED RELATED PROTEIN 1; SECRETED FRIZZLED RELATED PROTEIN 2; UNCLASSIFIED DRUG; WNT PROTEIN; BONE MORPHOGENETIC PROTEIN; DKK1 PROTEIN, HUMAN; SIGNAL PEPTIDE; SOST PROTEIN, HUMAN;

EID: 61449361112     PISSN: 15441873     EISSN: 15442241     Source Type: Journal    
DOI: 10.1007/s11914-008-0025-5     Document Type: Review
Times cited : (25)

References (75)
  • 1
    • 38949145700 scopus 로고    scopus 로고
    • Wnt signalling in development and disease. Max Delbruck Center for Molecular Medicine meeting on Wnt signaling in development and disease
    • Fuerer C, Nusse R, Ten Berge D: Wnt signalling in development and disease. Max Delbruck Center for Molecular Medicine meeting on Wnt signaling in development and disease. EMBO Rep 2008, 9:134-138.
    • (2008) EMBO Rep , vol.9 , pp. 134-138
    • Fuerer, C.1    Nusse, R.2    Ten Berge, D.3
  • 2
    • 0020216124 scopus 로고
    • Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
    • Nusse R, Varmus HE: Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 1982, 31:99-109.
    • (1982) Cell , vol.31 , pp. 99-109
    • Nusse, R.1    Varmus, H.E.2
  • 3
    • 18044386744 scopus 로고    scopus 로고
    • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    • Gong Y, Slee RB, Fukai N, et al.: LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 2001, 107:513-523.
    • (2001) Cell , vol.107 , pp. 513-523
    • Gong, Y.1    Slee, R.B.2    Fukai, N.3
  • 4
    • 0036138175 scopus 로고    scopus 로고
    • A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
    • Little RD, Carulli JP, Del Mastro RG, et al.: A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet 2002, 70:11-19.
    • (2002) Am J Hum Genet , vol.70 , pp. 11-19
    • Little, R.D.1    Carulli, J.P.2    Del Mastro, R.G.3
  • 5
    • 41549115361 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: New (and old) players and new insights
    • Huang H, He X: Wnt/betN-catenin signaling: new (and old) players and new insights. Curr Opin Cell Biol 2008, 20:119-125.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 119-125
    • Huang, H.1    He, X.2
  • 6
    • 33747339465 scopus 로고    scopus 로고
    • Wnt signaling: Multiple pathways, multiple receptors, and multiple transcription factors
    • Gordon MDM Nusse R: Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 2006, 281:22429-22433.
    • (2006) J Biol Chem , vol.281 , pp. 22429-22433
    • Gordon, M.D.1    Nusse, R.2
  • 7
    • 14744275847 scopus 로고    scopus 로고
    • Regulation of osteoblastogenesis and bone mass by Wnt10b
    • Bennett CN, Longo KA, Wright WS, et al.: Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci U S A 2005, 102:3324-3329.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 3324-3329
    • Bennett, C.N.1    Longo, K.A.2    Wright, W.S.3
  • 8
    • 34047250505 scopus 로고    scopus 로고
    • Wnt gene expression in the post-natal growth plate: Regulation with chondrocyte differentiation
    • Andrade AC, Nilsson O, Barnes KM, Baron J: Wnt gene expression in the post-natal growth plate: Regulation with chondrocyte differentiation. Bone 2007, 40:1361-1369.
    • (2007) Bone , vol.40 , pp. 1361-1369
    • Andrade, A.C.1    Nilsson, O.2    Barnes, K.M.3    Baron, J.4
  • 9
    • 33748768971 scopus 로고    scopus 로고
    • Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors
    • Rodda SJ, McMahon AP: Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development 2006, 133:3231-3244.
    • (2006) Development , vol.133 , pp. 3231-3244
    • Rodda, S.J.1    McMahon, A.P.2
  • 10
    • 33744919534 scopus 로고    scopus 로고
    • Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor
    • Dong YF, Soung do Y, Schwarz EM, et al.: Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor. J Cell Physiol 2006, 208:77-86.
    • (2006) J Cell Physiol , vol.208 , pp. 77-86
    • Dong, Y.F.1    Soung do, Y.2    Schwarz, E.M.3
  • 11
    • 38749086157 scopus 로고    scopus 로고
    • Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation
    • Bennett CN, Ouyang H, Ma YL, et al.: Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation. J Bone Miner Res 2007, 22:1924-1932.
    • (2007) J Bone Miner Res , vol.22 , pp. 1924-1932
    • Bennett, C.N.1    Ouyang, H.2    Ma, Y.L.3
  • 12
    • 20244373613 scopus 로고    scopus 로고
    • Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
    • Glass DA 2nd, Bialek P, Ahn JD, et al.: Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 2005, 8:751-764.
    • (2005) Dev Cell , vol.8 , pp. 751-764
    • Glass II, D.A.1    Bialek, P.2    Ahn, J.D.3
  • 13
    • 33845802651 scopus 로고    scopus 로고
    • Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation
    • Tu X, Joeng KS, Nakayama KI, et al.: Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell 2007, 12:113-127.
    • (2007) Dev Cell , vol.12 , pp. 113-127
    • Tu, X.1    Joeng, K.S.2    Nakayama, K.I.3
  • 14
    • 37249035650 scopus 로고    scopus 로고
    • Parathyroid hormone stimulation of noncanonical Wnt signaling in bone
    • Bergenstock MK, Partridge NC: Parathyroid hormone stimulation of noncanonical Wnt signaling in bone. Ann N Y Acad Sci 2007, 1116:354-359.
    • (2007) Ann N Y Acad Sci , vol.1116 , pp. 354-359
    • Bergenstock, M.K.1    Partridge, N.C.2
  • 15
    • 35648990464 scopus 로고    scopus 로고
    • Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK
    • Chang J, Sonoyama W, Wang Z, et al.: Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK. J Biol Chem 2007, 282:30938-30948.
    • (2007) J Biol Chem , vol.282 , pp. 30938-30948
    • Chang, J.1    Sonoyama, W.2    Wang, Z.3
  • 16
    • 37249051759 scopus 로고    scopus 로고
    • Suppression of PPAR transactivation switches cell fate of bone marrow stem cells from adipocytes into osteoblasts
    • Takada I, Suzawa M, Matsumoto K, Kato S: Suppression of PPAR transactivation switches cell fate of bone marrow stem cells from adipocytes into osteoblasts. Ann N Y Acad Sci 2007, 116:182-195.
    • (2007) Ann N Y Acad Sci , vol.116 , pp. 182-195
    • Takada, I.1    Suzawa, M.2    Matsumoto, K.3    Kato, S.4
  • 17
    • 0032938813 scopus 로고    scopus 로고
    • A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo
    • Yamaguchi TP, Bradley A, McMahon AP, Jones S: A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development 1999, 126:1211-1223.
    • (1999) Development , vol.126 , pp. 1211-1223
    • Yamaguchi, T.P.1    Bradley, A.2    McMahon, A.P.3    Jones, S.4
  • 18
    • 29244446792 scopus 로고    scopus 로고
    • Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and-independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT
    • Almeida M, Han L, Bellido T, et al.: Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and-independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT. J Biol Chem 2005, 280:41342-41351.
    • (2005) J Biol Chem , vol.280 , pp. 41342-41351
    • Almeida, M.1    Han, L.2    Bellido, T.3
  • 19
    • 0037030681 scopus 로고    scopus 로고
    • Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling
    • Mao B, Wu W, Davidson G, et al.: Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature 2002, 417:664-667.
    • (2002) Nature , vol.417 , pp. 664-667
    • Mao, B.1    Wu, W.2    Davidson, G.3
  • 20
    • 36849019961 scopus 로고    scopus 로고
    • Changes in osteoblast, chondrocyte, and adipocyte lineages mediate the bone anabolic actions of PTH and small molecule GSK-3 inhibitor
    • Kulkarni NH, Wei T, Kumar A, et al.: Changes in osteoblast, chondrocyte, and adipocyte lineages mediate the bone anabolic actions of PTH and small molecule GSK-3 inhibitor. J Cell Biochem 2007, 102:1504-1518.
    • (2007) J Cell Biochem , vol.102 , pp. 1504-1518
    • Kulkarni, N.H.1    Wei, T.2    Kumar, A.3
  • 21
    • 34250823973 scopus 로고    scopus 로고
    • Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton
    • Baron R, Rawadi G: Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton. Endocrinology 2007, 148:2635-2643.
    • (2007) Endocrinology , vol.148 , pp. 2635-2643
    • Baron, R.1    Rawadi, G.2
  • 22
    • 41849149688 scopus 로고    scopus 로고
    • Genetic analyses in a sample of individuals with high or low BMD shows association with multiple Wnt pathway genes
    • Sims AM, Shephard N, Carter K, et al.: Genetic analyses in a sample of individuals with high or low BMD shows association with multiple Wnt pathway genes. J Bone Miner Res 2008, 23:499-506.
    • (2008) J Bone Miner Res , vol.23 , pp. 499-506
    • Sims, A.M.1    Shephard, N.2    Carter, K.3
  • 23
    • 42549164807 scopus 로고    scopus 로고
    • Wnt signalling and its impact on development and cancer
    • Klaus A, Birchmeier W: Wnt signalling and its impact on development and cancer. Nat Rev Cancer 2008, 8:387-398.
    • (2008) Nat Rev Cancer , vol.8 , pp. 387-398
    • Klaus, A.1    Birchmeier, W.2
  • 24
    • 0032556910 scopus 로고    scopus 로고
    • Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
    • Glinka A, Wu W, Delius H, et al.: Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 1998, 391:357-362.
    • (1998) Nature , vol.391 , pp. 357-362
    • Glinka, A.1    Wu, W.2    Delius, H.3
  • 25
    • 0035902050 scopus 로고    scopus 로고
    • LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    • Mao B, Wu W, Li Y, et al.: LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 2001, 411:321-325.
    • (2001) Nature , vol.411 , pp. 321-325
    • Mao, B.1    Wu, W.2    Li, Y.3
  • 26
    • 25144448701 scopus 로고    scopus 로고
    • Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation
    • Li X, Liu P, Liu W, et al.: Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nat Genet 2005, 37:945-952.
    • (2005) Nat Genet , vol.37 , pp. 945-952
    • Li, X.1    Liu, P.2    Liu, W.3
  • 27
    • 25444433584 scopus 로고    scopus 로고
    • Down-regulation of Wnt signaling by increased expression of Dickkopf-1 and-2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells
    • van der Horst G, van der Werf SM, et al.: Down-regulation of Wnt signaling by increased expression of Dickkopf-1 and-2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells. J Bone Miner Res 2005, 20:1867-1877.
    • (2005) J Bone Miner Res , vol.20 , pp. 1867-1877
    • van der Horst, G.1    van der Werf, S.M.2
  • 28
    • 33748156090 scopus 로고    scopus 로고
    • Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia
    • Li J, Sarosi I, Cattley RC, et al.: Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia. Bone 2006, 39:754-766.
    • (2006) Bone , vol.39 , pp. 754-766
    • Li, J.1    Sarosi, I.2    Cattley, R.C.3
  • 29
    • 33646856033 scopus 로고    scopus 로고
    • Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass
    • Morvan F, Boulukos K, Clement-Lacroix P, et al.: Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J Bone Miner Res 2006, 21:934-945.
    • (2006) J Bone Miner Res , vol.21 , pp. 934-945
    • Morvan, F.1    Boulukos, K.2    Clement-Lacroix, P.3
  • 30
    • 47249140444 scopus 로고    scopus 로고
    • Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: A potential mechanism underlying osteolytic bone lesions in multiple myeloma
    • Qiang YW, Chen Y, Stephens O, et al.: Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: A potential mechanism underlying osteolytic bone lesions in multiple myeloma. Blood 2008, 112:196-207.
    • (2008) Blood , vol.112 , pp. 196-207
    • Qiang, Y.W.1    Chen, Y.2    Stephens, O.3
  • 31
    • 33744747265 scopus 로고    scopus 로고
    • Bone destruction in multiple myeloma
    • Matsumoto T, Abe M: Bone destruction in multiple myeloma. Ann N Y Acad Sci 2006, 1068:319-326.
    • (2006) Ann N Y Acad Sci , vol.1068 , pp. 319-326
    • Matsumoto, T.1    Abe, M.2
  • 32
    • 27744434628 scopus 로고    scopus 로고
    • Novel aspects of osteoclast activation and osteoblast inhibition in myeloma bone disease
    • Heider U, Hofbauer LC, Zavrski I, et al.: Novel aspects of osteoclast activation and osteoblast inhibition in myeloma bone disease. Biochem Biophys Res Commun 2005, 338:687-693.
    • (2005) Biochem Biophys Res Commun , vol.338 , pp. 687-693
    • Heider, U.1    Hofbauer, L.C.2    Zavrski, I.3
  • 33
    • 27644473781 scopus 로고    scopus 로고
    • Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2
    • Oshima T, Abe M, Asano J, et al.: Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2. Blood 2005, 106:3160-315.
    • (2005) Blood , vol.106 , pp. 3160-3165
    • Oshima, T.1    Abe, M.2    Asano, J.3
  • 34
    • 33846150682 scopus 로고    scopus 로고
    • The role of Wnts in bone metastases
    • Hall CL, Keller ET: The role of Wnts in bone metastases. Cancer Metastasis Rev 2006, 25:551-558.
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 551-558
    • Hall, C.L.1    Keller, E.T.2
  • 35
    • 34948859456 scopus 로고    scopus 로고
    • Increased Dickkopf-1 expression in breast cancer bone metastases
    • Voorzanger-Rousselot N, Goehrig D, Journe F, et al.: Increased Dickkopf-1 expression in breast cancer bone metastases. Br J Cancer 2007, 97:964-970.
    • (2007) Br J Cancer , vol.97 , pp. 964-970
    • Voorzanger-Rousselot, N.1    Goehrig, D.2    Journe, F.3
  • 36
    • 33847310346 scopus 로고    scopus 로고
    • Gene expression analysis in human osteoblasts exposed to dexamethasone identifies altered developmental pathways as putative drivers of osteoporosis
    • Hurson CJ, Butler JS, Keating DT, et al.: Gene expression analysis in human osteoblasts exposed to dexamethasone identifies altered developmental pathways as putative drivers of osteoporosis. BMC Musculoskelet Disord 2007, 8:12.
    • (2007) BMC Musculoskelet Disord , vol.8 , pp. 12
    • Hurson, C.J.1    Butler, J.S.2    Keating, D.T.3
  • 37
    • 45349088375 scopus 로고    scopus 로고
    • Glucocorticoid excess in mice results in early activation of osteoclastogenesis and adipogenesis and prolonged suppression of osteogenesis: A longitudinal study of gene expression in bone tissue from glucocorticoidtreated mice
    • Yao W, Cheng Z, Busse C, et al.: Glucocorticoid excess in mice results in early activation of osteoclastogenesis and adipogenesis and prolonged suppression of osteogenesis: A longitudinal study of gene expression in bone tissue from glucocorticoidtreated mice. Arthritis Rheum 2008, 58:1674-1686.
    • (2008) Arthritis Rheum , vol.58 , pp. 1674-1686
    • Yao, W.1    Cheng, Z.2    Busse, C.3
  • 38
    • 41549138806 scopus 로고    scopus 로고
    • Modulation of Dickkopf-1 attenuates glucocorticoid induction of osteoblast apoptosis, adipocytic differentiation, and bone mass loss
    • Wang FS, Ko JY, Yeh DW, et al.: Modulation of Dickkopf-1 attenuates glucocorticoid induction of osteoblast apoptosis, adipocytic differentiation, and bone mass loss. Endocrinology 2008, 149:1793-1801.
    • (2008) Endocrinology , vol.149 , pp. 1793-1801
    • Wang, F.S.1    Ko, J.Y.2    Yeh, D.W.3
  • 39
    • 33846025409 scopus 로고    scopus 로고
    • Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. A histomorphological study in ovariectomized rats
    • Wang FS, Ko JY, Lin CL, et al.: Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. A histomorphological study in ovariectomized rats. Bone 2007, 40:485-492.
    • (2007) Bone , vol.40 , pp. 485-492
    • Wang, F.S.1    Ko, J.Y.2    Lin, C.L.3
  • 40
    • 33846949349 scopus 로고    scopus 로고
    • Dickkopf-1 is a master regulator of joint remodeling
    • Diarra D, Stolina M, Polzer K, et al.: Dickkopf-1 is a master regulator of joint remodeling. Nat Med 2007, 13:156-163.
    • (2007) Nat Med , vol.13 , pp. 156-163
    • Diarra, D.1    Stolina, M.2    Polzer, K.3
  • 41
    • 33847397091 scopus 로고    scopus 로고
    • Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
    • Yaccoby S, Ling W, Zhan F, et al.: Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. Blood 2007, 109:2106-2111.
    • (2007) Blood , vol.109 , pp. 2106-2111
    • Yaccoby, S.1    Ling, W.2    Zhan, F.3
  • 42
    • 0035282968 scopus 로고    scopus 로고
    • Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
    • Balemans W, Ebeling M, Patel N, et al.: Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). Hum Mol Genet 2001, 10:537-543.
    • (2001) Hum Mol Genet , vol.10 , pp. 537-543
    • Balemans, W.1    Ebeling, M.2    Patel, N.3
  • 43
    • 43949094516 scopus 로고    scopus 로고
    • Matrix mineralization as a trigger for osteocyte maturation
    • Irie K, Ejiri S, Sakakura Y, et al.: Matrix mineralization as a trigger for osteocyte maturation. J Histochem Cytochem 2008, 56:561-567.
    • (2008) J Histochem Cytochem , vol.56 , pp. 561-567
    • Irie, K.1    Ejiri, S.2    Sakakura, Y.3
  • 44
    • 27744461726 scopus 로고    scopus 로고
    • Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
    • Poole KE, van Bezooijen RL, Loveridge N, et al.: Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation. FASEB J 2005, 19:1842-1844.
    • (2005) FASEB J , vol.19 , pp. 1842-1844
    • Poole, K.E.1    van Bezooijen, R.L.2    Loveridge, N.3
  • 45
    • 0038267120 scopus 로고    scopus 로고
    • Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity
    • Kusu N, Laurikkala J, Imanishi M, et al.: Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity. J Biol Chem 2003, 278:24113-24117.
    • (2003) J Biol Chem , vol.278 , pp. 24113-24117
    • Kusu, N.1    Laurikkala, J.2    Imanishi, M.3
  • 46
    • 5344234448 scopus 로고    scopus 로고
    • Sclerostin promotes the apoptosis of human osteoblastic cells: A novel regulation of bone formation
    • Sutherland MK, Geoghegan JC, Yu C, et al.: Sclerostin promotes the apoptosis of human osteoblastic cells: A novel regulation of bone formation. Bone 2004, 35:828-835.
    • (2004) Bone , vol.35 , pp. 828-835
    • Sutherland, M.K.1    Geoghegan, J.C.2    Yu, C.3
  • 47
    • 55249101949 scopus 로고    scopus 로고
    • The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations
    • Jun 3 (Epub ahead of print)
    • Balemans W, Piters E, Cleiren E, et al.: The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations. Calcif Tissue Int 2008 Jun 3 (Epub ahead of print).
    • (2008) Calcif Tissue Int
    • Balemans, W.1    Piters, E.2    Cleiren, E.3
  • 48
    • 33845994036 scopus 로고    scopus 로고
    • LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST
    • Semenov MV, He X: LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST. J Biol Chem 2006, 281:38276-38284.
    • (2006) J Biol Chem , vol.281 , pp. 38276-38284
    • Semenov, M.V.1    He, X.2
  • 49
    • 44449099165 scopus 로고    scopus 로고
    • Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength
    • Li X, Ominsky MS, Niu QT, et al.: Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res 2008, 23:860-869.
    • (2008) J Bone Miner Res , vol.23 , pp. 860-869
    • Li, X.1    Ominsky, M.S.2    Niu, Q.T.3
  • 50
    • 33846255350 scopus 로고    scopus 로고
    • Downregulation of SOST/sclerostin by PTH: A novel mechanism of hormonal control of bone formation mediated by osteocytes
    • Bellido T: Downregulation of SOST/scAerostin by PTH: a novel mechanism of hormonal control of bone formation mediated by osteocytes. J Musculoskelet Neuronal Interact 2006, 6:358-359.
    • (2006) J Musculoskelet Neuronal Interact , vol.6 , pp. 358-359
    • Bellido, T.1
  • 51
    • 41949089764 scopus 로고    scopus 로고
    • Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
    • Robling AG, Niziolek PJ, Baldridge LA, et al.: Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J Biol Chem 2008, 283:5866-5875.
    • (2008) J Biol Chem , vol.283 , pp. 5866-5875
    • Robling, A.G.1    Niziolek, P.J.2    Baldridge, L.A.3
  • 52
    • 38849186793 scopus 로고    scopus 로고
    • Anti-sclerostin antibody increases markers of bone formation in healthy postmenopausal women. Abstracts of the 29th Annual Meeting of the American Society for Bone and Mineral Research
    • Padhi D, Stouch B, Jang G, et al.: Anti-sclerostin antibody increases markers of bone formation in healthy postmenopausal women. Abstracts of the 29th Annual Meeting of the American Society for Bone and Mineral Research. J Bone Miner Res 2007, 22(Suppl 1):S37.
    • (2007) J Bone Miner Res , vol.22 , Issue.SUPPL. 1
    • Padhi, D.1    Stouch, B.2    Jang, G.3
  • 53
    • 42549096546 scopus 로고    scopus 로고
    • Beyond Wnt inhibition: New functions of secreted Frizzled-related proteins in development and disease
    • Bovolenta P, EsteNe P, Ruiz JM, et al.: Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease. J Cell Sci 2008, 121(Pt 6):737-746.
    • (2008) J Cell Sci , vol.121 , Issue.PART 6 , pp. 737-746
    • Bovolenta, P.1    Esteve, P.2    Ruiz, J.M.3
  • 54
    • 0029959105 scopus 로고    scopus 로고
    • Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis
    • Hoang B, Moos M Jr, Vukicevic S, Luyten FP: Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis. J Biol Chem 1996, 271:26131-26137.
    • (1996) J Biol Chem , vol.271 , pp. 26131-26137
    • Hoang, B.1    Moos Jr., M.2    Vukicevic, S.3    Luyten, F.P.4
  • 55
    • 16644392118 scopus 로고    scopus 로고
    • Effects of secreted frizzled-related protein 3 on osteoblasts in vitro
    • Chung YS, Baylink DJ, Srivastava AK, et al.: Effects of secreted frizzled-related protein 3 on osteoblasts in vitro. J Bone Miner Res 2004, 19:1395-1402.
    • (2004) J Bone Miner Res , vol.19 , pp. 1395-1402
    • Chung, Y.S.1    Baylink, D.J.2    Srivastava, A.K.3
  • 56
    • 11144296595 scopus 로고    scopus 로고
    • Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells
    • Boland GM, Perkins G, Hall DJ, Tuan RS: Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. J Cell Biochem 2004, 93:1210-1230.
    • (2004) J Cell Biochem , vol.93 , pp. 1210-1230
    • Boland, G.M.1    Perkins, G.2    Hall, D.J.3    Tuan, R.S.4
  • 57
    • 33845581657 scopus 로고    scopus 로고
    • Severe suppression of Frzb/sFRP3 transcription in osteogenic sarcoma
    • Mandal D, Srivastava A, Mahlum E, et al.: Severe suppression of Frzb/ sFRP3 transcription in osteogenic sarcoma. Gene 2007, 386:131-138.
    • (2007) Gene , vol.386 , pp. 131-138
    • Mandal, D.1    Srivastava, A.2    Mahlum, E.3
  • 58
    • 17244374729 scopus 로고    scopus 로고
    • Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites
    • Min JL, Meulenbelt I, Riyazi N, et al.: Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. Arthritis Rheum 2005, 52:1077-1080.
    • (2005) Arthritis Rheum , vol.52 , pp. 1077-1080
    • Min, J.L.1    Meulenbelt, I.2    Riyazi, N.3
  • 59
    • 35348917781 scopus 로고    scopus 로고
    • Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women
    • Lane NE, Nevitt MC, Lui LY, et al.: Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women. Arthritis Rheum 2007, 56:3319-3325.
    • (2007) Arthritis Rheum , vol.56 , pp. 3319-3325
    • Lane, N.E.1    Nevitt, M.C.2    Lui, L.Y.3
  • 60
    • 27944444857 scopus 로고    scopus 로고
    • The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis
    • Bodine PV, Billiard J, Moran RA, et al.: The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis. J Cell Biochem 2005, 96:1212-1230.
    • (2005) J Cell Biochem , vol.96 , pp. 1212-1230
    • Bodine, P.V.1    Billiard, J.2    Moran, R.A.3
  • 61
    • 33845665838 scopus 로고    scopus 로고
    • Bone anabolic effects of parathyroid hormone are blunted by deletion of the Wnt antagonist secreted frizzled-related protein-1
    • Bodine PV, Seestaller-Wehr L, Kharode YP, et al.: Bone anabolic effects of parathyroid hormone are blunted by deletion of the Wnt antagonist secreted frizzled-related protein-1. J Cell Physiol 2007, 210:352-357.
    • (2007) J Cell Physiol , vol.210 , pp. 352-357
    • Bodine, P.V.1    Seestaller-Wehr, L.2    Kharode, Y.P.3
  • 62
    • 77951998251 scopus 로고    scopus 로고
    • Overexpression of secreted frizzled-related protein 1 inhibits bone formation and attenuates pth bone anabolic effects
    • [abstract]. Presented at the Montreal, Quebec, Canada; September 12-16, 2008
    • Yao W, Cheng Z, Busse C, et al.: Overexpression of secreted frizzled-related protein 1 inhibits bone formation and attenuates pth bone anabolic effects [abstract]. Presented at the 30th Annual Meeting of the American Society for Bone and Mineral Research. Montreal, Quebec, Canada; September 12-16, 2008.
    • 30th Annual Meeting of the American Society for Bone and Mineral Research
    • Yao, W.1    Cheng, Z.2    Busse, C.3
  • 63
    • 16644399496 scopus 로고    scopus 로고
    • Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation
    • Hausler KD, Horwood NJ, Chuman Y, et al.: Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation. J Bone Miner Res 2004, 19:1873-1881.
    • (2004) J Bone Miner Res , vol.19 , pp. 1873-1881
    • Hausler, K.D.1    Horwood, N.J.2    Chuman, Y.3
  • 64
    • 34347232275 scopus 로고    scopus 로고
    • A DNA microarray analysis of chemokine and receptor genes in the rat dental follicle - Role of secreted frizzled-related protein-1 in osteoclastogenesis
    • Liu D, Wise GE: A DNA microarray analysis of chemokine and receptor genes in the rat dental follicle - role of secreted frizzled-related protein-1 in osteoclastogenesis. Bone 2007, 41:266-272.
    • (2007) Bone , vol.41 , pp. 266-272
    • Liu, D.1    Wise, G.E.2
  • 65
    • 2342529836 scopus 로고    scopus 로고
    • The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice
    • Bodine PV, Zhao W, Kharode YP, et al.: The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice. Mol Endocrinol 2004, 18:1222-1237.
    • (2004) Mol Endocrinol , vol.18 , pp. 1222-1237
    • Bodine, P.V.1    Zhao, W.2    Kharode, Y.P.3
  • 66
    • 42749095233 scopus 로고    scopus 로고
    • A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein (SFRP)-1 stimulates bone formation. Abstracts of the 29th Annual Meeting of the American Society for Bone and Mineral Research
    • Bodine P, Stauffer B, Ponce-de-Leon H, et al.: A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein (SFRP)-1 stimulates bone formation. Abstracts of the 29th Annual Meeting of the American Society for Bone and Mineral Research. J Bone Miner Res 2007, 22(Suppl 1):S4.
    • (2007) J Bone Miner Res , vol.22 , Issue.SUPPL. 1
    • Bodine, P.1    Stauffer, B.2    Ponce-de-Leon, H.3
  • 67
    • 33846425795 scopus 로고    scopus 로고
    • Secreted frizzledrelated protein 4 is a negative regulator of peak BMD in SAMP6 mice
    • Nakanishi R, Shimizu M, Mori M, et al.: Secreted frizzledrelated protein 4 is a negative regulator of peak BMD in SAMP6 mice. J Bone Miner Res 2006, 21:1713-1721.
    • (2006) J Bone Miner Res , vol.21 , pp. 1713-1721
    • Nakanishi, R.1    Shimizu, M.2    Mori, M.3
  • 68
    • 38549157655 scopus 로고    scopus 로고
    • Osteoblast-targeted expression of Sfrp4 in mice results in low bone mass
    • Nakanishi R, Akiyama H, Kimura H, et al.: Osteoblast-targeted expression of Sfrp4 in mice results in low bone mass. J Bone Miner Res 2008, 23:271-277.
    • (2008) J Bone Miner Res , vol.23 , pp. 271-277
    • Nakanishi, R.1    Akiyama, H.2    Kimura, H.3
  • 69
    • 85047693146 scopus 로고    scopus 로고
    • Secreted frizzledrelated protein 4 is a potent tumor-derived phosphaturic agent
    • Berndt T, Craig TA, Bowe AE, et al.: Secreted frizzledrelated protein 4 is a potent tumor-derived phosphaturic agent. J Clin Invest 2003, 112:785-794.
    • (2003) J Clin Invest , vol.112 , pp. 785-794
    • Berndt, T.1    Craig, T.A.2    Bowe, A.E.3
  • 70
    • 20944445330 scopus 로고    scopus 로고
    • Microarray analysis reveals expression regulation of Wnt antagonists in differentiating osteoblasts
    • Vaes BL, Dechering KJ, van Someren EP, et al.: Microarray analysis reveals expression regulation of Wnt antagonists in differentiating osteoblasts. Bone 2005, 36:803-811.
    • (2005) Bone , vol.36 , pp. 803-811
    • Vaes, B.L.1    Dechering, K.J.2    van Someren, E.P.3
  • 71
    • 28444438846 scopus 로고    scopus 로고
    • Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice
    • Clement-Lacroix P, Ai M, Morvan F, et al.: Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proc Natl Acad Sci U S A 2005, 102:17406-17411.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 17406-17411
    • Clement-Lacroix, P.1    Ai, M.2    Morvan, F.3
  • 72
    • 33646414025 scopus 로고    scopus 로고
    • Orally bioavailable GSK-3alpha/beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo
    • Kulkarni NH, Onyia JE, Zeng Q, et al.: Orally bioavailable GSK-3alpha/ beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo. J Bone Miner Res 2006, 21:910-920.
    • (2006) J Bone Miner Res , vol.21 , pp. 910-920
    • Kulkarni, N.H.1    Onyia, J.E.2    Zeng, Q.3
  • 73
  • 74
    • 41049108267 scopus 로고    scopus 로고
    • GSK-3beta controls osteogenesis through regulating Runx2 activity
    • Kugimiya F, Kawaguchi H, Ohba S, et al.: GSK-3beta controls osteogenesis through regulating Runx2 activity. PLoS ONE 2007, 2:e837.
    • (2007) PLoS ONE , vol.2
    • Kugimiya, F.1    Kawaguchi, H.2    Ohba, S.3
  • 75
    • 34547114509 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor kappaB target genes and induction of apoptosis in chronic lymphocytic leukemia B cells
    • Ougolkov AV, Bone ND, Fernandez-Zapico ME, et al.: Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor kappaB target genes and induction of apoptosis in chronic lymphocytic leukemia B cells. Blood 2007, 110:735-742.
    • (2007) Blood , vol.110 , pp. 735-742
    • Ougolkov, A.V.1    Bone, N.D.2    Fernandez-Zapico, M.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.