Dickkopf-1 is a master regulator of joint remodeling

Nature Medicine

Volumn 13, Issue 2, 2007, Pages 156-163

  Diarra, Danielle ^a,b   Stolina, Marina ^c   Polzer, Karin ^a   Zwerina, Jochen ^a   Ominsky, Michael S ^c   Dwyer, Denise ^c   Korb, Adelheid ^b   Smolen, Josef ^b   Hoffmann, Markus ^b   Scheinecker, Clemens ^b   Van Der Heide, Desiree ^d   Landewe, Robert ^d   Lacey, Dave ^c   Richards, William G ^c   Schett, Georg ^a,b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c AMGEN INC   (United States)

^d MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DICKKOPF 1 PROTEIN; PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHROPATHY; ARTICLE; BONE DESTRUCTION; BONE EROSION; DISEASE MODEL; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOARTHRITIS; OSTEOPHYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; RHEUMATOID ARTHRITIS;

ANALYSIS OF VARIANCE; ANIMALS; ANTIBODIES, MONOCLONAL; ARTHRITIS, RHEUMATOID; BONE RESORPTION; CYTOKINES; HUMANS; IMMUNOASSAY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, TRANSGENIC; OSTEOCALCIN; OSTEOGENESIS; SIGNAL TRANSDUCTION; SYNOVIAL FLUID; TUMOR NECROSIS FACTOR-ALPHA; WNT PROTEINS;

EID: 33846949349     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1538     Document Type: Article

References (32)

1. Firestein, G.S. Evolving concepts of rheumatoid arthritis. Nature 423, 356-361 (2003).
2. Walsh, N.C., Crotti, T.N., Goldring, S.R. & Gravallese, E.M. Rheumatic diseases: the effects of inflammation on bone. Immunol. Rev. 208, 228-251 (2005).
3. Klippel, J.H. Primer on the Rheumatic Diseases 12th edn. (Arthritis Foundation, Atlanta, 2001).
4. Smolen, J.S. & Steiner, G. Therapeutic strategies for rheumatoid arthritis. Nat. Rev. Drug Discov. 2, 473-488 (2003).
5. Feldmann, M. et al. Anti-TNF therapy: where have we got to in 2005? Autoimmunity 25, 26-28 (2005).
6. Lam, J. et al. TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J. Clin. Invest. 106, 1481-1488 (2000).
7. Bertolini, D.R., Nedwin, G.E., Bringman, T.S., Smith, D.D. & Mundy, G.R. Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors. Nature 319, 516-518 (1986).
8. Keffer, J. et al. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J. 10, 4025-4031 (1991).
9. Gravallese, E.M. et al. Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. Am. J. Pathol. 152, 943-951 (1998).
10. Kong, Y.Y. et al. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 397, 315-323 (1999).
11. Pettit, A.R. et al. TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. Am. J. Pathol. 159, 1689-1699 (2001).
12. Redlich, K. et al. Osteoclasts are essential for TNF-alpha-mediated joint destruction. J. Clin. Invest. 110, 1419-1427 (2002).
13. Miller, J.R. The Wnts. Genome Biol. [online] 3, 3001 (2002).
14. Mao, B. et al. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature 417, 664-667 (2002).
15. Holmen, S.L. et al. Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J. Bone Miner. Res. 19, 2033-2040 (2004).
16. Glinka, A. et al. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 391, 357-362 (1998).
17. Bafico, A., Liu, G., Yaniv, A., Gazit, A. & Aaronson, S.A. Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6. Nat. Cell Biol. 3, 683-686 (2001).
18. Morvan, F. et al. Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J. Bone Miner. Res. 21, 934-945 (2006).
19. Tian, E. et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N. Engl. J. Med. 349, 2483-2494 (2003).
20. Van Beuningen, H.M. et al. Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections. Osteoarthritis Cartilage 8, 25-33 (2000).
21. Scharstuhl, A. et al. Adenoviral overexpression of Smad-7 and Smad-6 differentially regulates TGF-beta-mediated chondrocyte proliferation and proteoglycan synthesis. Arthritis Rheum. 48, 3442-3451 (2003).
22. Peifer, M. & Polakis, P. Wnt signaling in oncogenesis and embryogenesis-a look outside the nucleus. Science 287, 1606-1609 (2000).
23. Lustig, B. et al. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol. Cell. Biol. 22, 1184-1193 (2002).
24. Glass, D.A. II et al. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev. Cell 8, 751-764 (2005).
25. Gong, Y. et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107, 513-523 (2001).
26. Zwerina, J. et al. Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: effects on synovial inflammation, bone erosion, and cartilage destruction. Arthritis Rheum. 50, 277-290 (2004).
27. Takeshita, F. Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. Proc. Natl. Acad. Sci. USA 102, 12177-12182 (2005).
28. Arnett, F.C. et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31, 315-324 (1988).
29. Van der Linden, S., Valkenburg, H.A. & Cats, A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum. 27, 361-368 (1984).
30. Van Gestel, A.M. et al. Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis. Comparison with the preliminary American College of Rheumatology and the World Health Organization/ International League Against Rheumatism Criteria. Arthritis Rheum. 39, 34-40 (1996).
31. Garrett, S. et al. A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J. Rheumatol. 21, 2286-2291 (1994).
32. Gortz, B. et al. Arthritis induces lymphocytic bone marrow inflammation and endosteal bone formation. J. Bone Miner. Res. 19, 990-998 (2004).