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Volumn 37, Issue 9, 2005, Pages 945-952

Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation

Author keywords

[No Author keywords available]

Indexed keywords

WNT PROTEIN; CARRIER PROTEIN; DKK2 PROTEIN, MOUSE; GLYCOPROTEIN; MUSCLE PROTEIN; MYOZ3 PROTEIN, HUMAN; MYOZ3 PROTEIN, MOUSE; ONCOPROTEIN; PROTEIN; SIGNAL PEPTIDE; WNT7B PROTEIN, MOUSE;

EID: 25144448701     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1614     Document Type: Article
Times cited : (277)

References (49)
  • 1
    • 0035857351 scopus 로고    scopus 로고
    • Osteoporosis prevention, diagnosis, and therapy
    • NIH Consensus Conference Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy
    • NIH Consensus Conference Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis prevention, diagnosis, and therapy. J. Am. Med. Assoc. 285, 785-795 (2001).
    • (2001) J. Am. Med. Assoc. , vol.285 , pp. 785-795
  • 2
    • 0033924069 scopus 로고    scopus 로고
    • Epidemiology of osteoporotic pelvic fractures in elderly people in Finland: Sharp increase in 1970-1997 and alarming projections for the new millennium
    • Kannus, P., Palvanen, M., Niemi, S., Parkkari, J. & Jarvinen, M. Epidemiology of osteoporotic pelvic fractures in elderly people in Finland: sharp increase in 1970-1997 and alarming projections for the new millennium. Osteoporos. Int. 11, 443-448 (2000).
    • (2000) Osteoporos. Int. , vol.11 , pp. 443-448
    • Kannus, P.1    Palvanen, M.2    Niemi, S.3    Parkkari, J.4    Jarvinen, M.5
  • 3
    • 0030883544 scopus 로고    scopus 로고
    • Epidemiology and predictors of fractures associated with osteoporosis
    • Lips, P. Epidemiology and predictors of fractures associated with osteoporosis. Am. J. Med. 103, 3S-8S (1997).
    • (1997) Am. J. Med. , vol.103
    • Lips, P.1
  • 4
  • 5
    • 0034480787 scopus 로고    scopus 로고
    • Peak bone mass
    • Heaney, R.P. et al. Peak bone mass. Osteoporos. Int. 11, 985-1009 (2000).
    • (2000) Osteoporos. Int. , vol.11 , pp. 985-1009
    • Heaney, R.P.1
  • 6
    • 18044386744 scopus 로고    scopus 로고
    • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    • Gong, Y. et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107, 513-523 (2001).
    • (2001) Cell , vol.107 , pp. 513-523
    • Gong, Y.1
  • 7
    • 0036138175 scopus 로고    scopus 로고
    • A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
    • Little, R.D. et al. A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am. J. Hum. Genet. 70, 11-19 (2002).
    • (2002) Am. J. Hum. Genet. , vol.70 , pp. 11-19
    • Little, R.D.1
  • 8
    • 0037118285 scopus 로고    scopus 로고
    • High bone density due to a mutation in LDL-receptor-related protein 5
    • Boyden, L.M. et al. High bone density due to a mutation in LDL-receptor-related protein 5. N. Engl. J. Med. 346, 1513-1521 (2002).
    • (2002) N. Engl. J. Med. , vol.346 , pp. 1513-1521
    • Boyden, L.M.1
  • 9
    • 0037373341 scopus 로고    scopus 로고
    • Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density
    • Van Wesenbeeck, L. et al. Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density. Am. J. Hum. Genet. 72, 763-771 (2003).
    • (2003) Am. J. Hum. Genet. , vol.72 , pp. 763-771
    • Van Wesenbeeck, L.1
  • 10
    • 0037092049 scopus 로고    scopus 로고
    • Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
    • Kato, M. et al. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J. Cell Biol. 157, 303-314 (2002).
    • (2002) J. Cell Biol. , vol.157 , pp. 303-314
    • Kato, M.1
  • 11
    • 10744224854 scopus 로고    scopus 로고
    • High bone mass in mice expressing a mutant LRP5 gene
    • Babij, P. et al. High bone mass in mice expressing a mutant LRP5 gene. J. Bone Miner. Res. 18, 960-974 (2003).
    • (2003) J. Bone Miner. Res. , vol.18 , pp. 960-974
    • Babij, P.1
  • 12
    • 2342529836 scopus 로고    scopus 로고
    • The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice
    • Bodine, P.V. et al. The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice. Mol. Endocrinol. 18, 1222-1237 (2004).
    • (2004) Mol. Endocrinol. , vol.18 , pp. 1222-1237
    • Bodine, P.V.1
  • 13
    • 0032128173 scopus 로고    scopus 로고
    • From cortical rotation to organizer gene expression: Toward a molecular explanation of axis specification in Xenopus
    • Moon, R.T. & Kimelman, D. From cortical rotation to organizer gene expression: toward a molecular explanation of axis specification in Xenopus. Bioessays 20, 536-545 (1998).
    • (1998) Bioessays , vol.20 , pp. 536-545
    • Moon, R.T.1    Kimelman, D.2
  • 14
    • 0034053069 scopus 로고    scopus 로고
    • Wnt signaling in oncogenesis and embryogenesis - A look outside the nucleus
    • Peifer, M. & Polakis, P. Wnt signaling in oncogenesis and embryogenesis - a look outside the nucleus. Science 287, 1606-1609 (2000).
    • (2000) Science , vol.287 , pp. 1606-1609
    • Peifer, M.1    Polakis, P.2
  • 15
    • 0032406715 scopus 로고    scopus 로고
    • Mechanisms of Wnt signaling in development
    • Wodarz, A. & Nusse, R. Mechanisms of Wnt signaling in development. Annu. Rev. Cell Dev. Biol. 14, 59-88 (1998).
    • (1998) Annu. Rev. Cell Dev. Biol. , vol.14 , pp. 59-88
    • Wodarz, A.1    Nusse, R.2
  • 16
    • 0034644526 scopus 로고    scopus 로고
    • Linking colorectal cancer to Wnt signaling
    • Bienz, M. & Clevers, H. Linking colorectal cancer to Wnt signaling. Cell 103, 311-320 (2000).
    • (2000) Cell , vol.103 , pp. 311-320
    • Bienz, M.1    Clevers, H.2
  • 17
    • 0033777043 scopus 로고    scopus 로고
    • Catenins, Wnt signaling and cancer
    • Barker, N. & Clevers, H. Catenins, Wnt signaling and cancer. Bioessays 22, 961-965 (2000).
    • (2000) Bioessays , vol.22 , pp. 961-965
    • Barker, N.1    Clevers, H.2
  • 18
    • 2342430345 scopus 로고    scopus 로고
    • LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: Arrows point the way
    • He, X., Semenov, M., Tamai, K. & Zeng, X. LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way. Development 131, 1663-1677 (2004).
    • (2004) Development , vol.131 , pp. 1663-1677
    • He, X.1    Semenov, M.2    Tamai, K.3    Zeng, X.4
  • 19
    • 0035115668 scopus 로고    scopus 로고
    • An arrow for wingless to take-off
    • Pandur, P. & Kuhl, M. An arrow for wingless to take-off. Bioessays 23, 207-210 (2001).
    • (2001) Bioessays , vol.23 , pp. 207-210
    • Pandur, P.1    Kuhl, M.2
  • 20
    • 0035902040 scopus 로고    scopus 로고
    • Developmental biology. Making head or tail of Dickkopf
    • Nusse, R. Developmental biology. Making head or tail of Dickkopf. Nature 411, 255-256 (2001).
    • (2001) Nature , vol.411 , pp. 255-256
    • Nusse, R.1
  • 21
    • 18244427021 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein-5 binds to axin and regulates the canonical wnt signaling pathway
    • Mao, J. et al. Low-density lipoprotein receptor-related protein-5 binds to axin and regulates the canonical wnt signaling pathway. Mol. Cell 7, 801-809 (2001).
    • (2001) Mol. Cell , vol.7 , pp. 801-809
    • Mao, J.1
  • 22
    • 0037343952 scopus 로고    scopus 로고
    • Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity
    • Tolwinski, N.S. et al. Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity. Dev. Cell 4, 407-418 (2003).
    • (2003) Dev. Cell , vol.4 , pp. 407-418
    • Tolwinski, N.S.1
  • 23
    • 0344413477 scopus 로고    scopus 로고
    • Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled
    • Wong, H.C. et al. Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol. Cell 12, 1251-1260 (2003).
    • (2003) Mol. Cell , vol.12 , pp. 1251-1260
    • Wong, H.C.1
  • 24
    • 0031666549 scopus 로고    scopus 로고
    • Propagation and localization of Wnt signaling
    • Gumbiner, B.M. Propagation and localization of Wnt signaling. Curr. Opin. Genet. Dev. 8, 430-435 (1998).
    • (1998) Curr. Opin. Genet. Dev. , vol.8 , pp. 430-435
    • Gumbiner, B.M.1
  • 25
    • 0032518695 scopus 로고    scopus 로고
    • Signal transduction by the Wnt family of ligands
    • Dale, T.C. Signal transduction by the Wnt family of ligands. Biochem. J. 329, 209-223 (1998).
    • (1998) Biochem. J. , vol.329 , pp. 209-223
    • Dale, T.C.1
  • 26
    • 21244480924 scopus 로고    scopus 로고
    • Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
    • Li, X. et al. Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling. J. Biol. Chem. 280, 19883-19887 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 19883-19887
    • Li, X.1
  • 27
    • 0032556910 scopus 로고    scopus 로고
    • Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
    • Glinka, A. et al. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 391, 357-362 (1998).
    • (1998) Nature , vol.391 , pp. 357-362
    • Glinka, A.1
  • 28
    • 0032819264 scopus 로고    scopus 로고
    • Dickkopf genes are co-ordinately expressed in mesodermal lineages
    • Monaghan, A.P. et al. Dickkopf genes are co-ordinately expressed in mesodermal lineages. Mech. Dev. 87, 45-56 (1999).
    • (1999) Mech. Dev. , vol.87 , pp. 45-56
    • Monaghan, A.P.1
  • 29
    • 0032850032 scopus 로고    scopus 로고
    • Functional and structural diversity of the human Dickkopf gene family
    • Krupnik, V.E. et al. Functional and structural diversity of the human Dickkopf gene family. Gene 238, 301-313 (1999).
    • (1999) Gene , vol.238 , pp. 301-313
    • Krupnik, V.E.1
  • 30
    • 0035902050 scopus 로고    scopus 로고
    • LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    • Mao, B. et al. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411, 321-325 (2001).
    • (2001) Nature , vol.411 , pp. 321-325
    • Mao, B.1
  • 31
    • 0035954281 scopus 로고    scopus 로고
    • Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6
    • Semenov, M.V. et al. Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr. Biol. 11, 951-961 (2001).
    • (2001) Curr. Biol. , vol.11 , pp. 951-961
    • Semenov, M.V.1
  • 32
    • 0034933057 scopus 로고    scopus 로고
    • Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
    • Bafico, A., Liu, G., Yaniv, A., Gazit, A. & Aaronson, S.A. Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat. Cell Biol. 3, 683-686 (2001).
    • (2001) Nat. Cell Biol. , vol.3 , pp. 683-686
    • Bafico, A.1    Liu, G.2    Yaniv, A.3    Gazit, A.4    Aaronson, S.A.5
  • 33
    • 0037030681 scopus 로고    scopus 로고
    • Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling
    • Mao, B. et al. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature 417, 664-667 (2002).
    • (2002) Nature , vol.417 , pp. 664-667
    • Mao, B.1
  • 34
    • 0037155185 scopus 로고    scopus 로고
    • Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled
    • Li, L., Mao, J., Sun, L., Liu, W. & Wu, D. Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J. Biol. Chem. 277, 5977-5981 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 5977-5981
    • Li, L.1    Mao, J.2    Sun, L.3    Liu, W.4    Wu, D.5
  • 35
    • 0036337388 scopus 로고    scopus 로고
    • Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins
    • Brott, B.K. & Sokol, S.Y. Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins. Mol. Cell. Biol. 22, 6100-6110 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 6100-6110
    • Brott, B.K.1    Sokol, S.Y.2
  • 36
    • 0032898364 scopus 로고    scopus 로고
    • Dishevelled proteins lead to two different signaling pathways; regulation of the JNK and b-catenin pathways
    • Li, L. et al. Dishevelled proteins lead to two different signaling pathways; regulation of the JNK and b-catenin pathways. J. Biol. Chem. 274, 129-134 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 129-134
    • Li, L.1
  • 37
    • 0033517102 scopus 로고    scopus 로고
    • Axin and Frat-1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1
    • Li, L. et al. Axin and Frat-1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J. 18, 4233-4240 (1999).
    • (1999) EMBO J. , vol.18 , pp. 4233-4240
    • Li, L.1
  • 38
    • 0031856533 scopus 로고    scopus 로고
    • Modulation of transcriptional regulation by Lef-1 in response to Wnt-1 signaling and association with beta-catenin
    • Hsu, S.C., Galceran, J. & Grosschedl, R. Modulation of transcriptional regulation by Lef-1 in response to Wnt-1 signaling and association with beta-catenin. Mol. Cell. Biol. 18, 4807-4818 (1998).
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 4807-4818
    • Hsu, S.C.1    Galceran, J.2    Grosschedl, R.3
  • 39
    • 0036133690 scopus 로고    scopus 로고
    • Use of type I collagen green fluorescent protein transgenes to identify subpopulations of cells at different stages of the osteoblast lineage
    • Kalajzic, I. et al. Use of type I collagen green fluorescent protein transgenes to identify subpopulations of cells at different stages of the osteoblast lineage. J. Bone Miner. Res. 17, 15-25 (2002).
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 15-25
    • Kalajzic, I.1
  • 40
    • 2442656675 scopus 로고    scopus 로고
    • The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd
    • Zhang, Y. et al. The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd. Mol. Cell. Biol. 24, 4677-4684 (2004).
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 4677-4684
    • Zhang, Y.1
  • 41
    • 0037043688 scopus 로고    scopus 로고
    • Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis
    • Pandur, P., Lasche, M., Eisenberg, L.M. & Kuhl, M. Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis. Nature 418, 636-641 (2002).
    • (2002) Nature , vol.418 , pp. 636-641
    • Pandur, P.1    Lasche, M.2    Eisenberg, L.M.3    Kuhl, M.4
  • 42
    • 0034649592 scopus 로고    scopus 로고
    • Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling
    • Wu, W., Glinka, A., Delius, H. & Niehrs, C. Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling. Curr. Biol. 10, 1611-1614 (2000).
    • (2000) Curr. Biol. , vol.10 , pp. 1611-1614
    • Wu, W.1    Glinka, A.2    Delius, H.3    Niehrs, C.4
  • 43
    • 20244373613 scopus 로고    scopus 로고
    • Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation
    • Glass, D.A. II et al. Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev. Cell 8, 751-764 (2005).
    • (2005) Dev. Cell , vol.8 , pp. 751-764
    • Glass II, D.A.1
  • 44
    • 18044399916 scopus 로고    scopus 로고
    • Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse
    • Mukhopadhyay, M. et al. Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev. Cell 1, 423-434 (2001).
    • (2001) Dev. Cell , vol.1 , pp. 423-434
    • Mukhopadhyay, M.1
  • 45
    • 0042346318 scopus 로고    scopus 로고
    • The Wnt signaling inhibitor Dkk-1 is required for re-entry into the cell cycle of human adult stem cells from bone marrow (hMSCs)
    • Gregory, C.A., Singh, H., Perry, A.S. & Prockop, D.J. The Wnt signaling inhibitor Dkk-1 is required for re-entry into the cell cycle of human adult stem cells from bone marrow (hMSCs). J. Biol. Chem. 278, 28067-28078 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 28067-28078
    • Gregory, C.A.1    Singh, H.2    Perry, A.S.3    Prockop, D.J.4
  • 46
    • 0037634326 scopus 로고    scopus 로고
    • Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption
    • Ke, H.Z. et al. Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption. Mol. Endocrinol. 17, 1356-1367 (2003).
    • (2003) Mol. Endocrinol. , vol.17 , pp. 1356-1367
    • Ke, H.Z.1
  • 47
    • 0002260196 scopus 로고    scopus 로고
    • Histomorphometric assay of the growing long bone
    • ed. Takahashi, N. Nishimusa, Niigata City
    • Jee, W.S.S. et al. Histomorphometric assay of the growing long bone. in Handbook of Bone Morphology (ed. Takahashi, N.) 87-112 (Nishimusa, Niigata City, 1997).
    • (1997) Handbook of Bone Morphology , pp. 87-112
    • Jee, W.S.S.1
  • 48
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl, M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29, e45 (2001).
    • (2001) Nucleic Acids Res. , vol.29
    • Pfaffl, M.W.1
  • 49
    • 0032030521 scopus 로고    scopus 로고
    • Alkaline phosphatase levels and osteoprogenitor cell numbers suggest bone formation may contribute to peak bone density differences between two inbred strains of mice
    • Dimai, H.P. et al. Alkaline phosphatase levels and osteoprogenitor cell numbers suggest bone formation may contribute to peak bone density differences between two inbred strains of mice. Bone 22, 211-216 (1998).
    • (1998) Bone , vol.22 , pp. 211-216
    • Dimai, H.P.1


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