The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations

Calcified Tissue International

Volumn 82, Issue 6, 2008, Pages 445-453

  Balemans, Wendy ^a   Piters, Elke ^a   Cleiren, Erna ^a,b   Ai, Minrong ^c   Van Wesenbeeck, Liesbeth ^a   Warman, Matthew L ^c,d   Van Hul, Wim ^a  

^a ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^b Discovery Lab Operations   (Belgium)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

DKK1; High bone mass; LRP5; Sclerostin

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; PROTEIN DICKKOPF1; REGULATOR PROTEIN; SCLEROSTIN; UNCLASSIFIED DRUG; WNT PROTEIN; BONE MORPHOGENETIC PROTEIN; DKK1 PROTEIN, HUMAN; LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; SIGNAL PEPTIDE; SOST PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; BONE MASS; EMBRYO; HUMAN; HUMAN CELL; INHIBITION KINETICS; MISSENSE MUTATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RADIOASSAY; SIGNAL TRANSDUCTION; WESTERN BLOTTING; WILD TYPE; ANIMAL; CELL LINE; CHEMISTRY; CULTURE MEDIUM; GENETIC MARKER; GENETICS; METABOLISM; MOUSE;

ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL LINE; CULTURE MEDIA, CONDITIONED; GENETIC MARKERS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LDL-RECEPTOR RELATED PROTEINS; MICE; PROTEIN BINDING; SIGNAL TRANSDUCTION;

EID: 55249101949     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-008-9130-9     Document Type: Article

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