-
1
-
-
33947594129
-
Hyperactive Ras in developmental disorders and cancer
-
Schubbert S., Shannon K., and Bollag G. Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer 7 (2007) 295-308
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 295-308
-
-
Schubbert, S.1
Shannon, K.2
Bollag, G.3
-
2
-
-
2342591455
-
The discovery of receptor tyrosine kinases: targets for cancer therapy
-
Gschwind A., Fischer O.M., and Ullrich A. The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer 4 (2004) 361-370
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 361-370
-
-
Gschwind, A.1
Fischer, O.M.2
Ullrich, A.3
-
3
-
-
0024376173
-
ras oncogenes in human cancer: a review
-
Bos J.L. ras oncogenes in human cancer: a review. Cancer Res 49 (1989) 4682-4689
-
(1989)
Cancer Res
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
4
-
-
0037264633
-
Targeting RAS signalling pathways in cancer therapy
-
Downward J. Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 3 (2003) 11-22
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
5
-
-
0036894746
-
BRAF and RAS mutations in human lung cancer and melanoma
-
Brose M.S., Volpe P., Feldman M., Kumar M., Rishi I., Gerrero R., Einhorn E., Herlyn M., Minna J., Nicholson A., et al. BRAF and RAS mutations in human lung cancer and melanoma. Cancer Res 62 (2002) 6997-7000
-
(2002)
Cancer Res
, vol.62
, pp. 6997-7000
-
-
Brose, M.S.1
Volpe, P.2
Feldman, M.3
Kumar, M.4
Rishi, I.5
Gerrero, R.6
Einhorn, E.7
Herlyn, M.8
Minna, J.9
Nicholson, A.10
-
6
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H., Bignell G.R., Cox C., Stephens P., Edkins S., Clegg S., Teague J., Woffendin H., Garnett M.J., Bottomley W., et al. Mutations of the BRAF gene in human cancer. Nature 417 (2002) 949-954
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
-
7
-
-
0037228055
-
High frequency of BRAF mutations in nevi
-
Pollock P.M., Harper U.L., Hansen K.S., Yudt L.M., Stark M., Robbins C.M., Moses T.Y., Hostetter G., Wagner U., Kakareka J., et al. High frequency of BRAF mutations in nevi. Nat Genet 33 (2003) 19-20
-
(2003)
Nat Genet
, vol.33
, pp. 19-20
-
-
Pollock, P.M.1
Harper, U.L.2
Hansen, K.S.3
Yudt, L.M.4
Stark, M.5
Robbins, C.M.6
Moses, T.Y.7
Hostetter, G.8
Wagner, U.9
Kakareka, J.10
-
8
-
-
0038697566
-
Raf proteins and cancer: B-Raf is identified as a mutational target
-
Mercer K.E., and Pritchard C.A. Raf proteins and cancer: B-Raf is identified as a mutational target. Biochim Biophys Acta 1653 (2003) 25-40
-
(2003)
Biochim Biophys Acta
, vol.1653
, pp. 25-40
-
-
Mercer, K.E.1
Pritchard, C.A.2
-
9
-
-
34548217651
-
Maximizing mouse cancer models
-
Frese K.K., and Tuveson D.A. Maximizing mouse cancer models. Nat Rev Cancer 7 (2007) 645-658
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 645-658
-
-
Frese, K.K.1
Tuveson, D.A.2
-
10
-
-
0041883654
-
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context
-
Guerra C., Mijimolle N., Dhawahir A., Dubus P., Barradas M., Serrano M., Campuzano V., and Barbacid M. Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell 4 (2003) 111-120
-
(2003)
Cancer Cell
, vol.4
, pp. 111-120
-
-
Guerra, C.1
Mijimolle, N.2
Dhawahir, A.3
Dubus, P.4
Barradas, M.5
Serrano, M.6
Campuzano, V.7
Barbacid, M.8
-
11
-
-
11144356354
-
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects
-
Tuveson D.A., Shaw A.T., Willis N.A., Silver D.P., Jackson E.L., Chang S., Mercer K.L., Grochow R., Hock H., Crowley D., et al. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell 5 (2004) 375-387
-
(2004)
Cancer Cell
, vol.5
, pp. 375-387
-
-
Tuveson, D.A.1
Shaw, A.T.2
Willis, N.A.3
Silver, D.P.4
Jackson, E.L.5
Chang, S.6
Mercer, K.L.7
Grochow, R.8
Hock, H.9
Crowley, D.10
-
12
-
-
0035893252
-
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
-
Jackson E.L., Willis N., Mercer K., Bronson R.T., Crowley D., Montoya R., Jacks T., and Tuveson D.A. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev 15 (2001) 3243-3248
-
(2001)
Genes Dev
, vol.15
, pp. 3243-3248
-
-
Jackson, E.L.1
Willis, N.2
Mercer, K.3
Bronson, R.T.4
Crowley, D.5
Montoya, R.6
Jacks, T.7
Tuveson, D.A.8
-
13
-
-
9144266295
-
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
-
Hingorani S.R., Petricoin E.F., Maitra A., Rajapakse V., King C., Jacobetz M.A., Ross S., Conrads T.P., Veenstra T.D., Hitt B.A., et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4 (2003) 437-450
-
(2003)
Cancer Cell
, vol.4
, pp. 437-450
-
-
Hingorani, S.R.1
Petricoin, E.F.2
Maitra, A.3
Rajapakse, V.4
King, C.5
Jacobetz, M.A.6
Ross, S.7
Conrads, T.P.8
Veenstra, T.D.9
Hitt, B.A.10
-
14
-
-
34247897276
-
Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
-
This study provides the first in vivo evidence for the cell biological responses to different expression levels of oncogenic Ras. High levels engaged the p19ARF-p53 tumor suppressor pathway to induce senescence, while low levels promoted hyperplastic growth of mammary epithelial cells.
-
Sarkisian C.J., Keister B.A., Stairs D.B., Boxer R.B., Moody S.E., and Chodosh L.A. Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nat Cell Biol 9 (2007) 493-505. This study provides the first in vivo evidence for the cell biological responses to different expression levels of oncogenic Ras. High levels engaged the p19ARF-p53 tumor suppressor pathway to induce senescence, while low levels promoted hyperplastic growth of mammary epithelial cells.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 493-505
-
-
Sarkisian, C.J.1
Keister, B.A.2
Stairs, D.B.3
Boxer, R.B.4
Moody, S.E.5
Chodosh, L.A.6
-
15
-
-
0346455774
-
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
-
Aguirre A.J., Bardeesy N., Sinha M., Lopez L., Tuveson D.A., Horner J., Redston M.S., and DePinho R.A. Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev 17 (2003) 3112-3126
-
(2003)
Genes Dev
, vol.17
, pp. 3112-3126
-
-
Aguirre, A.J.1
Bardeesy, N.2
Sinha, M.3
Lopez, L.4
Tuveson, D.A.5
Horner, J.6
Redston, M.S.7
DePinho, R.A.8
-
16
-
-
19344362405
-
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
-
Hingorani S.R., Wang L., Multani A.S., Combs C., Deramaudt T.B., Hruban R.H., Rustgi A.K., Chang S., and Tuveson D.A. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7 (2005) 469-483
-
(2005)
Cancer Cell
, vol.7
, pp. 469-483
-
-
Hingorani, S.R.1
Wang, L.2
Multani, A.S.3
Combs, C.4
Deramaudt, T.B.5
Hruban, R.H.6
Rustgi, A.K.7
Chang, S.8
Tuveson, D.A.9
-
17
-
-
33751251034
-
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer
-
Bardeesy N., Cheng K.H., Berger J.H., Chu G.C., Pahler J., Olson P., Hezel A.F., Horner J., Lauwers G.Y., Hanahan D., et al. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev 20 (2006) 3130-3146
-
(2006)
Genes Dev
, vol.20
, pp. 3130-3146
-
-
Bardeesy, N.1
Cheng, K.H.2
Berger, J.H.3
Chu, G.C.4
Pahler, J.5
Olson, P.6
Hezel, A.F.7
Horner, J.8
Lauwers, G.Y.9
Hanahan, D.10
-
18
-
-
33751247898
-
Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression
-
Ijichi H., Chytil A., Gorska A.E., Aakre M.E., Fujitani Y., Fujitani S., Wright C.V., and Moses H.L. Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes Dev 20 (2006) 3147-3160
-
(2006)
Genes Dev
, vol.20
, pp. 3147-3160
-
-
Ijichi, H.1
Chytil, A.2
Gorska, A.E.3
Aakre, M.E.4
Fujitani, Y.5
Fujitani, S.6
Wright, C.V.7
Moses, H.L.8
-
19
-
-
33847387472
-
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas
-
Izeradjene K., Combs C., Best M., Gopinathan A., Wagner A., Grady W.M., Deng C.X., Hruban R.H., Adsay N.V., Tuveson D.A., et al. Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. Cancer Cell 11 (2007) 229-243
-
(2007)
Cancer Cell
, vol.11
, pp. 229-243
-
-
Izeradjene, K.1
Combs, C.2
Best, M.3
Gopinathan, A.4
Wagner, A.5
Grady, W.M.6
Deng, C.X.7
Hruban, R.H.8
Adsay, N.V.9
Tuveson, D.A.10
-
20
-
-
34548205213
-
Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN
-
Siveke J.T., Einwachter H., Sipos B., Lubeseder-Martellato C., Kloppel G., and Schmid R.M. Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN. Cancer Cell 12 (2007) 266-279
-
(2007)
Cancer Cell
, vol.12
, pp. 266-279
-
-
Siveke, J.T.1
Einwachter, H.2
Sipos, B.3
Lubeseder-Martellato, C.4
Kloppel, G.5
Schmid, R.M.6
-
21
-
-
33847419143
-
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
-
Guerra C., Schuhmacher A.J., Canamero M., Grippo P.J., Verdaguer L., Perez-Gallego L., Dubus P., Sandgren E.P., and Barbacid M. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 11 (2007) 291-302
-
(2007)
Cancer Cell
, vol.11
, pp. 291-302
-
-
Guerra, C.1
Schuhmacher, A.J.2
Canamero, M.3
Grippo, P.J.4
Verdaguer, L.5
Perez-Gallego, L.6
Dubus, P.7
Sandgren, E.P.8
Barbacid, M.9
-
22
-
-
34248372925
-
The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia
-
Carriere C., Seeley E.S., Goetze T., Longnecker D.S., and Korc M. The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia. Proc Natl Acad Sci U S A 104 (2007) 4437-4442
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 4437-4442
-
-
Carriere, C.1
Seeley, E.S.2
Goetze, T.3
Longnecker, D.S.4
Korc, M.5
-
23
-
-
31444457129
-
Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma
-
Tuveson D.A., Zhu L., Gopinathan A., Willis N.A., Kachatrian L., Grochow R., Pin C.L., Mitin N.Y., Taparowsky E.J., Gimotty P.A., et al. Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma. Cancer Res 66 (2006) 242-247
-
(2006)
Cancer Res
, vol.66
, pp. 242-247
-
-
Tuveson, D.A.1
Zhu, L.2
Gopinathan, A.3
Willis, N.A.4
Kachatrian, L.5
Grochow, R.6
Pin, C.L.7
Mitin, N.Y.8
Taparowsky, E.J.9
Gimotty, P.A.10
-
24
-
-
20444397431
-
Identification of bronchioalveolar stem cells in normal lung and lung cancer
-
Kim C.F., Jackson E.L., Woolfenden A.E., Lawrence S., Babar I., Vogel S., Crowley D., Bronson R.T., and Jacks T. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 121 (2005) 823-835
-
(2005)
Cell
, vol.121
, pp. 823-835
-
-
Kim, C.F.1
Jackson, E.L.2
Woolfenden, A.E.3
Lawrence, S.4
Babar, I.5
Vogel, S.6
Crowley, D.7
Bronson, R.T.8
Jacks, T.9
-
25
-
-
39449134253
-
Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer
-
Iwanaga K., Yang Y., Raso M.G., Ma L., Hanna A.E., Thilaganathan N., Moghaddam S., Evans C.M., Li H., Cai W.W., et al. Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer. Cancer Res 68 (2008) 1119-1127
-
(2008)
Cancer Res
, vol.68
, pp. 1119-1127
-
-
Iwanaga, K.1
Yang, Y.2
Raso, M.G.3
Ma, L.4
Hanna, A.E.5
Thilaganathan, N.6
Moghaddam, S.7
Evans, C.M.8
Li, H.9
Cai, W.W.10
-
26
-
-
28544432790
-
The differential effects of mutant p53 alleles on advanced murine lung cancer
-
Jackson E.L., Olive K.P., Tuveson D.A., Bronson R., Crowley D., Brown M., and Jacks T. The differential effects of mutant p53 alleles on advanced murine lung cancer. Cancer Res 65 (2005) 10280-10288
-
(2005)
Cancer Res
, vol.65
, pp. 10280-10288
-
-
Jackson, E.L.1
Olive, K.P.2
Tuveson, D.A.3
Bronson, R.4
Crowley, D.5
Brown, M.6
Jacks, T.7
-
27
-
-
0036407230
-
Genetic and epigenetic alterations in colon cancer
-
Grady W.M., and Markowitz S.D. Genetic and epigenetic alterations in colon cancer. Annu Rev Genomics Hum Genet 3 (2002) 101-128
-
(2002)
Annu Rev Genomics Hum Genet
, vol.3
, pp. 101-128
-
-
Grady, W.M.1
Markowitz, S.D.2
-
28
-
-
33748988989
-
Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo
-
Sansom O.J., Meniel V., Wilkins J.A., Cole A.M., Oien K.A., Marsh V., Jamieson T.J., Guerra C., Ashton G.H., Barbacid M., et al. Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proc Natl Acad Sci U S A 103 (2006) 14122-14127
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 14122-14127
-
-
Sansom, O.J.1
Meniel, V.2
Wilkins, J.A.3
Cole, A.M.4
Oien, K.A.5
Marsh, V.6
Jamieson, T.J.7
Guerra, C.8
Ashton, G.H.9
Barbacid, M.10
-
29
-
-
42549127895
-
Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon
-
Calcagno S.R., Li S., Colon M., Kreinest P.A., Thompson E.A., Fields A.P., and Murray N.R. Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon. Int J Cancer 122 (2008) 2462-2470
-
(2008)
Int J Cancer
, vol.122
, pp. 2462-2470
-
-
Calcagno, S.R.1
Li, S.2
Colon, M.3
Kreinest, P.A.4
Thompson, E.A.5
Fields, A.P.6
Murray, N.R.7
-
30
-
-
42649125571
-
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
-
Haigis et al. describe oncogene-specific effects in the colon, where K-Ras but not N-Ras induced hyperplasia, suggesting that Ras family members are oncogenic only in cell type-specific contexts.
-
Haigis K.M., Kendall K.R., Wang Y., Cheung A., Haigis M.C., Glickman J.N., Niwa-Kawakita M., Sweet-Cordero A., Sebolt-Leopold J., Shannon K.M., et al. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet 40 (2008) 600-608. Haigis et al. describe oncogene-specific effects in the colon, where K-Ras but not N-Ras induced hyperplasia, suggesting that Ras family members are oncogenic only in cell type-specific contexts.
-
(2008)
Nat Genet
, vol.40
, pp. 600-608
-
-
Haigis, K.M.1
Kendall, K.R.2
Wang, Y.3
Cheung, A.4
Haigis, M.C.5
Glickman, J.N.6
Niwa-Kawakita, M.7
Sweet-Cordero, A.8
Sebolt-Leopold, J.9
Shannon, K.M.10
-
31
-
-
13444269246
-
Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer
-
Dinulescu D.M., Ince T.A., Quade B.J., Shafer S.A., Crowley D., and Jacks T. Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer. Nat Med 11 (2005) 63-70
-
(2005)
Nat Med
, vol.11
, pp. 63-70
-
-
Dinulescu, D.M.1
Ince, T.A.2
Quade, B.J.3
Shafer, S.A.4
Crowley, D.5
Jacks, T.6
-
32
-
-
34547660321
-
A spatially and temporally restricted mouse model of soft tissue sarcoma
-
Kirsch D.G., Dinulescu D.M., Miller J.B., Grimm J., Santiago P.M., Young N.P., Nielsen G.P., Quade B.J., Chaber C.J., Schultz C.P., et al. A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med 13 (2007) 992-997
-
(2007)
Nat Med
, vol.13
, pp. 992-997
-
-
Kirsch, D.G.1
Dinulescu, D.M.2
Miller, J.B.3
Grimm, J.4
Santiago, P.M.5
Young, N.P.6
Nielsen, G.P.7
Quade, B.J.8
Chaber, C.J.9
Schultz, C.P.10
-
33
-
-
0345743699
-
Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder
-
Braun B.S., Tuveson D.A., Kong N., Le D.T., Kogan S.C., Rozmus J., Le Beau M.M., Jacks T.E., and Shannon K.M. Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Proc Natl Acad Sci U S A 101 (2004) 597-602
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 597-602
-
-
Braun, B.S.1
Tuveson, D.A.2
Kong, N.3
Le, D.T.4
Kogan, S.C.5
Rozmus, J.6
Le Beau, M.M.7
Jacks, T.E.8
Shannon, K.M.9
-
34
-
-
85047690606
-
Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease
-
Chan I.T., Kutok J.L., Williams I.R., Cohen S., Kelly L., Shigematsu H., Johnson L., Akashi K., Tuveson D.A., Jacks T., et al. Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease. J Clin Invest 113 (2004) 528-538
-
(2004)
J Clin Invest
, vol.113
, pp. 528-538
-
-
Chan, I.T.1
Kutok, J.L.2
Williams, I.R.3
Cohen, S.4
Kelly, L.5
Shigematsu, H.6
Johnson, L.7
Akashi, K.8
Tuveson, D.A.9
Jacks, T.10
-
35
-
-
33748177343
-
Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease
-
Chan I.T., Kutok J.L., Williams I.R., Cohen S., Moore S., Shigematsu H., Ley T.J., Akashi K., Le Beau M.M., and Gilliland D.G. Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease. Blood 108 (2006) 1708-1715
-
(2006)
Blood
, vol.108
, pp. 1708-1715
-
-
Chan, I.T.1
Kutok, J.L.2
Williams, I.R.3
Cohen, S.4
Moore, S.5
Shigematsu, H.6
Ley, T.J.7
Akashi, K.8
Le Beau, M.M.9
Gilliland, D.G.10
-
36
-
-
33749320394
-
Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice
-
Parikh C., Subrahmanyam R., and Ren R. Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice. Blood 108 (2006) 2349-2357
-
(2006)
Blood
, vol.108
, pp. 2349-2357
-
-
Parikh, C.1
Subrahmanyam, R.2
Ren, R.3
-
37
-
-
34547621066
-
Oncogenic NRAS, KRAS, and HRAS exhibit different leukemogenic potentials in mice
-
Parikh C., Subrahmanyam R., and Ren R. Oncogenic NRAS, KRAS, and HRAS exhibit different leukemogenic potentials in mice. Cancer Res 67 (2007) 7139-7146
-
(2007)
Cancer Res
, vol.67
, pp. 7139-7146
-
-
Parikh, C.1
Subrahmanyam, R.2
Ren, R.3
-
38
-
-
0030729474
-
Cooperative effects of INK4a and ras in melanoma susceptibility in vivo
-
Chin L., Pomerantz J., Polsky D., Jacobson M., Cohen C., Cordon-Cardo C., Horner II J.W., and DePinho R.A. Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. Genes Dev 11 (1997) 2822-2834
-
(1997)
Genes Dev
, vol.11
, pp. 2822-2834
-
-
Chin, L.1
Pomerantz, J.2
Polsky, D.3
Jacobson, M.4
Cohen, C.5
Cordon-Cardo, C.6
Horner II, J.W.7
DePinho, R.A.8
-
39
-
-
1642535593
-
Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations
-
Harada N., Oshima H., Katoh M., Tamai Y., Oshima M., and Taketo M.M. Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations. Cancer Res 64 (2004) 48-54
-
(2004)
Cancer Res
, vol.64
, pp. 48-54
-
-
Harada, N.1
Oshima, H.2
Katoh, M.3
Tamai, Y.4
Oshima, M.5
Taketo, M.M.6
-
40
-
-
45749098853
-
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
-
G12V germline mouse model, which did not develop cancer but displayed phenotypes resembling human Costello syndrome.
-
G12V germline mouse model, which did not develop cancer but displayed phenotypes resembling human Costello syndrome.
-
(2008)
J Clin Invest
, vol.118
, pp. 2169-2179
-
-
Schuhmacher, A.J.1
Guerra, C.2
Sauzeau, V.3
Canamero, M.4
Bustelo, X.R.5
Barbacid, M.6
-
41
-
-
29244487538
-
Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts
-
••]
-
••]
-
(2005)
Cancer Res
, vol.65
, pp. 11493-11500
-
-
Mercer, K.1
Giblett, S.2
Green, S.3
Lloyd, D.4
DaRocha Dias, S.5
Plumb, M.6
Marais, R.7
Pritchard, C.8
-
42
-
-
33847201454
-
A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors
-
••] describe the generation of conditional oncogenic B-Raf mutant mice. Upon activation by Cre in the appropriate cell type, these mice developed haematopoietic and pulmonary malignancies.
-
••] describe the generation of conditional oncogenic B-Raf mutant mice. Upon activation by Cre in the appropriate cell type, these mice developed haematopoietic and pulmonary malignancies.
-
(2007)
Genes Dev
, vol.21
, pp. 379-384
-
-
Dankort, D.1
Filenova, E.2
Collado, M.3
Serrano, M.4
Jones, K.5
McMahon, M.6
-
43
-
-
22444444402
-
Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse
-
Collier L.S., Carlson C.M., Ravimohan S., Dupuy A.J., and Largaespada D.A. Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse. Nature 436 (2005) 272-276
-
(2005)
Nature
, vol.436
, pp. 272-276
-
-
Collier, L.S.1
Carlson, C.M.2
Ravimohan, S.3
Dupuy, A.J.4
Largaespada, D.A.5
-
44
-
-
0034036430
-
Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein
-
Kerkhoff E., Fedorov L.M., Siefken R., Walter A.O., Papadopoulos T., and Rapp U.R. Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein. Cell Growth Diff 11 (2000) 185-190
-
(2000)
Cell Growth Diff
, vol.11
, pp. 185-190
-
-
Kerkhoff, E.1
Fedorov, L.M.2
Siefken, R.3
Walter, A.O.4
Papadopoulos, T.5
Rapp, U.R.6
-
45
-
-
34547609385
-
Disruption of tumor cell adhesion promotes angiogenic switch and progression to micrometastasis in RAF-driven murine lung cancer
-
Ceteci F., Ceteci S., Karreman C., Kramer B.W., Asan E., Gotz R., and Rapp U.R. Disruption of tumor cell adhesion promotes angiogenic switch and progression to micrometastasis in RAF-driven murine lung cancer. Cancer Cell 12 (2007) 145-159
-
(2007)
Cancer Cell
, vol.12
, pp. 145-159
-
-
Ceteci, F.1
Ceteci, S.2
Karreman, C.3
Kramer, B.W.4
Asan, E.5
Gotz, R.6
Rapp, U.R.7
-
46
-
-
43249118923
-
Constitutive activation of Raf-1 induces glioma formation in mice
-
Lyustikman Y., Momota H., Pao W., and Holland E.C. Constitutive activation of Raf-1 induces glioma formation in mice. Neoplasia 10 (2008) 501-510
-
(2008)
Neoplasia
, vol.10
, pp. 501-510
-
-
Lyustikman, Y.1
Momota, H.2
Pao, W.3
Holland, E.C.4
-
47
-
-
34347372927
-
Tumor microenvironment and neurofibromatosis type I. connecting the GAPs
-
Le L.Q., and Parada L.F. Tumor microenvironment and neurofibromatosis type I. connecting the GAPs. Oncogene 26 (2007) 4609-4616
-
(2007)
Oncogene
, vol.26
, pp. 4609-4616
-
-
Le, L.Q.1
Parada, L.F.2
-
48
-
-
21744443319
-
Neurofibromatosis type 1 - a model for nervous system tumour formation?
-
Rubin J.B., and Gutmann D.H. Neurofibromatosis type 1 - a model for nervous system tumour formation?. Nat Rev Cancer 5 (2005) 557-564
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 557-564
-
-
Rubin, J.B.1
Gutmann, D.H.2
-
49
-
-
41049103244
-
Sprouty proteins, masterminds of receptor tyrosine kinase signaling
-
Cabrita M.A., and Christofori G. Sprouty proteins, masterminds of receptor tyrosine kinase signaling. Angiogenesis 11 (2008) 53-62
-
(2008)
Angiogenesis
, vol.11
, pp. 53-62
-
-
Cabrita, M.A.1
Christofori, G.2
-
50
-
-
33947326561
-
Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis
-
Shaw A.T., Meissner A., Dowdle J.A., Crowley D., Magendantz M., Ouyang C., Parisi T., Rajagopal J., Blank L.J., Bronson R.T., et al. Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev 21 (2007) 694-707
-
(2007)
Genes Dev
, vol.21
, pp. 694-707
-
-
Shaw, A.T.1
Meissner, A.2
Dowdle, J.A.3
Crowley, D.4
Magendantz, M.5
Ouyang, C.6
Parisi, T.7
Rajagopal, J.8
Blank, L.J.9
Bronson, R.T.10
-
51
-
-
33947698363
-
Regulation of innate immunity by MAPK dual-specificity phosphatases: knockout models reveal new tricks of old genes
-
Salojin K., and Oravecz T. Regulation of innate immunity by MAPK dual-specificity phosphatases: knockout models reveal new tricks of old genes. J Leukoc Biol 81 (2007) 860-869
-
(2007)
J Leukoc Biol
, vol.81
, pp. 860-869
-
-
Salojin, K.1
Oravecz, T.2
-
52
-
-
17444406711
-
Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development
-
••]
-
••]
-
(2005)
Cancer Cell
, vol.7
, pp. 313-324
-
-
Mijimolle, N.1
Velasco, J.2
Dubus, P.3
Guerra, C.4
Weinbaum, C.A.5
Casey, P.J.6
Campuzano, V.7
Barbacid, M.8
-
53
-
-
33846191877
-
Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative disease
-
••]
-
••]
-
(2007)
Blood
, vol.109
, pp. 763-768
-
-
Wahlstrom, A.M.1
Cutts, B.A.2
Karlsson, C.3
Andersson, K.M.4
Liu, M.5
Sjogren, A.K.6
Swolin, B.7
Young, S.G.8
Bergo, M.O.9
-
54
-
-
34248177249
-
GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer
-
••]
-
••]
-
(2007)
J Clin Invest
, vol.117
, pp. 1294-1304
-
-
Sjogren, A.K.1
Andersson, K.M.2
Liu, M.3
Cutts, B.A.4
Karlsson, C.5
Wahlstrom, A.M.6
Dalin, M.7
Weinbaum, C.8
Casey, P.J.9
Tarkowski, A.10
-
55
-
-
51649099589
-
Inactivating Icmt ameliorates K-RAS-induced myeloproliferative disease
-
G12D-driven tumorigenesis was impaired, while loss of Rce1 enhanced tumorigenicity.
-
G12D-driven tumorigenesis was impaired, while loss of Rce1 enhanced tumorigenicity.
-
(2008)
Blood
, vol.112
, pp. 1357-1365
-
-
Wahlstrom, A.M.1
Cutts, B.A.2
Liu, M.3
Lindskog, A.4
Karlsson, C.5
Sjogren, A.K.6
Andersson, K.M.7
Young, S.G.8
Bergo, M.O.9
-
56
-
-
34249026448
-
Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice
-
•]
-
•]
-
(2007)
Cell
, vol.129
, pp. 957-968
-
-
Gupta, S.1
Ramjaun, A.R.2
Haiko, P.3
Wang, Y.4
Warne, P.H.5
Nicke, B.6
Nye, E.7
Stamp, G.8
Alitalo, K.9
Downward, J.10
-
57
-
-
34548583283
-
Requirement for Rac1 in a K-ras induced lung cancer in the mouse
-
•]
-
•]
-
(2007)
Cancer Res
, vol.67
, pp. 8089-8094
-
-
Kissil, J.L.1
Walmsley, M.J.2
Hanlon, L.3
Haigis, K.M.4
Bender Kim, C.F.5
Sweet-Cordero, A.6
Eckman, M.S.7
Tuveson, D.A.8
Capobianco, A.J.9
Tybulewicz, V.L.10
-
58
-
-
20444410041
-
Activation of RalA is critical for Ras-induced tumorigenesis of human cells
-
•] showed the importance of different Ras effector pathways for Ras-mediated tumorigenesis, distinguishing these pathways as relevant therapeutic targets.
-
•] showed the importance of different Ras effector pathways for Ras-mediated tumorigenesis, distinguishing these pathways as relevant therapeutic targets.
-
(2005)
Cancer Cell
, vol.7
, pp. 533-545
-
-
Lim, K.H.1
Baines, A.T.2
Fiordalisi, J.J.3
Shipitsin, M.4
Feig, L.A.5
Cox, A.D.6
Der, C.J.7
Counter, C.M.8
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