Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development

Cancer Cell

Volumn 7, Issue 4, 2005, Pages 313-324

  Mijimolle, Nieves ^a   Velasco, Juan ^a,d   Dubus, Pierre ^b   Guerra, Carmen ^a   Weinbaum, Carolyn A ^c   Casey, Patrick J ^c   Campuzano, Victoria ^a,e   Barbacid, Mariano ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d ELI LILLY AND COMPANY   (Spain)

^e UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN FARNESYLTRANSFERASE;

ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CANCER MODEL; CARBOXY TERMINAL SEQUENCE; CELL MOTILITY; CELL PROLIFERATION; CELL ULTRASTRUCTURE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENZYME INHIBITION; ENZYME SUBSTRATE; ERYTHROID CELL; GENE TARGETING; HOMEOSTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; TUMOR GROWTH; WOUND HEALING IMPAIRMENT;

EID: 17444406711     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2005.03.004     Document Type: Article

References (39)

1. S.A. Armstrong, V.C. Hannah, J.L. Goldstein, and M.S. Brown CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB J. Biol. Chem. 270 1995 7864 7868
2. A. Balmain, and I.B. Pragnell Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene Nature 303 1983 72 74
3. M.O. Bergo, G.K. Leung, P. Ambroziak, J.C. Otto, P.J. Casey, A.Q. Gomes, M.C. Seabra, and S.G. Young Isoprenylcysteine carboxyl methyltransferase deficiency in mice J. Biol. Chem. 276 2001 5841 5845
4. M.O. Bergo, P. Ambroziak, C. Gregory, A. George, J.C. Otto, E. Kim, H. Nagase, P.J. Casey, A. Balmain, and S.G. Young Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation Mol. Cell. Biol. 22 2002 171 181
5. M.O. Bergo, B.J. Gavino, C. Hong, A.P. Beigneux, M. McMahon, P.J. Casey, and S.G. Young Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf J. Clin. Invest. 113 2004 539 550
6. V.L. Boyartchuk, M.N. Ashby, and J. Rine Modulation of Ras and a-factor function by carboxyl-terminal proteolysis Science 275 1997 1796 1800
7. J. Brocard, X. Warot, O. Wendling, N. Messaddeq, J.L. Vonesch, P. Chambon, and D. Metzger Spatio-temporally controlled site-specific somatic mutagenesis in the mouse Proc. Natl. Acad. Sci. USA 94 1997 14559 14563
8. P.J. Casey, P.A. Solski, C.J. Der, and J.E. Buss p21ras is modified by a farnesyl isoprenoid Proc. Natl. Acad. Sci. USA 86 1989 8323 8327
9. Q. Dai, E. Choy, V. Chium, J. Romano, S.R. Slivka, S.A. Steitz, S. Michaelis, and M.R. Philips Mammalian prenylcysteine carboxl methyltransferase is in the endoplasmic reticulum J. Biol. Chem. 273 1998 15030 15034
10. A.R. Davis, Y.G. Alevy, A. Chellaiah, M.T. Quinn, and T. Mohanakumar Characterization of HDJ-2, a human 40 kD heat shock protein Int. J. Biochem. Cell Biol. 30 1998 1203 1221
11. J. Downward Targeting RAS signalling pathways in cancer therapy Nat. Rev. Cancer 3 2003 11 22
12. W. Du, P.F. Lebowitz, and G.C. Prendergast Cell growth inhibition by farnesyltrasnferase inhibitors is mediated by gain of geranylgeranylated RhoB Mol. Cell. Biol. 19 1999 1831 1840
13. J.J. Fiordalisi, R.L. Johnson II, C.A. Weinbaum, K. Sakabe, Z. Chen, P.J. Casey, and A.D. Cox High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors J. Biol. Chem. 278 2003 41718 41727
14. J.B. Gibbs, A. Oliff, and N.E. Kohl Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic Cell 77 1994 175 178
15. J.A. Glomset, M.H. Gelb, and C.C. Farnsworth Prenyl proteins in eukaryotic cells: a new type of membrane anchor Trends Biochem. Sci. 15 1990 139 142
16. C. Guerra, N. Mijimolle, A. Dhawahir, P. Dubus, M. Barradas, M. Serrano, V. Campuzano, and M. Barbacid Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context Cancer Cell 4 2003 111 120
17. J.F. Hancock, A.I. Magee, J.E. Childs, and C.J. Marshall All Ras proteins are polyisoprenylated but only some are palmitoylated Cell 57 1989 1167 1177
18. G.M. Higgins, and R.M. Anderson Restoration of the liver of the white rat following partial surgical removal Arch. Pathol. 12 1931 186 202
19. C.A. Hrycyna, S.K. Sappertein, S. Clarke, and S. Michaeli The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins EMBO J. 10 1991 1699 1709
20. G.L. James, J.L. Goldstein, and M.S. Brown Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro J. Biol. Chem. 270 1995 6221 6226
21. E. Kim, P. Ambroziak, J.C. Otto, B. Taylor, M. Ashaby, K. Shannon, P.J. Casey, and S.G. Young Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells J. Biol. Chem. 274 1999 8383 8390
22. N.E. Kohl, F.R. Wilson, S.D. Mosser, E. Giuliani, S.J. deSolms, M.W. Conner, N.J. Anthony, W.J. Holtz, R.P. Gomez, and T.J. Lee Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice Proc. Natl. Acad. Sci. USA 91 1994 9141 9145
23. N.E. Kohl, C.A. Omer, M.W. Conner, N.J. Anthony, J.P. Davide, S.J. deSolms, E.A. Giuliani, R.P. Gomez, S.L. Graham, and K. Hamilton Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice Nat. Med. 1 1995 792 797
24. P.F. Lebowitz, J.P. Davide, and G.C. Predergast Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity Mol. Cell. Biol. 15 1995 6613 6622
25. E.C. Lerner, T.T. Zhang, D.B. Knowles, Y. Qian, A.D. Hamilton, and S.M. Sebti Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines Oncogene 15 1997 1283 1288
26. M. Malumbres, R. Sotillo, D. Santamaría, J. Galán, A. Cerezo, S. Ortega, P. Dubus, and M. Barbacid Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6 Cell 118 2004 493 504
27. J.C. Otto, E. Kim, S.G. Young, and P.J. Casey Cloning and characterization of mammalian prenyl protein-specific portease J. Biol. Chem. 274 1999 8379 8382
28. S. Powers, S. Michaelis, D. Broek, S. Santa Anna, J. Field, I. Hereskowitz, and M. Wigler RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor Cell 47 1986 413 422
29. G.C. Prendergast Actin' up: RhoB in cancer and apoptosis Nat. Rev. Cancer 1 2001 162 168
30. T.S. Reid, K.L. Terry, P.J. Casey, and L.S Beese Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity J. Mol. Biol. 343 2004 417 433
31. C.A. Rowell, J.J. Kowalczyk, M.D. Lewis, and A.M. Garcia Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo J. Biol. Chem. 272 1997 14093 14097
32. F. Schwenk, U. Baron, and K. Rajewsky A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells Nucleic Acids Res. 23 1995 5080 5081
33. M.C. Seabra, E.H. Mules, and A.N. Hume Rab GTPases, intracellular traffic and disease Trends Mol. Med. 8 2002 23 30
34. S.M. Sebti, and C.J. Der Opinion: Searching for the elusive targets of farnesyltransferase inhibitors Nat. Rev. Cancer 3 2003 945 951
35. C.E. Trueblood, Y. Ohya, and J. Rine Genetic evidence for in vivo cross specificity of the CaaX-box protein prenyltransferases farnesyltransferase and geranylgeranyltransferase-I in Saccharomyces cerevisiae Mol. Cell. Biol. 13 1993 4260 4275
36. D.B. Whyte, P. Kirschmeier, T.N. Hockenberry, I. Nuñez-Oliva, L. James, J.J. Catino, W.R. Bishop, and J.K. Pai K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors J. Biol. Chem. 272 1997 14459 14464
37. B.M. Willumsen, A. Christensen, N.L. Hubbert, A.G. Papageorge, and D.R. Lowy The p21 ras C-terminus is required for transformation and membrane association Nature 310 1984 583 586
38. B.M. Willumsen, K. Norris, A.G. Papageorge, N.L. Hubbert, and D.R. Lowy Harvey murine sarcoma virus p 21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus EMBO J. 3 1984 2581 2585
39. F.L. Zhang, and P.J. Casey Protein prenylation: molecular mechanisms and functional consequences Annu. Rev. Biochem. 65 1996 241 269