In vitro screening techniques for reactive metabolites for minimizing bioactivation potential in drug discovery

Current Drug Metabolism

Volumn 9, Issue 9, 2008, Pages 952-964

  Prakash, Chandra ^a,c   Sharma, Raman ^a   Gleave, Michelle ^b   Nedderman, Angus ^b  

^a PFIZER INC   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c BIOGEN   (United States)

Author keywords

Adverse drug reactions; Bioactivation; Covalent binding; Idiosyneractic response; In vitro; Mass spectrometry; Reactive intermediates; Trapping agents

Indexed keywords

ACY GLUCURONIDE; AROMATIC AMINE; ARZOXIFENE; CARBOXYLIC ACID; CYTOCHROME P450 3A4; DANSYLATED GLUTATHIONE; DISULFIRAM; DRUG METABOLIZING ENZYME; ELECTROPHILE; FREE RADICAL; GLUCURONIDE; GLUTATHIONE DERIVATIVE; MELOXICAM; NONSTEROID ANTIINFLAMMATORY AGENT; PHENCYCLIDINE; QUATERNARY AMMONIUM DERIVATIVE; SUDOXICAM; SYNTHETIC PEPTIDE; TROGLITAZONE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT; DRUG;

ACCURACY; COMPUTER MODEL; COVALENT BOND; DRUG CONJUGATION; DRUG DETERMINATION; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; DRUG TRANSFORMATION; ENZYME METABOLISM; HIGH THROUGHPUT SCREENING; HUMAN; IN VITRO STUDY; INTERMETHOD COMPARISON; LIVER CELL; LIVER MICROSOME; LIVER TOXICITY; MASS SPECTROMETRY; METABOLIC REGULATION; NONHUMAN; REVIEW; RISK BENEFIT ANALYSIS; SENSITIVITY AND SPECIFICITY; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING; TOXICOKINETICS; UNSPECIFIED SIDE EFFECT; ANIMAL; ARTICLE; BIOTRANSFORMATION; CELL CULTURE; COMPUTER SIMULATION; DRUG DESIGN; METABOLISM; METHODOLOGY; PHYSIOLOGY; PROTEIN BINDING;

ANIMALS; BIOTRANSFORMATION; CELLS, CULTURED; COMPUTER SIMULATION; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; GLUCURONIDES; HUMANS; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING;

EID: 60749088028     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920008786485209     Document Type: Review

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