Possible bioactivation pathways of lamotrigine

Drug Metabolism and Disposition

Volumn 35, Issue 7, 2007, Pages 1050-1056

  Lu, Wei ^a   Uetrecht, Jack P ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; FREE RADICAL; HYDROGEN PEROXIDE; HYPOCHLOROUS ACID; LAMOTRIGINE; MONOPHENOL MONOOXYGENASE; MYELOPEROXIDASE; N ACETYLHISTIDINE; PROSTAGLANDIN SYNTHASE; SULFOTRANSFERASE;

AGRANULOCYTOSIS; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; COVALENT BOND; DRUG ACTIVITY; DRUG OXIDATION; DRUG PROTEIN BINDING; DRUG SULFATION; FEMALE; IN VIVO STUDY; INCUBATION TIME; ISOTOPE LABELING; LIPID PEROXIDATION; LIVER MICROSOME; METABOLIC ACTIVATION; METABOLITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RASH; RAT; SKIN;

ANIMALS; ANTICONVULSANTS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOSOL; DRUG ERUPTIONS; FEMALE; HUMANS; HYDROLYSIS; HYPOCHLOROUS ACID; MALE; MICE; MICE, INBRED C57BL; MICROSOMES, LIVER; MOLECULAR STRUCTURE; NEUTROPHILS; OXIDANTS; OXIDATION-REDUCTION; PEROXIDASE; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SULFATES; TANDEM MASS SPECTROMETRY; TRIAZINES;

RATTUS;

EID: 34250728560     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.015271     Document Type: Article

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