A semi-automated method for measuring the potential for protein covalent binding in drug discovery

Journal of Pharmacological and Toxicological Methods

Volumn 52, Issue 2, 2005, Pages 278-285

  Day, S H ^a   Mao, A ^b   White, R ^b   Schulz Utermoehl, T ^c   Miller, R ^b   Beconi, M G ^b,d  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b MERCK RESEARCH LABORATORIES   (United States)

^c Merck Sharp & Dohme Limited   (United Kingdom)

^d GLAXOSMITHKLINE   (United States)

Author keywords

Covalent protein binding; Human; Idiosyncratic drug reactions; In vitro methods; Radiolabeled compounds; Rat; Reactive metabolites

Indexed keywords

2 CYANO 7 [3 FLUORO 5 (3 HYDROXY 6,8 DIOXABICYCLO[3.2.1]OCT 3 YL)PHENOXYMETHYL] 4 (3 FURYL)QUINOLINE; CARBON 14; DICLOFENAC; GLASS FIBER; IMIPRAMINE; LIPOXYGENASE INHIBITOR; NAPHTHALENE; PROTEIN; TRITIUM;

ANIMAL TISSUE; ARTICLE; AUTOMATION; BINDING AFFINITY; CENTRIFUGATION; CONTROLLED STUDY; CORRELATION ANALYSIS; COVALENT BOND; DEVICE; DRUG BINDING; DRUG STRUCTURE; EXTRACTION; FILTER; HUMAN; HUMAN TISSUE; ISOTOPE LABELING; LABORATORY TEST; LIVER MICROSOME; NONHUMAN; PRECIPITATION; RAT; REPRODUCIBILITY;

ANIMALS; AUTOMATION; CARBON RADIOISOTOPES; CENTRIFUGATION; DICLOFENAC; FILTRATION; HEPATOCYTES; HUMANS; MICROSOMES, LIVER; MOLECULAR STRUCTURE; NAPHTHALENES; PHARMACEUTICAL PREPARATIONS; PRECIPITATION; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; REPRODUCIBILITY OF RESULTS; SOLVENTS; TRITIUM;

EID: 23944461010     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2004.11.006     Document Type: Article

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