Metabolic activation of a novel 3-substituted indole-containing TNF-α inhibitor: Dehydrogenation and inactivation of CYP3A4

Chemical Research in Toxicology

Volumn 21, Issue 2, 2008, Pages 374-385

  Sun, Hao ^a   Yost, Garold S ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6,7 DIMETHYL 3 [[METHYL [2 [METHYL [1 (3 TRIFLUOROMETHYLPHENYL) 1H INDOL 3 YLMETHYL]AMINO]ETHYL]AMINO]METHYL]CHROMEN 4 ONE; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; GLUTATHIONE; SPD 304; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; CHROMAN DERIVATIVE; CYTOCHROME P450 3A; DRUG DERIVATIVE; ENZYME INHIBITOR; EPOXIDE; INDOLE DERIVATIVE; SKATOLE; SPD-304; UNCLASSIFIED DRUG;

ARTICLE; DEALKYLATION; DEHYDROGENATION; DRUG ACTIVATION; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME ACTIVE SITE; ENZYME INACTIVATION; EPOXIDATION; HUMAN; LIVER MICROSOME METABOLISM; MOLECULAR DOCKING; REACTION ANALYSIS; TANDEM MASS SPECTROMETRY; ALKYLATION; AUDIOVISUAL EQUIPMENT; CHEMISTRY; DRUG ANTAGONISM; DRUG INTERACTION; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGENATION; LIVER MICROSOME; METABOLISM;

ALKYLATION; CHROMANS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP3A; DRUG INTERACTIONS; ENZYME INHIBITORS; EPOXY COMPOUNDS; GLUTATHIONE; HUMANS; HYDROGENATION; INDOLES; MICROSOMES, LIVER; MODELS, STRUCTURAL; SKATOLE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 37549065671     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx700294g     Document Type: Article

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