Visualization of first-pass drug metabolism of terfenadine by MALDI-imaging mass spectrometry

Drug Metabolism Letters

Volumn 2, Issue 1, 2008, Pages 1-4

  Chen, Jiwen ^a,b   Hsieh, Yunsheng ^a   Knemeyer, Ian ^a   Crossman, Lee ^a   Korfmacher, Walter A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

First pass metabolism; Imaging mass spectrometry; MALDI

Indexed keywords

FEXOFENADINE; PRAVASTATIN; TERFENADINE; UNCLASSIFIED DRUG; ZIVAST;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; DRUG BIOAVAILABILITY; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG METABOLISM; FIRST PASS EFFECT; LIVER METABOLISM; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE;

ANIMALS; BIOLOGICAL AVAILABILITY; HISTAMINE H1 ANTAGONISTS, NON-SEDATING; INTESTINES; LIVER; MALE; MICE; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TERFENADINE; TISSUE DISTRIBUTION;

RATTUS;

EID: 40949111095     PISSN: 18723128     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231208783478461     Document Type: Article

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